Nutrient metabolism and cancer in the in vivo context: a metabolic game of give and take
Published 2020 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Nutrient metabolism and cancer in the
in vivo
context: a metabolic game of give and take
Authors
Keywords
-
Journal
EMBO REPORTS
Volume 21, Issue 10, Pages -
Publisher
EMBO
Online
2020-09-23
DOI
10.15252/embr.202050635
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Dynamic ROS Regulation by TIGAR: Balancing Anti-cancer and Pro-metastasis Effects
- (2020) Sarah-Maria Fendt et al. CANCER CELL
- Dynamic ROS Control by TIGAR Regulates the Initiation and Progression of Pancreatic Cancer
- (2020) Eric C. Cheung et al. CANCER CELL
- Stable Isotopes for Tracing Mammalian-Cell Metabolism In Vivo
- (2020) Juan Fernández-García et al. TRENDS IN BIOCHEMICAL SCIENCES
- Energy Restriction and Colorectal Cancer: A Call for Additional Research
- (2020) Maria Castejón et al. Nutrients
- Remodeling of Metastatic Vasculature Reduces Lung Colonization and Sensitizes Overt Metastases to Immunotherapy
- (2020) Bo He et al. Cell Reports
- Extracellular serine controls epidermal stem cell fate and tumour initiation
- (2020) Sanjeethan C. Baksh et al. NATURE CELL BIOLOGY
- Alterations of gut microbiome accelerate multiple myeloma progression by increasing the relative abundances of nitrogen-recycling bacteria
- (2020) Xingxing Jian et al. Microbiome
- mTOR Signaling and SREBP Activity Increase FADS2 Expression and Can Activate Sapienate Biosynthesis
- (2020) Mouna Triki et al. Cell Reports
- Improving the metabolic fidelity of cancer models with a physiological cell culture medium
- (2019) Johan Vande Voorde et al. Science Advances
- A Mediterranean Diet Mix Has Chemopreventive Effects in a Murine Model of Colorectal Cancer Modulating Apoptosis and the Gut Microbiota
- (2019) Giulia Piazzi et al. Frontiers in Oncology
- High-fructose corn syrup enhances intestinal tumor growth in mice
- (2019) Marcus D. Goncalves et al. SCIENCE
- MSC-regulated lncRNA MACC1-AS1 promotes stemness and chemoresistance through fatty acid oxidation in gastric cancer
- (2019) Wanming He et al. ONCOGENE
- Evidence for an alternative fatty acid desaturation pathway increasing cancer plasticity
- (2019) Kim Vriens et al. NATURE
- Breast cancer cells rely on environmental pyruvate to shape the metastatic niche
- (2019) Ilaria Elia et al. NATURE
- Increased Serine Synthesis Provides an Advantage for Tumors Arising in Tissues Where Serine Levels Are Limiting
- (2019) Mark R. Sullivan et al. Cell Metabolism
- Obesogenic high-fat diet heightens aerobic glycolysis through hyperactivation of oncogenic KRAS
- (2019) Dan Wang et al. Cell Communication and Signaling
- Epithelial-Mesenchymal Plasticity in Cancer Progression and Metastasis
- (2019) Wei Lu et al. DEVELOPMENTAL CELL
- Cystine/glutamate antiporter xCT (SLC7A11) facilitates oncogenic RAS transformation by preserving intracellular redox balance
- (2019) Jonathan K. M. Lim et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Cystine–glutamate antiporter xCT deficiency suppresses tumor growth while preserving antitumor immunity
- (2019) Michael D. Arensman et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Quantification of microenvironmental metabolites in murine cancers reveals determinants of tumor nutrient availability
- (2019) Mark R Sullivan et al. eLife
- Trial watch: dietary interventions for cancer therapy
- (2019) Sarah Lévesque et al. OncoImmunology
- The Non-Essential Amino Acid Cysteine Becomes Essential for Tumor Proliferation and Survival
- (2019) Joseph A. Combs et al. Cancers
- Interactions in the (Pre)metastatic Niche Support Metastasis Formation
- (2019) Ginevra Doglioni et al. Frontiers in Oncology
- Nrf2 Activation Promotes Lung Cancer Metastasis by Inhibiting the Degradation of Bach1
- (2019) Luca Lignitto et al. CELL
- Macrophages and Metabolism in the Tumor Microenvironment
- (2019) Ilio Vitale et al. Cell Metabolism
- Determinants of nutrient limitation in cancer
- (2019) Mark R. Sullivan et al. CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY
- Dietary methionine influences therapy in mouse cancer models and alters human metabolism
- (2019) Xia Gao et al. NATURE
- Immunoregulatory Interplay Between Arginine and Tryptophan Metabolism in Health and Disease
- (2019) Giada Mondanelli et al. Frontiers in Immunology
- Monocarboxylate transporters in cancer
- (2019) Valéry L. Payen et al. Molecular Metabolism
- The phenotypes of proliferating glioblastoma cells reside on a single axis of variation
- (2019) Lin Wang et al. Cancer Discovery
- Lineage-Restricted Regulation of SCD and Fatty Acid Saturation by MITF Controls Melanoma Phenotypic Plasticity
- (2019) Yurena Vivas-García et al. MOLECULAR CELL
- Metabolic landscape of the tumor microenvironment at single cell resolution
- (2019) Zhengtao Xiao et al. Nature Communications
- Adapt and conquer: Metabolic flexibility in cancer growth, invasion and evasion
- (2019) Peter Kreuzaler et al. Molecular Metabolism
- Targeting extracellular nutrient dependencies of cancer cells
- (2019) Javier Garcia-Bermudez et al. Molecular Metabolism
- Metabolic heterogeneity confers differences in melanoma metastatic potential
- (2019) Alpaslan Tasdogan et al. NATURE
- Multi-dimensional roles of ketone bodies in cancer biology: Opportunities for cancer therapy
- (2019) Siqi Feng et al. PHARMACOLOGICAL RESEARCH
- Targeting uptake transporters for cancer imaging and treatment
- (2019) Yuchen Zhang et al. Acta Pharmaceutica Sinica B
- Cancer stem cells (CSCs): metabolic strategies for their identification and eradication
- (2018) Ernestina M. De Francesco et al. BIOCHEMICAL JOURNAL
- The effects of short-term fasting on quality of life and tolerance to chemotherapy in patients with breast and ovarian cancer: a randomized cross-over pilot study
- (2018) Stephan P. Bauersfeld et al. BMC CANCER
- Multiclonal Invasion in Breast Tumors Identified by Topographic Single Cell Sequencing
- (2018) Anna K. Casasent et al. CELL
- Toward Minimal Residual Disease-Directed Therapy in Melanoma
- (2018) Florian Rambow et al. CELL
- As Extracellular Glutamine Levels Decline, Asparagine Becomes an Essential Amino Acid
- (2018) Natalya N. Pavlova et al. Cell Metabolism
- Asparagine and Glutamine: Co-conspirators Fueling Metastasis
- (2018) Ming Luo et al. Cell Metabolism
- Metabolic reprogramming-based characterization of circulating tumor cells in prostate cancer
- (2018) Jing Chen et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- A simple diet- and chemical-induced murine NASH model with rapid progression of steatohepatitis, fibrosis and liver cancer
- (2018) Takuma Tsuchida et al. JOURNAL OF HEPATOLOGY
- Asparagine bioavailability governs metastasis in a model of breast cancer
- (2018) Simon R. V. Knott et al. NATURE
- An aberrant SREBP-dependent lipogenic program promotes metastatic prostate cancer
- (2018) Ming Chen et al. NATURE GENETICS
- Phenotype molding of stromal cells in the lung tumor microenvironment
- (2018) Diether Lambrechts et al. NATURE MEDICINE
- The nutrient environment affects therapy
- (2018) Alexander Muir et al. SCIENCE
- Metabolic Hallmarks of Metastasis Formation
- (2018) Ilaria Elia et al. TRENDS IN CELL BIOLOGY
- Uncoupling Hepatic Oxidative Phosphorylation Reduces Tumor Growth in Two Murine Models of Colon Cancer
- (2018) Yongliang Wang et al. Cell Reports
- Isotope Tracing of Human Clear Cell Renal Cell Carcinomas Demonstrates Suppressed Glucose Oxidation In Vivo
- (2018) Kevin D. Courtney et al. Cell Metabolism
- Suppression of insulin feedback enhances the efficacy of PI3K inhibitors
- (2018) Benjamin D. Hopkins et al. NATURE
- Cellular Metabolism in Lung Health and Disease
- (2018) Gang Liu et al. Annual Review of Physiology
- Co-occurring KRAS mutation/LKB1 loss in non-small cell lung cancer cells results in enhanced metabolic activity susceptible to caloric restriction: an in vitro integrated multilevel approach
- (2018) Elisa Caiola et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- Tumour microenvironment and metabolic plasticity in cancer and cancer stem cells: Perspectives on metabolic and immune regulatory signatures in chemoresistant ovarian cancer stem cells
- (2018) Nuzhat Ahmed et al. SEMINARS IN CANCER BIOLOGY
- Long term but not short term exposure to obesity related microbiota promotes host insulin resistance
- (2018) Kevin P. Foley et al. Nature Communications
- In Vivo Relationship Between Hypoxia and Angiogenesis in Human Glioblastoma: A Multimodal Imaging Study
- (2017) Keven Ferreira da Ponte et al. JOURNAL OF NUCLEAR MEDICINE
- Western diet enhances intestinal tumorigenesis in Min/+ mice, associating with mucosal metabolic and inflammatory stress and loss of Apc heterozygosity
- (2017) Mikael Niku et al. JOURNAL OF NUTRITIONAL BIOCHEMISTRY
- Regulation of stem-like cancer cells by glutamine through β-catenin pathway mediated by redox signaling
- (2017) Jianwei Liao et al. Molecular Cancer
- Modulating the therapeutic response of tumours to dietary serine and glycine starvation
- (2017) Oliver D. K. Maddocks et al. NATURE
- Anticancer effects of the microbiome and its products
- (2017) Laurence Zitvogel et al. NATURE REVIEWS MICROBIOLOGY
- HMDB 4.0: the human metabolome database for 2018
- (2017) David S Wishart et al. NUCLEIC ACIDS RESEARCH
- Metabolic origins of spatial organization in the tumor microenvironment
- (2017) Carlos Carmona-Fontaine et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Gut microbiome modulates response to anti–PD-1 immunotherapy in melanoma patients
- (2017) V. Gopalakrishnan et al. SCIENCE
- Gut microbiome influences efficacy of PD-1–based immunotherapy against epithelial tumors
- (2017) Bertrand Routy et al. SCIENCE
- Metabolic interactions in cancer: cellular metabolism at the interface between the microenvironment, the cancer cell phenotype and the epigenetic landscape
- (2017) Gianmarco Rinaldi et al. Wiley Interdisciplinary Reviews-Systems Biology and Medicine
- Proline metabolism supports metastasis formation and could be inhibited to selectively target metastasizing cancer cells
- (2017) Ilaria Elia et al. Nature Communications
- High Shear Stresses under Exercise Condition Destroy Circulating Tumor Cells in a Microfluidic System
- (2017) Sagar Regmi et al. Scientific Reports
- Dietary Uncoupling of Gut Microbiota and Energy Harvesting from Obesity and Glucose Tolerance in Mice
- (2017) Matthew J. Dalby et al. Cell Reports
- Environmental cystine drives glutamine anaplerosis and sensitizes cancer cells to glutaminase inhibition
- (2017) Alexander Muir et al. eLife
- Increased utilization of fructose has a positive effect on the development of breast cancer
- (2017) Xiajing Fan et al. PeerJ
- Safety and feasibility of fasting in combination with platinum-based chemotherapy
- (2016) Tanya B. Dorff et al. BMC CANCER
- Upregulated Glucose Metabolism Correlates Inversely with CD8 + T-cell Infiltration and Survival in Squamous Cell Carcinoma
- (2016) Christian H. Ottensmeier et al. CANCER RESEARCH
- A Sucrose-Enriched Diet Promotes Tumorigenesis in Mammary Gland in Part through the 12-Lipoxygenase Pathway
- (2016) Y. Jiang et al. CANCER RESEARCH
- Metabolic Heterogeneity in Human Lung Tumors
- (2016) Christopher T. Hensley et al. CELL
- Targeting Stromal Glutamine Synthetase in Tumors Disrupts Tumor Microenvironment-Regulated Cancer Cell Growth
- (2016) Lifeng Yang et al. Cell Metabolism
- Differential Glutamate Metabolism in Proliferating and Quiescent Mammary Epithelial Cells
- (2016) Jonathan L. Coloff et al. Cell Metabolism
- Environment Impacts the Metabolic Dependencies of Ras-Driven Non-Small Cell Lung Cancer
- (2016) Shawn M. Davidson et al. Cell Metabolism
- Molecular Portrait of Metastasis-Competent Circulating Tumor Cells in Colon Cancer Reveals the Crucial Role of Genes Regulating Energy Metabolism and DNA Repair
- (2016) Catherine Alix-Panabières et al. CLINICAL CHEMISTRY
- Dietary fructose-induced hepatocellular carcinoma development manifested in mice lacking apoptosis inhibitor of macrophage (AIM)
- (2016) Takayuki Ozawa et al. GENES TO CELLS
- Obesity but not high-fat diet impairs lymphatic function
- (2016) G D García Nores et al. INTERNATIONAL JOURNAL OF OBESITY
- Cancer metabolism at a glance
- (2016) Alexei Vazquez et al. JOURNAL OF CELL SCIENCE
- A diet-induced animal model of non-alcoholic fatty liver disease and hepatocellular cancer
- (2016) Amon Asgharpour et al. JOURNAL OF HEPATOLOGY
- Reductive carboxylation supports redox homeostasis during anchorage-independent growth
- (2016) Lei Jiang et al. NATURE
- Pancreatic stellate cells support tumour metabolism through autophagic alanine secretion
- (2016) Cristovão M. Sousa et al. NATURE
- Mutant Kras copy number defines metabolic reprogramming and therapeutic susceptibilities
- (2016) Emma M. Kerr et al. NATURE
- Targeting metastasis-initiating cells through the fatty acid receptor CD36
- (2016) Gloria Pascual et al. NATURE
- Regional glutamine deficiency in tumours promotes dedifferentiation through inhibition of histone demethylation
- (2016) Min Pan et al. NATURE CELL BIOLOGY
- Metabolite concentrations, fluxes and free energies imply efficient enzyme usage
- (2016) Junyoung O Park et al. Nature Chemical Biology
- Systemic depletion of L-cyst(e)ine with cyst(e)inase increases reactive oxygen species and suppresses tumor growth
- (2016) Shira L Cramer et al. NATURE MEDICINE
- Direct evidence for cancer-cell-autonomous extracellular protein catabolism in pancreatic tumors
- (2016) Shawn M Davidson et al. NATURE MEDICINE
- Diet, nutrition and cancer: past, present and future
- (2016) Susan T. Mayne et al. Nature Reviews Clinical Oncology
- High-fat Western diet–induced obesity contributes to increased tumor growth in mouse models of human colon cancer
- (2016) Ann Marie O'Neill et al. NUTRITION RESEARCH
- Glutamine activates STAT3 to control cancer cell proliferation independently of glutamine metabolism
- (2016) A Cacace et al. ONCOGENE
- Effects of high-fat diet on plasma profiles of eicosanoid metabolites in mice
- (2016) Weicang Wang et al. PROSTAGLANDINS & OTHER LIPID MEDIATORS
- Tissue of origin dictates branched-chain amino acid metabolism in mutant Kras-driven cancers
- (2016) J. R. Mayers et al. SCIENCE
- Tissue-specific and convergent metabolic transformation of cancer correlates with metastatic potential and patient survival
- (2016) Edoardo Gaude et al. Nature Communications
- Asparagine promotes cancer cell proliferation through use as an amino acid exchange factor
- (2016) Abigail S. Krall et al. Nature Communications
- High expression of MnSOD promotes survival of circulating breast cancer cells and increases their resistance to doxorubicin
- (2016) Afu Fu et al. Oncotarget
- Resistance to Antiangiogenic Therapies by Metabolic Symbiosis in Renal Cell Carcinoma PDX Models and Patients
- (2016) Gabriela Jiménez-Valerio et al. Cell Reports
- Metabolic Symbiosis Enables Adaptive Resistance to Anti-angiogenic Therapy that Is Dependent on mTOR Signaling
- (2016) Elizabeth Allen et al. Cell Reports
- Targeting Metabolic Symbiosis to Overcome Resistance to Anti-angiogenic Therapy
- (2016) Laura Pisarsky et al. Cell Reports
- Breast Cancer-Derived Lung Metastases Show Increased Pyruvate Carboxylase-Dependent Anaplerosis
- (2016) Stefan Christen et al. Cell Reports
- Revised Estimates for the Number of Human and Bacteria Cells in the Body
- (2016) Ron Sender et al. PLOS BIOLOGY
- In vivo cancer metabolism is defined by the nutrient microenvironment
- (2016) Ilaria Elia et al. Translational Cancer Research
- Metabolic control of signalling pathways and metabolic auto-regulation
- (2015) Doriane Lorendeau et al. BIOLOGY OF THE CELL
- The effects of short-term fasting on tolerance to (neo) adjuvant chemotherapy in HER2-negative breast cancer patients: a randomized pilot study
- (2015) Stefanie de Groot et al. BMC CANCER
- Human Pancreatic Cancer Tumors Are Nutrient Poor and Tumor Cells Actively Scavenge Extracellular Protein
- (2015) J. J. Kamphorst et al. CANCER RESEARCH
- TGF-β Promotes Heterogeneity and Drug Resistance in Squamous Cell Carcinoma
- (2015) Naoki Oshimori et al. CELL
- PDK1-Dependent Metabolic Reprogramming Dictates Metastatic Potential in Breast Cancer
- (2015) Fanny Dupuy et al. Cell Metabolism
- A Supplemented High-Fat Low-Carbohydrate Diet for the Treatment of Glioblastoma
- (2015) R. T. Martuscello et al. CLINICAL CANCER RESEARCH
- Mass-Spectrometry-Based Serum Metabolomics of a C57BL/6J Mouse Model of High-Fat-Diet-Induced Non-alcoholic Fatty Liver Disease Development
- (2015) Yi-Syuan Lai et al. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
- Potentiated DNA Damage Response in Circulating Breast Tumor Cells Confers Resistance to Chemotherapy
- (2015) Chang Gong et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Pyruvate carboxylase is critical for non–small-cell lung cancer proliferation
- (2015) Katherine Sellers et al. JOURNAL OF CLINICAL INVESTIGATION
- Oxidative stress inhibits distant metastasis by human melanoma cells
- (2015) Elena Piskounova et al. NATURE
- Glutamine synthetase activity fuels nucleotide biosynthesis and supports growth of glutamine-restricted glioblastoma
- (2015) Saverio Tardito et al. NATURE CELL BIOLOGY
- Breast-cancer-secreted miR-122 reprograms glucose metabolism in premetastatic niche to promote metastasis
- (2015) Miranda Y. Fong et al. NATURE CELL BIOLOGY
- Antioxidants can increase melanoma metastasis in mice
- (2015) Kristell Le Gal et al. Science Translational Medicine
- Tissue invasion and metastasis: Molecular, biological and clinical perspectives
- (2015) W.G. Jiang et al. SEMINARS IN CANCER BIOLOGY
- Gut microbiome development along the colorectal adenoma–carcinoma sequence
- (2015) Qiang Feng et al. Nature Communications
- Reactive Oxygen Species Regulate Hematopoietic Stem Cell Self-Renewal, Migration and Development, As Well As Their Bone Marrow Microenvironment
- (2014) Aya Ludin et al. ANTIOXIDANTS & REDOX SIGNALING
- A lactate shuttle system between tumour and stromal cells is associated with poor prognosis in prostate cancer
- (2014) Nelma Pértega-Gomes et al. BMC CANCER
- Acetate Is a Bioenergetic Substrate for Human Glioblastoma and Brain Metastases
- (2014) Tomoyuki Mashimo et al. CELL
- High-fat-diet-mediated dysbiosis promotes intestinal carcinogenesis independently of obesity
- (2014) Manon D. Schulz et al. NATURE
- Microbiota organization is a distinct feature of proximal colorectal cancers
- (2014) Christine M. Dejea et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The Dormancy Dilemma: Quiescence versus Balanced Proliferation
- (2013) Alan Wells et al. CANCER RESEARCH
- Sugar for the brain: the role of glucose in physiological and pathological brain function
- (2013) Philipp Mergenthaler et al. TRENDS IN NEUROSCIENCES
- Reciprocal Metabolic Reprogramming through Lactate Shuttle Coordinately Influences Tumor-Stroma Interplay
- (2012) T. Fiaschi et al. CANCER RESEARCH
- The Metabolic Profile of Tumors Depends on Both the Responsible Genetic Lesion and Tissue Type
- (2012) Mariia O. Yuneva et al. Cell Metabolism
- Analysis of Tumor Metabolism Reveals Mitochondrial Glucose Oxidation in Genetically Diverse Human Glioblastomas in the Mouse Brain In Vivo
- (2012) Isaac Marin-Valencia et al. Cell Metabolism
- Clonal selection drives genetic divergence of metastatic medulloblastoma
- (2012) Xiaochong Wu et al. NATURE
- Clonal evolution in relapsed acute myeloid leukaemia revealed by whole-genome sequencing
- (2012) Li Ding et al. NATURE
- Metabolism of [U-13C]glucose in human brain tumorsin vivo
- (2012) Elizabeth A. Maher et al. NMR IN BIOMEDICINE
- Variable Clonal Repopulation Dynamics Influence Chemotherapy Response in Colorectal Cancer
- (2012) A. Kreso et al. SCIENCE
- Surgical Stress Resistance Induced by Single Amino Acid Deprivation Requires Gcn2 in Mice
- (2012) W. Peng et al. Science Translational Medicine
- Behavior of seeds and soil in the mechanism of metastasis: A deeper understanding
- (2011) Lucy Mathot et al. CANCER SCIENCE
- Hallmarks of Cancer: The Next Generation
- (2011) Douglas Hanahan et al. CELL
- 13C-Pyruvate Imaging Reveals Alterations in Glycolysis that Precede c-Myc-Induced Tumor Formation and Regression
- (2011) Simon Hu et al. Cell Metabolism
- A high-fat diet increases angiogenesis, solid tumor growth, and lung metastasis of CT26 colon cancer cells in obesity-resistant BALB/c mice
- (2011) Heesook Park et al. MOLECULAR CARCINOGENESIS
- Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth
- (2011) Kristin M Nieman et al. NATURE MEDICINE
- Inhibition of fatty acid oxidation by etomoxir impairs NADPH production and increases reactive oxygen species resulting in ATP depletion and cell death in human glioblastoma cells
- (2010) Lisa S. Pike et al. BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS
- Tumor heterogeneity: Causes and consequences
- (2009) Andriy Marusyk et al. BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
- Acetate transport and utilization in the rat brain
- (2009) Dinesh K. Deelchand et al. JOURNAL OF NEUROCHEMISTRY
- Altered regulation of metabolic pathways in human lung cancer discerned by 13C stable isotope-resolved metabolomics (SIRM)
- (2009) Teresa WM Fan et al. Molecular Cancer
- Antioxidant and oncogene rescue of metabolic defects caused by loss of matrix attachment
- (2009) Zachary T. Schafer et al. NATURE
Find the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
SearchBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started