Macrophages Are Key Regulators of Stem Cells during Skeletal Muscle Regeneration and Diseases

Aging-related effects of bed rest followed by eccentric exercise rehabilitation on skeletal muscle macrophages and insulin sensitivity

(2018) Paul T. Reidy et al.   EXPERIMENTAL GERONTOLOGY

Recruitment and therapeutic application of macrophages in skeletal muscles after hind limb ischemia

(2018) Pei-Ling Hsieh et al.   JOURNAL OF VASCULAR SURGERY

Mesenchymal stem cells and extracellular matrix scaffold promote muscle regeneration by synergistically regulating macrophage polarization toward the M2 phenotype

(2018) Xinyu Qiu et al.   Stem Cell Research & Therapy

Skeletal muscle in aged mice reveals extensive transformation of muscle gene expression

(2018) I-Hsuan Lin et al.   BMC GENETICS

Aging of the immune system causes reductions in muscle stem cell populations, promotes their shift to a fibrogenic phenotype, and modulates sarcopenia

(2018) Ying Wang et al.   FASEB JOURNAL

Dynamics of cellular states of fibro-adipogenic progenitors during myogenesis and muscular dystrophy

(2018) Barbora Malecova et al.   Nature Communications

Incorporation of macrophages into engineered skeletal muscle enables enhanced muscle regeneration

(2018) Mark Juhas et al.   Nature Biomedical Engineering

Muscle Satellite Cell Cross-Talk with a Vascular Niche Maintains Quiescence via VEGF and Notch Signaling

(2018) Mayank Verma et al.   Cell Stem Cell

AMPK Activation Regulates LTBP4-Dependent TGF-β1 Secretion by Pro-inflammatory Macrophages and Controls Fibrosis in Duchenne Muscular Dystrophy

(2018) Gaëtan Juban et al.   Cell Reports

Involvement of JNK signaling in IL4-induced M2 macrophage polarization

(2017) Jin Hao et al.   EXPERIMENTAL CELL RESEARCH

CCR2 deficiency does not provide sustained improvement of muscular dystrophy in mdx5cv mice

(2017) Wanming Zhao et al.   FASEB JOURNAL

In situ macrophage phenotypic transition is affected by altered cellular composition prior to acute sterile muscle injury

(2017) Andreas Patsalos et al.   JOURNAL OF PHYSIOLOGY-LONDON

Prostaglandin E2 is essential for efficacious skeletal muscle stem-cell function, augmenting regeneration and strength

(2017) Andrew T. V. Ho et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Macrophage-released ADAMTS1 promotes muscle stem cell activation

(2017) Hongqing Du et al.   Nature Communications

IGF1 Shapes Macrophage Activation in Response to Immunometabolic Challenge

(2017) Olga Spadaro et al.   Cell Reports

Coupling between Myogenesis and Angiogenesis during Skeletal Muscle Regeneration Is Stimulated by Restorative Macrophages

(2017) Claire Latroche et al.   Stem Cell Reports

Spatially localized recruitment of anti-inflammatory monocytes by SDF-1α-releasing hydrogels enhances microvascular network remodeling

(2016) J.R. Krieger et al.   BIOMATERIALS

Safety and Therapeutic Potential of M2 Macrophages in Stroke Treatment

(2016) Elena R. Chernykh et al.   CELL TRANSPLANTATION

Macrophage PPARγ, a Lipid Activated Transcription Factor Controls the Growth Factor GDF3 and Skeletal Muscle Regeneration

(2016) Tamas Varga et al.   IMMUNITY

M2 Macrophage Transplantation Ameliorates Cognitive Dysfunction in Amyloid-β-Treated Rats Through Regulation of Microglial Polarization

(2016) Dan Zhu et al.   JOURNAL OF ALZHEIMERS DISEASE

Osteopontin ablation ameliorates muscular dystrophy by shifting macrophages to a pro-regenerative phenotype

(2016) Joana Capote et al.   JOURNAL OF CELL BIOLOGY

Highly Dynamic Transcriptional Signature of Distinct Macrophage Subsets during Sterile Inflammation, Resolution, and Tissue Repair

(2016) Tamas Varga et al.   JOURNAL OF IMMUNOLOGY

Divergent impact of Toll-like receptor 2 deficiency on repair mechanisms in healthy muscle versus Duchenne muscular dystrophy

(2016) Kamalika Mojumdar et al.   JOURNAL OF PATHOLOGY

Inflammation et régénération musculaire

(2016) Sébastien S. Dufresne et al.   M S-MEDECINE SCIENCES

Effects of fish oil containing eicosapentaenoic acid and docosahexaenoic acid on dystrophic mdx mice hearts at later stages of dystrophy

(2016) Adriana Fogagnolo Mauricio et al.   NUTRITION

Patrolling monocytes promote intravascular neutrophil activation and glomerular injury in the acutely inflamed glomerulus

(2016) Michaela Finsterbusch et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RNAi targeting multiple cell adhesion molecules reduces immune cell recruitment and vascular inflammation after myocardial infarction

(2016) Hendrik B. Sager et al.   Science Translational Medicine

MiRNA-Mediated Macrophage Polarization and its Potential Role in the Regulation of Inflammatory Response

(2016) Kobina Essandoh et al.   SHOCK

Shrimp Protein Hydrolysate Modulates the Timing of Proinflammatory Macrophages in Bupivacaine-Injured Skeletal Muscles in Rats

(2016) Junio Dort et al.   Biomed Research International

Biomaterial-based delivery for skeletal muscle repair

(2015) Christine A. Cezar et al.   ADVANCED DRUG DELIVERY REVIEWS

Increases of M2a macrophages and fibrosis in aging muscle are influenced by bone marrow aging and negatively regulated by muscle-derived nitric oxide

(2015) Ying Wang et al.   AGING CELL

Selective Retinoic Acid Receptor γ Agonists Promote Repair of Injured Skeletal Muscle in Mouse

(2015) Agnese Di Rocco et al.   AMERICAN JOURNAL OF PATHOLOGY

Long-Term Therapy With Omega-3 Ameliorates Myonecrosis and Benefits Skeletal Muscle Regeneration inMdxMice

(2015) Leticia Montanholi Apolinário et al.   Anatomical Record-Advances in Integrative Anatomy and Evolutionary Biology

Biomaterials based strategies for skeletal muscle tissue engineering: Existing technologies and future trends

(2015) Taimoor H. Qazi et al.   BIOMATERIALS

Involvement of IGF-1 and Akt in M1/M2 activation state in bone marrow-derived macrophages

(2015) James P. Barrett et al.   EXPERIMENTAL CELL RESEARCH

miR-132 inhibits lipopolysaccharide-induced inflammation in alveolar macrophages by the cholinergic anti-inflammatory pathway

(2015) Fen Liu et al.   EXPERIMENTAL LUNG RESEARCH

Silencing collapsin response mediator protein-2 reprograms macrophage phenotype and improves infarct healing in experimental myocardial infarction model

(2015) Long-Shu Zhou et al.   Journal of Inflammation-London

Monocyte/Macrophage-derived IGF-1 Orchestrates Murine Skeletal Muscle Regeneration and Modulates Autocrine Polarization

(2015) Joanne Tonkin et al.   MOLECULAR THERAPY

Dystrophin expression in muscle stem cells regulates their polarity and asymmetric division

(2015) Nicolas A Dumont et al.   NATURE MEDICINE

Nilotinib reduces muscle fibrosis in chronic muscle injury by promoting TNF-mediated apoptosis of fibro/adipogenic progenitors

(2015) Dario R Lemos et al.   NATURE MEDICINE

Macrophages decide between regeneration and fibrosis in muscle

(2015) Pura Muñoz-Cánoves et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Lack of robust satellite cell activation and muscle regeneration during the progression of Pompe disease

(2015) Gerben J. Schaaf et al.   Acta Neuropathologica Communications

Toll-like receptor 4 ablation in mdx mice reveals innate immunity as a therapeutic target in Duchenne muscular dystrophy

(2015) Christian Giordano et al.   HUMAN MOLECULAR GENETICS

The Development of Macrophage-Mediated Cell Therapy to Improve Skeletal Muscle Function after Injury

(2015) Viktoriya Rybalko et al.   PLoS One

Strain-dependent modulation of macrophage polarization within scaffolds

(2014) Virginia Ballotta et al.   BIOMATERIALS

Macrophage polarization in response to ECM coated polypropylene mesh

(2014) Matthew T. Wolf et al.   BIOMATERIALS

The role of macrophage phenotype in vascularization of tissue engineering scaffolds

(2014) Kara L. Spiller et al.   BIOMATERIALS

Tissue-Specific Signals Control Reversible Program of Localization and Functional Polarization of Macrophages

(2014) Yasutaka Okabe et al.   CELL

Clinical Experience with Autologous M2 Macrophages in Children with Severe Cerebral Palsy

(2014) Elena R. Chernykh et al.   CELL TRANSPLANTATION

Physical and mechanical regulation of macrophage phenotype and function

(2014) Frances Y. McWhorter et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Inflammatory monocytes promote progression of Duchenne muscular dystrophy and can be therapeutically targeted via CCR2

(2014) K. Mojumdar et al.   EMBO Molecular Medicine

Macrophage Activation and Polarization: Nomenclature and Experimental Guidelines

(2014) Peter J. Murray et al.   IMMUNITY

Transcriptome-Based Network Analysis Reveals a Spectrum Model of Human Macrophage Activation

(2014) Jia Xue et al.   IMMUNITY

Gamma-tocotrienol attenuates high-fat diet-induced obesity and insulin resistance by inhibiting adipose inflammation and M1 macrophage recruitment

(2014) L Zhao et al.   INTERNATIONAL JOURNAL OF OBESITY

Asynchronous remodeling is a driver of failed regeneration in Duchenne muscular dystrophy

(2014) Sherry Dadgar et al.   JOURNAL OF CELL BIOLOGY

Rac2 Controls Tumor Growth, Metastasis and M1-M2 Macrophage Differentiation In Vivo

(2014) Shweta Joshi et al.   PLoS One

Pericytes: multitasking cells in the regeneration of injured, diseased, and aged skeletal muscle

(2014) Alexander Birbrair et al.   Frontiers in Aging Neuroscience

Rethinking Regenerative Medicine: A Macrophage-Centered Approach

(2014) Bryan N. Brown et al.   Frontiers in Immunology

Impact of 3-D printed PLA- and chitosan-based scaffolds on human monocyte/macrophage responses: Unraveling the effect of 3-D structures on inflammation

(2013) Catarina R. Almeida et al.   Acta Biomaterialia

Macrophage functional polarization (M1/M2) in response to varying fiber and pore dimensions of electrospun scaffolds

(2013) Koyal Garg et al.   BIOMATERIALS

Angiogenic capacity of M1- and M2-polarized macrophages is determined by the levels of TIMP-1 complexed with their secreted proMMP-9

(2013) E. Zajac et al.   BLOOD

Monocyte depletion increases local proliferation of macrophage subsets after skeletal muscle injury

(2013) Claude H Côté et al.   BMC MUSCULOSKELETAL DISORDERS

Cell plasticity in wound healing: paracrine factors of M1/ M2 polarized macrophages influence the phenotypical state of dermal fibroblasts

(2013) Diana TA Ploeger et al.   Cell Communication and Signaling

AMPKα1 Regulates Macrophage Skewing at the Time of Resolution of Inflammation during Skeletal Muscle Regeneration

(2013) Rémi Mounier et al.   Cell Metabolism

Fibroadipogenic progenitors mediate the ability of HDAC inhibitors to promote regeneration in dystrophic muscles of young, but not old Mdx mice

(2013) Chiara Mozzetta et al.   EMBO Molecular Medicine

Cellular dynamics in the muscle satellite cell niche

(2013) C Florian Bentzinger et al.   EMBO REPORTS

Tissue-Resident Macrophages Self-Maintain Locally throughout Adult Life with Minimal Contribution from Circulating Monocytes

(2013) Daigo Hashimoto et al.   IMMUNITY

Glucocorticoid-induced skeletal muscle atrophy

(2013) O. Schakman et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

MicroRNA-9 regulates the expression of peroxisome proliferator-activated receptor δ in human monocytes during the inflammatory response

(2013) PETRA THULIN et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Progress in microRNA delivery

(2013) Yu Zhang et al.   JOURNAL OF CONTROLLED RELEASE

MicroRNA let-7c Regulates Macrophage Polarization

(2013) S. Banerjee et al.   JOURNAL OF IMMUNOLOGY

Akt2 Deficiency Protects from Acute Lung Injury via Alternative Macrophage Activation and miR-146a Induction in Mice

(2013) E. Vergadi et al.   JOURNAL OF IMMUNOLOGY

Macrophage activation and skeletal muscle healing following traumatic injury

(2013) Margaret L Novak et al.   JOURNAL OF PATHOLOGY

IL-4/IL-13-Dependent and Independent Expression of miR-124 and Its Contribution to M2 Phenotype of Monocytic Cells in Normal Conditions and during Allergic Inflammation

(2013) Tatyana Veremeyko et al.   PLoS One

Beneficial Effects of Cod Protein on Inflammatory Cell Accumulation in Rat Skeletal Muscle after Injury Are Driven by Its High Levels of Arginine, Glycine, Taurine and Lysine

(2013) Junio Dort et al.   PLoS One

Nitric Oxide Controls Fat Deposition in Dystrophic Skeletal Muscle by Regulating Fibro-Adipogenic Precursor Differentiation

(2013) Nicoletta Cordani et al.   STEM CELLS

Intra-articular controlled release of anti-inflammatory siRNA with biodegradable polymer microparticles ameliorates temporomandibular joint inflammation

(2012) Paschalia M. Mountziaris et al.   Acta Biomaterialia

Tunable hydrogel-microsphere composites that modulate local inflammation and collagen bulking

(2012) Elena Tous et al.   Acta Biomaterialia

Beneficial effects of cod protein on skeletal muscle repair following injury

(2012) Junio Dort et al.   Applied Physiology Nutrition and Metabolism

The effect of source animal age upon the in vivo remodeling characteristics of an extracellular matrix scaffold

(2012) Brian M. Sicari et al.   BIOMATERIALS

Macrophage polarization: An opportunity for improved outcomes in biomaterials and regenerative medicine

(2012) Bryan N. Brown et al.   BIOMATERIALS

Angiogenic neutrophils: a novel subpopulation paradigm

(2012) E. Kolaczkowska et al.   BLOOD

Endothelial cells provide an instructive niche for the differentiation and functional polarization of M2-like macrophages

(2012) H. He et al.   BLOOD

Omega-3 polyunsaturated fatty acids and inflammatory processes: nutrition or pharmacology?

(2012) Philip C. Calder   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Interleukin-6/Signal Transducer and Activator of Transcription 3 (STAT3) Pathway Is Essential for Macrophage Infiltration and Myoblast Proliferation during Muscle Regeneration

(2012) Congcong Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Efficient Clearance of Early Apoptotic Cells by Human Macrophages Requires M2c Polarization and MerTK Induction

(2012) G. Zizzo et al.   JOURNAL OF IMMUNOLOGY

IL-10 Triggers Changes in Macrophage Phenotype That Promote Muscle Growth and Regeneration

(2012) B. Deng et al.   JOURNAL OF IMMUNOLOGY

Proinflammatory Macrophages Enhance the Regenerative Capacity of Human Myoblasts by Modifying Their Kinetics of Proliferation and Differentiation

(2012) Maximilien Bencze et al.   MOLECULAR THERAPY

Low Macrophage Accumulation in Skeletal Muscle of Obese Type 2 Diabetics and Elderly Subjects

(2012) Charmaine S. Tam et al.   Obesity

Omega-3 Polyunsaturated Fatty Acids Antagonize Macrophage Inflammation via Activation of AMPK/SIRT1 Pathway

(2012) Bingzhong Xue et al.   PLoS One

A Lineage of Myeloid Cells Independent of Myb and Hematopoietic Stem Cells

(2012) C. Schulz et al.   SCIENCE

Differentially Activated Macrophages Orchestrate Myogenic Precursor Cell Fate During Human Skeletal Muscle Regeneration

(2012) Marielle Saclier et al.   STEM CELLS

Implantable Devices: Issues and Challenges

(2012) Kateryna Bazaka et al.   Electronics

Satellite cells, connective tissue fibroblasts and their interactions are crucial for muscle regeneration

(2011) M. M. Murphy et al.   DEVELOPMENT

A quantifiable proliferative burst of tissue macrophages restores homeostatic macrophage populations after acute inflammation

(2011) Luke C. Davies et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Acute skeletal muscle injury: CCL2 expression by both monocytes and injured muscle is required for repair

(2011) Haiyan Lu et al.   FASEB JOURNAL

Vitamin D3: a helpful immuno-modulator

(2011) Michelino Di Rosa et al.   IMMUNOLOGY

p38/MKP-1–regulated AKT coordinates macrophage transitions and resolution of inflammation during tissue repair

(2011) Eusebio Perdiguero et al.   JOURNAL OF CELL BIOLOGY

An unrestrained proinflammatory M1 macrophage population induced by iron impairs wound healing in humans and mice

(2011) Anca Sindrilaru et al.   JOURNAL OF CLINICAL INVESTIGATION

MicroRNA-125b Potentiates Macrophage Activation

(2011) Aadel A. Chaudhuri et al.   JOURNAL OF IMMUNOLOGY

Macrophages in Injured Skeletal Muscle: A Perpetuum Mobile Causing and Limiting Fibrosis, Prompting or Restricting Resolution and Regeneration

(2011) Lidia Bosurgi et al.   Frontiers in Immunology

Induction of specific macrophage subtypes by defined micro-patterned structures

(2010) Matthias Bartneck et al.   Acta Biomaterialia

Macrophages Protect against Muscle Atrophy and Promote Muscle Recovery in Vivo and in Vitro

(2010) Nicolas Dumont et al.   AMERICAN JOURNAL OF PATHOLOGY

Regulation of skeletal muscle regeneration by CCR2-activating chemokines is directly related to macrophage recruitment

(2010) Carlo O. Martinez et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Regulatory interactions between muscle and the immune system during muscle regeneration

(2010) James G. Tidball et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Cytosolic phospholipase A2α gene silencing in the myeloid lineage alters development of Th1 responses and reduces disease severity in collagen-induced arthritis

(2010) G. Courties et al.   ARTHRITIS AND RHEUMATISM

Taurine supplementation decreases oxidative stress in skeletal muscle after eccentric exercise

(2010) Luciano A. Silva et al.   CELL BIOCHEMISTRY AND FUNCTION

Vitamin D: modulator of the immune system

(2010) Femke Baeke et al.   CURRENT OPINION IN PHARMACOLOGY

Macrophages recruited via CCR2 produce insulin-like growth factor-1 to repair acute skeletal muscle injury

(2010) Haiyan Lu et al.   FASEB JOURNAL

Activation of human mononuclear cells by porcine biologic meshes in vitro

(2010) S. B. Orenstein et al.   Hernia

Interleukin-10 reduces the pathology of mdx muscular dystrophy by deactivating M1 macrophages and modulating macrophage phenotype

(2010) S. A. Villalta et al.   HUMAN MOLECULAR GENETICS

The Interleukin 13 (IL-13) Pathway in Human Macrophages Is Modulated by MicroRNA-155 via Direct Targeting of Interleukin 13 Receptor α1 (IL13Rα1)

(2010) Rocio T. Martinez-Nunez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Biomaterial topography alters healing in vivo and monocyte/macrophage activation in vitro

(2010) Paige C. S. Bota et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Mesenchymal progenitors distinct from satellite cells contribute to ectopic fat cell formation in skeletal muscle

(2010) Akiyoshi Uezumi et al.   NATURE CELL BIOLOGY

Muscle injury activates resident fibro/adipogenic progenitors that facilitate myogenesis

(2010) Aaron W. B. Joe et al.   NATURE CELL BIOLOGY

Arginine Metabolism by Macrophages Promotes Cardiac and Muscle Fibrosis in mdx Muscular Dystrophy

(2010) Michelle Wehling-Henricks et al.   PLoS One

Omega-3 Fatty Acids and Inflammatory Processes

(2010) Philip C. Calder   Nutrients

Macrophage phenotype and remodeling outcomes in response to biologic scaffolds with and without a cellular component

(2009) Bryan N. Brown et al.   BIOMATERIALS

Role of antioxidant activity of taurine in diabetesThis article is one of a selection of papers from the NATO Advanced Research Workshop on Translational Knowledge for Heart Health (published in part 1 of a 2-part Special Issue).

(2009) Stephen W. Schaffer et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

Autocrine and Paracrine Angiopoietin 1/Tie-2 Signaling Promotes Muscle Satellite Cell Self-Renewal

(2009) Rana Abou-Khalil et al.   Cell Stem Cell

Defective Phagocytosis of Apoptotic Cells by Macrophages in Atherosclerotic Lesions of ob/ob Mice and Reversal by a Fish Oil Diet

(2009) Suzhao Li et al.   CIRCULATION RESEARCH

Interleukin-10: new perspectives on an old cytokine

(2009) David M. Mosser et al.   IMMUNOLOGICAL REVIEWS

Acceleration of muscle regeneration by local injection of muscle-specific microRNAs in rat skeletal muscle injury model

(2009) Tomoyuki Nakasa et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

A CREB-C/EBP  cascade induces M2 macrophage-specific gene expression and promotes muscle injury repair

(2009) D. Ruffell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Perioperative Glycine Treatment Attenuates Ischemia/Reperfusion Injury and Ameliorates Smooth Muscle Dysfunction in Intestinal Transplantation

(2009) Nico Schaefer et al.   TRANSPLANTATION

The Nuclear Factor NF- B Pathway in Inflammation

(2009) T. Lawrence   Cold Spring Harbor Perspectives in Biology

l-Arginine Decreases Inflammation and Modulates the Nuclear Factor-κB/Matrix Metalloproteinase Cascade in Mdx Muscle Fibers

(2008) Karim Hnia et al.   AMERICAN JOURNAL OF PATHOLOGY

Glycine regulates the production of pro-inflammatory cytokines in lean and monosodium glutamate-obese mice

(2008) F.J. Alarcon-Aguilar et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Bone marrow-derived cell regulation of skeletal muscle regeneration

(2008) Dongxu Sun et al.   FASEB JOURNAL

Fibrinogen drives dystrophic muscle fibrosis via a TGF /alternative macrophage activation pathway

(2008) B. Vidal et al.   GENES & DEVELOPMENT

Shifts in macrophage phenotypes and macrophage competition for arginine metabolism affect the severity of muscle pathology in muscular dystrophy

(2008) S. A. Villalta et al.   HUMAN MOLECULAR GENETICS

An antiinflammatory role for IKKβ through the inhibition of “classical” macrophage activation

(2008) Carol Ho Yan Fong et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The Inflammatory Response to Skeletal Muscle Injury

(2008) Carine Smith et al.   SPORTS MEDICINE

Macrophage Phenotype as a Determinant of Biologic Scaffold Remodeling

(2008) Stephen F. Badylak et al.   TISSUE ENGINEERING PART A