Mechanistic insights into cardiovascular protection for omega-3 fatty acids and their bioactive lipid metabolites

Eicosapentaenoic acid (EPA) has optimal chain length and degree of unsaturation to inhibit oxidation of small dense LDL and membrane cholesterol domains as compared to related fatty acids in vitro

(2020) Samuel C.R. Sherratt et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

The return of triglycerides and revival of omega-3 fatty acids!

(2020) Jean Ferrières   Archives of Cardiovascular Diseases

Emerging Mechanisms of Cardiovascular Protection for the Omega-3 Fatty Acid Eicosapentaenoic Acid

(2020) R. Preston Mason et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Preferential Incorporation of Administered Eicosapentaenoic Acid Into Thin-Cap Atherosclerotic Plaques

(2019) Tomohito Sato et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Most important advances in preventive cardiology during this past decade: Viewpoint from the American Society for Preventive Cardiology

(2019) Nathan D. Wong et al.   TRENDS IN CARDIOVASCULAR MEDICINE

Eicosapentaenoic acid inhibits oxidation of high density lipoprotein particles in a manner distinct from docosahexaenoic acid

(2018) Samuel C.R. Sherratt et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Eicosapentaenoic acid improves endothelial function and nitric oxide bioavailability in a manner that is enhanced in combination with a statin

(2018) R. Preston Mason et al.   BIOMEDICINE & PHARMACOTHERAPY

Eicosapentaenoic acid and docosahexaenoic acid have distinct membrane locations and lipid interactions as determined by X-ray diffraction

(2018) Samuel C.R. Sherratt et al.   CHEMISTRY AND PHYSICS OF LIPIDS

Eicosapentaenoic Acid-Enriched High-Density Lipoproteins Exhibit Anti-Atherogenic Properties

(2018) Nobuaki Tanaka et al.   CIRCULATION JOURNAL

Maresin 1 attenuates pro-inflammatory reactions and ER stress in HUVECs via PPARα-mediated pathway

(2018) Tae Woo Jung et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Cardiac effects of fish oil in a rat model of streptozotocin-induced diabetes

(2018) F. Mayyas et al.   NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES

Abnormal lipoprotein oxylipins in metabolic syndrome and partial correction by omega-3 fatty acids

(2018) Gregory C. Shearer et al.   PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS

Effects of n−3 Fatty Acid Supplements in Diabetes Mellitus

(2018)   NEW ENGLAND JOURNAL OF MEDICINE

Marine n−3 Fatty Acids and Prevention of Cardiovascular Disease and Cancer

(2018) JoAnn E. Manson et al.   NEW ENGLAND JOURNAL OF MEDICINE

Cardiovascular Risk Reduction with Icosapent Ethyl for Hypertriglyceridemia

(2018) Deepak L. Bhatt et al.   NEW ENGLAND JOURNAL OF MEDICINE

Role of NLRP3 Inflammasomes in Atherosclerosis

(2017) Tadayoshi Karasawa et al.   Journal of Atherosclerosis and Thrombosis

Heart failure–induced activation of phospholipase iPLA2γ generates hydroxyeicosatetraenoic acids opening the mitochondrial permeability transition pore

(2017) Sung Ho Moon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The role of polyunsaturated fatty acids and GPR40 receptor in brain

(2017) Muhammad Zahid Khan et al.   NEUROPHARMACOLOGY

Potential benefits of eicosapentaenoic acid on atherosclerotic plaques

(2017) J.R. Nelson et al.   VASCULAR PHARMACOLOGY

Detection of omega-3 oxylipins in human plasma and response to treatment with omega-3 acid ethyl esters

(2017) Gregory C. Shearer et al.   JOURNAL OF LIPID RESEARCH

Association between cholesterol crystals and culprit lesion vulnerability in patients with acute coronary syndrome: An optical coherence tomography study

(2016) Jiannan Dai et al.   ATHEROSCLEROSIS

Eicosapentaenoic acid reduces membrane fluidity, inhibits cholesterol domain formation, and normalizes bilayer width in atherosclerotic-like model membranes

(2016) R. Preston Mason et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Complex Pharmacology of Free Fatty Acid Receptors

(2016) Graeme Milligan et al.   CHEMICAL REVIEWS

Effect of Omega-3 Acid Ethyl Esters on Left Ventricular Remodeling After Acute Myocardial InfarctionClinical Perspective

(2016) Bobak Heydari et al.   CIRCULATION

Eicosapentaenoic Acid Inhibits Oxidation of ApoB-containing Lipoprotein Particles of Different Size In Vitro When Administered Alone or in Combination With Atorvastatin Active Metabolite Compared With Other Triglyceride-lowering Agents

(2016) R. Preston Mason et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Effects of oral eicosapentaenoic acid versus docosahexaenoic acid on human peripheral blood mononuclear cell gene expression

(2015) Fumiyoshi Tsunoda et al.   ATHEROSCLEROSIS

Eicosapentaenoic acid inhibits glucose-induced membrane cholesterol crystalline domain formation through a potent antioxidant mechanism

(2015) R. Preston Mason et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

How polyunsaturated fatty acids modify molecular organization in membranes: Insight from NMR studies of model systems

(2015) Saame Raza Shaikh et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Cytochrome P450 epoxygenase pathway of polyunsaturated fatty acid metabolism

(2015) Arthur A. Spector et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Activity of dietary fatty acids on FFA1 and FFA4 and characterisation of pinolenic acid as a dual FFA1/FFA4 agonist with potential effect against metabolic diseases

(2015) Elisabeth Christiansen et al.   BRITISH JOURNAL OF NUTRITION

The peroxisome proliferator-activated receptors in cardiovascular diseases: experimental benefits and clinical challenges

(2015) Wai San Cheang et al.   BRITISH JOURNAL OF PHARMACOLOGY

Characterizing pharmacological ligands to study the long-chain fatty acid receptors GPR40/FFA1 and GPR120/FFA4

(2015) G Milligan et al.   BRITISH JOURNAL OF PHARMACOLOGY

Omega-3-fatty acid adds to the protective effect of flax lignan concentrate in pressure overload-induced myocardial hypertrophy in rats via modulation of oxidative stress and apoptosis

(2015) Arvindkumar E. Ghule et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

EPA, not DHA, prevents fibrosis in pressure overload-induced heart failure: potential role of free fatty acid receptor 4

(2015) Julie A. Eclov et al.   JOURNAL OF LIPID RESEARCH

Resolvin D1 activates the inflammation resolving response at splenic and ventricular site following myocardial infarction leading to improved ventricular function

(2015) Vasundhara Kain et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Docosahexaenoic acid induces M2 macrophage polarization through peroxisome proliferator-activated receptor γ activation

(2015) Hae Yeun Chang et al.   LIFE SCIENCES

Effects of omega-3 carboxylic acids on lipoprotein particles and other cardiovascular risk markers in high-risk statin-treated patients with residual hypertriglyceridemia: a randomized, controlled, double-blind trial

(2015) Richard L. Dunbar et al.   Lipids in Health and Disease

Advances in Our Understanding of Oxylipins Derived from Dietary PUFAs

(2015) Melissa Gabbs et al.   Advances in Nutrition

Endogenously Generated Omega-3 Fatty Acids Attenuate Vascular Inflammation and Neointimal Hyperplasia by Interaction With Free Fatty Acid Receptor 4 in Mice

(2015) X. Li et al.   Journal of the American Heart Association

Do Fish Oil Omega-3 Fatty Acids Enhance Antioxidant Capacity and Mitochondrial Fatty Acid Oxidation in Human Atrial Myocardium via PPARγ Activation?

(2014) Ethan J. Anderson et al.   ANTIOXIDANTS & REDOX SIGNALING

Effects of Fenofibric Acid on Carotid Intima-Media Thickness in Patients With Mixed Dyslipidemia on Atorvastatin Therapy

(2014) Michael H. Davidson et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Administration of high dose eicosapentaenoic acid enhances anti-inflammatory properties of high-density lipoprotein in Japanese patients with dyslipidemia

(2014) Nobuaki Tanaka et al.   ATHEROSCLEROSIS

Discovery of a Class of Endogenous Mammalian Lipids with Anti-Diabetic and Anti-inflammatory Effects

(2014) Mark M. Yore et al.   CELL

Evaluation of the insulin-releasing and glucose-lowering effects of GPR120 activation in pancreaticβ-cells

(2014) B. M. Moran et al.   DIABETES OBESITY & METABOLISM

GPR120 (FFAR4) is preferentially expressed in pancreatic delta cells and regulates somatostatin secretion from murine islets of Langerhans

(2014) Virginia M. Stone et al.   DIABETOLOGIA

The fish oil ingredient, docosahexaenoic acid, activates cytosolic phospholipase A2via GPR120 receptor to produce prostaglandin E2and plays an anti-inflammatory role in macrophages

(2014) Yueqin Liu et al.   IMMUNOLOGY

Alteration of the Glucagon Axis in GPR120 (FFAR4) Knockout Mice

(2014) Arthur T. Suckow et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

18-HEPE, an n-3 fatty acid metabolite released by macrophages, prevents pressure overload–induced maladaptive cardiac remodeling

(2014) Jin Endo et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Discovery of essential fatty acids

(2014) Arthur A. Spector et al.   JOURNAL OF LIPID RESEARCH

Fish oil constituent eicosapentaenoic acid inhibits endothelin-induced cardiomyocyte hypertrophy via PPAR-α

(2014) Nobutake Shimojo et al.   LIFE SCIENCES

Effects of Extended-Release Niacin with Laropiprant in High-Risk Patients

(2014)   NEW ENGLAND JOURNAL OF MEDICINE

Peroxisome proliferator-activated receptors and their ligands: nutritional and clinical implications - a review

(2014) Bogna Grygiel-Górniak   Nutrition Journal

Inhibition of soluble epoxide hydrolase modulates inflammation and autophagy in obese adipose tissue and liver: Role for omega-3 epoxides

(2014) Cristina López-Vicario et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Icosapent Ethyl, a Pure Ethyl Ester of Eicosapentaenoic Acid: Effects on Circulating Markers of Inflammation from the MARINE and ANCHOR Studies

(2013) Harold E. Bays et al.   American Journal of Cardiovascular Drugs

Activation of FFA1 mediates GLP-1 secretion in mice. Evidence for allosterism at FFA1

(2013) Yumei Xiong et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

n–3 Fatty Acids in Patients with Multiple Cardiovascular Risk Factors

(2013)   NEW ENGLAND JOURNAL OF MEDICINE

Icosapent ethyl, a pure EPA omega-3 fatty acid: Effects on plasma and red blood cell fatty acids in patients with very high triglyceride levels (results from the MARINE study)

(2013) Rene A. Braeckman et al.   PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS

Cholesterol Crystals and Inflammation

(2013) Alena Grebe et al.   Current Rheumatology Reports

Seven transmembrane G protein-coupled receptor repertoire of gastric ghrelin cells

(2013) Maja S. Engelstoft et al.   Molecular Metabolism

Efficacy and Safety of Eicosapentaenoic Acid Ethyl Ester (AMR101) Therapy in Statin-Treated Patients With Persistent High Triglycerides (from the ANCHOR Study)

(2012) Christie M. Ballantyne et al.   AMERICAN JOURNAL OF CARDIOLOGY

Nitro-Fatty Acids: Formation, Redox Signaling, and Therapeutic Potential

(2012) Andrés Trostchansky et al.   ANTIOXIDANTS & REDOX SIGNALING

Fatty Acids Regulate Endothelial Lipase and Inflammatory Markers in Macrophages and in Mouse Aorta

(2012) Un Ju Jung et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Docosahexaenoic and Eicosapentaenoic Acids Segregate Differently between Raft and Nonraft Domains

(2012) Justin A. Williams et al.   BIOPHYSICAL JOURNAL

Docosahexaenoic Acid, but Not Eicosapentaenoic Acid, Supplementation Reduces Vulnerability to Atrial Fibrillation

(2012) Andrew Ramadeen et al.   Circulation-Arrhythmia and Electrophysiology

PPAR  Activation Protects Endothelial Function in Diabetic Mice

(2012) X. Y. Tian et al.   DIABETES

Highly Purified Eicosapentaenoic Acid Increases Interleukin-10 Levels of Peripheral Blood Monocytes in Obese Patients With Dyslipidemia

(2012) N. Satoh-Asahara et al.   DIABETES CARE

Activation of peroxisome proliferator-activated receptor-β/-δ (PPARβ/δ) prevents endothelial dysfunction in type 1 diabetic rats

(2012) Ana María Quintela et al.   FREE RADICAL BIOLOGY AND MEDICINE

Eicosapentaenoic acid suppresses adverse effects of C-reactive protein overexpression on pressure overload-induced cardiac remodeling

(2012) Toshiyuki Nagai et al.   HEART AND VESSELS

Effects of ALA, EPA and DHA in high-carbohydrate, high-fat diet-induced metabolic syndrome in rats

(2012) Hemant Poudyal et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Eicosapentaenoic Acid Ethyl Ester (AMR101) Therapy in Patients With Very High Triglyceride Levels (from the Multi-center, plAcebo-controlled, Randomized, double-blINd, 12-week study with an open-label Extension [MARINE] Trial)

(2011) Harold E. Bays et al.   AMERICAN JOURNAL OF CARDIOLOGY

Eicosapentaenoic acid prevents atrial fibrillation associated with heart failure in a rabbit model

(2011) Kazuhisa Kitamura et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

5-Hydroxy-eicosapentaenoic acid is an endogenous GPR119 agonist and enhances glucose-dependent insulin secretion

(2011) Ryouta Kogure et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Suppressed liver tumorigenesis in fat-1 mice with elevated omega-3 fatty acids is associated with increased omega-3 derived lipid mediators and reduced TNF- 

(2011) K. H. Weylandt et al.   CARCINOGENESIS

PPARα-Sirt1 Complex Mediates Cardiac Hypertrophy and Failure through Suppression of the ERR Transcriptional Pathway

(2011) Shinichi Oka et al.   Cell Metabolism

Adiponectin Is Required for PPARγ-Mediated Improvement of Endothelial Function in Diabetic Mice

(2011) Wing Tak Wong et al.   Cell Metabolism

Diet-induced Obesity Up-regulates the Abundance of GPR43 and GPR120 in a Tissue Specific Manner

(2011) Lauren M. Cornall et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

G Protein-Coupled Receptors in Human Fat Taste Perception

(2011) M. M. Galindo et al.   CHEMICAL SENSES

Omega-3 Fatty Acids Prevent Pressure Overload–Induced Cardiac Fibrosis Through Activation of Cyclic GMP/Protein Kinase G Signaling in Cardiac Fibroblasts

(2011) Jinghai Chen et al.   CIRCULATION

Biophysical and biochemical mechanisms by which dietary N-3 polyunsaturated fatty acids from fish oil disrupt membrane lipid rafts

(2011) Saame Raza Shaikh   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Niacin in Patients with Low HDL Cholesterol Levels Receiving Intensive Statin Therapy

(2011)   NEW ENGLAND JOURNAL OF MEDICINE

Agonism with the omega-3 fatty acids α-linolenic acid and docosahexaenoic acid mediates phosphorylation of both the short and long isoforms of the human GPR120 receptor

(2010) Rebecca N. Burns et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

GPR120 Is an Omega-3 Fatty Acid Receptor Mediating Potent Anti-inflammatory and Insulin-Sensitizing Effects

(2010) Da Young Oh et al.   CELL

OMEGA, a Randomized, Placebo-Controlled Trial to Test the Effect of Highly Purified Omega-3 Fatty Acids on Top of Modern Guideline-Adjusted Therapy After Myocardial Infarction

(2010) Bernhard Rauch et al.   CIRCULATION

Potential role of the lipoxygenase derived lipid mediators in atherosclerosis: leukotrienes, lipoxins and resolvins

(2010) Martin Hersberger   CLINICAL CHEMISTRY AND LABORATORY MEDICINE

The G-Protein−Coupled Receptor GPR40 Directly Mediates Long-Chain Fatty Acid−Induced Secretion of Cholecystokinin

(2010) Alice P. Liou et al.   GASTROENTEROLOGY

n–3 Fatty Acids and Cardiovascular Events after Myocardial Infarction

(2010) Daan Kromhout et al.   NEW ENGLAND JOURNAL OF MEDICINE

Effects of Combination Lipid Therapy in Type 2 Diabetes Mellitus

(2010)   NEW ENGLAND JOURNAL OF MEDICINE

Purified Eicosapentaenoic Acid Induces Prolonged Survival of Cardiac Allografts and Generates Regulatory T Cells

(2009) D. Iwami et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Glucose promotes membrane cholesterol crystalline domain formation by lipid peroxidation

(2009) Yehudi Self-Medlin et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Impact of circulating esterified eicosanoids and other oxylipins on endothelial function

(2009) Gregory C. Shearer et al.   Current Atherosclerosis Reports

n-3 Polyunsaturated fatty acids alter expression of fibrotic and hypertrophic genes in a dog model of atrial cardiomyopathy

(2009) Andrew Ramadeen et al.   HEART RHYTHM

Interaction Between P450 Eicosanoids and Nitric Oxide in the Control of Arterial Tone in Mice

(2008) Hantz C. Hercule et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Docosahexaenoic Acid Enhances Segregation of Lipids between Raft and Nonraft Domains: 2H-NMR Study

(2008) Smita P. Soni et al.   BIOPHYSICAL JOURNAL

Cardiac hypertrophy is enhanced in PPAR -/- mice in response to chronic pressure overload

(2008) P. J.H. Smeets et al.   CARDIOVASCULAR RESEARCH

Docosahexaenoic acid domains: the ultimate non-raft membrane domain

(2008) Stephen R. Wassall et al.   CHEMISTRY AND PHYSICS OF LIPIDS

Eicosapentaenoic acid is more effective than docosahexaenoic acid in inhibiting proinflammatory mediator production and transcription from LPS-induced human asthmatic alveolar macrophage cells

(2008) Timothy D. Mickleborough et al.   CLINICAL NUTRITION

Gpr40 Is Expressed in Enteroendocrine Cells and Mediates Free Fatty Acid Stimulation of Incretin Secretion

(2008) S. Edfalk et al.   DIABETES

Nutrient-dependent secretion of glucose-dependent insulinotropic polypeptide from primary murine K cells

(2008) H. E. Parker et al.   DIABETOLOGIA

Inflammatory Pathways Are Activated during Cardiomyocyte Hypertrophy and Attenuated by Peroxisome Proliferator-activated Receptors PPARα and PPARδ

(2008) Pascal J. H. Smeets et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Arachidonic acid cytochrome P450 epoxygenase pathway

(2008) Arthur A. Spector   JOURNAL OF LIPID RESEARCH

Effect of n-3 polyunsaturated fatty acids in patients with chronic heart failure (the GISSI-HF trial): a randomised, double-blind, placebo-controlled trial

(2008) GISSI-HF investigators   LANCET

Cloning and characterization of the rat free fatty acid receptor GPR120: in vivo effect of the natural ligand on GLP-1 secretion and proliferation of pancreatic β cells

(2008) Toshiki Tanaka et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Dietary n-3 fatty acids attenuate cardiac allograft vasculopathy via activating peroxisome proliferator-activated receptor-γ

(2008) Rong Yin et al.   PEDIATRIC TRANSPLANTATION

Multiple antiapoptotic targets of the PI3K/Akt survival pathway are activated by epoxyeicosatrienoic acids to protect cardiomyocytes from hypoxia/anoxia

(2007) Anuradha Dhanasekaran et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Pioglitazone ameliorates endothelial dysfunction and restores ischemia-induced angiogenesis in diabetic mice

(2007) Po-Hsun Huang et al.   BIOMEDICINE & PHARMACOTHERAPY