Differential activities and mechanisms of the four R-spondins in potentiating Wnt/β-catenin signaling

R-spondins can potentiate WNT signaling without LGRs

(2018) Andres M Lebensohn et al.   eLife

LGR5 receptor promotes cell–cell adhesion in stem cells and colon cancer cells via the IQGAP1–Rac1 pathway

(2017) Kendra S. Carmon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Non-equivalence of Wnt and R-spondin ligands during Lgr5+ intestinal stem-cell self-renewal

(2017) Kelley S. Yan et al.   NATURE

Therapeutic Targeting of Tumor-Derived R-Spondin Attenuates  -Catenin Signaling and Tumorigenesis in Multiple Cancer Types

(2015) C. Chartier et al.   CANCER RESEARCH

Crystal structure of R-spondin 2 in complex with the ectodomains of its receptors LGR5 and ZNRF3

(2015) Matthias Zebisch et al.   JOURNAL OF STRUCTURAL BIOLOGY

Crystal Structure of LGR4-Rspo1 Complex

(2014) Jin-Gen Xu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Improved vectors and genome-wide libraries for CRISPR screening

(2014) Neville E Sanjana et al.   NATURE METHODS

Aberrant RSPO3-LGR4 signaling in Keap1-deficient lung adenocarcinomas promotes tumor aggressiveness

(2014) X Gong et al.   ONCOGENE

RSPO–LGR4 functions via IQGAP1 to potentiate Wnt signaling

(2014) Kendra S. Carmon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reconstitution of R-Spondin:LGR4:ZNRF3 Adult Stem Cell Growth Factor Signaling Complexes with Recombinant Proteins Produced in Escherichia coli

(2013) Heather E. Moad et al.   BIOCHEMISTRY

Interaction with both ZNRF3 and LGR4 is required for the signalling activity of R-spondin

(2013) Yang Xie et al.   EMBO REPORTS

The structural basis of R-spondin recognition by LGR5 and RNF43

(2013) P.-H. Chen et al.   GENES & DEVELOPMENT

Constitutive Internalization of the Leucine-rich G Protein-coupled Receptor-5 (LGR5) to the Trans-Golgi Network

(2013) Joshua C. Snyder et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Analysis of LGR4 Receptor Distribution in Human and Mouse Tissues

(2013) Jing Yi et al.   PLoS One

Crystal Structures of Lgr4 and Its Complex with R-Spondin1

(2013) Kai Xu et al.   STRUCTURE

Structural and molecular basis of ZNRF3/RNF43 transmembrane ubiquitin ligase inhibition by the Wnt agonist R-spondin

(2013) Matthias Zebisch et al.   Nature Communications

Structure of Stem Cell Growth Factor R-spondin 1 in Complex with the Ectodomain of Its Receptor LGR5

(2013) Weng Chuan Peng et al.   Cell Reports

LGR5 Interacts and Cointernalizes with Wnt Receptors To Modulate Wnt/ -Catenin Signaling

(2012) K. S. Carmon et al.   MOLECULAR AND CELLULAR BIOLOGY

Recurrent R-spondin fusions in colon cancer

(2012) Somasekar Seshagiri et al.   NATURE

ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner

(2012) Huai-Xiang Hao et al.   NATURE

Tumour suppressor RNF43 is a stem-cell E3 ligase that induces endocytosis of Wnt receptors

(2012) Bon-Kyoung Koo et al.   NATURE

R-Spondin Potentiates Wnt/β-Catenin Signaling through Orphan Receptors LGR4 and LGR5

(2012) Heinz Ruffner et al.   PLoS One

Rspo3 Binds Syndecan 4 and Induces Wnt/PCP Signaling via Clathrin-Mediated Endocytosis to Promote Morphogenesis

(2011) Bisei Ohkawara et al.   DEVELOPMENTAL CELL

LGR4 and LGR5 are R-spondin receptors mediating Wnt/β-catenin and Wnt/PCP signalling

(2011) Andrei Glinka et al.   EMBO REPORTS

Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling

(2011) Wim de Lau et al.   NATURE

R-spondins function as ligands of the orphan receptors LGR4 and LGR5 to regulate Wnt/ -catenin signaling

(2011) K. S. Carmon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

OLFM4 Is a Robust Marker for Stem Cells in Human Intestine and Marks a Subset of Colorectal Cancer Cells

(2009) Laurens G. van der Flier et al.   GASTROENTEROLOGY

Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

(2009) Toshiro Sato et al.   NATURE

The Wnt signaling regulator R-spondin 3 promotes angioblast and vascular development

(2008) O. Kazanskaya et al.   DEVELOPMENT

R-spondin 2 is required for normal laryngeal-tracheal, lung and limb morphogenesis

(2008) S. M. Bell et al.   DEVELOPMENT

R-Spondin Family Members Regulate the Wnt Pathway by a Common Mechanism

(2008) Kyung-Ah Kim et al.   MOLECULAR BIOLOGY OF THE CELL