Investigational melatonin receptor agonists

Selective 5HT2A and 5HT6 Receptor Antagonists Promote Sleep in Rats

(2017) Stephen R. Morairty et al.   SLEEP

Clinical update: melatonin and sleep disorders

(2013) J. Arendt et al.   CLINICAL MEDICINE

Parkinson's Disease as a Neuroendocrine Disorder of Circadian Function: Dopamine-Melatonin Imbalance and the Visual System in the Genesis and Progression of the Degenerative Process

(2011) Gregory L. Willis   REVIEWS IN THE NEUROSCIENCES

New approaches in the management of insomnia: weighing the advantages of prolonged-release melatonin and synthetic melatoninergic agonists

(2010) Ruediger Hardeland   Neuropsychiatric Disease and Treatment

Melatonin Provides Anxiolysis, Enhances Analgesia, Decreases Intraocular Pressure, and Promotes Better Operating Conditions During Cataract Surgery Under Topical Anesthesia

(2009) Salah A. Ismail et al.   ANESTHESIA AND ANALGESIA

Melatonin: Signaling mechanisms of a pleiotropic agent

(2009) Rüdiger Hardeland   BIOFACTORS

N-(Anilinoethyl)amides: Design and Synthesis of Metabolically Stable, Selective Melatonin Receptor Ligands

(2009) Silvia Rivara et al.   ChemMedChem

Antagonism of serotonergic 5-HT2A/2Creceptors: mutual improvement of sleep, cognition and mood?

(2009) H.-P. Landolt et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Melatonin and Melatonergic Drugs on Sleep: Possible Mechanisms of Action

(2009) Venkataramanujan Srinivasan et al.   INTERNATIONAL JOURNAL OF NEUROSCIENCE

Long-term follow-up of melatonin treatment in children with ADHD and chronic sleep onset insomnia

(2009) Michel Hoebert et al.   JOURNAL OF PINEAL RESEARCH

Kynuramines, metabolites of melatonin and other indoles: the resurrection of an almost forgotten class of biogenic amines

(2009) Rüdiger Hardeland et al.   JOURNAL OF PINEAL RESEARCH

NEU-P11, a novel melatonin agonist, inhibits weight gain and improves insulin sensitivity in high-fat/high-sucrose-fed rats

(2009) Meihua She et al.   PHARMACOLOGICAL RESEARCH

Pathophysiology of depression: Role of sleep and the melatonergic system

(2009) Venkataramanujan Srinivasan et al.   PSYCHIATRY RESEARCH

Melatonin, hormone of darkness and more – occurrence, control mechanisms, actions and bioactive metabolites

(2008) R. Hardeland   CELLULAR AND MOLECULAR LIFE SCIENCES

Melatonin Receptor Agonists: SAR and Applications to the Treatment of Sleep-Wake Disorders

(2008) Silvia Rivara et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Preoperative Anxiolytic Effect of Melatonin and Clonidine on Postoperative Pain and Morphine Consumption in Patients Undergoing Abdominal Hysterectomy: A Double-Blind, Randomized, Placebo-Controlled Study

(2008) Wolnei Caumo et al.   JOURNAL OF PAIN

Melatonin and ischemiareperfusion injury of the brain

(2008) Miguel Cervantes et al.   JOURNAL OF PINEAL RESEARCH

The role of the thalamus in sleep, pineal melatonin production, and circadian rhythm sleep disorders

(2008) James E. Jan et al.   JOURNAL OF PINEAL RESEARCH

Let there be sleep—on time

(2008) Daniel P Cardinali et al.   LANCET

Melatonin agonist tasimelteon (VEC-162) for transient insomnia after sleep-time shift: two randomised controlled multicentre trials

(2008) Shantha MW Rajaratnam et al.   LANCET