An Interleukin-6 Receptor-dependent Molecular Switch Mediates Signal Transduction of the IL-27 Cytokine Subunit p28 (IL-30) via a gp130 Protein Receptor Homodimer

A designer hyper interleukin 11 (H11) is a biologically active cytokine

(2012) Hanna Dams-Kozlowska et al.   BMC BIOTECHNOLOGY

Plasticity and cross-talk of Interleukin 6-type cytokines

(2012) Christoph Garbers et al.   CYTOKINE & GROWTH FACTOR REVIEWS

The pro- and anti-inflammatory properties of the cytokine interleukin-6

(2011) Jürgen Scheller et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Interleukin-30: A novel antiinflammatory cytokine candidate for prevention and treatment of inflammatory cytokine-induced liver injury

(2011) Denada Dibra et al.   HEPATOLOGY

Inhibition of Classic Signaling Is a Novel Function of Soluble Glycoprotein 130 (sgp130), Which Is Controlled by the Ratio of Interleukin 6 and Soluble Interleukin 6 Receptor

(2011) Christoph Garbers et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Therapeutic strategies for the clinical blockade of IL-6/gp130 signaling

(2011) Simon A. Jones et al.   JOURNAL OF CLINICAL INVESTIGATION

ADAM17: a molecular switch to control inflammation and tissue regeneration

(2011) Jürgen Scheller et al.   TRENDS IN IMMUNOLOGY

New directions in the basic and translational biology of interleukin-27

(2011) Elia D. Tait Wojno et al.   TRENDS IN IMMUNOLOGY

Viral Interleukin-6: Structure, pathophysiology and strategies of neutralization

(2010) Jan Suthaus et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

A role for IL-27p28 as an antagonist of gp130-mediated signaling

(2010) Jason S Stumhofer et al.   NATURE IMMUNOLOGY

The IL-27 p28 Subunit Binds Cytokine-Like Factor 1 to Form a Cytokine Regulating NK and T Cell Activities Requiring IL-6R for Signaling

(2009) S. Crabe et al.   JOURNAL OF IMMUNOLOGY

Unraveling Viral Interleukin-6 Binding to gp130 and Activation of STAT-Signaling Pathways Independently of the Interleukin-6 Receptor

(2009) N. Adam et al.   JOURNAL OF VIROLOGY

Structure-guided Optimization of the Interleukin-6 Trans-signaling Antagonist sgp130

(2008) Stephanie Tenhumberg et al.   JOURNAL OF BIOLOGICAL CHEMISTRY