Structural Understanding of Interleukin 6 Family Cytokine Signaling and Targeted Therapies: Focus on Interleukin 11

Activating the interleukin-6-Gp130-STAT3 pathway ameliorates ventricular electrical stability in myocardial infarction rats by modulating neurotransmitters in the paraventricular nucleus

(2020) Meng Gao et al.   BMC Cardiovascular Disorders

A pneumonia outbreak associated with a new coronavirus of probable bat origin

(2020) Peng Zhou et al.   NATURE

Long-term safety of siltuximab in patients with idiopathic multicentric Castleman disease: a prespecified, open-label, extension analysis of two trials

(2020) Frits van Rhee et al.   Lancet Haematology

COVID‐19 pneumonia in a kidney transplant recipient successfully treated with tocilizumab and hydroxychloroquine

(2020) Francesco Fontana et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Use of Tocilizumab for COVID-19-Induced Cytokine Release Syndrome

(2020) Jared Radbel et al.   CHEST

The structure of the extracellular domains of human interleukin 11 α-receptor reveals mechanisms of cytokine engagement

(2020) Riley D. Metcalfe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Clinical and immunological features of severe and moderate coronavirus disease 2019

(2020) Guang Chen et al.   JOURNAL OF CLINICAL INVESTIGATION

Historical overview of the interleukin-6 family cytokine

(2020) Sujin Kang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Tocilizumab treatment in COVID-19: A single center experience

(2020) Pan Luo et al.   JOURNAL OF MEDICAL VIROLOGY

Tocilizumab for the treatment of severe coronavirus disease 2019

(2020) Rand Alattar et al.   JOURNAL OF MEDICAL VIROLOGY

Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study

(2020) Fei Zhou et al.   LANCET

COVID-19: consider cytokine storm syndromes and immunosuppression

(2020) Puja Mehta et al.   LANCET

Effective treatment of severe COVID-19 patients with tocilizumab

(2020) Xiaoling Xu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bazedoxifene Attenuates Abdominal Aortic Aneurysm Formation via Downregulation of Interleukin-6/Glycoprotein 130/Signal Transducer and Activator of Transcription 3 Signaling Pathway in Apolipoprotein E–Knockout Mice

(2020) Dan Yan et al.   Frontiers in Pharmacology

Discovery of bazedoxifene analogues targeting glycoprotein 130

(2020) Dongmei Song et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Can we use interleukin-6 (IL-6) blockade for coronavirus disease 2019 (COVID-19)-induced cytokine release syndrome (CRS)?

(2020) Bingwen Liu et al.   JOURNAL OF AUTOIMMUNITY

De novo design of potent and selective mimics of IL-2 and IL-15

(2019) Daniel-Adriano Silva et al.   NATURE

Repurposing the selective estrogen receptor modulator bazedoxifene to suppress gastrointestinal cancer growth

(2019) Pathum Thilakasiri et al.   EMBO Molecular Medicine

Bazedoxifene is a novel IL-6/GP130 inhibitor for treating triple-negative breast cancer

(2019) Jilai Tian et al.   BREAST CANCER RESEARCH AND TREATMENT

Baricitinib: The Second FDA-Approved JAK Inhibitor for the Treatment of Rheumatoid Arthritis

(2019) Amanda Mogul et al.   ANNALS OF PHARMACOTHERAPY

Inhibiting Interleukin 11 Signaling Reduces Hepatocyte Death and Liver Fibrosis, Inflammation, and Steatosis in Mouse Models of Non-Alcoholic Steatohepatitis

(2019) Anissa A. Widjaja et al.   GASTROENTEROLOGY

Targeting Interleukin-6 Signaling in Clinic

(2019) Sujin Kang et al.   IMMUNITY

Modeling of Fibrotic Lung Disease Using 3D Organoids Derived from Human Pluripotent Stem Cells

(2019) Alexandros Strikoudis et al.   Cell Reports

Treatment of type 2 diabetes with the designer cytokine IC7Fc

(2019) Maria Findeisen et al.   NATURE

Interleukin-11 is a therapeutic target in idiopathic pulmonary fibrosis

(2019) Benjamin Ng et al.   Science Translational Medicine

A Potent and Selective Small-Molecule Degrader of STAT3 Achieves Complete Tumor Regression In Vivo

(2019) Longchuan Bai et al.   CANCER CELL

Structural basis of the signal transduction via transmembrane domain of the human growth hormone receptor

(2018) Eduard V. Bocharov et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

The SNP rs4252548 (R112H) which is associated with reduced human height compromises the stability of IL-11

(2018) Juliane Lokau et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

IL11RA- related Crouzon-like autosomal recessive craniosynostosis in ten new patients: resemblances and differences

(2018) E. Brischoux-Boucher et al.   CLINICAL GENETICS

Sarilumab: A Review in Moderate to Severe Rheumatoid Arthritis

(2018) Yvette N. Lamb et al.   DRUGS

The length of the interleukin-11 receptor stalk determines its capacity for classic signaling

(2018) Juliane Lokau et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Interleukin-6: designing specific therapeutics for a complex cytokine

(2018) Christoph Garbers et al.   NATURE REVIEWS DRUG DISCOVERY

The molecular basis of JAK/STAT inhibition by SOCS1

(2018) Nicholas P. D. Liau et al.   Nature Communications

Curcumin interacts directly with the Cysteine 259 residue of STAT3 and induces apoptosis in H-Ras transformed human mammary epithelial cells

(2018) Young-Il Hahn et al.   Scientific Reports

Breast Cancer-Derived Exosomes Alter Macrophage Polarization via gp130/STAT3 Signaling

(2018) Sunyoung Ham et al.   Frontiers in Immunology

Generation of and characterization of anti-IL-11 antibodies using newly established Il11-deficient mice

(2018) Yutaka Deguchi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The molecular details of cytokine signalling via the JAK/STAT pathway

(2018) Rhiannon Morris et al.   PROTEIN SCIENCE

OUP accepted manuscript

(2018)   RHEUMATOLOGY

Meta-analysis of Icelandic and UK data sets identifies missense variants in SMO, IL11, COL11A1 and 13 more new loci associated with osteoarthritis

(2018) Unnur Styrkarsdottir et al.   NATURE GENETICS

Soluble gp130 prevents interleukin-6 and interleukin-11 cluster signaling but not intracellular autocrine responses

(2018) Larissa Lamertz et al.   Science Signaling

Mutations in Craniosynostosis Patients Cause Defective Interleukin-11 Receptor Maturation and Drive Craniosynostosis-like Disease in Mice

(2018) Maria Agthe et al.   Cell Reports

STAT3 antisense oligonucleotide AZD9150 in a subset of patients with heavily pretreated lymphoma: results of a phase 1b trial

(2018) Matthew J. Reilley et al.   Journal for ImmunoTherapy of Cancer

Do STAT3 inhibitors have potential in the future for cancer therapy?

(2017) Andrea L.A. Wong et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Blocking gp130 signaling suppresses autotaxin expression in adipocytes and improves insulin sensitivity in diet-induced obesity

(2017) Shuhong Sun et al.   JOURNAL OF LIPID RESEARCH

The Essential Medicinal Chemistry of Curcumin

(2017) Kathryn M. Nelson et al.   JOURNAL OF MEDICINAL CHEMISTRY

Rare and low-frequency coding variants alter human adult height

(2017) Eirini Marouli et al.   NATURE

IL11 is a crucial determinant of cardiovascular fibrosis

(2017) Sebastian Schafer et al.   NATURE

JAK inhibition as a therapeutic strategy for immune and inflammatory diseases

(2017) Daniella M. Schwartz et al.   NATURE REVIEWS DRUG DISCOVERY

Interleukin-11 classic but not trans-signaling is essential for fertility in mice

(2017) Maria Agthe et al.   PLACENTA

Discovery of a junctional epitope antibody that stabilizes IL-6 and gp80 protein:protein interaction and modulates its downstream signaling

(2017) Ralph Adams et al.   Scientific Reports

Repositioning Bazedoxifene as a novel IL-6/GP130 signaling antagonist for human rhabdomyosarcoma therapy

(2017) Hui Xiao et al.   PLoS One

Structure–activity relationship study of a series of novel oxazolidinone derivatives as IL-6 signaling blockers

(2016) Sarbjit Singh et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

IL-6 trans-signaling is essential for the development of hepatocellular carcinoma in mice

(2016) Juri Bergmann et al.   HEPATOLOGY

A Conserved Ectodomain-Transmembrane Domain Linker Motif Tunes the Allosteric Regulation of Cell Surface Receptors

(2016) Thomas Schmidt et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Mimicry of Receptor Interaction by Antagonistic Interleukin-6 (IL-6) Antibodies

(2016) Christophe Blanchetot et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Evolution of Cytokine Receptor Signaling

(2016) Clifford Liongue et al.   JOURNAL OF IMMUNOLOGY

Targeting Interleukin-11 Receptor-  Impairs Human Endometrial Cancer Cell Proliferation and Invasion In Vitro and Reduces Tumor Growth and Metastasis In Vivo

(2016) A. L. Winship et al.   MOLECULAR CANCER THERAPEUTICS

Trans-presentation of IL-6 by dendritic cells is required for the priming of pathogenic TH17 cells

(2016) Sylvia Heink et al.   NATURE IMMUNOLOGY

The Structural Basis for Class II Cytokine Receptor Recognition by JAK1

(2016) Ryan Ferrao et al.   STRUCTURE

A combined computational and structural model of the full-length human prolactin receptor

(2016) Katrine Bugge et al.   Nature Communications

Bazedoxifene enhances the anti-tumor effects of cisplatin and radiation treatment by blocking IL-6 signaling in head and neck cancer

(2016) Arti Yadav et al.   Oncotarget

Proteolytic Cleavage Governs Interleukin-11 Trans-signaling

(2016) Juliane Lokau et al.   Cell Reports

Phase I and biomarker study of OPB-51602, a novel signal transducer and activator of transcription (STAT) 3 inhibitor, in patients with refractory solid malignancies

(2015) A. L. Wong et al.   ANNALS OF ONCOLOGY

Tocilizumab in early progressive rheumatoid arthritis: FUNCTION, a randomised controlled trial

(2015) Gerd R Burmester et al.   ANNALS OF THE RHEUMATIC DISEASES

Intrinsically disordered cytoplasmic domains of two cytokine receptors mediate conserved interactions with membranes

(2015) Gitte W. Haxholm et al.   BIOCHEMICAL JOURNAL

Modular organization of Interleukin-6 and Interleukin-11 α-receptors

(2015) Rebecca Nitz et al.   BIOCHIMIE

Glycoprotein130 (Gp130)/interleukin-6 (IL-6) signalling in osteoclasts promotes bone formation in periosteal and trabecular bone

(2015) Rachelle W. Johnson et al.   BONE

The cytokine storm of severe influenza and development of immunomodulatory therapy

(2015) Qiang Liu et al.   Cellular & Molecular Immunology

The βc receptor family – Structural insights and their functional implications

(2015) Sophie E. Broughton et al.   CYTOKINE

Emerging roles for IL-11 signaling in cancer development and progression: Focus on breast cancer

(2015) Cameron N. Johnstone et al.   CYTOKINE & GROWTH FACTOR REVIEWS

“Family reunion” – A structured view on the composition of the receptor complexes of interleukin-6-type and interleukin-12-type cytokines

(2015) Stefan Rose-John et al.   CYTOKINE & GROWTH FACTOR REVIEWS

A Novel Small-Molecule Inhibitor Targeting the IL-6 Receptor β Subunit, Glycoprotein 130

(2015) Soon-Sun Hong et al.   JOURNAL OF IMMUNOLOGY

Interleukin-11 alters placentation and causes preeclampsia features in mice

(2015) Amy L. Winship et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

AZD9150, a next-generation antisense oligonucleotide inhibitor of STAT3 with early evidence of clinical activity in lymphoma and lung cancer

(2015) David Hong et al.   Science Translational Medicine

Systematic review and meta-analysis of serious infections with tofacitinib and biologic disease-modifying antirheumatic drug treatment in rheumatoid arthritis clinical trials

(2015) Vibeke Strand et al.   ARTHRITIS RESEARCH & THERAPY

Side Effects of Cytokines Approved for Therapy

(2014) Brian A. Baldo   DRUG SAFETY

Reconstruction of an active SOCS3-based E3 ubiquitin ligase complexin vitro: identification of the active components and JAK2 and gp130 as substrates

(2014) Nadia J. Kershaw et al.   GROWTH FACTORS

Drug Design Targeting Protein–Protein Interactions (PPIs) Using Multiple Ligand Simultaneous Docking (MLSD) and Drug Repositioning: Discovery of Raloxifene and Bazedoxifene as Novel Inhibitors of IL-6/GP130 Interface

(2014) Huameng Li et al.   JOURNAL OF MEDICINAL CHEMISTRY

Safety and Efficacy of Tofacitinib, an Oral Janus Kinase Inhibitor, for the Treatment of Rheumatoid Arthritis in Open-label, Longterm Extension Studies

(2014) J. Wollenhaupt et al.   JOURNAL OF RHEUMATOLOGY

Discovery and characterization of olokizumab

(2014) Stevan Shaw et al.   mAbs

Structural basis of recognition of interferon-α receptor by tyrosine kinase 2

(2014) Heidi J A Wallweber et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structure of the pseudokinase-kinase domains from protein kinase TYK2 reveals a mechanism for Janus kinase (JAK) autoinhibition

(2014) P. J. Lupardus et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanism of Activation of Protein Kinase JAK2 by the Growth Hormone Receptor

(2014) A. J. Brooks et al.   SCIENCE

IL-6 in Inflammation, Immunity, and Disease

(2014) T. Tanaka et al.   Cold Spring Harbor Perspectives in Biology

The structure of human interleukin-11 reveals receptor-binding site features and structural differences from interleukin-6

(2014) Tracy L. Putoczki et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Upd3 – An ancestor of the four-helix bundle cytokines

(2013) Mirja Oldefest et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

gp130 activation is regulated by D2–D3 interdomain connectivity

(2013) Antje Schütt et al.   BIOCHEMICAL JOURNAL

Interleukin-11 Is the Dominant IL-6 Family Cytokine during Gastrointestinal Tumorigenesis and Can Be Targeted Therapeutically

(2013) Tracy L. Putoczki et al.   CANCER CELL

Signalling by the βc family of cytokines

(2013) Timothy R. Hercus et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Evidence for Tissue-Specific JAK/STAT Target Genes in Drosophila Optic Lobe Development

(2013) H. Wang et al.   GENETICS

Minimal Interleukin 6 (IL-6) Receptor Stalk Composition for IL-6 Receptor Shedding and IL-6 Classic Signaling

(2013) Paul Baran et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

IL-6 trans-signaling promotes pancreatitis-associated lung injury and lethality

(2013) Hong Zhang et al.   JOURNAL OF CLINICAL INVESTIGATION

Delayed induction of proinflammatory cytokines and suppression of innate antiviral response by the novel Middle East respiratory syndrome coronavirus: implications for pathogenesis and treatment

(2013) S. K. P. Lau et al.   JOURNAL OF GENERAL VIROLOGY

Structure-guided studies of the SHP-1/JAK1 interaction provide new insights into phosphatase catalytic domain substrate recognition

(2013) Nilda L. Alicea-Velázquez et al.   JOURNAL OF STRUCTURAL BIOLOGY

Bone metastasis from breast cancer involves elevated IL-11 expression and the gp130/STAT3 pathway

(2013) Li Ren et al.   MEDICAL ONCOLOGY

Analysis of the Human Tissue-specific Expression by Genome-wide Integration of Transcriptomics and Antibody-based Proteomics

(2013) Linn Fagerberg et al.   MOLECULAR & CELLULAR PROTEOMICS

Discovery of a Novel Orally Active Small-Molecule gp130 Inhibitor for the Treatment of Ovarian Cancer

(2013) S. Xu et al.   MOLECULAR CANCER THERAPEUTICS

Therapeutic modulators of STAT signalling for human diseases

(2013) Gabriella Miklossy et al.   NATURE REVIEWS DRUG DISCOVERY

SOCS3 binds specific receptor–JAK complexes to control cytokine signaling by direct kinase inhibition

(2013) Nadia J Kershaw et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Chimeric Antigen Receptor–Modified T Cells for Acute Lymphoid Leukemia

(2013) Stephan A. Grupp et al.   NEW ENGLAND JOURNAL OF MEDICINE

Mutations in the interleukin receptorIL11RAcause autosomal recessive Crouzon-like craniosynostosis

(2013) Katharina Keupp et al.   Molecular Genetics & Genomic Medicine

Randomized Phase 2b Trial of Tofacitinib (CP-690,550) in De Novo Kidney Transplant Patients: Efficacy, Renal Function and Safety at 1 Year

(2012) F. Vincenti et al.   AMERICAN JOURNAL OF TRANSPLANTATION

A designer hyper interleukin 11 (H11) is a biologically active cytokine

(2012) Hanna Dams-Kozlowska et al.   BMC BIOTECHNOLOGY

Dependency of Colorectal Cancer on a TGF-β-Driven Program in Stromal Cells for Metastasis Initiation

(2012) Alexandre Calon et al.   CANCER CELL

Crystal Structure of Interleukin-21 Receptor (IL-21R) Bound to IL-21 Reveals That Sugar Chain Interacting with WSXWS Motif Is Integral Part of IL-21R

(2012) Ole J. Hamming et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An Interleukin-6 Receptor-dependent Molecular Switch Mediates Signal Transduction of the IL-27 Cytokine Subunit p28 (IL-30) via a gp130 Protein Receptor Homodimer

(2012) Christoph Garbers et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

IL-6 Controls the Innate Immune Response against Listeria monocytogenes via Classical IL-6 Signaling

(2012) J. Hoge et al.   JOURNAL OF IMMUNOLOGY

Mechanistic and structural insight into the functional dichotomy between IL-2 and IL-15

(2012) Aaron M Ring et al.   NATURE IMMUNOLOGY

The composition and signaling of the IL-35 receptor are unconventional

(2012) Lauren W Collison et al.   NATURE IMMUNOLOGY

Ruxolitinib

(2012) Ruben A. Mesa et al.   NATURE REVIEWS DRUG DISCOVERY

Placebo-Controlled Trial of Tofacitinib Monotherapy in Rheumatoid Arthritis

(2012) Roy Fleischmann et al.   NEW ENGLAND JOURNAL OF MEDICINE

The WSXWS Motif in Cytokine Receptors Is a Molecular Switch Involved in Receptor Activation: Insight from Structures of the Prolactin Receptor

(2012) Robert Dagil et al.   STRUCTURE

Inactivation of IL11 Signaling Causes Craniosynostosis, Delayed Tooth Eruption, and Supernumerary Teeth

(2011) Pekka Nieminen et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Stat3/Socs3 Activation by IL-6 Transsignaling Promotes Progression of Pancreatic Intraepithelial Neoplasia and Development of Pancreatic Cancer

(2011) Marina Lesina et al.   CANCER CELL

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

A role for interleukin-2 trans-presentation in dendritic cell–mediated T cell activation in humans, as revealed by daclizumab therapy

(2011) Simone C Wuest et al.   NATURE MEDICINE

Interleukin-11 Drives Early Lung Inflammation during Mycobacterium tuberculosis Infection in Genetically Susceptible Mice

(2011) Marina A. Kapina et al.   PLoS One

Structural Snapshots of Full-Length Jak1, a Transmembrane gp130/IL-6/IL-6Rα Cytokine Receptor Complex, and the Receptor-Jak1 Holocomplex

(2011) Patrick J. Lupardus et al.   STRUCTURE

Meta-analysis of Dense Genecentric Association Studies Reveals Common and Uncommon Variants Associated with Height

(2010) Matthew B. Lanktree et al.   AMERICAN JOURNAL OF HUMAN GENETICS

A phase I/II study of siltuximab (CNTO 328), an anti-interleukin-6 monoclonal antibody, in metastatic renal cell cancer

(2010) J-F Rossi et al.   BRITISH JOURNAL OF CANCER

Discovery of a novel quinoxalinhydrazide with a broad-spectrum anticancer activity

(2010) Carmen Plasencia et al.   CANCER BIOLOGY & THERAPY

Curcumin Inhibits Constitutive STAT3 Phosphorylation in Human Pancreatic Cancer Cell lines and Downregulation of Survivin/BIRC5 Gene Expression

(2010) W. Glienke et al.   CANCER INVESTIGATION

Therapeutic Activation of Signal Transducer and Activator of Transcription 3 by Interleukin-11 Ameliorates Cardiac Fibrosis After Myocardial Infarction

(2010) Masanori Obana et al.   CIRCULATION

The soluble Interleukin 6 receptor: Generation and role in inflammation and cancer

(2010) Athena Chalaris et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Crystal Structure of the Entire Ectodomain of gp130

(2010) Yibin Xu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A role for IL-27p28 as an antagonist of gp130-mediated signaling

(2010) Jason S Stumhofer et al.   NATURE IMMUNOLOGY

Interleukin 11 is upregulated in uterine lavage and endometrial cancer cells in women with endometrial carcinoma

(2010) Joanne Yap et al.   Reproductive Biology and Endocrinology

Comparison of tocilizumab monotherapy versus methotrexate monotherapy in patients with moderate to severe rheumatoid arthritis: the AMBITION study

(2009) G. Jones et al.   ANNALS OF THE RHEUMATIC DISEASES

IL11 Antagonist Inhibits Uterine Stromal Differentiation, Causing Pregnancy Failure in Mice1

(2009) Ellen Menkhorst et al.   BIOLOGY OF REPRODUCTION

Frequent in-frame somatic deletions activate gp130 in inflammatory hepatocellular tumors

(2009) M. M. Spannbauer et al.   HEPATOLOGY

The dark side of curcumin

(2009) Estefanía Burgos-Morón et al.   INTERNATIONAL JOURNAL OF CANCER

The IL-27 p28 Subunit Binds Cytokine-Like Factor 1 to Form a Cytokine Regulating NK and T Cell Activities Requiring IL-6R for Signaling

(2009) S. Crabe et al.   JOURNAL OF IMMUNOLOGY

The SOCS Box Encodes a Hierarchy of Affinities for Cullin5: Implications for Ubiquitin Ligase Formation and Cytokine Signalling Suppression

(2009) Jeffrey J. Babon et al.   JOURNAL OF MOLECULAR BIOLOGY

Endogenous IL-11 Signaling Is Essential in Th2- and IL-13–Induced Inflammation and Mucus Production

(2008) Chun Geun Lee et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Long-term safety and efficacy of tocilizumab, an anti-IL-6 receptor monoclonal antibody, in monotherapy, in patients with rheumatoid arthritis (the STREAM study): evidence of safety and efficacy in a 5-year extension study

(2008) N Nishimoto et al.   ANNALS OF THE RHEUMATIC DISEASES

Interleukin 11 Inhibits Human Trophoblast Invasion Indicating a Likely Role in the Decidual Restraint of Trophoblast Invasion During Placentation1

(2008) Premila Paiva et al.   BIOLOGY OF REPRODUCTION

The Structure of the GM-CSF Receptor Complex Reveals a Distinct Mode of Cytokine Receptor Activation

(2008) Guido Hansen et al.   CELL

Molecular and Structural Basis of Cytokine Receptor Pleiotropy in the Interleukin-4/13 System

(2008) Sherry L. LaPorte et al.   CELL

STAT3 and STAT1 mediate IL-11–dependent and inflammation-associated gastric tumorigenesis in gp130 receptor mutant mice

(2008) Matthias Ernst et al.   JOURNAL OF CLINICAL INVESTIGATION

The Structure of Interleukin-23 Reveals the Molecular Basis of p40 Subunit Sharing with Interleukin-12

(2008) Patrick J. Lupardus et al.   JOURNAL OF MOLECULAR BIOLOGY

Crystal Structures of the Pro-Inflammatory Cytokine Interleukin-23 and Its Complex with a High-Affinity Neutralizing Antibody

(2008) Brian M. Beyer et al.   JOURNAL OF MOLECULAR BIOLOGY

Structural Organization of a Full-Length gp130/LIF-R Cytokine Receptor Transmembrane Complex

(2008) Georgios Skiniotis et al.   MOLECULAR CELL

Structural Biology of Shared Cytokine Receptors

(2007) Xinquan Wang et al.   Annual Review of Immunology