A basic overview of multiple sclerosis immunopathology

The formation of inflammatory demyelinated lesions in cerebral white matter

(2014) Pietro Maggi et al.   ANNALS OF NEUROLOGY

Targets of the humoral autoimmune response in multiple sclerosis

(2014) Judith Fraussen et al.   AUTOIMMUNITY REVIEWS

Disease exacerbation of multiple sclerosis is characterized by loss of terminally differentiated autoregulatory CD8+ T cells

(2014) Khrishen Cunnusamy et al.   CLINICAL IMMUNOLOGY

Clinical Relevance of Brain Volume Measures in Multiple Sclerosis

(2014) Nicola De Stefano et al.   CNS DRUGS

High-throughput sequencing of TCR repertoires in multiple sclerosis reveals intrathecal enrichment of EBV-reactive CD8+T cells

(2014) Andreas Lossius et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Gut microbiome and the risk factors in central nervous system autoimmunity

(2014) Javier Ochoa-Repáraz et al.   FEBS LETTERS

Mechanisms of white matter damage in multiple sclerosis

(2014) Hans Lassmann   GLIA

Expansion and preferential activation of the CD14+ CD16+ monocyte subset during multiple sclerosis

(2014) Delgertsetseg Chuluundorj et al.   IMMUNOLOGY AND CELL BIOLOGY

Differential roles of microglia and monocytes in the inflamed central nervous system

(2014) Ryo Yamasaki et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Gut Commensalism, Cytokines, and Central Nervous System Demyelination

(2014) Kiel Telesford et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Interactions Between Microglia and T Cells in Multiple Sclerosis Pathobiology

(2014) Megan Strachan-Whaley et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Multiple sclerosis deep grey matter: the relation between demyelination, neurodegeneration, inflammation and iron

(2014) Lukas Haider et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

IL-35-producing B cells are critical regulators of immunity during autoimmune and infectious diseases

(2014) Ping Shen et al.   NATURE

Regulation of astrocyte activation by glycolipids drives chronic CNS inflammation

(2014) Lior Mayo et al.   NATURE MEDICINE

Immunoglobulin class-switched B cells form an active immune axis between CNS and periphery in multiple sclerosis

(2014) A. Palanichamy et al.   Science Translational Medicine

B cells populating the multiple sclerosis brain mature in the draining cervical lymph nodes

(2014) J. N. H. Stern et al.   Science Translational Medicine

Drugs in Development for Relapsing Multiple Sclerosis

(2013) Rehiana Ali et al.   DRUGS

Multiple sclerosis: Lessons from molecular neuropathology

(2013) Hans Lassmann   EXPERIMENTAL NEUROLOGY

CD8+T cells in multiple sclerosis

(2013) Aleksandar Denic et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Impact of alemtuzumab treatment on the survival and function of human regulatory T cellsin vitro

(2013) Evis Havari et al.   IMMUNOLOGY

Specific peripheral B cell tolerance defects in patients with multiple sclerosis

(2013) Tuure Kinnunen et al.   JOURNAL OF CLINICAL INVESTIGATION

Differential Reconstitution of T Cell Subsets following Immunodepleting Treatment with Alemtuzumab (Anti-CD52 Monoclonal Antibody) in Patients with Relapsing-Remitting Multiple Sclerosis

(2013) X. Zhang et al.   JOURNAL OF IMMUNOLOGY

High Fat Diet Exacerbates Neuroinflammation in an Animal Model of Multiple Sclerosis by Activation of the Renin Angiotensin System

(2013) Silke Timmermans et al.   Journal of Neuroimmune Pharmacology

The Immune Pathogenesis of Multiple Sclerosis

(2013) Robert Weissert   Journal of Neuroimmune Pharmacology

Fingolimod: Direct CNS effects of sphingosine 1-phosphate (S1P) receptor modulation and implications in multiple sclerosis therapy

(2013) Aran Groves et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Dendritic cells in multiple sclerosis: key players in the immunopathogenesis, key players for new cellular immunotherapies?

(2013) AH Nuyts et al.   Multiple Sclerosis Journal

Sodium chloride drives autoimmune disease by the induction of pathogenic TH17 cells

(2013) Markus Kleinewietfeld et al.   NATURE

M2 microglia and macrophages drive oligodendrocyte differentiation during CNS remyelination

(2013) Veronique E Miron et al.   NATURE NEUROSCIENCE

Reprogramming the immune repertoire with alemtuzumab in MS

(2013) Heinz Wiendl et al.   Nature Reviews Neurology

Emerging roles of astrocytes in neural circuit development

(2013) Laura E. Clarke et al.   NATURE REVIEWS NEUROSCIENCE

Upregulation of IL-17, but not of IL-9, in circulating cells of CIS and relapsing MS patients. Impact of corticosteroid therapy on the cytokine network

(2012) Nathalie Muls et al.   JOURNAL OF NEUROIMMUNOLOGY

A Lineage of Myeloid Cells Independent of Myb and Hematopoietic Stem Cells

(2012) C. Schulz et al.   SCIENCE

Enriched CD161highCCR6+γδ T Cells in the Cerebrospinal Fluid of Patients With Multiple Sclerosis

(2012) Lucas Schirmer et al.   JAMA Neurology

Central nervous system recruitment of effector memory CD8+ T lymphocytes during neuroinflammation is dependent on  4 integrin

(2011) I. Ifergan et al.   BRAIN

The Yin and Yang of Microglia

(2011) Melinda Czeh et al.   DEVELOPMENTAL NEUROSCIENCE

Role of CD8 T cell subsets in the pathogenesis of multiple sclerosis

(2011) A. Saxena et al.   FEBS LETTERS

How do immune cells overcome the blood-brain barrier in multiple sclerosis?

(2011) Catherine Larochelle et al.   FEBS LETTERS

Th17 Cells Induce Ectopic Lymphoid Follicles in Central Nervous System Tissue Inflammation

(2011) Anneli Peters et al.   IMMUNITY

Ocrelizumab in relapsing-remitting multiple sclerosis: a phase 2, randomised, placebo-controlled, multicentre trial

(2011) Ludwig Kappos et al.   LANCET

Commensal microbiota and myelin autoantigen cooperate to trigger autoimmune demyelination

(2011) Kerstin Berer et al.   NATURE

Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis

(2011) Stephen Sawcer et al.   NATURE

RORγt drives production of the cytokine GM-CSF in helper T cells, which is essential for the effector phase of autoimmune neuroinflammation

(2011) Laura Codarri et al.   NATURE IMMUNOLOGY

Infiltration of Th1 and Th17 cells and activation of microglia in the CNS during the course of experimental autoimmune encephalomyelitis

(2010) Áine C. Murphy et al.   BRAIN BEHAVIOR AND IMMUNITY

Mechanism of Action of Oral Fingolimod (FTY720) in Multiple Sclerosis

(2010) Jerold Chun et al.   CLINICAL NEUROPHARMACOLOGY

Inhibition of reactive astrocytosis in established experimental autoimmune encephalomyelitis favors infiltration by myeloid cells over T cells and enhances severity of disease

(2010) Henrik Toft-Hansen et al.   GLIA

γδ T Cells Enhance Autoimmunity by Restraining Regulatory T Cell Responses via an Interleukin-23-Dependent Mechanism

(2010) Franziska Petermann et al.   IMMUNITY

GM-CSF–dependent, CD103+dermal dendritic cells play a critical role in Th effector cell differentiation after subcutaneous immunization

(2010) Irah L. King et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A polysaccharide from the human commensal Bacteroides fragilis protects against CNS demyelinating disease

(2010) J Ochoa-Repáraz et al.   Mucosal Immunology

Multiple sclerosis genetics—is the glass half full, or half empty?

(2010) Jorge R. Oksenberg et al.   Nature Reviews Neurology

Th17 central memory T cells are reduced by FTY720 in patients with multiple sclerosis

(2010) M. Mehling et al.   NEUROLOGY

Proinflammatory T-cell responses to gut microbiota promote experimental autoimmune encephalomyelitis

(2010) Y. K. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages

(2010) F. Ginhoux et al.   SCIENCE

Multiple sclerosis – candidate mechanisms underlying CNS atrophy

(2010) Volker Siffrin et al.   TRENDS IN NEUROSCIENCES

T-helper 17 cells expand in multiple sclerosis and are inhibited by interferon-β

(2009) Luca Durelli et al.   ANNALS OF NEUROLOGY

Preferential recruitment of interferon-γ-expressing TH17 cells in multiple sclerosis

(2009) Hania Kebir et al.   ANNALS OF NEUROLOGY

Circulating Ly-6C+ myeloid precursors migrate to the CNS and play a pathogenic role during autoimmune demyelinating disease

(2009) I. L. King et al.   BLOOD

Phenotypical and functional characterization of T helper 17 cells in multiple sclerosis

(2009) Verena Brucklacher-Waldert et al.   BRAIN

Mitochondrial changes within axons in multiple sclerosis

(2009) D. J. Mahad et al.   BRAIN

Intrathecal immune responses to EBV in early MS

(2009) Emilie Jaquiéry et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Protective effects of microglia in multiple sclerosis

(2009) Isabella Napoli et al.   EXPERIMENTAL NEUROLOGY

Cellular mechanisms of IL-17-induced blood-brain barrier disruption

(2009) Jula Huppert et al.   FASEB JOURNAL

Interleukin-1 and IL-23 Induce Innate IL-17 Production from γδ T Cells, Amplifying Th17 Responses and Autoimmunity

(2009) Caroline E. Sutton et al.   IMMUNITY

Th1, Th17, and Th9 Effector Cells Induce Experimental Autoimmune Encephalomyelitis with Different Pathological Phenotypes

(2009) A. Jager et al.   JOURNAL OF IMMUNOLOGY

Clonally expanded plasma cells in the cerebrospinal fluid of patients with central nervous system autoimmune demyelination produce “oligoclonal bands”

(2009) Hans-Christian von Büdingen et al.   JOURNAL OF NEUROIMMUNOLOGY

Functional interleukin-17 receptor A is expressed in central nervous system glia and upregulated in experimental autoimmune encephalomyelitis

(2009) Jayasri Sarma et al.   Journal of Neuroinflammation

Clinical trials of multiple sclerosis therapies: improvements to demonstrate long-term patient benefit

(2009) WM Carroll   Multiple Sclerosis Journal

Natalizumab treatment is associated with peripheral sequestration of proinflammatory T cells

(2009) P. Kivisakk et al.   NEUROLOGY

Diagnosis of inflammatory demyelination in biopsy specimens: a practical approach

(2008) Tanja Kuhlmann et al.   ACTA NEUROPATHOLOGICA

CD16+ γδ T cells mediate antibody dependent cellular cytotoxicity: Potential mechanism in the pathogenesis of multiple sclerosis

(2008) Zhihong Chen et al.   CLINICAL IMMUNOLOGY

Production and functions of IL-17 in microglia

(2008) Jun Kawanokuchi et al.   JOURNAL OF NEUROIMMUNOLOGY

Multiple sclerosis

(2008) Alastair Compston et al.   LANCET

Differential regulation of central nervous system autoimmunity by TH1 and TH17 cells

(2008) Ingunn M Stromnes et al.   NATURE MEDICINE

The blood-brain barrier induces differentiation of migrating monocytes into Th17-polarizing dendritic cells

(2007) I. Ifergan et al.   BRAIN