Metabolic interactions in cancer: cellular metabolism at the interface between the microenvironment, the cancer cell phenotype and the epigenetic landscape
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Title
Metabolic interactions in cancer: cellular metabolism at the interface between the microenvironment, the cancer cell phenotype and the epigenetic landscape
Authors
Keywords
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Journal
Wiley Interdisciplinary Reviews-Systems Biology and Medicine
Volume 10, Issue 1, Pages e1397
Publisher
Wiley
Online
2017-08-31
DOI
10.1002/wsbm.1397
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Note: Only part of the references are listed.- Review of metabolic pathways activated in cancer cells as determined through isotopic labeling and network analysis
- (2017) Wentao Dong et al. METABOLIC ENGINEERING
- Metabolic interactions with cancer epigenetics
- (2017) Xia Gao et al. MOLECULAR ASPECTS OF MEDICINE
- Metabolic origins of spatial organization in the tumor microenvironment
- (2017) Carlos Carmona-Fontaine et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Collagen-derived proline promotes pancreatic ductal adenocarcinoma cell survival under nutrient limited conditions
- (2017) Orianne Olivares et al. Nature Communications
- Proline metabolism supports metastasis formation and could be inhibited to selectively target metastasizing cancer cells
- (2017) Ilaria Elia et al. Nature Communications
- Acetate Recapturing by Nuclear Acetyl-CoA Synthetase 2 Prevents Loss of Histone Acetylation during Oxygen and Serum Limitation
- (2017) Vinay Bulusu et al. Cell Reports
- Vitamin C and l -Proline Antagonistic Effects Capture Alternative States in the Pluripotency Continuum
- (2017) Cristina D'Aniello et al. Stem Cell Reports
- Metabolic Hallmarks of Tumor and Immune Cells in the Tumor Microenvironment
- (2017) Kathrin Renner et al. Frontiers in Immunology
- Macrophage Metabolism As Therapeutic Target for Cancer, Atherosclerosis, and Obesity
- (2017) Xenia Geeraerts et al. Frontiers in Immunology
- Metabolic Heterogeneity in Human Lung Tumors
- (2016) Christopher T. Hensley et al. CELL
- Oncogenic Ras differentially regulates metabolism and anoikis in extracellular matrix-detached cells
- (2016) J A Mason et al. CELL DEATH AND DIFFERENTIATION
- Acidosis Drives the Reprogramming of Fatty Acid Metabolism in Cancer Cells through Changes in Mitochondrial and Histone Acetylation
- (2016) Cyril Corbet et al. Cell Metabolism
- The Emerging Hallmarks of Cancer Metabolism
- (2016) Natalya N. Pavlova et al. Cell Metabolism
- α-Ketoglutarate Accelerates the Initial Differentiation of Primed Human Pluripotent Stem Cells
- (2016) Tara TeSlaa et al. Cell Metabolism
- Differential Glutamate Metabolism in Proliferating and Quiescent Mammary Epithelial Cells
- (2016) Jonathan L. Coloff et al. Cell Metabolism
- Reversal of Cytosolic One-Carbon Flux Compensates for Loss of the Mitochondrial Folate Pathway
- (2016) Gregory S. Ducker et al. Cell Metabolism
- Environment Impacts the Metabolic Dependencies of Ras-Driven Non-Small Cell Lung Cancer
- (2016) Shawn M. Davidson et al. Cell Metabolism
- PKM2, cancer metabolism, and the road ahead
- (2016) Talya L Dayton et al. EMBO REPORTS
- Folate deficiency affects histone methylation
- (2016) Benjamin A. Garcia et al. MEDICAL HYPOTHESES
- Tumour hypoxia causes DNA hypermethylation by reducing TET activity
- (2016) Bernard Thienpont et al. NATURE
- Reductive carboxylation supports redox homeostasis during anchorage-independent growth
- (2016) Lei Jiang et al. NATURE
- Pancreatic stellate cells support tumour metabolism through autophagic alanine secretion
- (2016) Cristovão M. Sousa et al. NATURE
- Metastatic colonization by circulating tumour cells
- (2016) Joan Massagué et al. NATURE
- Metabolite concentrations, fluxes and free energies imply efficient enzyme usage
- (2016) Junyoung O Park et al. Nature Chemical Biology
- Tissue of origin dictates branched-chain amino acid metabolism in mutant Kras-driven cancers
- (2016) J. R. Mayers et al. SCIENCE
- Integrative modelling of tumour DNA methylation quantifies the contribution of metabolism
- (2016) Mahya Mehrmohamadi et al. Nature Communications
- Lipids Reprogram Metabolism to Become a Major Carbon Source for Histone Acetylation
- (2016) Eoin McDonnell et al. Cell Reports
- Breast Cancer-Derived Lung Metastases Show Increased Pyruvate Carboxylase-Dependent Anaplerosis
- (2016) Stefan Christen et al. Cell Reports
- In vivo cancer metabolism is defined by the nutrient microenvironment
- (2016) Ilaria Elia et al. Translational Cancer Research
- Fundamentals of cancer metabolism
- (2016) R. J. DeBerardinis et al. Science Advances
- One-carbon metabolism and epigenetics: understanding the specificity
- (2015) Samantha J. Mentch et al. Annals of the New York Academy of Sciences
- Metabolism and Epigenetics
- (2015) Ryan Janke et al. Annual Review of Cell and Developmental Biology
- Metabolic control of signalling pathways and metabolic auto-regulation
- (2015) Doriane Lorendeau et al. BIOLOGY OF THE CELL
- Acetyl-CoA Synthetase 2 Promotes Acetate Utilization and Maintains Cancer Cell Growth under Metabolic Stress
- (2015) Zachary T. Schug et al. CANCER CELL
- Human Pancreatic Cancer Tumors Are Nutrient Poor and Tumor Cells Actively Scavenge Extracellular Protein
- (2015) J. J. Kamphorst et al. CANCER RESEARCH
- An Essential Role of the Mitochondrial Electron Transport Chain in Cell Proliferation Is to Enable Aspartate Synthesis
- (2015) Kıvanç Birsoy et al. CELL
- Supporting Aspartate Biosynthesis Is an Essential Function of Respiration in Proliferating Cells
- (2015) Lucas B. Sullivan et al. CELL
- Histone Methylation Dynamics and Gene Regulation Occur through the Sensing of One-Carbon Metabolism
- (2015) Samantha J. Mentch et al. Cell Metabolism
- A roadmap for interpreting 13 C metabolite labeling patterns from cells
- (2015) Joerg M Buescher et al. CURRENT OPINION IN BIOTECHNOLOGY
- How to measure metabolic fluxes: a taxonomic guide for 13 C fluxomics
- (2015) Sebastian Niedenführ et al. CURRENT OPINION IN BIOTECHNOLOGY
- Hexosamine pathway and (ER) protein quality control
- (2015) Martin S Denzel et al. CURRENT OPINION IN CELL BIOLOGY
- Pyruvate carboxylase is critical for non–small-cell lung cancer proliferation
- (2015) Katherine Sellers et al. JOURNAL OF CLINICAL INVESTIGATION
- Pyruvate Kinase Isoform Expression Alters Nucleotide Synthesis to Impact Cell Proliferation
- (2015) Sophia Y. Lunt et al. MOLECULAR CELL
- Function and information content of DNA methylation
- (2015) Dirk Schübeler NATURE
- Oxidative stress inhibits distant metastasis by human melanoma cells
- (2015) Elena Piskounova et al. NATURE
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- (2015) Devon A. Lawson et al. NATURE
- Glutamine synthetase activity fuels nucleotide biosynthesis and supports growth of glutamine-restricted glioblastoma
- (2015) Saverio Tardito et al. NATURE CELL BIOLOGY
- Metabolic pathways promoting cancer cell survival and growth
- (2015) Lindsey K. Boroughs et al. NATURE CELL BIOLOGY
- Dysregulated metabolism contributes to oncogenesis
- (2015) Matthew D. Hirschey et al. SEMINARS IN CANCER BIOLOGY
- Famine versus feast: understanding the metabolism of tumors in vivo
- (2015) Jared R. Mayers et al. TRENDS IN BIOCHEMICAL SCIENCES
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- (2014) Maddaly Ravi et al. JOURNAL OF CELLULAR PHYSIOLOGY
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- (2014) Bryce W. Carey et al. NATURE
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- (2014) Bart Ghesquière et al. NATURE
- Elevation of circulating branched-chain amino acids is an early event in human pancreatic adenocarcinoma development
- (2014) Jared R Mayers et al. NATURE MEDICINE
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- (2014) Chunaram Choudhary et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Crystal structure of the histone lysine specific demethylase LSD1 complexed with tetrahydrofolate
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- (2014) Ivano Amelio et al. TRENDS IN BIOCHEMICAL SCIENCES
- DNA Sequence Explains Seemingly Disordered Methylation Levels in Partially Methylated Domains of Mammalian Genomes
- (2014) Dimos Gaidatzis et al. PLoS Genetics
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- (2013) S.-M. Fendt et al. CANCER RESEARCH
- IDH1 and IDH2 Mutations in Gliomas
- (2013) Adam L. Cohen et al. Current Neurology and Neuroscience Reports
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- (2013) E. White GENES & DEVELOPMENT
- Metabolic Pathways in Immune Cell Activation and Quiescence
- (2013) Erika L. Pearce et al. IMMUNITY
- Glutamine and cancer: cell biology, physiology, and clinical opportunities
- (2013) Christopher T. Hensley et al. JOURNAL OF CLINICAL INVESTIGATION
- Medicinal Chemistry of Nicotinamide Phosphoribosyltransferase (NAMPT) Inhibitors
- (2013) Ubaldina Galli et al. JOURNAL OF MEDICINAL CHEMISTRY
- Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells
- (2013) Cosimo Commisso et al. NATURE
- A community-driven global reconstruction of human metabolism
- (2013) Ines Thiele et al. NATURE BIOTECHNOLOGY
- BCAT1 promotes cell proliferation through amino acid catabolism in gliomas carrying wild-type IDH1
- (2013) Martje Tönjes et al. NATURE MEDICINE
- Histone lysine demethylases as targets for anticancer therapy
- (2013) Jonas W. Højfeldt et al. NATURE REVIEWS DRUG DISCOVERY
- Strengthened glycolysis under hypoxia supports tumor symbiosis and hexosamine biosynthesis in pancreatic adenocarcinoma
- (2013) F. Guillaumond et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Acetyl-CoA induces transcription of the key G1 cyclin CLN3 to promote entry into the cell division cycle in Saccharomyces cerevisiae
- (2013) L. Shi et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Epigenetic Reprogramming in Cancer
- (2013) M. L. Suva et al. SCIENCE
- Measurement of acetylation turnover at distinct lysines in human histones identifies long-lived acetylation sites
- (2013) Yupeng Zheng et al. Nature Communications
- Reductive glutamine metabolism is a function of the α-ketoglutarate to citrate ratio in cells
- (2013) Sarah-Maria Fendt et al. Nature Communications
- Lactate stimulates angiogenesis and accelerates the healing of superficial and ischemic wounds in mice
- (2012) Paolo E. Porporato et al. ANGIOGENESIS
- Connecting Threads: Epigenetics and Metabolism
- (2012) Sayako Katada et al. CELL
- Oncogenic Kras Maintains Pancreatic Tumors through Regulation of Anabolic Glucose Metabolism
- (2012) Haoqiang Ying et al. CELL
- Staying alive
- (2012) James R. Valcourt et al. CELL CYCLE
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- (2012) Mariia O. Yuneva et al. Cell Metabolism
- Analysis of Tumor Metabolism Reveals Mitochondrial Glucose Oxidation in Genetically Diverse Human Glioblastomas in the Mouse Brain In Vivo
- (2012) Isaac Marin-Valencia et al. Cell Metabolism
- The Pancreas Cancer Microenvironment
- (2012) C. Feig et al. CLINICAL CANCER RESEARCH
- Inhibition of -KG-dependent histone and DNA demethylases by fumarate and succinate that are accumulated in mutations of FH and SDH tumor suppressors
- (2012) M. Xiao et al. GENES & DEVELOPMENT
- Involvement of p53 in the cytotoxic activity of the NAMPT inhibitor FK866 in myeloid leukemic cells
- (2012) Basant Kumar Thakur et al. INTERNATIONAL JOURNAL OF CANCER
- Acetyl-CoA Carboxylase Regulates Global Histone Acetylation
- (2012) Luciano Galdieri et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- A fatty acid-binding protein 7/RXRβ pathway enhances survival and proliferation in triple-negative breast cancer
- (2012) Rong-Zong Liu et al. JOURNAL OF PATHOLOGY
- Glucose Oxidation Modulates Anoikis and Tumor Metastasis
- (2012) S. Kamarajugadda et al. MOLECULAR AND CELLULAR BIOLOGY
- Histone methylation: a dynamic mark in health, disease and inheritance
- (2012) Eric L. Greer et al. NATURE REVIEWS GENETICS
- Reprogramming of proline and glutamine metabolism contributes to the proliferative and metabolic responses regulated by oncogenic transcription factor c-MYC
- (2012) W. Liu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Metabolite Profiling Identifies a Key Role for Glycine in Rapid Cancer Cell Proliferation
- (2012) M. Jain et al. SCIENCE
- Dietary folate, but not choline, modifies neural tube defect risk in Shmt1 knockout mice
- (2011) Anna E Beaudin et al. AMERICAN JOURNAL OF CLINICAL NUTRITION
- Association of FABP5 Expression With Poor Survival in Triple-Negative Breast Cancer
- (2011) Rong-Zong Liu et al. AMERICAN JOURNAL OF PATHOLOGY
- Aerobic Glycolysis: Meeting the Metabolic Requirements of Cell Proliferation
- (2011) Sophia Y. Lunt et al. Annual Review of Cell and Developmental Biology
- Lactate Influx through the Endothelial Cell Monocarboxylate Transporter MCT1 Supports an NF- B/IL-8 Pathway that Drives Tumor Angiogenesis
- (2011) F. Vegran et al. CANCER RESEARCH
- Hallmarks of Cancer: The Next Generation
- (2011) Douglas Hanahan et al. CELL
- The reverse Warburg effect: Aerobic glycolysis in cancer associated fibroblasts and the tumor stroma
- (2011) Stephanos Pavlides et al. CELL CYCLE
- Erk regulation of pyruvate dehydrogenase flux through PDK4 modulates cell proliferation
- (2011) A. R. Grassian et al. GENES & DEVELOPMENT
- Lipoprotein Lipase Links Dietary Fat to Solid Tumor Cell Proliferation
- (2011) N. B. Kuemmerle et al. MOLECULAR CANCER THERAPEUTICS
- Methionine Adenosyltransferase II Serves as a Transcriptional Corepressor of Maf Oncoprotein
- (2011) Yasutake Katoh et al. MOLECULAR CELL
- Acetyl-CoA Induces Cell Growth and Proliferation by Promoting the Acetylation of Histones at Growth Genes
- (2011) Ling Cai et al. MOLECULAR CELL
- Reductive carboxylation supports growth in tumour cells with defective mitochondria
- (2011) Andrew R. Mullen et al. NATURE
- Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia
- (2011) Christian M. Metallo et al. NATURE
- Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth
- (2011) Kristin M Nieman et al. NATURE MEDICINE
- Frequent Mutation of Isocitrate Dehydrogenase (IDH)1 and IDH2 in Cholangiocarcinoma Identified Through Broad-Based Tumor Genotyping
- (2011) D. R. Borger et al. ONCOLOGIST
- The Human Serum Metabolome
- (2011) Nikolaos Psychogios et al. PLoS One
- Pyruvate carboxylase is required for glutamine-independent growth of tumor cells
- (2011) T. Cheng et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Hypoxia promotes isocitrate dehydrogenase-dependent carboxylation of -ketoglutarate to citrate to support cell growth and viability
- (2011) D. R. Wise et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The Essence of Quiescence
- (2011) H. A. Coller SCIENCE
- Identification of a CpG Island Methylator Phenotype that Defines a Distinct Subgroup of Glioma
- (2010) Houtan Noushmehr et al. CANCER CELL
- Leukemic IDH1 and IDH2 Mutations Result in a Hypermethylation Phenotype, Disrupt TET2 Function, and Impair Hematopoietic Differentiation
- (2010) Maria E. Figueroa et al. CANCER CELL
- Myc-dependent Mitochondrial Generation of Acetyl-CoA Contributes to Fatty Acid Biosynthesis and Histone Acetylation during Cell Cycle Entry
- (2010) Fionnuala Morrish et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- IDH1 and IDH2 Mutations Are Frequent Genetic Alterations in Acute Myeloid Leukemia and Confer Adverse Prognosis in Cytogenetically Normal Acute Myeloid Leukemia With NPM1 Mutation Without FLT3 Internal Tandem Duplication
- (2010) Peter Paschka et al. JOURNAL OF CLINICAL ONCOLOGY
- Defects in succinate dehydrogenase in gastrointestinal stromal tumors lacking KIT and PDGFRA mutations
- (2010) K. A. Janeway et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Quiescent Fibroblasts Exhibit High Metabolic Activity
- (2010) Johanna M. S. Lemons et al. PLOS BIOLOGY
- Epigenetics in cancer
- (2009) S. Sharma et al. CARCINOGENESIS
- Altered regulation of metabolic pathways in human lung cancer discerned by 13C stable isotope-resolved metabolomics (SIRM)
- (2009) Teresa WM Fan et al. Molecular Cancer
- Antioxidant and oncogene rescue of metabolic defects caused by loss of matrix attachment
- (2009) Zachary T. Schafer et al. NATURE
- Overexpression of fatty acid binding protein-7 correlates with basal-like subtype of breast cancer
- (2009) Xiao Yan Tang et al. PATHOLOGY RESEARCH AND PRACTICE
- ATP-Citrate Lyase Links Cellular Metabolism to Histone Acetylation
- (2009) K. E. Wellen et al. SCIENCE
- Histone methyltransferases in cancer
- (2009) Mareike Albert et al. SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
- Analysis of the IDH1 codon 132 mutation in brain tumors
- (2008) Jörg Balss et al. ACTA NEUROPATHOLOGICA
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