eATP/P2X7R Axis: An Orchestrated Pathway Triggering Inflammasome Activation in Muscle Diseases

Toward targeting inflammasomes: insights into their regulation and activation

(2020) Shelbi Christgen et al.   CELL RESEARCH

Connexin-43 reduction prevents muscle defects in a mouse model of manifesting Duchenne muscular dystrophy female carriers

(2020) Julie Nouet et al.   Scientific Reports

Pannexin 1 Channels as a Therapeutic Target: Structure, Inhibition, and Outlook

(2020) Kathleen E. Navis et al.   ACS Chemical Neuroscience

Purine Release, Metabolism, and Signaling in the Inflammatory Response

(2019) Joel Linden et al.   Annual Review of Immunology

The NLRP3 Inflammasome: An Overview of Mechanisms of Activation and Regulation

(2019) Nathan Kelley et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Macrophages Are Key Regulators of Stem Cells during Skeletal Muscle Regeneration and Diseases

(2019) Junio Dort et al.   Stem Cells International

Novel biologics targeting the P2X7 ion channel

(2019) Friedrich Koch-Nolte et al.   CURRENT OPINION IN PHARMACOLOGY

Blockade of the Adenosine A3 Receptor Attenuates Caspase 1 Activation in Renal Tubule Epithelial Cells and Decreases Interleukins IL-1β and IL-18 in Diabetic Rats

(2019) Wallys Garrido et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

ATP and adenosine: Role in the immunopathogenesis of rheumatoid arthritis

(2019) Jean L.G. da Silva et al.   IMMUNOLOGY LETTERS

Muscular dystrophies

(2019) Eugenio Mercuri et al.   LANCET

Pharmacological Inhibitors of the NLRP3 Inflammasome

(2019) Ayesha Zahid et al.   Frontiers in Immunology

The P2X7 receptor: A main player in inflammation

(2018) Elena Adinolfi et al.   BIOCHEMICAL PHARMACOLOGY

Modulation of innate and adaptive immunity by P2X ion channels

(2018) Francesco Di Virgilio et al.   CURRENT OPINION IN IMMUNOLOGY

Adenosine signaling and the immune system: When a lot could be too much

(2018) Luca Antonioli et al.   IMMUNOLOGY LETTERS

Expression of Pannexin 1 and Pannexin 3 during skeletal muscle development, regeneration, and Duchenne muscular dystrophy

(2018) Tammy L. Pham et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Diagnosis and management of Duchenne muscular dystrophy, part 3: primary care, emergency management, psychosocial care, and transitions of care across the lifespan

(2018) David J Birnkrant et al.   LANCET NEUROLOGY

The Elusive P2X7 Macropore

(2018) Francesco Di Virgilio et al.   TRENDS IN CELL BIOLOGY

P2RX7 Purinoceptor as a Therapeutic Target—The Second Coming?

(2018) Chris N. J. Young et al.   Frontiers in Chemistry

Zidovudine ameliorates pathology in the mouse model of Duchenne muscular dystrophy via P2RX7 purinoceptor antagonism

(2018) Rasha Al-Khalidi et al.   Acta Neuropathologica Communications

Targeting RAGE as a potential therapeutic approach to Duchenne muscular dystrophy

(2018) Roberta Sagheddu et al.   HUMAN MOLECULAR GENETICS

Re-evaluation of neuronal P2X7 expression using novel mouse models and a P2X7-specific nanobody

(2018) Karina Kaczmarek-Hajek et al.   eLife

Extracellular nucleotides and nucleosides as signalling molecules

(2018) Anna Lisa Giuliani et al.   IMMUNOLOGY LETTERS

The Danger Signal Extracellular ATP Is Involved in the Immunomediated Damage of α-Sarcoglycan–Deficient Muscular Dystrophy

(2018) Elisabetta Gazzerro et al.   AMERICAN JOURNAL OF PATHOLOGY

The P2X7 Receptor in Infection and Inflammation

(2017) Francesco Di Virgilio et al.   IMMUNITY

Endotoxin-induced autocrine ATP signaling inhibits neutrophil chemotaxis through enhancing myosin light chain phosphorylation

(2017) Xu Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

On the permeation of large organic cations through the pore of ATP-gated P2X receptors

(2017) Mahboubi Harkat et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The potential of P2X7 receptors as a therapeutic target, including inflammation and tumour progression

(2017) Geoffrey Burnstock et al.   Purinergic Signalling

The P2X7 receptor forms a dye-permeable pore independent of its intracellular domain but dependent on membrane lipid composition

(2017) Akira Karasawa et al.   eLife

Increased Number of Circulating CD8/CD26 T Cells in the Blood of Duchenne Muscular Dystrophy Patients Is Associated with Augmented Binding of Adenosine Deaminase and Higher Muscular Strength Scores

(2017) Jonathan H. Soslow et al.   Frontiers in Pharmacology

Coupling between Myogenesis and Angiogenesis during Skeletal Muscle Regeneration Is Stimulated by Restorative Macrophages

