Mitophagy in degenerative joint diseases

FOXO3 protects nucleus pulposus cells against apoptosis under nutrient deficiency via autophagy

(2020) Yanqiu Wang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The mitochondria‐targeted anti‐oxidant MitoQ protects against intervertebral disc degeneration by ameliorating mitochondrial dysfunction and redox imbalance

(2020) Liang Kang et al.   CELL PROLIFERATION

Adenosine A2A receptor (A2AR) stimulation enhances mitochondrial metabolism and mitigates reactive oxygen species‐mediated mitochondrial injury

(2020) Cristina M. Castro et al.   FASEB JOURNAL

Autophagy and autophagy-related proteins in cancer

(2020) Xiaohua Li et al.   Molecular Cancer

Mfn2 is involved in intervertebral disc degeneration through autophagy modulation

(2020) Y. Chen et al.   OSTEOARTHRITIS AND CARTILAGE

Urolithin A-induced mitophagy suppresses apoptosis and attenuates intervertebral disc degeneration via the AMPK signaling pathway

(2020) Jialiang Lin et al.   FREE RADICAL BIOLOGY AND MEDICINE

Intervertebral Disc Diseases PART 2: A Review of the Current Diagnostic and Treatment Strategies for Intervertebral Disc Disease

(2020) Pang Hung Wu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Compression‐induced senescence of nucleus pulposus cells by promoting mitophagy activation via the PINK1/PARKIN pathway

(2020) Donghua Huang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Mitophagy: An Emerging Role in Aging and Age-Associated Diseases

(2020) Guo Chen et al.   Frontiers in Cell and Developmental Biology

MitophAging: Mitophagy in Aging and Disease

(2020) Daniela Bakula et al.   Frontiers in Cell and Developmental Biology

Spermidine rescues the deregulated autophagic response to oxidative stress of osteoarthritic chondrocytes

(2020) Stefania D'Adamo et al.   FREE RADICAL BIOLOGY AND MEDICINE

PHF23 negatively regulates the autophagy of chondrocytes in osteoarthritis

(2020) Talatibaike Maimaitijuma et al.   LIFE SCIENCES

Melatonin ameliorates intervertebral disc degeneration via the potential mechanisms of mitophagy induction and apoptosis inhibition

(2019) Yu Chen et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Mitophagy inhibits amyloid-β and tau pathology and reverses cognitive deficits in models of Alzheimer’s disease

(2019) Evandro F. Fang et al.   NATURE NEUROSCIENCE

Osteoarthritis

(2019) David J Hunter et al.   LANCET

Mitophagy is a protective response against oxidative damage in bone marrow mesenchymal stem cells

(2019) Pan Fan et al.   LIFE SCIENCES

PGC-1α acts as an mediator of Sirtuin2 to protect annulus fibrosus from apoptosis induced by oxidative stress through restraining mitophagy

(2019) Wen-Ning Xu et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

The biogenesis, biology and characterization of circular RNAs

(2019) Lasse S. Kristensen et al.   NATURE REVIEWS GENETICS

Age-Related Alterations Affecting the Chondrogenic Differentiation of Synovial Fluid Mesenchymal Stromal Cells in an Equine Model

(2019) Mazzotti et al.   Cells

Mitochondrial NDUFA4L2 attenuates the apoptosis of nucleus pulposus cells induced by oxidative stress via the inhibition of mitophagy

(2019) Wen-Ning Xu et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

CircERCC2 ameliorated intervertebral disc degeneration by regulating mitophagy and apoptosis through miR-182-5p/SIRT1 axis

(2019) Lin Xie et al.   Cell Death & Disease

Pink1-Mediated Chondrocytic Mitophagy Contributes to Cartilage Degeneration in Osteoarthritis

(2019) Hyo Jung Shin et al.   Journal of Clinical Medicine

Parkin and Nrf2 prevent oxidative stress-induced apoptosis in intervertebral endplate chondrocytes via inducing mitophagy and anti-oxidant defenses

(2019) Liang Kang et al.   LIFE SCIENCES

Alpha-synuclein delays mitophagy and targeting Miro rescues neuron loss in Parkinson’s models

(2018) Atossa Shaltouki et al.   ACTA NEUROPATHOLOGICA

BNIP3L/NIX-dependent mitophagy regulates cell differentiation via metabolic reprogramming

(2018) Lorena Esteban-Martínez et al.   Autophagy

PINK1 protects against oxidative stress induced senescence of human nucleus pulposus cells via regulating mitophagy

(2018) Yiyang Wang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Mitophagy and Quality Control Mechanisms in Mitochondrial Maintenance

(2018) Sarah Pickles et al.   CURRENT BIOLOGY

Autophagy induction by trehalose: Molecular mechanisms and therapeutic impacts

(2018) Kiana Hosseinpour-Moghaddam et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Building and decoding ubiquitin chains for mitophagy

(2018) J. Wade Harper et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Bone morphogenetic proteins for articular cartilage regeneration

(2018) Z.H. Deng et al.   OSTEOARTHRITIS AND CARTILAGE

Parkin clearance of dysfunctional mitochondria regulates ROS levels and increases survival of human chondrocytes

(2018) M.Y. Ansari et al.   OSTEOARTHRITIS AND CARTILAGE

Spermidine in health and disease

(2018) Frank Madeo et al.   SCIENCE

Resveratrol attenuates oxidative damage through activating mitophagy in an in vitro model of Alzheimer’s disease

(2018) Hui Wang et al.   TOXICOLOGY LETTERS

DUSP1 alleviates cardiac ischemia/reperfusion injury by suppressing the Mff-required mitochondrial fission and Bnip3-related mitophagy via the JNK pathways

(2018) Qinhua Jin et al.   Redox Biology

MELATONIN AS A HORMONE: NEW PHYSIOLOGICAL AND CLINICAL INSIGHTS

(2018) José Cipolla-Neto et al.   ENDOCRINE REVIEWS

Mechanisms of mitophagy in cellular homeostasis, physiology and pathology

(2018) Konstantinos Palikaras et al.   NATURE CELL BIOLOGY

Parkin-mediated mitophagy as a potential therapeutic target for intervertebral disc degeneration

(2018) Zengjie Zhang et al.   Cell Death & Disease

Miro proteins prime mitochondria for Parkin translocation and mitophagy

(2018) Dzhamilja Safiulina et al.   EMBO JOURNAL

Parkin inhibits BAK and BAX apoptotic function by distinct mechanisms during mitophagy

(2018) Jonathan P Bernardini et al.   EMBO JOURNAL

Protective effects of metformin against osteoarthritis through upregulation of SIRT3-mediated PINK1/Parkin-dependent mitophagy in primary chondrocytes

(2018) Chenzhong Wang et al.   BioScience Trends

Non-specific low back pain

(2017) Chris Maher et al.   LANCET

Nutrient deprivation induces apoptosis of nucleus pulposus cells via activation of the BNIP3/AIF signalling pathway

(2017) Jie Liu et al.   Molecular Medicine Reports

Trehalose ameliorates oxidative stress-mediated mitochondrial dysfunction and ER stress via selective autophagy stimulation and autophagic flux restoration in osteoarthritis development

(2017) Qian Tang et al.   Cell Death & Disease

Endogenous adenosine maintains cartilage homeostasis and exogenous adenosine inhibits osteoarthritis progression

(2017) Carmen Corciulo et al.   Nature Communications

Nutrition deficiency promotes apoptosis of cartilage endplate stem cells in a caspase-independent manner partially through upregulating BNIP3

(2016) Zhiliang He et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

FOXO3a regulates BNIP3 and modulates mitochondrial calcium, dynamics, and function in cardiac stress

(2016) Antoine H. Chaanine et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Mitophagy receptor FUNDC1 regulates mitochondrial dynamics and mitophagy

(2016) Ming Chen et al.   Autophagy

FUNDC1 regulates mitochondrial dynamics at the ER–mitochondrial contact site under hypoxic conditions

(2016) Wenxian Wu et al.   EMBO JOURNAL

Melatonin enhances mitophagy and mitochondrial biogenesis in rats with carbon tetrachloride-induced liver fibrosis

(2016) Jung-Woo Kang et al.   JOURNAL OF PINEAL RESEARCH

Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents

(2016) Dongryeol Ryu et al.   NATURE MEDICINE

Ageing and the pathogenesis of osteoarthritis

(2016) Richard F. Loeser et al.   Nature Reviews Rheumatology

Cadherin-6 promotes EMT and cancer metastasis by restraining autophagy

(2016) M Gugnoni et al.   ONCOGENE

Structure of phosphorylated UBL domain and insights into PINK1-orchestrated parkin activation

(2016) Jacob D. Aguirre et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Miro phosphorylation sites regulate Parkin recruitment and mitochondrial motility

(2016) Evgeny Shlevkov et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Deubiquitinating enzymes regulate PARK2-mediated mitophagy

(2015) Yuqing Wang et al.   Autophagy

Defining the phenotype of young healthy nucleus pulposus cells: Recommendations of the Spine Research Interest Group at the 2014 annual ORS meeting

(2015) Makarand V. Risbud et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy

(2015) Michael Lazarou et al.   NATURE

Mechanics and biology in intervertebral disc degeneration: a vicious circle

(2015) P.-P.A. Vergroesen et al.   OSTEOARTHRITIS AND CARTILAGE

Honokiol blocks and reverses cardiac hypertrophy in mice by activating mitochondrial Sirt3

(2015) Vinodkumar B. Pillai et al.   Nature Communications

Mitochondrial dynamics and mitochondrial quality control

(2015) Hong-Min Ni et al.   Redox Biology

AMBRA1 is able to induce mitophagy via LC3 binding, regardless of PARKIN and p62/SQSTM1

(2014) F Strappazzon et al.   CELL DEATH AND DIFFERENTIATION

ULK1 translocates to mitochondria and phosphorylates FUNDC1 to regulate mitophagy

(2014) W. Wu et al.   EMBO REPORTS

The deubiquitinase USP15 antagonizes Parkin-mediated mitochondrial ubiquitination and mitophagy

(2014) Tom Cornelissen et al.   HUMAN MOLECULAR GENETICS

A Regulatory Signaling Loop Comprising the PGAM5 Phosphatase and CK2 Controls Receptor-Mediated Mitophagy

(2014) Guo Chen et al.   MOLECULAR CELL

Quantitative Proteomics Reveal a Feedforward Mechanism for Mitochondrial PARKIN Translocation and Ubiquitin Chain Synthesis

(2014) Alban Ordureau et al.   MOLECULAR CELL

Ubiquitin is phosphorylated by PINK1 to activate parkin

(2014) Fumika Koyano et al.   NATURE

The mitochondrial deubiquitinase USP30 opposes parkin-mediated mitophagy

(2014) Baris Bingol et al.   NATURE

Optineurin is an autophagy receptor for damaged mitochondria in parkin-mediated mitophagy that is disrupted by an ALS-linked mutation

(2014) Yvette C. Wong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

FOXO transcription factors: key regulators of cellular quality control

(2014) Ashley E. Webb et al.   TRENDS IN BIOCHEMICAL SCIENCES

PINK1 is degraded through the N-end rule pathway

(2013) Koji Yamano et al.   Autophagy

Mitochondrial Dynamics in the Regulation of Nutrient Utilization and Energy Expenditure

(2013) Marc Liesa et al.   Cell Metabolism

A mitochondrial bioenergetic etiology of disease

(2013) Douglas C. Wallace   JOURNAL OF CLINICAL INVESTIGATION

Cardiolipin externalization to the outer mitochondrial membrane acts as an elimination signal for mitophagy in neuronal cells

(2013) Charleen T. Chu et al.   NATURE CELL BIOLOGY

Novel genetic variants associated with lumbar disc degeneration in northern Europeans: a meta-analysis of 4600 subjects

(2012) Frances M K Williams et al.   ANNALS OF THE RHEUMATIC DISEASES

Voltage-dependent Anion Channels (VDACs) Recruit Parkin to Defective Mitochondria to Promote Mitochondrial Autophagy

(2012) Yu Sun et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ceramide targets autophagosomes to mitochondria and induces lethal mitophagy

(2012) R David Sentelle et al.   Nature Chemical Biology

BNIP3 and NIX Mediate Mieap-Induced Accumulation of Lysosomal Proteins within Mitochondria

(2012) Yasuyuki Nakamura et al.   PLoS One

PINK1-mediated phosphorylation of the Parkin ubiquitin-like domain primes mitochondrial translocation of Parkin and regulates mitophagy

(2012) Kahori Shiba-Fukushima et al.   Scientific Reports

PINK1 is activated by mitochondrial membrane potential depolarization and stimulates Parkin E3 ligase activity by phosphorylating Serine 65

(2012) C. Kondapalli et al.   Open Biology

Upregulation of BNIP3 and translocation to mitochondria in nutrition deprivation induced apoptosis in nucleus pulposus cells

(2011) Jie Liu et al.   JOINT BONE SPINE

The mitochondrial intramembrane protease PARL cleaves human Pink1 to regulate Pink1 trafficking

(2011) Cathrin Meissner et al.   JOURNAL OF NEUROCHEMISTRY

Loss of the Parkinson's disease-linked gene DJ-1 perturbs mitochondrial dynamics

(2010) I. Irrcher et al.   HUMAN MOLECULAR GENETICS

Proteasome and p97 mediate mitophagy and degradation of mitofusins induced by Parkin

(2010) Atsushi Tanaka et al.   JOURNAL OF CELL BIOLOGY

Mitochondrial membrane potential regulates PINK1 import and proteolytic destabilization by PARL

(2010) Seok Min Jin et al.   JOURNAL OF CELL BIOLOGY

PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1

(2010) Sven Geisler et al.   NATURE CELL BIOLOGY

Role of proinflammatory cytokines in the pathophysiology of osteoarthritis

(2010) Mohit Kapoor et al.   Nature Reviews Rheumatology

Nix is a selective autophagy receptor for mitochondrial clearance

(2009) Ivana Novak et al.   EMBO REPORTS

BH3-only proteins in apoptosis and beyond: an overview

(2009) E Lomonosova et al.   ONCOGENE

The Basic Science of Articular Cartilage: Structure, Composition, and Function

(2009) Alice J. Sophia Fox et al.   Sports Health-A Multidisciplinary Approach

Mitochondrial Autophagy Is an HIF-1-dependent Adaptive Metabolic Response to Hypoxia

(2008) Huafeng Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Parkin is recruited selectively to impaired mitochondria and promotes their autophagy

(2008) Derek Narendra et al.   JOURNAL OF CELL BIOLOGY