Microglial Phagocytosis—Rational but Challenging Therapeutic Target in Multiple Sclerosis
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Title
Microglial Phagocytosis—Rational but Challenging Therapeutic Target in Multiple Sclerosis
Authors
Keywords
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Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 21, Issue 17, Pages 5960
Publisher
MDPI AG
Online
2020-08-19
DOI
10.3390/ijms21175960
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Note: Only part of the references are listed.- Microglia in the developing retina couple phagocytosis with the progression of apoptosis via P2RY12 signaling
- (2020) Zachary I. Blume et al. DEVELOPMENTAL DYNAMICS
- Lipid-droplet-accumulating microglia represent a dysfunctional and proinflammatory state in the aging brain
- (2020) Julia Marschallinger et al. NATURE NEUROSCIENCE
- A dual effect of ursolic acid to the treatment of multiple sclerosis through both immunomodulation and direct remyelination
- (2020) Yuan Zhang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Lipid and Lipoprotein Metabolism in Microglia
- (2020) Bailey A. Loving et al. Frontiers in Physiology
- Complement targets newborn retinal ganglion cells for phagocytic elimination by microglia
- (2019) Sarah R Anderson et al. JOURNAL OF NEUROSCIENCE
- Targeting MAPK Pathways by Naringenin Modulates Microglia M1/M2 Polarization in Lipopolysaccharide-Stimulated Cultures
- (2019) Bei Zhang et al. Frontiers in Cellular Neuroscience
- Targeting Microglia and Macrophages: A Potential Treatment Strategy for Multiple Sclerosis
- (2019) Jiaying Wang et al. Frontiers in Pharmacology
- Microglial Phagocytosis of Newborn Cells Is Induced by Endocannabinoids and Sculpts Sex Differences in Juvenile Rat Social Play
- (2019) Jonathan W. VanRyzin et al. NEURON
- Synaptic Elimination in Neurological Disorders
- (2019) Fabíola M. Ribeiro et al. Current Neuropharmacology
- Phagocytosis in the Brain: Homeostasis and Disease
- (2019) Dylan A. Galloway et al. Frontiers in Immunology
- Regulatory Control of Microglial Phagocytosis by Estradiol and Prostaglandin E2 in the Developing Rat Cerebellum
- (2019) Miguel Perez-Pouchoulen et al. CEREBELLUM
- Microglia Biology: One Century of Evolving Concepts
- (2019) Marco Prinz et al. CELL
- Pseudoginsenoside-F11 Accelerates Microglial Phagocytosis of Myelin Debris and Attenuates Cerebral Ischemic Injury Through Complement Receptor 3
- (2019) Yinglu Liu et al. NEUROSCIENCE
- The antibody rHIgM22 facilitates hippocampal remyelination and ameliorates memory deficits in the cuprizone mouse model of demyelination
- (2018) Charlene Cui et al. BRAIN RESEARCH
- Macrophages and lipid metabolism
- (2018) Anneleen Remmerie et al. CELLULAR IMMUNOLOGY
- A novel PADRE-Kv1.3 vaccine effectively induces therapeutic antibodies and ameliorates experimental autoimmune encephalomyelitis in rats
- (2018) Cheng Fan et al. CLINICAL IMMUNOLOGY
- The Microglial Innate Immune Receptor TREM2 Is Required for Synapse Elimination and Normal Brain Connectivity
- (2018) Fabia Filipello et al. IMMUNITY
- Microglia-Mediated Synapse Loss in Alzheimer's Disease
- (2018) Lawrence Rajendran et al. JOURNAL OF NEUROSCIENCE
- Dietary naringenin supplementation attenuates experimental autoimmune encephalomyelitis by modulating autoimmune inflammatory responses in mice
- (2018) Junpeng Wang et al. JOURNAL OF NUTRITIONAL BIOCHEMISTRY
- Defective cholesterol clearance limits remyelination in the aged central nervous system
- (2018) Ludovico Cantuti-Castelvetri et al. SCIENCE
- Cholesterol crystals impede nerve repair
- (2018) Yanan Chen et al. SCIENCE
- Multiple Sclerosis
- (2018) Raed Alroughani et al. SEMINARS IN NEUROLOGY
- Human IgM antibody rHIgM22 promotes phagocytic clearance of myelin debris by microglia
- (2018) Yana Zorina et al. Scientific Reports
- Cyclic AMP Pathway Suppress Autoimmune Neuroinflammation by Inhibiting Functions of Encephalitogenic CD4 T Cells and Enhancing M2 Macrophage Polarization at the Site of Inflammation
- (2018) Tatyana Veremeyko et al. Frontiers in Immunology
- Multiple sclerosis and cognition: synaptic failure and network dysfunction
- (2018) Massimiliano Di Filippo et al. NATURE REVIEWS NEUROSCIENCE
- The endocannabinoid 2-AG enhances spontaneous remyelination by targeting microglia
- (2018) M. Mecha et al. BRAIN BEHAVIOR AND IMMUNITY
- CD47 Protects Synapses from Excess Microglia-Mediated Pruning during Development
- (2018) Emily K. Lehrman et al. NEURON
- The physiology of foamy phagocytes in multiple sclerosis
- (2018) Elien Grajchen et al. Acta Neuropathologica Communications
- FTY720/fingolimod increases NPC1 and NPC2 expression and reduces cholesterol and sphingolipid accumulation in Niemann-Pick type C mutant fibroblasts
- (2017) Jason Newton et al. FASEB JOURNAL
- Multiple sclerosis: The resolving lesion revealed
- (2017) Cedric S. Raine JOURNAL OF NEUROIMMUNOLOGY
- Staining of HLA-DR, Iba1 and CD68 in human microglia reveals partially overlapping expression depending on cellular morphology and pathology
- (2017) Debbie A.E. Hendrickx et al. JOURNAL OF NEUROIMMUNOLOGY
- Myelin as an inflammatory mediator: Myelin interactions with complement, macrophages, and microglia in spinal cord injury
- (2017) Timothy J. Kopper et al. JOURNAL OF NEUROSCIENCE RESEARCH
- Evaluation of the Effect of Fingolimod Treatment on Microglial Activation Using Serial PET Imaging in Multiple Sclerosis
- (2017) Marcus Sucksdorff et al. JOURNAL OF NUCLEAR MEDICINE
- Clemastine fumarate as a remyelinating therapy for multiple sclerosis (ReBUILD): a randomised, controlled, double-blind, crossover trial
- (2017) Ari J Green et al. LANCET
- Quantitative Analysis of the Proteome Response to the Histone Deacetylase Inhibitor (HDACi) Vorinostat in Niemann-Pick Type C1 disease
- (2017) Kanagaraj Subramanian et al. MOLECULAR & CELLULAR PROTEOMICS
- rHIgM22 enhances remyelination in the brain of the cuprizone mouse model of demyelination
- (2017) Ariana P. Mullin et al. NEUROBIOLOGY OF DISEASE
- Complement C3 deficiency protects against neurodegeneration in aged plaque-rich APP/PS1 mice
- (2017) Qiaoqiao Shi et al. Science Translational Medicine
- MerTK Is a Functional Regulator of Myelin Phagocytosis by Human Myeloid Cells
- (2016) Luke M. Healy et al. JOURNAL OF IMMUNOLOGY
- Role of Microglia in Neurological Disorders and Their Potentials as a Therapeutic Target
- (2016) Li Du et al. MOLECULAR NEUROBIOLOGY
- TAM receptors regulate multiple features of microglial physiology
- (2016) Lawrence Fourgeaud et al. NATURE
- Microglial P2Y12 is necessary for synaptic plasticity in mouse visual cortex
- (2016) G. O. Sipe et al. Nature Communications
- Loss of Myelin Basic Protein Function Triggers Myelin Breakdown in Models of Demyelinating Diseases
- (2016) Marie-Theres Weil et al. Cell Reports
- Developmental Apoptosis Mediates Entry and Positioning of Microglia in the Zebrafish Brain
- (2016) Alessandra Maria Casano et al. Cell Reports
- Fingolimod for multiple sclerosis and emerging indications: appropriate patient selection, safety precautions, and special considerations
- (2016) Ingo Kleiter et al. Therapeutics and Clinical Risk Management
- TREM2 regulates microglial cell activation in response to demyelination in vivo
- (2015) Claudia Cantoni et al. ACTA NEUROPATHOLOGICA
- Complement C1q-C3-associated synaptic changes in multiple sclerosis hippocampus
- (2015) Iliana Michailidou et al. ANNALS OF NEUROLOGY
- Reconstruction of single cortical projection neurons reveals primary spine loss in multiple sclerosis
- (2015) Tanja Jürgens et al. BRAIN
- Neuroinflammatory TNFα Impairs Memory via Astrocyte Signaling
- (2015) Samia Habbas et al. CELL
- A basic overview of multiple sclerosis immunopathology
- (2015) N. Grigoriadis et al. EUROPEAN JOURNAL OF NEUROLOGY
- TREM2 sustains microglial expansion during aging and response to demyelination
- (2015) Pietro Luigi Poliani et al. JOURNAL OF CLINICAL INVESTIGATION
- Inefficient clearance of myelin debris by microglia impairs remyelinating processes
- (2015) Antoine Lampron et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Complement C3-Deficient Mice Fail to Display Age-Related Hippocampal Decline
- (2015) Q. Shi et al. JOURNAL OF NEUROSCIENCE
- Demyelination Causes Adult CNS Progenitors to Revert to an Immature State and Express Immune Cues That Support Their Migration
- (2015) S. Moyon et al. JOURNAL OF NEUROSCIENCE
- Glia Disease and Repair—Remyelination
- (2015) Robin J.M. Franklin et al. Cold Spring Harbor Perspectives in Biology
- Structural-functional connectivity deficits of neocortical circuits in the Fmr1-/y mouse model of autism
- (2015) M. G. Haberl et al. Science Advances
- Scavenger Receptor Structure and Function in Health and Disease
- (2015) Izma Zani et al. Cells
- Macrophage subsets and microglia in multiple sclerosis
- (2014) Jeroen F. J. Bogie et al. ACTA NEUROPATHOLOGICA
- Macrophages: A double-edged sword in experimental autoimmune encephalomyelitis
- (2014) Zhilong Jiang et al. IMMUNOLOGY LETTERS
- Activation of Neuronal NMDA Receptors Triggers Transient ATP-Mediated Microglial Process Outgrowth
- (2014) L. Dissing-Olesen et al. JOURNAL OF NEUROSCIENCE
- Structural plasticity: mechanisms and contribution to developmental psychiatric disorders
- (2014) Yann Bernardinelli et al. Frontiers in Neuroanatomy
- n-3 PUFA supplementation benefits microglial responses to myelin pathology
- (2014) Songela Chen et al. Scientific Reports
- Insufficient OPC migration into demyelinated lesions is a cause of poor remyelination in MS and mouse models
- (2013) Amanda Boyd et al. ACTA NEUROPATHOLOGICA
- Microglia Promote Learning-Dependent Synapse Formation through Brain-Derived Neurotrophic Factor
- (2013) Christopher N. Parkhurst et al. CELL
- Phagocytic glial cells: sculpting synaptic circuits in the developing nervous system
- (2013) Dorothy P. Schafer et al. CURRENT OPINION IN NEUROBIOLOGY
- Myelin inhibits oligodendroglial maturation and regulates oligodendrocytic transcription factor expression
- (2013) Jason R. Plemel et al. GLIA
- Selective Upregulation of Scavenger Receptors in and Around Demyelinating Areas in Multiple Sclerosis
- (2013) Debbie A.E. Hendrickx et al. JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
- Tumor necrosis factor is elevated in progressive multiple sclerosis and causes excitotoxic neurodegeneration
- (2013) Silvia Rossi et al. Multiple Sclerosis Journal
- Layer V cortical neurons require microglial support for survival during postnatal development
- (2013) Masaki Ueno et al. NATURE NEUROSCIENCE
- M2 microglia and macrophages drive oligodendrocyte differentiation during CNS remyelination
- (2013) Veronique E Miron et al. NATURE NEUROSCIENCE
- Galectin-3 controls the response of microglial cells to limit cuprizone-induced demyelination
- (2013) H.C. Hoyos et al. NEUROBIOLOGY OF DISEASE
- Microglia Actively Regulate the Number of Functional Synapses
- (2013) Kyungmin Ji et al. PLoS One
- Default mode network connectivity and reciprocal social behavior in 22q11.2 deletion syndrome
- (2013) Matthew J. Schreiner et al. Social Cognitive and Affective Neuroscience
- Alemtuzumab: evidence for its potential in relapsing–remitting multiple sclerosis
- (2013) William Brown et al. Drug Design Development and Therapy
- Myelin alters the inflammatory phenotype of macrophages by activating PPARs
- (2013) Jeroen FJ Bogie et al. Acta Neuropathologica Communications
- The Complement System: An Unexpected Role in Synaptic Pruning During Development and Disease
- (2012) Alexander H. Stephan et al. Annual Review of Neuroscience
- Imaging Microglial/Macrophage Activation in Spinal Cords of Experimental Autoimmune Encephalomyelitis Rats by Positron Emission Tomography Using the Mitochondrial 18 kDa Translocator Protein Radioligand [18F]DPA-714
- (2012) G. Abourbeh et al. JOURNAL OF NEUROSCIENCE
- PPAR /RXR -Induced and CD36-Mediated Microglial Amyloid- Phagocytosis Results in Cognitive Improvement in Amyloid Precursor Protein/Presenilin 1 Mice
- (2012) M. Yamanaka et al. JOURNAL OF NEUROSCIENCE
- Animal models of multiple sclerosis: the good, the bad and the bottom line
- (2012) Richard M Ransohoff NATURE NEUROSCIENCE
- Microglia Sculpt Postnatal Neural Circuits in an Activity and Complement-Dependent Manner
- (2012) Dorothy P. Schafer et al. NEURON
- Myelin-Derived Lipids Modulate Macrophage Activity by Liver X Receptor Activation
- (2012) Jeroen F. J. Bogie et al. PLoS One
- Microglial physiopathology: how to explain the dual role of microglia after acute neural disorders?
- (2012) Walace Gomes-Leal Brain and Behavior
- Oxidative damage in multiple sclerosis lesions
- (2011) L. Haider et al. BRAIN
- Galectin-3 drives oligodendrocyte differentiation to control myelin integrity and function
- (2011) L A Pasquini et al. CELL DEATH AND DIFFERENTIATION
- Myelin ingestion alters macrophage antigen-presenting function in vitro and in vivo
- (2011) M. van Zwam et al. JOURNAL OF LEUKOCYTE BIOLOGY
- Myelin down-regulates myelin phagocytosis by microglia and macrophages through interactions between CD47 on myelin and SIRPα (signal regulatory protein-α) on phagocytes
- (2011) Miri Gitik et al. Journal of Neuroinflammation
- Histone deacetylase inhibitor treatment dramatically reduces cholesterol accumulation in Niemann-Pick type C1 mutant human fibroblasts
- (2011) N. H. Pipalia et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Synaptic Pruning by Microglia Is Necessary for Normal Brain Development
- (2011) R. C. Paolicelli et al. SCIENCE
- Fingolimod (FTY720) Enhances Remyelination Following Demyelination of Organotypic Cerebellar Slices
- (2010) Veronique E. Miron et al. AMERICAN JOURNAL OF PATHOLOGY
- Demyelination causes synaptic alterations in hippocampi from multiple sclerosis patients
- (2010) Ranjan Dutta et al. ANNALS OF NEUROLOGY
- CNS-Resident Glial Progenitor/Stem Cells Produce Schwann Cells as well as Oligodendrocytes during Repair of CNS Demyelination
- (2010) Malgorzata Zawadzka et al. Cell Stem Cell
- FTY720 Stimulates 27-Hydroxycholesterol Production and Confers Atheroprotective Effects in Human Primary Macrophages
- (2010) Tomas Blom et al. CIRCULATION RESEARCH
- Galantamine-induced Amyloid-β Clearance Mediated via Stimulation of Microglial Nicotinic Acetylcholine Receptors
- (2010) Kazuyuki Takata et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Microglia in neurodegenerative disease
- (2010) V. Hugh Perry et al. Nature Reviews Neurology
- Myelin Activates FAK/Akt/NF-κB Pathways and Provokes CR3-Dependent Inflammatory Response in Murine System
- (2010) Xin Sun et al. PLoS One
- Microglial Interactions with Synapses Are Modulated by Visual Experience
- (2010) Marie-Ève Tremblay et al. PLOS BIOLOGY
- MicroRNA profiling of multiple sclerosis lesions identifies modulators of the regulatory protein CD47
- (2009) Andreas Junker et al. BRAIN
- Liver X receptor in cholesterol metabolism
- (2009) Chunyan Zhao et al. JOURNAL OF ENDOCRINOLOGY
- The Multifaceted Profile of Activated Microglia
- (2009) Marina A. Lynch MOLECULAR NEUROBIOLOGY
- Adenosine A2A receptor mediates microglial process retraction
- (2009) Anna G Orr et al. NATURE NEUROSCIENCE
- The mechanism of action of glatiramer acetate treatment in multiple sclerosis
- (2009) M. K. Racke et al. NEUROLOGY
- Regional hippocampal atrophy in multiple sclerosis
- (2008) N. L. Sicotte et al. BRAIN
- Debris clearance by microglia: an essential link between degeneration and regeneration
- (2008) H. Neumann et al. BRAIN
- Substantial Archaeocortical Atrophy and Neuronal Loss in Multiple Sclerosis
- (2008) Dimitrios Papadopoulos et al. BRAIN PATHOLOGY
- Bone-marrow-derived microglia: myth or reality?
- (2008) Denis Soulet et al. CURRENT OPINION IN PHARMACOLOGY
- Synthetic LXR agonist attenuates plaque formation in apoE-/- mice without inducing liver steatosis and hypertriglyceridemia
- (2008) Adelheid Kratzer et al. JOURNAL OF LIPID RESEARCH
- Multiple sclerosis
- (2008) Alastair Compston et al. LANCET
- Neuroinflammation and synaptic plasticity: theoretical basis for a novel, immune-centred, therapeutic approach to neurological disorders
- (2008) Massimiliano Di Filippo et al. TRENDS IN PHARMACOLOGICAL SCIENCES
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