Journal
PROSTAGLANDINS & OTHER LIPID MEDIATORS
Volume 127, Issue -, Pages 9-13Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.prostaglandins.2016.11.003
Keywords
Obesity; High-fat diet; Eicosanoids; Leukotoxins; Epoxyoctadecenoic acids
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Funding
- USDA [NIFA2016-67017-24423]
- Armstrong Fund of Science Award from UMass-Amherst
- new faculty start-up fund
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Obesity is a serious health problem in the US and is associated with increased risks of various human diseases. To date, the mechanisms by which obesity increases the risks of a wide range of human diseases are not well understood. Here we used a LC-MS/MS-based lipidomics, which can analyze >100 bioactive lipid mediators produced by cyclooxygenase, lipoxygenase, and cytochrome P450 enzymes, to analyze plasma profiles of lipid mediators in high-fat diet induced obesity in C57BL/6 mice. Our results show that the plasma concentrations of epoxyoctadecenoic acids (EpOMEs, also termed as leukotoxins) are significantly increased in plasma of high-fat diet-fed mice, in addition, EpOMEs are among the most abundant lipid mediators detected in mouse plasma. Since substantial studies have shown that EpOMEs and their metabolites have a large array of detrimental effects on health, enhanced levels of EpOMEs could contribute to the pathology of obesity. (C) 2016 Elsevier Inc. All rights reserved.
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