Activity of dietary fatty acids on FFA1 and FFA4 and characterisation of pinolenic acid as a dual FFA1/FFA4 agonist with potential effect against metabolic diseases

From microbe to man: the role of microbial short chain fatty acid metabolites in host cell biology

(2014) Niranjana Natarajan et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Diet, insulin secretion and insulin sensitivity – the Dose–Responses to Exercise Training (DR's EXTRA) Study (ISRCTN45977199)

(2014) Harri M. Heikkilä et al.   BRITISH JOURNAL OF NUTRITION

G-protein-coupled receptors for free fatty acids: nutritional and therapeutic targets

(2014) Graeme Milligan et al.   BRITISH JOURNAL OF NUTRITION

Branched-chain fatty acid content of foods and estimated intake in the USA

(2014) Rinat Rivka Ran-Ressler et al.   BRITISH JOURNAL OF NUTRITION

GPR120 (FFAR4) is preferentially expressed in pancreatic delta cells and regulates somatostatin secretion from murine islets of Langerhans

(2014) Virginia M. Stone et al.   DIABETOLOGIA

PGE2 production is suppressed by chemically-synthesized Δ7-eicosatrienoic acid in macrophages through the competitive inhibition of COX-2

(2014) Wen-Cheng Huang et al.   FOOD AND CHEMICAL TOXICOLOGY

Activation of the omega-3 fatty acid receptor GPR120 mediates anti-inflammatory actions in immortalized hypothalamic neurons

(2014) Leigh Wellhauser et al.   Journal of Neuroinflammation

Metabolic Conversion of C20 Polymethylene-Interrupted Polyunsaturated Fatty Acids to Essential Fatty Acids

(2014) Tamotsu Tanaka et al.   LIPIDS

Associations between dairy foods, diabetes, and metabolic health: Potential mechanisms and future directions

(2014) Kristin M. Hirahatake et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Expression of the Fatty Acid Receptor GPR120 in the Gut of Diet-Induced-Obese Rats and Its Role in GLP-1 Secretion

(2014) Sarah Juel Paulsen et al.   PLoS One

G protein-coupled receptor 120 signaling regulates ghrelin secretion in vivo and in vitro

(2013) Zhi Gong et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Free Fatty Acid (FFA) and Hydroxy Carboxylic Acid (HCA) Receptors

(2013) Stefan Offermanns   Annual Review of Pharmacology and Toxicology

Drugs or diet? - Developing novel therapeutic strategies targeting the free fatty acid family of GPCRs

(2013) H J Dranse et al.   BRITISH JOURNAL OF PHARMACOLOGY

Gut microbiota, enteroendocrine functions and metabolism

(2013) Patrice D Cani et al.   CURRENT OPINION IN PHARMACOLOGY

Coffee and caffeine intake and incidence of type 2 diabetes mellitus: a meta-analysis of prospective studies

(2013) Xiubo Jiang et al.   EUROPEAN JOURNAL OF NUTRITION

Cyclooxygenase-2 induction in macrophages is modulated by docosahexaenoic acid via interactions with free fatty acid receptor 4 (FFA4)

(2013) Xinzhi Li et al.   FASEB JOURNAL

The eosinophil chemoattractant 5-oxo-ETE and the OXE receptor

(2013) William S. Powell et al.   PROGRESS IN LIPID RESEARCH

Regulation of energy metabolism by long-chain fatty acids

(2013) Manabu T. Nakamura et al.   PROGRESS IN LIPID RESEARCH

The fatty acid receptor FFA1/GPR40 a decade later: how much do we know?

(2013) Arturo D. Mancini et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Seven transmembrane G protein-coupled receptor repertoire of gastric ghrelin cells

(2013) Maja S. Engelstoft et al.   Molecular Metabolism

Omega-3 fatty acids and incident type 2 diabetes: a systematic review and meta-analysis

(2012) Jason H. Y. Wu et al.   BRITISH JOURNAL OF NUTRITION

Dietary exposure to perfluoroalkyl acids for the Swedish population in 1999, 2005 and 2010

(2012) Robin Vestergren et al.   ENVIRONMENT INTERNATIONAL

Chemically engineering ligand selectivity at the free fatty acid receptor 2 based on pharmacological variation between species orthologs

(2012) Brian D. Hudson et al.   FASEB JOURNAL

Diet Enriched with Korean Pine Nut Oil Improves Mitochondrial Oxidative Metabolism in Skeletal Muscle and Brown Adipose Tissue in Diet-Induced Obesity

(2012) Ngoc Hoan Le et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Discovery of a Potent and Selective GPR120 Agonist

(2012) Bharat Shimpukade et al.   JOURNAL OF MEDICINAL CHEMISTRY

Free Fatty Acid Receptor 1 (FFA1/GPR40) Agonists: Mesylpropoxy Appendage Lowers Lipophilicity and Improves ADME Properties

(2012) Elisabeth Christiansen et al.   JOURNAL OF MEDICINAL CHEMISTRY

TAK-875 versus placebo or glimepiride in type 2 diabetes mellitus: a phase 2, randomised, double-blind, placebo-controlled trial

(2012) Charles F Burant et al.   LANCET

Dysfunction of lipid sensor GPR120 leads to obesity in both mouse and human

(2012) Atsuhiko Ichimura et al.   NATURE

Stearidonic acid as a supplemental source of ω-3 polyunsaturated fatty acids to enhance status for improved human health

(2012) Celia G. Walker et al.   NUTRITION

Unsaturated Fatty Acids Revert Diet-Induced Hypothalamic Inflammation in Obesity

(2012) Dennys E. Cintra et al.   PLoS One

A Potent Class of GPR40 Full Agonists Engages the EnteroInsular Axis to Promote Glucose Control in Rodents

(2012) Jian Luo et al.   PLoS One

Mediterranean Diet Rich in Olive Oil and Obesity, Metabolic Syndrome and Diabetes Mellitus

(2011) Pablo Perez-Martinez et al.   CURRENT PHARMACEUTICAL DESIGN

Conjugated Linoleic Acids Mediate Insulin Release through Islet G Protein-coupled Receptor FFA1/GPR40

(2011) Johannes Schmidt et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Applying label-free dynamic mass redistribution technology to frame signaling of G protein–coupled receptors noninvasively in living cells

(2011) Ralf Schröder et al.   Nature Protocols

Non-Esterified Fatty Acids Generate Distinct Low-Molecular Weight Amyloid-β (Aβ42) Oligomers along Pathway Different from Fibril Formation

(2011) Amit Kumar et al.   PLoS One

A concise synthesis of the potent inflammatory mediator 5-oxo-ETE

(2011) Rahul Tyagi et al.   MedChemComm

GPR120 Is an Omega-3 Fatty Acid Receptor Mediating Potent Anti-inflammatory and Insulin-Sensitizing Effects

(2010) Da Young Oh et al.   CELL

The G-Protein−Coupled Receptor GPR40 Directly Mediates Long-Chain Fatty Acid−Induced Secretion of Cholecystokinin

(2010) Alice P. Liou et al.   GASTROENTEROLOGY

Deconvolution of complex G protein–coupled receptor signaling in live cells using dynamic mass redistribution measurements

(2010) Ralf Schröder et al.   NATURE BIOTECHNOLOGY

Antiobesity mechanisms of action of conjugated linoleic acid

(2009) Arion Kennedy et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Uptake and Incorporation of Pinolenic Acid Reduces n-6 Polyunsaturated Fatty Acid and Downstream Prostaglandin Formation in Murine Macrophage

(2009) Lu-Te Chuang et al.   LIPIDS

Trans fatty acids: effects on metabolic syndrome, heart disease and diabetes

(2009) Renata Micha et al.   Nature Reviews Endocrinology

G-protein-coupled receptor 40 (GPR40) expression and its regulation in human pancreatic islets: The role of type 2 diabetes and fatty acids

(2009) S. Del Guerra et al.   NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES

Identification of a Lipokine, a Lipid Hormone Linking Adipose Tissue to Systemic Metabolism

(2008) Haiming Cao et al.   CELL

Gpr40 Is Expressed in Enteroendocrine Cells and Mediates Free Fatty Acid Stimulation of Incretin Secretion

(2008) S. Edfalk et al.   DIABETES

Discovery of Potent and Selective Agonists for the Free Fatty Acid Receptor 1 (FFA1/GPR40), a Potential Target for the Treatment of Type II Diabetes

(2008) Elisabeth Christiansen et al.   JOURNAL OF MEDICINAL CHEMISTRY

The effect of Korean pine nut oil on in vitro CCK release, on appetite sensations and on gut hormones in post-menopausal overweight women

(2008) Wilrike J Pasman et al.   Lipids in Health and Disease