Evaluation of the insulin-releasing and glucose-lowering effects of GPR120 activation in pancreaticβ-cells

Multiple mechanisms of GW-9508, a selective G protein-coupled receptor 40 agonist, in the regulation of glucose homeostasis and insulin sensitivity

(2013) Horng-Yih Ou et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Activation of GPR119 by fatty acid agonists augments insulin release from clonal β-cells and isolated pancreatic islets and improves glucose tolerance in mice

(2013) Brian M. Moran et al.   BIOLOGICAL CHEMISTRY

Evaluation of the insulin releasing and antihyperglycaemic activities of GPR55 lipid agonists using clonal beta-cells, isolated pancreatic islets and mice

(2013) A M McKillop et al.   BRITISH JOURNAL OF PHARMACOLOGY

Free fatty acids and protein kinase C activation induce GPR120 (free fatty acid receptor 4) phosphorylation

(2013) Omar B. Sánchez-Reyes et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

GW9508 inhibits insulin secretion by activating ATP-sensitive potassium channels in rat pancreatic β-cells

(2013) Yu-Feng Zhao et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Omega-3 and omega-6 PUFAs induce the same GPR120-mediated signalling events, but with different kinetics and intensity in Caco-2 cells

(2013) Kaia Mobraten et al.   Lipids in Health and Disease

Discovery of a Potent and Selective GPR120 Agonist

(2012) Bharat Shimpukade et al.   JOURNAL OF MEDICINAL CHEMISTRY

TAK-875 versus placebo or glimepiride in type 2 diabetes mellitus: a phase 2, randomised, double-blind, placebo-controlled trial

(2012) Charles F Burant et al.   LANCET

Dysfunction of lipid sensor GPR120 leads to obesity in both mouse and human

(2012) Atsuhiko Ichimura et al.   NATURE

GPR40-induced insulin secretion by the novel agonist TAK-875: first clinical findings in patients with type 2 diabetes

(2011) T. Araki et al.   DIABETES OBESITY & METABOLISM

Free Fatty Acid Receptors FFAR1 and GPR120 as Novel Therapeutic Targets for Metabolic Disorders

(2011) Takafumi Hara et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Agonism with the omega-3 fatty acids α-linolenic acid and docosahexaenoic acid mediates phosphorylation of both the short and long isoforms of the human GPR120 receptor

(2010) Rebecca N. Burns et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Pharmacological characterization of the cytoprotective effects of polyunsaturated fatty acids in insulin-secreting BRIN-BD11 cells

(2010) Shalinee Dhayal et al.   BRITISH JOURNAL OF PHARMACOLOGY

GPR120 Is an Omega-3 Fatty Acid Receptor Mediating Potent Anti-inflammatory and Insulin-Sensitizing Effects

(2010) Da Young Oh et al.   CELL

Role of metabolically generated reactive oxygen species for lipotoxicity in pancreatic β-cells

(2010) W. Gehrmann et al.   DIABETES OBESITY & METABOLISM

Taste Preference for Fatty Acids Is Mediated by GPR40 and GPR120

(2010) C. Cartoni et al.   JOURNAL OF NEUROSCIENCE

Structure-Activity Relationships of GPR120 Agonists Based on a Docking Simulation

(2010) Q. Sun et al.   MOLECULAR PHARMACOLOGY

Cloning, expression, and pharmacological characterization of the GPR120 free fatty acid receptor from cynomolgus monkey: Comparison with human GPR120 splice variants

(2009) Kristina Moore et al.   COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY

Lipid receptors and islet function: therapeutic implications?

(2009) M. A. Kebede et al.   DIABETES OBESITY & METABOLISM

Accuracy and precision in quantitative fluorescence microscopy

(2009) Jennifer C. Waters   JOURNAL OF CELL BIOLOGY

Novel selective ligands for free fatty acid receptors GPR120 and GPR40

(2009) Takafumi Hara et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Structural requirements for the cytoprotective actions of mono-unsaturated fatty acids in the pancreatic β-cell line, BRIN-BD11

(2008) S Dhayal et al.   BRITISH JOURNAL OF PHARMACOLOGY

Nutrient-dependent secretion of glucose-dependent insulinotropic polypeptide from primary murine K cells

(2008) H. E. Parker et al.   DIABETOLOGIA

Identification of G protein-coupled receptor 120-selective agonists derived from PPARγ agonists

(2008) Takayoshi Suzuki et al.   JOURNAL OF MEDICINAL CHEMISTRY

Cloning and characterization of the rat free fatty acid receptor GPR120: in vivo effect of the natural ligand on GLP-1 secretion and proliferation of pancreatic β cells

(2008) Toshiki Tanaka et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY