Reactive Oxygen Species Regulate Hematopoietic Stem Cell Self-Renewal, Migration and Development, As Well As Their Bone Marrow Microenvironment

Direct measurement of local oxygen concentration in the bone marrow of live animals

(2014) Joel A. Spencer et al.   NATURE

Glucose metabolism impacts the spatiotemporal onset and magnitude of HSC induction in vivo

(2013) J. M. Harris et al.   BLOOD

Prostaglandin E2 regulates murine hematopoietic stem/progenitor cells directly via EP4 receptor and indirectly through mesenchymal progenitor cells

(2013) Y. M. Ikushima et al.   BLOOD

AML1-ETO mediates hematopoietic self-renewal and leukemogenesis through a COX/ -catenin signaling pathway

(2013) Y. Zhang et al.   BLOOD

A Pan-BCL2 Inhibitor Renders Bone-Marrow-Resident Human Leukemia Stem Cells Sensitive to Tyrosine Kinase Inhibition

(2013) Daniel J. Goff et al.   Cell Stem Cell

Regulation of Glycolysis by Pdk Functions as a Metabolic Checkpoint for Cell Cycle Quiescence in Hematopoietic Stem Cells

(2013) Keiyo Takubo et al.   Cell Stem Cell

Metabolic Regulation by the Mitochondrial Phosphatase PTPMT1 Is Required for Hematopoietic Stem Cell Differentiation

(2013) Wen-Mei Yu et al.   Cell Stem Cell

BCL-2 Inhibition Targets Oxidative Phosphorylation and Selectively Eradicates Quiescent Human Leukemia Stem Cells

(2013) Eleni D. Lagadinou et al.   Cell Stem Cell

Fibroblast growth factor signaling promotes physiological bone remodeling and stem cell self-renewal

(2013) Tomer Itkin et al.   CURRENT OPINION IN HEMATOLOGY

GSK3β regulates physiological migration of stem/progenitor cells via cytoskeletal rearrangement

(2013) Kfir Lapid et al.   JOURNAL OF CLINICAL INVESTIGATION

CXCL12 in early mesenchymal progenitors is required for haematopoietic stem-cell maintenance

(2013) Adam Greenbaum et al.   NATURE

Haematopoietic stem cells and early lymphoid progenitors occupy distinct bone marrow niches

(2013) Lei Ding et al.   NATURE

FOXO3A directs a protective autophagy program in haematopoietic stem cells

(2013) Matthew R. Warr et al.   NATURE

Nrf2 regulates haematopoietic stem cell function

(2013) Jennifer J. Tsai et al.   NATURE CELL BIOLOGY

Quantitative imaging of haematopoietic stem and progenitor cell localization and hypoxic status in the bone marrow microenvironment

(2013) César Nombela-Arrieta et al.   NATURE CELL BIOLOGY

Myeloablative Transplantation using either Cord Blood or Bone Marrow leads to Immune Recovery, High Long-Term Donor Chimerism and Excellent Survival in Chronic Granulomatous Disease

(2012) Priti Tewari et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

FGF signaling facilitates postinjury recovery of mouse hematopoietic system

(2012) M. Zhao et al.   BLOOD

Pharmacologic stabilization of HIF-1  increases hematopoietic stem cell quiescence in vivo and accelerates blood recovery after severe irradiation

(2012) C. E. Forristal et al.   BLOOD

FGF-2 expands murine hematopoietic stem and progenitor cells via proliferation of stromal cells, c-Kit activation, and CXCL12 down-regulation

(2012) T. Itkin et al.   BLOOD

S1P promotes murine progenitor cell egress and mobilization via S1P1-mediated ROS signaling and SDF-1 release

(2012) K. Golan et al.   BLOOD

Mouse hematopoietic cell-targeted STAT3 deletion: stem/progenitor cell defects, mitochondrial dysfunction, ROS overproduction, and a rapid aging-like phenotype

(2012) C. Mantel et al.   BLOOD

Homeostatic and Tissue Reparation Defaults in Mice Carrying Selective Genetic Invalidation of CXCL12/Proteoglycan Interactions

(2012) Patricia Rueda et al.   CIRCULATION

Hypoxia regulates glutamate receptor trafficking through an HIF-independent mechanism

(2012) Eun Chan Park et al.   EMBO JOURNAL

GSK3 inactivation is involved in mitochondrial complex IV defect in transforming growth factor (TGF) β1-induced senescence

(2012) Hae-Ok Byun et al.   EXPERIMENTAL CELL RESEARCH

Redox regulation of stem/progenitor cells and bone marrow niche

(2012) Norifumi Urao et al.   FREE RADICAL BIOLOGY AND MEDICINE

Reactive Oxygen Species-Induced Actin Glutathionylation Controls Actin Dynamics in Neutrophils

(2012) Jiro Sakai et al.   IMMUNITY

High Density Lipoprotein Protects Mesenchymal Stem Cells from Oxidative Stress-Induced Apoptosis via Activation of the PI3K/Akt Pathway and Suppression of Reactive Oxygen Species

(2012) Jianfeng Xu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The HIF1 target gene NOX2 promotes angiogenesis through urotensin-II

(2012) Isabel Diebold et al.   JOURNAL OF CELL SCIENCE

A role for GPx3 in activity of normal and leukemia stem cells

(2012) Olivier Herault et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Hyperinflammation of chronic granulomatous disease is abolished by NOX2 reconstitution in macrophages and dendritic cells

(2012) Christine Deffert et al.   JOURNAL OF PATHOLOGY

Expansion of bone marrow neutrophils following G-CSF administration in mice results in osteolineage cell apoptosis and mobilization of hematopoietic stem and progenitor cells

(2012) P Singh et al.   LEUKEMIA

Wnt/β-catenin signaling induces the aging of mesenchymal stem cells through promoting the ROS production

(2012) Da-yong Zhang et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Endothelial and perivascular cells maintain haematopoietic stem cells

(2012) Lei Ding et al.   NATURE

The ATM–BID pathway regulates quiescence and survival of haematopoietic stem cells

(2012) Maria Maryanovich et al.   NATURE CELL BIOLOGY

Monocytes-macrophages that express α-smooth muscle actin preserve primitive hematopoietic cells in the bone marrow

(2012) Aya Ludin et al.   NATURE IMMUNOLOGY

A PML–PPAR-δ pathway for fatty acid oxidation regulates hematopoietic stem cell maintenance

(2012) Keisuke Ito et al.   NATURE MEDICINE

Hypoxia Promotes Osteogenesis but Suppresses Adipogenesis of Human Mesenchymal Stromal Cells in a Hypoxia-Inducible Factor-1 Dependent Manner

(2012) Markus Wagegg et al.   PLoS One

Connexin-43 prevents hematopoietic stem cell senescence through transfer of reactive oxygen species to bone marrow stromal cells

(2012) E. Taniguchi Ishikawa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NADPH Oxidase 2 Regulates Bone Marrow Microenvironment Following Hindlimb Ischemia: Role in Reparative Mobilization of Progenitor Cells

(2012) Norifumi Urao et al.   STEM CELLS

Prostaglandin E2 Increases Hematopoietic Stem Cell Survival and Accelerates Hematopoietic Recovery After Radiation Injury

(2012) Rebecca L. Porter et al.   STEM CELLS

Oxidative Stress and Heme Oxygenase-1 Regulated Human Mesenchymal Stem Cells Differentiation

(2012) Luca Vanella et al.   International Journal of Hypertension

Lack of autophagy in the hematopoietic system leads to loss of hematopoietic stem cell function and dysregulated myeloid proliferation

(2011) Monika Mortensen et al.   Autophagy

Inhibition of cellular senescence by developmentally regulated FGF receptors in mesenchymal stem cells

(2011) D. L. Coutu et al.   BLOOD

Do reactive oxygen species play a role in myeloid leukemias?

(2011) P. S. Hole et al.   BLOOD

The redox-sensitive transcription factor Nrf2 regulates murine hematopoietic stem cell survival independently of ROS levels

(2011) A. A. Merchant et al.   BLOOD

Leptin promotes the mobilization of vascular progenitor cells and neovascularization by NOX2-mediated activation of MMP9

(2011) Marco R. Schroeter et al.   CARDIOVASCULAR RESEARCH

Nonmyelinating Schwann Cells Maintain Hematopoietic Stem Cell Hibernation in the Bone Marrow Niche

(2011) Satoshi Yamazaki et al.   CELL

Metabolic Regulation of Hematopoietic Stem Cells in the Hypoxic Niche

(2011) Toshio Suda et al.   Cell Stem Cell

Current Concepts of Hyperinflammation in Chronic Granulomatous Disease

(2011) Nikolaus Rieber et al.   Clinical & Developmental Immunology

Regulation of reactive oxygen species in stem cells and cancer stem cells

(2011) Chiharu I. Kobayashi et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Expression of the G-CSF receptor in monocytic cells is sufficient to mediate hematopoietic progenitor mobilization by G-CSF in mice

(2011) Matthew J. Christopher et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Bone marrow CD169+macrophages promote the retention of hematopoietic stem and progenitor cells in the mesenchymal stem cell niche

(2011) Andrew Chow et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Intracellular reactive oxygen species are essential for PI3K/Akt/mTOR-dependent IL-7-mediated viability of T-cell acute lymphoblastic leukemia cells

(2011) A Silva et al.   LEUKEMIA

Regulation of autophagy in hematological malignancies: role of reactive oxygen species

(2011) Ganchimeg Ishdorj et al.   LEUKEMIA & LYMPHOMA

Reactive oxygen species mediate adipocyte differentiation in mesenchymal stem cells

(2011) Yasunari Kanda et al.   LIFE SCIENCES

CXCL12 secretion by bone marrow stromal cells is dependent on cell contact and mediated by connexin-43 and connexin-45 gap junctions

(2011) Amir Schajnovitz et al.   NATURE IMMUNOLOGY

Hypoxia. 2. Hypoxia regulates cellular metabolism

(2010) William W. Wheaton et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

AKT1 and AKT2 maintain hematopoietic stem cell function by regulating reactive oxygen species

(2010) M. M. Juntilla et al.   BLOOD

Enhanced c-Met activity promotes G-CSF-induced mobilization of hematopoietic progenitor cells via ROS signaling

(2010) M. Tesio et al.   BLOOD

Loss of Cxcl12/Sdf-1 in adult mice decreases the quiescent state of hematopoietic stem/progenitor cells and alters the pattern of hematopoietic regeneration after myelosuppression

(2010) Y.-S. Tzeng et al.   BLOOD

Positioning of bone marrow hematopoietic and stromal cells relative to blood flow in vivo: serially reconstituting hematopoietic stem cells reside in distinct nonperfused niches

(2010) I. G. Winkler et al.   BLOOD

Mdm2 Is Required for Survival of Hematopoietic Stem Cells/Progenitors via Dampening of ROS-Induced p53 Activity

(2010) Hussein A. Abbas et al.   Cell Stem Cell

Regulation of the HIF-1α Level Is Essential for Hematopoietic Stem Cells

(2010) Keiyo Takubo et al.   Cell Stem Cell

The Essential Functions of Adipo-osteogenic Progenitors as the Hematopoietic Stem and Progenitor Cell Niche

(2010) Yoshiki Omatsu et al.   IMMUNITY

The Prostaglandin E2 E-Prostanoid 4 Receptor Exerts Anti-Inflammatory Effects in Brain Innate Immunity

(2010) J. Shi et al.   JOURNAL OF IMMUNOLOGY

Innate immunity as orchestrator of stem cell mobilization

(2010) M Z Ratajczak et al.   LEUKEMIA

Gene Therapy of Chronic Granulomatous Disease: The Engraftment Dilemma

(2010) Manuel Grez et al.   MOLECULAR THERAPY

Mesenchymal and haematopoietic stem cells form a unique bone marrow niche

(2010) Simón Méndez-Ferrer et al.   NATURE

Genomic instability and myelodysplasia with monosomy 7 consequent to EVI1 activation after gene therapy for chronic granulomatous disease

(2010) Stefan Stein et al.   NATURE MEDICINE

Human Mesenchymal Stem Cells Efficiently Manage Oxidative Stress

(2010) Araceli Valle-Prieto et al.   STEM CELLS AND DEVELOPMENT

Regulation Mechanisms and Signaling Pathways of Autophagy

(2009) Congcong He et al.   Annual Review of Genetics

The humanHIF(hypoxia-inducible factor)-3α gene is a HIF-1 target gene and may modulate hypoxic gene induction

(2009) Tetsuhiro Tanaka et al.   BIOCHEMICAL JOURNAL

Prostaglandin E2 enhances hematopoietic stem cell homing, survival, and proliferation

(2009) J. Hoggatt et al.   BLOOD

Restoration of NET formation by gene therapy in CGD controls aspergillosis

(2009) M. Bianchi et al.   BLOOD

Genetic Interaction of PGE2 and Wnt Signaling Regulates Developmental Specification of Stem Cells and Regeneration

(2009) Wolfram Goessling et al.   CELL

Role of NADPH oxidase-2 in lipopolysaccharide-induced matrix metalloproteinase expression and cell migration

(2009) So-Yeon Kim et al.   IMMUNOLOGY AND CELL BIOLOGY

MT1-MMP and RECK are involved in human CD34+ progenitor cell retention, egress, and mobilization

(2009) Yaron Vagima et al.   JOURNAL OF CLINICAL INVESTIGATION

Reactive oxygen species prime Drosophila haematopoietic progenitors for differentiation

(2009) Edward Owusu-Ansah et al.   NATURE

The prostaglandin E2EP2 receptor accelerates disease progression and inflammation in a model of amyotrophic lateral sclerosis

(2008) Xibin Liang et al.   ANNALS OF NEUROLOGY

Protein Tyrosine Phosphorylation and Protein Tyrosine Nitration in Redox Signaling

(2008) Hugo P. Monteiro et al.   ANTIOXIDANTS & REDOX SIGNALING

Regulation of Reactive Oxygen Species and Genomic Stability in Hematopoietic Stem Cells

(2008) Kazuhito Naka et al.   ANTIOXIDANTS & REDOX SIGNALING

Genomic instability in myeloid malignancies: Increased reactive oxygen species (ROS), DNA double strand breaks (DSBs) and error-prone repair

(2008) Annahita Sallmyr et al.   CANCER LETTERS

Hematopoietic Stem Cells Reversibly Switch from Dormancy to Self-Renewal during Homeostasis and Repair

(2008) Anne Wilson et al.   CELL

CXCR4 is required for the quiescence of primitive hematopoietic cells

(2008) Yuchun Nie et al.   JOURNAL OF EXPERIMENTAL MEDICINE

TSC–mTOR maintains quiescence and function of hematopoietic stem cells by repressing mitochondrial biogenesis and reactive oxygen species

(2008) Chong Chen et al.   JOURNAL OF EXPERIMENTAL MEDICINE

mTORC1-dependent and -independent regulation of stem cell renewal, differentiation, and mobilization

(2008) B. Gan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA