Compression‐induced senescence of nucleus pulposus cells by promoting mitophagy activation via the PINK1/PARKIN pathway

ROS-Mediated Mitochondrial Dysfunction and ER Stress Contribute to Compression-Induced Neuronal Injury

(2019) Tao Chen et al.   NEUROSCIENCE

Pioglitazone Protects Compression-Mediated Apoptosis in Nucleus Pulposus Mesenchymal Stem Cells by Suppressing Oxidative Stress

(2019) Yiqiang Hu et al.   Oxidative Medicine and Cellular Longevity

Monoamine oxidase-A is a novel driver of stress-induced premature senescence through inhibition of parkin-mediated mitophagy

(2018) Nicola Manzella et al.   AGING CELL

Critical contribution of RIPK1 mediated mitochondrial dysfunction and oxidative stress to compression-induced rat nucleus pulposus cells necroptosis and apoptosis

(2018) Songfeng Chen et al.   APOPTOSIS

PINK1 protects against oxidative stress induced senescence of human nucleus pulposus cells via regulating mitophagy

(2018) Yiyang Wang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Nucleus pulposus cell senescence is alleviated by resveratrol through regulating the ROS/NF-κB pathway under high-magnitude compression

(2018) Yanhai Jiang et al.   BIOSCIENCE REPORTS

CsA attenuates compression-induced nucleus pulposus mesenchymal stem cells apoptosis via alleviating mitochondrial dysfunction and oxidative stress

(2018) Zhiliang Li et al.   LIFE SCIENCES

Autophagy in Aging and Alzheimer's Disease: Pathologic or Protective?

(2018) Aaron Barnett et al.   JOURNAL OF ALZHEIMERS DISEASE

Chondrocyte death after mechanically overloading degenerated human intervertebral disk explants is associated with a structurally impaired pericellular matrix

(2018) Ulf Krister Hofmann et al.   Journal of Tissue Engineering and Regenerative Medicine

Parkin-mediated mitophagy as a potential therapeutic target for intervertebral disc degeneration

(2018) Zengjie Zhang et al.   Cell Death & Disease

Involvement of PINK1/Parkin-mediated mitophagy in AGE-induced cardiomyocyte aging

(2017) Zhimin Zha et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Pink1 and Parkin regulate Drosophila intestinal stem cell proliferation during stress and aging

(2017) Christopher L. Koehler et al.   JOURNAL OF CELL BIOLOGY

Static Compression Induces ECM Remodeling and Integrin α2β1 Expression and Signaling in a Rat Tail Caudal Intervertebral Disc Degeneration Model

(2017) ZhanJun Yan et al.   SPINE

The Mitochondrial Basis of Aging and Age-Related Disorders

(2017) Sarika Srivastava   Genes

The mitochondria-targeted antioxidant MitoQ ameliorated tubular injury mediated by mitophagy in diabetic kidney disease via Nrf2/PINK1

(2017) Li Xiao et al.   Redox Biology

Disc cell senescence in intervertebral disc degeneration: Causes and molecular pathways

(2016) Chencheng Feng et al.   CELL CYCLE

Mitophagy receptors sense stress signals and couple mitochondrial dynamic machinery for mitochondrial quality control

(2016) Hao Wu et al.   FREE RADICAL BIOLOGY AND MEDICINE

Parkin-dependent mitophagy in the heart

(2016) Gerald W. Dorn   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Aging and age related stresses: a senescence mechanism of intervertebral disc degeneration

(2016) F. Wang et al.   OSTEOARTHRITIS AND CARTILAGE

Impaired mitophagy leads to cigarette smoke stress-induced cellular senescence: implications for chronic obstructive pulmonary disease

(2015) Tanveer Ahmad et al.   FASEB JOURNAL

Parkin structure and function

(2015) Marjan Seirafi et al.   FEBS Journal

Functions and characteristics of PINK1 and Parkin in cancer

(2015) Satoru Matsuda   Frontiers in Bioscience-Landmark

Stem cell therapy for intervertebral disc regeneration: obstacles and solutions

(2015) Daisuke Sakai et al.   Nature Reviews Rheumatology

The Roles of PINK1, Parkin, and Mitochondrial Fidelity in Parkinson’s Disease

(2015) Alicia M. Pickrell et al.   NEURON

ISSLS Prize Winner

(2015) Sarah E. Gullbrand et al.   SPINE

Functional impact of integrin α5β1 on the homeostasis of intervertebral discs: a study of mechanotransduction pathways using a novel dynamic loading organ culture system

(2015) Takuto Kurakawa et al.   Spine Journal

PINK1-induced mitophagy promotes neuroprotection in Huntington’s disease

(2015) B Khalil et al.   Cell Death & Disease

Notochordal cell disappearance and modes of apoptotic cell death in a rat tail static compression-induced disc degeneration model

(2014) Takashi Yurube et al.   ARTHRITIS RESEARCH & THERAPY

Role of mitochondrial dysfunction and altered autophagy in cardiovascular aging and disease: from mechanisms to therapeutics

(2013) Emanuele Marzetti et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Autophagy is activated in compression-induced cell degeneration and is mediated by reactive oxygen species in nucleus pulposus cells exposed to compression

(2013) K.-G. Ma et al.   OSTEOARTHRITIS AND CARTILAGE

Parkin overexpression during aging reduces proteotoxicity, alters mitochondrial dynamics, and extends lifespan

(2013) A. Rana et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cytosolic p53 inhibits Parkin-mediated mitophagy and promotes mitochondrial dysfunction in the mouse heart

(2013) Atsushi Hoshino et al.   Nature Communications

Role of mitochondrial pathway in compression-induced apoptosis of nucleus pulposus cells

(2012) Fan Ding et al.   APOPTOSIS

The effects of dynamic loading on the intervertebral disc

(2011) Samantha C. W. Chan et al.   EUROPEAN SPINE JOURNAL

Effect of Polyphenols on Oxidative Stress and Mitochondrial Dysfunction in Neuronal Death and Brain Edema in Cerebral Ischemia

(2011) Kiran S. Panickar et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Human intervertebral disc internal strain in compression: The effect of disc region, loading position, and degeneration

(2010) Grace D. O'Connell et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Improving Bioscience Research Reporting: The ARRIVE Guidelines for Reporting Animal Research

(2010) Carol Kilkenny et al.   PLOS BIOLOGY

Senescence mechanisms of nucleus pulposus chondrocytes in human intervertebral discs

(2009) Ki-Won Kim et al.   Spine Journal

Senescent cells in the intervertebral disc: numbers and mechanisms

(2009) Dimitris Kletsas   Spine Journal

Expression of cartilage-derived morphogenetic protein in human intervertebral discs and its effect on matrix synthesis in degenerate human nucleus pulposus cells

(2009) Christine L Le Maitre et al.   ARTHRITIS RESEARCH & THERAPY

Pathophysiology of the human intervertebral disc

(2008) Alessandra Colombini et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY