gp130 activation is regulated by D2–D3 interdomain connectivity

Constitutively Active Mutant gp130 Receptor Protein from Inflammatory Hepatocellular Adenoma Is Inhibited by an Anti-gp130 Antibody That Specifically Neutralizes Interleukin 11 Signaling

(2012) J. Sommer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ligand-Induced Architecture of the Leptin Receptor Signaling Complex

(2012) Liliya V. Mancour et al.   MOLECULAR CELL

Structure of the Human Obesity Receptor Leptin-Binding Domain Reveals the Mechanism of Leptin Antagonism by a Monoclonal Antibody

(2012) Byron Carpenter et al.   STRUCTURE

The pro- and anti-inflammatory properties of the cytokine interleukin-6

(2011) Jürgen Scheller et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Somatic mutations activating STAT3 in human inflammatory hepatocellular adenomas

(2011) Camilla Pilati et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Structural Snapshots of Full-Length Jak1, a Transmembrane gp130/IL-6/IL-6Rα Cytokine Receptor Complex, and the Receptor-Jak1 Holocomplex

(2011) Patrick J. Lupardus et al.   STRUCTURE

Crystal Structure of the Entire Ectodomain of gp130

(2010) Yibin Xu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Forced Homo- and Heterodimerization of All gp130-Type Receptor Complexes Leads to Constitutive Ligand-independent Signaling and Cytokine-independent Growth

(2010) Jan Suthaus et al.   MOLECULAR BIOLOGY OF THE CELL

The signal transducer gp130: Solution structure of the carboxy-terminal domain of the cytokine receptor homology region

(2010) Thomas Kernebeck et al.   PROTEIN SCIENCE

IL-6 and Stat3 Are Required for Survival of Intestinal Epithelial Cells and Development of Colitis-Associated Cancer

(2009) Sergei Grivennikov et al.   CANCER CELL

Autocrine IL-6 Signaling: A Key Event in Tumorigenesis?

(2008) Sergei Grivennikov et al.   CANCER CELL

Frequent in-frame somatic deletions activate gp130 in inflammatory hepatocellular tumours

(2008) Sandra Rebouissou et al.   NATURE