(2017) Claire Latroche et al.   Stem Cell Reports

Connexins and Pannexins in Bone and Skeletal Muscle

(2017) Lilian I. Plotkin et al.   Current Osteoporosis Reports

The NLRP3 and Pyrin Inflammasomes: Implications in the Pathophysiology of Autoinflammatory Diseases

(2017) Carlos de Torre-Minguela et al.   Frontiers in Immunology

The absence of dysferlin induces the expression of functional connexin-based hemichannels in human myotubes

(2016) Luis A. Cea et al.   BMC CELL BIOLOGY

NADPH oxidases in oxidant production by microglia: activating receptors, pharmacology and association with disease

(2016) J Haslund-Vinding et al.   BRITISH JOURNAL OF PHARMACOLOGY

Fast skeletal myofibers of mdx mouse, model of Duchenne muscular dystrophy, express connexin hemichannels that lead to apoptosis

(2016) Luis A. Cea et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Impact of P2RX7 ablation on the morphological, mechanical and tissue properties of bones in a murine model of duchenne muscular dystrophy

(2016) N.S. Mohamad et al.   JOURNAL OF BIOMECHANICS

NEK7 is an essential mediator of NLRP3 activation downstream of potassium efflux

(2016) Yuan He et al.   NATURE

Molecular circuitry of stem cell fate in skeletal muscle regeneration, ageing and disease

(2016) Albert E. Almada et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Tolerability and efficacy study of P2X7 inhibition in experimental Charcot-Marie-Tooth type 1A (CMT1A) neuropathy

(2016) Giovanna Sociali et al.   NEUROBIOLOGY OF DISEASE

P2X receptors

(2016) R. Alan North   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Nanobodies that block gating of the P2X7 ion channel ameliorate inflammation

(2016) W. Danquah et al.   Science Translational Medicine

Structural basis for subtype-specific inhibition of the P2X7 receptor

(2016) Akira Karasawa et al.   eLife

Effect of the IL-1 Receptor Antagonist Kineret® on Disease Phenotype in mdx Mice

(2016) Margaret E. Benny Klimek et al.   PLoS One

Enhancement of Muscle T Regulatory Cells and Improvement of Muscular Dystrophic Process in mdx Mice by Blockade of Extracellular ATP/P2X Axis

(2015) Elisabetta Gazzerro et al.   AMERICAN JOURNAL OF PATHOLOGY

A novel mechanism of autophagic cell death in dystrophic muscle regulated by P2RX7 receptor large-pore formation and HSP90

(2015) Christopher NJ Young et al.   Autophagy

Toll-like receptors: Activation, signalling and transcriptional modulation

(2015) Dominic De Nardo   CYTOKINE

NLRP3 activation and mitosis are mutually exclusive events coordinated by NEK7, a new inflammasome component

(2015) Hexin Shi et al.   NATURE IMMUNOLOGY

The P2X7 receptor is a key modulator of the PI3K/GSK3β/VEGF signaling network: evidence in experimental neuroblastoma

(2015) F Amoroso et al.   ONCOGENE

P2X7 receptor stimulates breast cancer cell invasion and migration via the AKT pathway

(2015) JIYI XIA et al.   ONCOLOGY REPORTS

P2RX7 Purinoceptor: A Therapeutic Target for Ameliorating the Symptoms of Duchenne Muscular Dystrophy

(2015) Anthony Sinadinos et al.   PLOS MEDICINE

P2X7 on Mouse T Cells: One Channel, Many Functions

(2015) Björn Rissiek et al.   Frontiers in Immunology

Upregulated IL-1β in dysferlin-deficient muscle attenuates regeneration by blunting the response to pro-inflammatory macrophages

(2015) Tatiana V. Cohen et al.   Skeletal Muscle

ROS Production via P2Y1-PKC-NOX2 Is Triggered by Extracellular ATP after Electrical Stimulation of Skeletal Muscle Cells

(2015) Alexis Díaz-Vegas et al.   PLoS One

Nucleotides Released From Palmitate-Challenged Muscle Cells Through Pannexin-3 Attract Monocytes

(2014) Nicolas J. Pillon et al.   DIABETES

Pannexin 1 and Pannexin 3 Channels Regulate Skeletal Muscle Myoblast Proliferation and Differentiation

(2014) Stéphanie Langlois et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

P2X7 Mediates ATP-Driven Invasiveness in Prostate Cancer Cells

(2014) Ying Qiu et al.   PLoS One

Nucleoside reverse transcriptase inhibitors possess intrinsic anti-inflammatory activity

(2014) B. J. Fowler et al.   SCIENCE

Regulatory T cells suppress muscle inflammation and injury in muscular dystrophy

(2014) S. A. Villalta et al.   Science Translational Medicine

ATP/P2X7 axis modulates myeloid-derived suppressor cell functions in neuroblastoma microenvironment

(2014) G Bianchi et al.   Cell Death & Disease

Pannexin 1 channels in skeletal muscles

(2014) Luis A. Cea et al.   Frontiers in Physiology

A Special Population of Regulatory T Cells Potentiates Muscle Repair

(2013) Dalia Burzyn et al.   CELL

Effect of the Purinergic Inhibitor Oxidized ATP in a Model of Islet Allograft Rejection

(2013) A. Vergani et al.   DIABETES

The effect of P2X7 receptor activation on nuclear factor-kappa B phosphorylation induced by status epilepticus in the rat hippocampus

(2013) Ji-Eun Kim et al.   HIPPOCAMPUS

K+ Efflux Is the Common Trigger of NLRP3 Inflammasome Activation by Bacterial Toxins and Particulate Matter

(2013) Raúl Muñoz-Planillo et al.   IMMUNITY

Cav1.1 controls frequency-dependent events regulating adult skeletal muscle plasticity

(2013) G. Jorquera et al.   JOURNAL OF CELL SCIENCE

P2X Receptor Intermediate Activation States Have Altered Nucleotide Selectivity

(2013) L. E. Browne et al.   JOURNAL OF NEUROSCIENCE

The ATP required for potentiation of skeletal muscle contraction is released via pannexin hemichannels

(2013) Manuel A. Riquelme et al.   NEUROPHARMACOLOGY

Satellite Cells and the Muscle Stem Cell Niche

(2013) Hang Yin et al.   PHYSIOLOGICAL REVIEWS

P2X7 Cell Death Receptor Activation and Mitochondrial Impairment in Oxaliplatin-Induced Apoptosis and Neuronal Injury: Cellular Mechanisms and In Vivo Approach

(2013) France Massicot et al.   PLoS One

Immunogenic Cell Death in Cancer Therapy

(2012) Guido Kroemer et al.   Annual Review of Immunology

Paracrine signaling through plasma membrane hemichannels

(2012) Nan Wang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

The participation of plasma membrane hemichannels to purinergic signaling

(2012) Alberto Baroja-Mazo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

P2X7 Receptors: Channels, Pores and More

(2012) C. Volonte et al.   CNS & Neurological Disorders-Drug Targets

Electrical Stimuli Release ATP to Increase GLUT4 Translocation and Glucose Uptake via PI3K -Akt-AS160 in Skeletal Muscle Cells

(2012) C. Osorio-Fuentealba et al.   DIABETES

Purinergic P2X7 Receptor Drives T Cell Lineage Choice and Shapes Peripheral    Cells

(2012) M. Frascoli et al.   JOURNAL OF IMMUNOLOGY

Connexin- and Pannexin-Based Channels in Normal Skeletal Muscles and Their Possible Role in Muscle Atrophy

(2012) Luis A. Cea et al.   JOURNAL OF MEMBRANE BIOLOGY

Adora2b Adenosine Receptor Engagement Enhances Regulatory T Cell Abundance during Endotoxin-Induced Pulmonary Inflammation

(2012) Heidi Ehrentraut et al.   PLoS One

Pharmacologic P2X purinergic receptor antagonism in the treatment of collagen-induced arthritis

(2011) Vittoria Ardissone et al.   ARTHRITIS AND RHEUMATISM

Adenosine promotes alternative macrophage activation via A2A and A2B receptors

(2011) Balázs Csóka et al.   FASEB JOURNAL

P2X7 purinoceptor alterations in dystrophic mdx mouse muscles: relationship to pathology and potential target for treatment

(2011) Christopher N. J. Young et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

IFN-γ Promotes Muscle Damage in the mdx Mouse Model of Duchenne Muscular Dystrophy by Suppressing M2 Macrophage Activation and Inhibiting Muscle Cell Proliferation

(2011) S. Armando Villalta et al.   JOURNAL OF IMMUNOLOGY

Extracellular ATP signaling during differentiation of C2C12 skeletal muscle cells: role in proliferation

(2011) Tiziana Martinello et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

ATP Inhibits the Generation and Function of Regulatory T Cells Through the Activation of Purinergic P2X Receptors

(2011) U. Schenk et al.   Science Signaling

Inflammasome Up-Regulation and Activation in Dysferlin-Deficient Skeletal Muscle

(2010) Rashmi Rawat et al.   AMERICAN JOURNAL OF PATHOLOGY

Regulatory interactions between muscle and the immune system during muscle regeneration

(2010) James G. Tidball et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Microglia: Proliferation and activation driven by the P2X7 receptor

(2010) Mastura Monif et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Diadenosine Homodinucleotide Products of ADP-ribosyl Cyclases Behave as Modulators of the Purinergic Receptor P2X7

(2010) Santina Bruzzone et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Immunological and Inflammatory Functions of the Interleukin-1 Family

(2009) Charles A. Dinarello   Annual Review of Immunology

P2X7-mediated Increased Intracellular Calcium Causes Functional Derangement in Schwann Cells from Rats with CMT1A Neuropathy

(2009) Lucilla Nobbio et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Biglycan, a Danger Signal That Activates the NLRP3 Inflammasome via Toll-like and P2X Receptors

(2009) Andrea Babelova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The A2B Adenosine Receptor Impairs the Maturation and Immunogenicity of Dendritic Cells

(2009) J. M. Wilson et al.   JOURNAL OF IMMUNOLOGY

Molecular mechanisms involved in inflammasome activation

(2009) Clare Bryant et al.   TRENDS IN CELL BIOLOGY