RHBDD1 promotes colorectal cancer metastasis through the Wnt signaling pathway and its downstream target ZEB1

MEF2D Transduces Microenvironment Stimuli to ZEB1 to Promote Epithelial-Mesenchymal Transition and Metastasis in Colorectal Cancer

(2016) L. Su et al.   CANCER RESEARCH

ZEB1 drives epithelial-to-mesenchymal transition in lung cancer

(2016) Jill E. Larsen et al.   JOURNAL OF CLINICAL INVESTIGATION

Rhomboid intramembrane protease RHBDL4 triggers ER-export and non-canonical secretion of membrane-anchored TGFα

(2016) Lina Wunderle et al.   Scientific Reports

A Patient-Derived, Pan-Cancer EMT Signature Identifies Global Molecular Alterations and Immune Target Enrichment Following Epithelial-to-Mesenchymal Transition

(2015) M. P. Mak et al.   CLINICAL CANCER RESEARCH

Epithelial–mesenchymal transition in colorectal cancer metastasis: A system review

(2015) Hui Cao et al.   PATHOLOGY RESEARCH AND PRACTICE

Rhomboid domain containing 1 promotes colorectal cancer growth through activation of the EGFR signalling pathway

(2015) Wei Song et al.   Nature Communications

The Rhomboid-Like Superfamily: Molecular Mechanisms and Biological Roles

(2014) Matthew Freeman   Annual Review of Cell and Developmental Biology

Metastatic Stem Cells: Sources, Niches, and Vital Pathways

(2014) Thordur Oskarsson et al.   Cell Stem Cell

ASPP2 controls epithelial plasticity and inhibits metastasis through β-catenin-dependent regulation of ZEB1

(2014) Yihua Wang et al.   NATURE CELL BIOLOGY

CUL4A Induces Epithelial–Mesenchymal Transition and Promotes Cancer Metastasis by Regulating ZEB1 Expression

(2013) Yunshan Wang et al.   CANCER RESEARCH

Epithelial-mesenchymal plasticity in carcinoma metastasis

(2013) J. H. Tsai et al.   GENES & DEVELOPMENT

Colorectal cancer

(2013) Hermann Brenner et al.   LANCET

Multiplex Genome Engineering Using CRISPR/Cas Systems

(2013) L. Cong et al.   SCIENCE

Rhomboid family gene expression profiling in breast normal tissue and tumor samples

(2013) R. Canzoneri et al.   TUMOR BIOLOGY

Dependency of Colorectal Cancer on a TGF-β-Driven Program in Stromal Cells for Metastasis Initiation

(2012) Alexandre Calon et al.   CANCER CELL

Involvement of ZEB1 and E-cadherin in the invasion of lung squamous cell carcinoma

(2012) Jiaxing Zhang et al.   MOLECULAR BIOLOGY REPORTS

Ubiquitin-Dependent Intramembrane Rhomboid Protease Promotes ERAD of Membrane Proteins

(2012) Lina Fleig et al.   MOLECULAR CELL

Exosome-Related Multi-Pass Transmembrane Protein TSAP6 Is a Target of Rhomboid Protease RHBDD1-Induced Proteolysis

(2012) Chunhua Wan et al.   PLoS One

RHBDD2: a 5-fluorouracil responsive gene overexpressed in the advanced stages of colorectal cancer

(2012) Ezequiel Lacunza et al.   TUMOR BIOLOGY

Wnt Signaling in Cancer

(2012) P. Polakis   Cold Spring Harbor Perspectives in Biology

Tumor Metastasis: Molecular Insights and Evolving Paradigms

(2011) Scott Valastyan et al.   CELL

The Intestinal Stem Cell Signature Identifies Colorectal Cancer Stem Cells and Predicts Disease Relapse

(2011) Anna Merlos-Suárez et al.   Cell Stem Cell

 -catenin/TCF4 complex induces the epithelial-to-mesenchymal transition (EMT)-activator ZEB1 to regulate tumor invasiveness

(2011) E. Sanchez-Tillo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Perspective on Cancer Cell Metastasis

(2011) C. L. Chaffer et al.   SCIENCE

The rhomboid protease family: a decade of progress on function and mechanism

(2011) Sinisa Urban et al.   GENOME BIOLOGY

Single nucleotide polymorphisms in Wnt signaling and cell death pathway genes and susceptibility to colorectal cancer

(2010) B. Frank et al.   CARCINOGENESIS

Downregulation of miRNA-200c Links Breast Cancer Stem Cells with Normal Stem Cells

(2009) Yohei Shimono et al.   CELL

The EMT-activator ZEB1 promotes tumorigenicity by repressing stemness-inhibiting microRNAs

(2009) Ulrich Wellner et al.   NATURE CELL BIOLOGY

Rhomboid Proteases and their Biological Functions

(2008) Matthew Freeman   Annual Review of Genetics

The Transcriptional Repressor ZEB1 Promotes Metastasis and Loss of Cell Polarity in Cancer

(2008) S. Spaderna et al.   CANCER RESEARCH

A novel member of the Rhomboid family, RHBDD1, regulates BIK-mediated apoptosis

(2008) Y. Wang et al.   CELLULAR AND MOLECULAR LIFE SCIENCES