Cellular Mechanisms of Melatonin: Insight from Neurodegenerative Diseases

Post-translational Modifications of the Peptidyl-Prolyl Isomerase Pin1

(2020) Dongmei Chen et al.   Frontiers in Cell and Developmental Biology

Melatonin directly binds and inhibits death‐associated protein kinase 1 function in Alzheimer’s disease

(2020) Dongmei Chen et al.   JOURNAL OF PINEAL RESEARCH

Peptidyl-Prolyl Cis/Trans Isomerase Pin1 and Alzheimer’s Disease

(2020) Long Wang et al.   Frontiers in Cell and Developmental Biology

COVID-19: Melatonin as a potential adjuvant treatment

(2020) Rui Zhang et al.   LIFE SCIENCES

Melatonin prevents lung injury by regulating apelin 13 to improve mitochondrial dysfunction

(2019) Lu Zhang et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Death-Associated Protein Kinase 1 Phosphorylation in Neuronal Cell Death and Neurodegenerative Disease

(2019) Nami Kim et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Melatonin: Clinical Perspectives in Neurodegeneration

(2019) Daniel P. Cardinali   Frontiers in Endocrinology

Deciphering the Molecular Basis of Melatonin Protective Effects on Breast Cells Treated with Doxorubicin: TWIST1 a Transcription Factor Involved in EMT and Metastasis, a Novel Target of Melatonin

(2019) Javier Menéndez-Menéndez et al.   Cancers

Neuroprotective Effects of Melatonin during Demyelination and Remyelination Stages in a Mouse Model of Multiple Sclerosis

(2019) Hanin Abdulbaset Abo Taleb et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Melatonin: A review of its potential functions and effects on neurological diseases

(2019) M. Gunata et al.   REVUE NEUROLOGIQUE

Phosphorylation Signaling in APP Processing in Alzheimer’s Disease

(2019) Tao Zhang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The role of melatonin in Multiple Sclerosis

(2019) Charalampos Skarlis et al.   NEUROLOGICAL SCIENCES

Melatonin Rescues Mesenchymal Stem Cells from Senescence Induced by the Uremic Toxin p-Cresol via Inhibiting mTOR-Dependent Autophagy

(2018) Seung Pil Yun et al.   Biomolecules & Therapeutics

Melatonin ameliorates Aβ42 -induced alteration of βAPP-processing secretases via the melatonin receptor through the Pin1/GSK3β/NF-κB pathway in SH-SY5Y cells

(2018) Vorapin Chinchalongporn et al.   JOURNAL OF PINEAL RESEARCH

Melatonin resists oxidative stress-induced apoptosis in nucleus pulposus cells

(2018) Ruijun He et al.   LIFE SCIENCES

Melatonin and Cancer Hallmarks

(2018) Wamidh Talib   MOLECULES

Melatonin Mitigates Kainic Acid-Induced Neuronal Tau Hyperphosphorylation and Memory Deficits through Alleviating ER Stress

(2018) Cai Shi et al.   Frontiers in Molecular Neuroscience

Melatonin ameliorates brain oxidative stress and upregulates senescence marker protein-30 and osteopontin in a rat model of vascular dementia

(2018) I Bin-Jaliah et al.   Physiology International

Converging pathways in neurodegeneration, from genetics to mechanisms

(2018) Li Gan et al.   NATURE NEUROSCIENCE

Death-Associated Protein Kinase 1 As A Promising Drug Target In Cancer and Alzheimer’s Disease

(2018) Dongmei Chen et al.   Recent Patents on Anti-Cancer Drug Discovery

Melatonin, a Full Service Anti-Cancer Agent: Inhibition of Initiation, Progression and Metastasis

(2017) Russel Reiter et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Melatonin reduces inflammatory response in peripheral T helper lymphocytes from relapsing-remitting multiple sclerosis patients

(2017) Nuria Álvarez-Sánchez et al.   JOURNAL OF PINEAL RESEARCH

Amyloid-β and tau complexity — towards improved biomarkers and targeted therapies

(2017) Juan Carlos Polanco et al.   Nature Reviews Neurology

Melatonin improves survival and respiratory activity of yeast cells challenged by alpha-synuclein and menadione

(2017) Mariana A. Zampol et al.   YEAST

Melatonin Mediates Protective Effects against Kainic Acid-Induced Neuronal Death through Safeguarding ER Stress and Mitochondrial Disturbance

(2017) Feixiao Xue et al.   Frontiers in Molecular Neuroscience

Constant Illumination Induces Alzheimer-Like Damages with Endoplasmic Reticulum Involvement and the Protection of Melatonin

(2017) Zhi-Qun Ling et al.   JOURNAL OF ALZHEIMERS DISEASE

Neuroimaging Findings Related to Behavioral Disturbances in Alzheimer's Disease: A Systematic Review

(2016) Gilberto Alves et al.   Current Alzheimer Research

Effect of Melatonin and Resveratrol against Memory Impairment and Hippocampal Damage in a Rat Model of Vascular Dementia

(2016) Dongfang Shen et al.   NEUROIMMUNOMODULATION

Melatonin attenuates MPTP-induced neurotoxicity via preventing CDK5-mediated autophagy and SNCA/α-synuclein aggregation

(2015) Ling-Yan Su et al.   Autophagy

Melatonin Contributes to the Seasonality of Multiple Sclerosis Relapses

(2015) Mauricio F. Farez et al.   CELL

Neuroprotective Effects of Agomelatine and Vinpocetine Against Chronic Cerebral Hypoperfusion Induced Vascular Dementia

(2015) Surbhi Gupta et al.   CURRENT NEUROVASCULAR RESEARCH

Disruption of the NF-κB/NLRP3 connection by melatonin requires retinoid-related orphan receptor-α and blocks the septic response in mice

(2015) José A. García et al.   FASEB JOURNAL

Melatonin ameliorates amyloid beta-induced memory deficits, tau hyperphosphorylation and neurodegeneration via PI3/Akt/GSk3β pathway in the mouse hippocampus

(2015) Tahir Ali et al.   JOURNAL OF PINEAL RESEARCH

Disruption of melatonin circadian rhythm production is related to multiple sclerosis severity: A preliminary study

(2015) Alfredo Damasceno et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Melatonin promotes Bax sequestration to mitochondria reducing cell susceptibility to apoptosis via the lipoxygenase metabolite 5-hydroxyeicosatetraenoic acid

(2015) F. Radogna et al.   MITOCHONDRION

The Effect of Melatonin on Behavioral, Molecular, and Histopathological Changes in Cuprizone Model of Demyelination

(2015) Gelareh Vakilzadeh et al.   MOLECULAR NEUROBIOLOGY

Multiple Sclerosis: Current Knowledge and Future Outlook

(2014) Christian P. Kamm et al.   EUROPEAN NEUROLOGY

Melatonin Regulates Aging and Neurodegeneration through Energy Metabolism, Epigenetics, Autophagy and Circadian Rhythm Pathways

(2014) Anorut Jenwitheesuk et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Melatonin prevents cell death and mitochondrial dysfunction via a SIRT1-dependent mechanism during ischemic-stroke in mice

(2014) Yang Yang et al.   JOURNAL OF PINEAL RESEARCH

Melatonin feedback on clock genes: a theory involving the proteasome

(2014) Jerry Vriend et al.   JOURNAL OF PINEAL RESEARCH

Melatonin attenuates D-galactose-induced memory impairment, neuroinflammation and neurodegeneration via RAGE/NF-KB/JNK signaling pathway in aging mouse model

(2014) Tahir Ali et al.   JOURNAL OF PINEAL RESEARCH

Unveiling the role of melatonin MT2 receptors in sleep, anxiety and other neuropsychiatric diseases: a novel target in psychopharmacology

(2014) Stefano Comai et al.   JOURNAL OF PSYCHIATRY & NEUROSCIENCE

Plasma melatonin is reduced in Huntington's disease

(2014) Eirini Kalliolia et al.   MOVEMENT DISORDERS

Melatonin Reduces Projection Neuronal Injury Induced by 3-Nitropropionic Acid in the Rat Striatum

(2014) Shuhua Mu et al.   Neurodegenerative Diseases

The Intersection of Amyloid Beta and Tau at Synapses in Alzheimer’s Disease

(2014) Tara L. Spires-Jones et al.   NEURON

Protective Effects of Cannabidiol Against Hippocampal Cell Death and Cognitive Impairment Induced by Bilateral Common Carotid Artery Occlusion in Mice

(2014) Angélica Pupin Schiavon et al.   NEUROTOXICITY RESEARCH

Protective effects of melatonin against mitochondrial injury in a mouse model of multiple sclerosis

(2014) Iraj Ragerdi Kashani et al.   EXPERIMENTAL BRAIN RESEARCH

Serum levels of melatonin and cytokines in multiple sclerosis

(2014) Naser Farhadi et al.   Biomedical Journal

Melatonin for Sundown Syndrome and Delirium in Dementia: Is It Effective?

(2013) Michiel Lammers et al.   JOURNAL OF THE AMERICAN GERIATRICS SOCIETY

IL-27 acts on DCs to suppress the T cell response and autoimmunity by inducing expression of the immunoregulatory molecule CD39

(2013) Ivan D Mascanfroni et al.   NATURE IMMUNOLOGY

Disease-modified glycogen synthase kinase-3β intervention by melatonin arrests the pathology and memory deficits in an Alzheimer's animal model

(2013) Cai-Xia Peng et al.   NEUROBIOLOGY OF AGING

Melatonin inhibits the caspase-1/cytochrome c/caspase-3 cell death pathway, inhibits MT1 receptor loss and delays disease progression in a mouse model of amyotrophic lateral sclerosis

(2013) Yi Zhang et al.   NEUROBIOLOGY OF DISEASE

RETRACTED: Neuronal damage, central cholinergic dysfunction and oxidative damage correlate with cognitive deficits in rats with chronic cerebral hypoperfusion

(2013) Ye Xi et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Biomarker Modeling of Alzheimer’s Disease

(2013) Clifford R. Jack et al.   NEURON

BDNF-induced local protein synthesis and synaptic plasticity

(2013) Graciano Leal et al.   NEUROPHARMACOLOGY

Synaptic regulation of affective behaviors; role of BDNF

(2013) Ipe Ninan   NEUROPHARMACOLOGY

Reciprocal interactions between sleep, circadian rhythms and Alzheimer's disease: Focus on the role of hypocretin and melatonin

(2012) Diane Slats et al.   AGEING RESEARCH REVIEWS

Simultaneous modulation of COX-2, p300, Akt, and Apaf-1 signaling by melatonin to inhibit proliferation and induce apoptosis in breast cancer cells

(2012) Jingshu Wang et al.   JOURNAL OF PINEAL RESEARCH

A review of the molecular aspects of melatonin’s anti-inflammatory actions: recent insights and new perspectives

(2012) José L. Mauriz et al.   JOURNAL OF PINEAL RESEARCH

Melatonin may play a role in modulation of bax and bcl-2 expression levels to protect rat peripheral blood lymphocytes from gamma irradiation-induced apoptosis

(2012) Mehran Mohseni et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Melatonin Antioxidative Defense: Therapeutical Implications for Aging and Neurodegenerative Processes

(2012) Seithikurippu R. Pandi-Perumal et al.   NEUROTOXICITY RESEARCH

Energy deficit in Huntington disease: why it matters

(2011) Fanny Mochel et al.   JOURNAL OF CLINICAL INVESTIGATION

The Melatonin MT1 Receptor Axis Modulates Mutant Huntingtin-Mediated Toxicity

(2011) X. Wang et al.   JOURNAL OF NEUROSCIENCE

Melatonin reduces the expression of alpha-synuclein in the dopamine containing neuronal regions of amphetamine-treated postnatal rats

(2011) Kwankanit Sae-Ung et al.   JOURNAL OF PINEAL RESEARCH

Melatonin attenuates kainic acid-induced neurotoxicity in mouse hippocampus via inhibition of autophagy and α-synuclein aggregation

(2011) Chia-Fu Chang et al.   JOURNAL OF PINEAL RESEARCH

Melatonin dysregulation, sleep disturbances and fatigue in multiple sclerosis

(2011) Lena Melamud et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Aβ1–42 inhibition of LTP is mediated by a signaling pathway involving caspase-3, Akt1 and GSK-3β

(2011) Jihoon Jo et al.   NATURE NEUROSCIENCE

Melatonin protects against neurobehavioral and mitochondrial deficits in a chronic mouse model of Parkinson's disease

(2011) Gaurav Patki et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Sundown Syndrome in Persons with Dementia: An Update

(2011) Nina Khachiyants et al.   Psychiatry Investigation

Parkinson's Disease as a Neuroendocrine Disorder of Circadian Function: Dopamine-Melatonin Imbalance and the Visual System in the Genesis and Progression of the Degenerative Process

(2011) Gregory L. Willis   REVIEWS IN THE NEUROSCIENCES

Osteopontin Reduced Hypoxia–Ischemia Neonatal Brain Injury by Suppression of Apoptosis in a Rat Pup Model

(2011) Wanqiu Chen et al.   STROKE

Neurodegenerative processes in Huntington's disease

(2011) D Bano et al.   Cell Death & Disease

Melatonin Receptor Agonists: New Options for Insomnia and Depression Treatment

(2010) Gilberto Spadoni et al.   CNS Neuroscience & Therapeutics

Protective effects of recombinant osteopontin on early brain injury after subarachnoid hemorrhage in rats*

(2010) Hidenori Suzuki et al.   CRITICAL CARE MEDICINE

Clinical Aspects of Melatonin Intervention in Alzheimers Disease Progression

(2010) Daniel P. Cardinali et al.   Current Neuropharmacology

Investigational melatonin receptor agonists

(2010) Rüdiger Hardeland   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Effectiveness of melatonin treatment on circadian rhythm disturbances in dementia. Are there implications for delirium? A systematic review

(2010) A. de Jonghe et al.   INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY

Melatonin or silymarin reduces maneb- and paraquat-induced Parkinson’s disease phenotype in the mouse

(2010) Naveen Kumar Singhal et al.   JOURNAL OF PINEAL RESEARCH

The inhibition of apoptosis by melatonin in VSC4.1 motoneurons exposed to oxidative stress, glutamate excitotoxicity, or TNF-α toxicity involves membrane melatonin receptors

(2010) Arabinda Das et al.   JOURNAL OF PINEAL RESEARCH

Amyloid-β neurotoxicity in organotypic culture is attenuated by melatonin: involvement of GSK-3β,tauand neuroinflammation

(2010) Juliana Bender Hoppe et al.   JOURNAL OF PINEAL RESEARCH

Melatonin ameliorates Alzheimer-like pathological changes and spatial memory retention impairment induced by calyculin A

(2010) Xifei Yang et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Huntington's disease: from molecular pathogenesis to clinical treatment

(2010) Christopher A Ross et al.   LANCET NEUROLOGY

Intracellular Ca2+ release through ryanodine receptors contributes to AMPA receptor-mediated mitochondrial dysfunction and ER stress in oligodendrocytes

(2010) A Ruiz et al.   Cell Death & Disease

The Antiapoptotic Activity of Melatonin in Neurodegenerative Diseases

(2009) Xin Wang   CNS Neuroscience & Therapeutics

Light-Mediated Perturbations of Circadian Timing and Cancer Risk: A Mechanistic Analysis

(2009) Russel J. Reiter et al.   INTEGRATIVE CANCER THERAPIES

Oxidative stress and mitochondrial dysfunction as determinants of ischemic neuronal death and survival

(2009) Kuniyasu Niizuma et al.   JOURNAL OF NEUROCHEMISTRY

Beyond the brain: widespread pathology in Huntington's disease

(2009) Jorien MM van der Burg et al.   LANCET NEUROLOGY

Tau pathophysiology in neurodegeneration: a tangled issue

(2009) Tara L. Spires-Jones et al.   TRENDS IN NEUROSCIENCES

Recent progress in elucidating the molecular mechanism of the mitochondrial permeability transition pore

(2008) Anna W.C. Leung et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Intraocular microinjections repair experimental Parkinson's disease

(2008) Gregory L. Willis   BRAIN RESEARCH

REM sleep behaviour disorder treated with melatonin in a patient with Alzheimer's disease

(2008) Kirstie N. Anderson et al.   CLINICAL NEUROLOGY AND NEUROSURGERY

Effect of Bright Light and Melatonin on Cognitive and Noncognitive Function in Elderly Residents of Group Care Facilities

(2008) Rixt F. Riemersma-van der Lek   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Parkinson's disease: clinical features and diagnosis

(2008) J Jankovic   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Melatonin and Bright-Light Treatment for Rest–Activity Disruption in Institutionalized Patients with Alzheimer's Disease

(2008) Glenna A. Dowling et al.   JOURNAL OF THE AMERICAN GERIATRICS SOCIETY

Multiple sclerosis

(2008) Alastair Compston et al.   LANCET

Alzheimer's disease and vascular dementia in developing countries: prevalence, management, and risk factors

(2008) Raj N Kalaria et al.   LANCET NEUROLOGY

Effect of Melatonin and Melatonylvalpromide on β-amyloid and Neurofilaments in N2a Cells

(2008) Xiao-Chuan Wang et al.   NEUROCHEMICAL RESEARCH

Stimulatory effects of a melatonin receptor agonist, ramelteon, on BDNF in mouse cerebellar granule cells

(2008) Marta Imbesi et al.   NEUROSCIENCE LETTERS

Physiological effects of melatonin: Role of melatonin receptors and signal transduction pathways

(2008) S PANDIPERUMAL et al.   PROGRESS IN NEUROBIOLOGY

The association of nocturnal serum melatonin levels with major depression in patients with acute multiple sclerosis

(2008) Zehra Akpınar et al.   PSYCHIATRY RESEARCH

Melatonin antagonizes the intrinsic pathway of apoptosis via mitochondrial targeting of Bcl-2

(2007) Flavia Radogna et al.   JOURNAL OF PINEAL RESEARCH

Phosphatidylinositol-3-kinase activation blocks amyloid beta-induced neurotoxicity

(2007) Kyu-Yong Lee et al.   TOXICOLOGY