Structural Mimicry of Receptor Interaction by Antagonistic Interleukin-6 (IL-6) Antibodies

Combining somatic mutations present in differentin vivoaffinity-matured antibodies isolated from immunizedLama glamayields ultra-potent antibody therapeutics

(2016) Alex Klarenbeek et al.   PROTEIN ENGINEERING DESIGN & SELECTION

IL-6 targeting compared to TNF targeting in rheumatoid arthritis: studies of olokizumab, sarilumab and sirukumab

(2014) Yoshiya Tanaka et al.   ANNALS OF THE RHEUMATIC DISEASES

Cutting Edge: Soluble IL-6R Is Produced by IL-6R Ectodomain Shedding in Activated CD4 T Cells

(2014) E. M. Briso et al.   JOURNAL OF IMMUNOLOGY

Discovery and characterization of olokizumab

(2014) Stevan Shaw et al.   mAbs

Anti-interleukin-6 receptor antibody, tocilizumab, for the treatment of autoimmune diseases

(2011) Toshio Tanaka et al.   FEBS LETTERS

Therapeutic strategies for the clinical blockade of IL-6/gp130 signaling

(2011) Simon A. Jones et al.   JOURNAL OF CLINICAL INVESTIGATION

XDS

(2010) Wolfgang Kabsch   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Tocilizumab inhibits structural joint damage in rheumatoid arthritis patients with inadequate responses to methotrexate: Results from the double-blind treatment phase of a randomized placebo-controlled trial of tocilizumab safety and prevention of structu

(2010) Joel M. Kremer et al.   ARTHRITIS AND RHEUMATISM

The soluble Interleukin 6 receptor: Generation and role in inflammation and cancer

(2010) Athena Chalaris et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Structural Basis for Broad and Potent Neutralization of HIV-1 by Antibody VRC01

(2010) T. Zhou et al.   SCIENCE

Molecular replacement withMOLREP

(2009) Alexei Vagin et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Impact of interleukin-6 classic- and trans-signaling on liver damage and regeneration

(2009) Claudia Drucker et al.   JOURNAL OF AUTOIMMUNITY

Antibody Recognition of a Highly Conserved Influenza Virus Epitope

(2009) D. C. Ekiert et al.   SCIENCE

Efficacy and safety of tocilizumab in patients with systemic-onset juvenile idiopathic arthritis: a randomised, double-blind, placebo-controlled, withdrawal phase III trial

(2008) Shumpei Yokota et al.   LANCET

A cytokine-neutralizing antibody as a structural mimetic of 2 receptor interactions

(2008) C. Grutter et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA