P2X7 Cell Death Receptor Activation and Mitochondrial Impairment in Oxaliplatin-Induced Apoptosis and Neuronal Injury: Cellular Mechanisms and In Vivo Approach

Dynamic Increase in Extracellular ATP Accelerates Photoreceptor Cell Apoptosis via Ligation of P2RX7 in Subretinal Hemorrhage

(2013) Shoji Notomi et al.   PLoS One

The music of lipids: How lipid composition orchestrates cellular behaviour

(2012) Zachary T. Schug et al.   ACTA ONCOLOGICA

P2X7 Receptors: Channels, Pores and More

(2012) C. Volonte et al.   CNS & Neurological Disorders-Drug Targets

Mitochondrial dysfunction is involved in P2X7 receptor-mediated neuronal cell death

(2012) Kentaro Nishida et al.   JOURNAL OF NEUROCHEMISTRY

Oxaliplatin-Induced Neuropathy: Oxidative Stress as Pathological Mechanism. Protective Effect of Silibinin

(2012) Lorenzo Di Cesare Mannelli et al.   JOURNAL OF PAIN

N-Acetyl-Cysteine Causes Analgesia by Reinforcing the Endogenous Activation of Type-2 Metabotropic Glutamate Receptors

(2012) Matteo Bernabucci et al.   Molecular Pain

Genetically determined P2X7 receptor pore formation regulates variability in chronic pain sensitivity

(2012) Robert E Sorge et al.   NATURE MEDICINE

Antinociceptive effects of fluoxetine in a mouse model of anxiety/depression

(2012) Guillaume Hache et al.   NEUROREPORT

Cortical effect of oxaliplatin associated with sustained neuropathic pain: Exacerbation of cortical activity and down-regulation of potassium channel expression in somatosensory cortex

(2012) Karine Thibault et al.   PAIN

Hyaluronan Fragments Improve Wound Healing on In Vitro Cutaneous Model through P2X7 Purinoreceptor Basal Activation: Role of Molecular Weight

(2012) Kamelia Ghazi et al.   PLoS One

Anticancer drug oxaliplatin induces acute cooling-aggravated neuropathy via sodium channel subtype NaV1.6-resurgent and persistent current

(2012) R. Sittl et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Oxaliplatin-induced cold hypersensitivity is due to remodelling of ion channel expression in nociceptors

(2011) Juliette Descoeur et al.   EMBO Molecular Medicine

Goshajinkigan reduces oxaliplatin-induced peripheral neuropathy without affecting anti-tumour efficacy in rodents

(2011) Soichiro Ushio et al.   EUROPEAN JOURNAL OF CANCER

Purinergic systems, neuropathic pain and the role of microglia

(2011) Kazuhide Inoue et al.   EXPERIMENTAL NEUROLOGY

Delayed treatment with vitamin C and N-acetyl-l-cysteine protects Schwann cells without compromising the anti-myeloma activity of bortezomib

(2011) Ayako Nakano et al.   INTERNATIONAL JOURNAL OF HEMATOLOGY

Role of prostaglandin E2 in the synthesis of the pro-inflammatory cytokine interleukin-6 in primary sensory neurons: an in vivo and in vitro study

(2011) Bruno St-Jacques et al.   JOURNAL OF NEUROCHEMISTRY

Peripheral Nerve Injury Alters Blood-Spinal Cord Barrier Functional and Molecular Integrity through a Selective Inflammatory Pathway

(2011) S. Echeverry et al.   JOURNAL OF NEUROSCIENCE

P2X7 receptor blockade prevents ATP excitotoxicity in neurons and reduces brain damage after ischemia

(2011) Joana Arbeloa et al.   NEUROBIOLOGY OF DISEASE

Oxaliplatin elicits mechanical and cold allodynia in rodents via TRPA1 receptor stimulation

(2011) Romina Nassini et al.   PAIN

Paclitaxel therapy potentiates cold hyperalgesia in streptozotocin-induced diabetic rats through enhanced mitochondrial reactive oxygen species production and TRPA1 sensitization

(2011) David André Barrière et al.   PAIN

Differential involvement of mitochondrial dysfunction, cytochrome P450 activity, and active transport in the toxicity of structurally related NSAIDs

(2011) Jolanda S. van Leeuwen et al.   TOXICOLOGY IN VITRO

Utilizing natural activity to dissect the pathophysiology of acute oxaliplatin-induced neuropathy

(2010) Susanna B. Park et al.   EXPERIMENTAL NEUROLOGY

Caspase-1 is Involved in the Genesis of Inflammatory Hypernociception by Contributing to Peripheral IL-1β Maturation

(2010) Thiago M Cunha et al.   Molecular Pain

Sensitization of Capsaicin and Icilin Responses in Oxaliplatin Treated Adult Rat DRG Neurons

(2010) Uma Anand et al.   Molecular Pain

Macrophage inflammatory protein-1α mediates the development of neuropathic pain following peripheral nerve injury through interleukin-1β up-regulation

(2010) Norikazu Kiguchi et al.   PAIN

Central sensitization: Implications for the diagnosis and treatment of pain

(2010) Clifford J. Woolf   PAIN

Discovery and Biological Evaluation of Novel Cyanoguanidine P2X7Antagonists with Analgesic Activity in a Rat Model of Neuropathic Pain

(2009) Arturo Perez-Medrano et al.   JOURNAL OF MEDICINAL CHEMISTRY

Persistent Pain Is Dependent on Spinal Mitochondrial Antioxidant Levels

(2009) E. S. Schwartz et al.   JOURNAL OF NEUROSCIENCE

Comparison of Oxaliplatin- and Cisplatin-Induced Painful Peripheral Neuropathy in the Rat

(2009) Elizabeth K. Joseph et al.   JOURNAL OF PAIN

New insights into the biotransformation and pharmacokinetics of oxaliplatin

(2009) Elin Jerremalm et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Acetaminophen protects brain endothelial cells against oxidative stress

(2009) Debjani Tripathy et al.   MICROVASCULAR RESEARCH

Oxaliplatin-Induced Loss of Phosphorylated Heavy Neurofilament Subunit Neuronal Immunoreactivity in Rat Drg Tissue

(2009) Stephen MF Jamieson et al.   Molecular Pain

Supraspinal role of protein kinase C in oxaliplatin-induced neuropathy in rat

(2009) M. Norcini et al.   PAIN

L-DOPA Neurotoxicity Is Mediated by Up-Regulation of DMT1−IRE Expression

(2009) Fang Du et al.   PLoS One

Determination of intact oxaliplatin in human plasma using high performance liquid chromatography-tandem mass spectrometry

(2008) Wenjiang Zhang et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Oxaliplatin Acts on IB4-Positive Nociceptors to Induce an Oxidative Stress-Dependent Acute Painful Peripheral Neuropathy

(2008) Elizabeth K. Joseph et al.   JOURNAL OF PAIN

Cytotoxicity of contact lens multipurpose solutions: Role of oxidative stress, mitochondrial activity and P2X7 cell death receptor activation

(2007) Mélody Dutot et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES