Historical overview of the interleukin-6 family cytokine

Targeting Interleukin-6 Signaling in Clinic

(2019) Sujin Kang et al.   IMMUNITY

Loss of the interleukin-6 receptor causes immunodeficiency, atopy, and abnormal inflammatory responses

(2019) Sarah Spencer et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Post-transcriptional regulation of immune responses by RNA binding proteins

(2018) Takashi MINO et al.   PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES

Regulation of inflammatory responses by dynamic subcellular localization of RNA-binding protein Arid5a

(2018) Mitsuru Higa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Two-Faced Cytokine IL-6 in Host Defense and Diseases

(2018) Masashi Narazaki et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

IL-17 integrates multiple self-reinforcing, feed-forward mechanisms through the RNA binding protein Arid5a

(2018) Nilesh Amatya et al.   Science Signaling

A biallelic mutation in IL6ST encoding the GP130 co-receptor causes immunodeficiency and craniosynostosis

(2017) Tobias Schwerd et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Regnase-1 and Roquin Nonredundantly Regulate Th1 Differentiation Causing Cardiac Inflammation and Fibrosis

(2017) Xiaotong Cui et al.   JOURNAL OF IMMUNOLOGY

TLR4-induced NF-κB and MAPK signaling regulate the IL-6 mRNA stabilizing protein Arid5a

(2017) Kishan K. Nyati et al.   NUCLEIC ACIDS RESEARCH

Interleukin-6 Family Cytokines

(2017) Stefan Rose-John   Cold Spring Harbor Perspectives in Biology

Interleukin (IL)-39 [IL-23p19/Epstein-Barr virus-induced 3 (Ebi3)] induces differentiation/expansion of neutrophils in lupus-prone mice

(2016) X. Wang et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

A novel IL-23p19/Ebi3 (IL-39) cytokine mediates inflammation in Lupus-like mice

(2016) Xiaoqian Wang et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Arid5a regulates naive CD4+T cell fate through selective stabilization of Stat3 mRNA

(2016) Kazuya Masuda et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Trans-presentation of IL-6 by dendritic cells is required for the priming of pathogenic TH17 cells

(2016) Sylvia Heink et al.   NATURE IMMUNOLOGY

MiR-26 down-regulates TNF-α/NF-κB signalling and IL-6 expression by silencing HMGA1 and MALT1

(2016) Chyi-Ying A. Chen et al.   NUCLEIC ACIDS RESEARCH

Arid5a exacerbates IFN-γ–mediated septic shock by stabilizing T-bet mRNA

(2016) Mohammad Mahabub-Uz Zaman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Expanding Diversity in Molecular Structures and Functions of the IL-6/IL-12 Heterodimeric Cytokine Family

(2016) Hideaki Hasegawa et al.   Frontiers in Immunology

Regnase-1 and Roquin Regulate a Common Element in Inflammatory mRNAs by Spatiotemporally Distinct Mechanisms

(2015) Takashi Mino et al.   CELL

Asymmetric Action of STAT Transcription Factors Drives Transcriptional Outputs and Cytokine Specificity

(2015) Kiyoshi Hirahara et al.   IMMUNITY

Expression of the IL-11 Gene in Metastatic Cells Is Supported by Runx2-Smad and Runx2-cJun Complexes Induced by TGFβ1

(2015) Xuhui Zhang et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

A gp130–Src–YAP module links inflammation to epithelial regeneration

(2015) Koji Taniguchi et al.   NATURE

IL-6 as a keystone cytokine in health and disease

(2015) Christopher A Hunter et al.   NATURE IMMUNOLOGY

A Soluble Form of IL-27R  Is a Natural IL-27 Antagonist

(2014) C. Dietrich et al.   JOURNAL OF IMMUNOLOGY

A new era for the treatment of inflammatory autoimmune diseases by interleukin-6 blockade strategy

(2014) Toshio Tanaka et al.   SEMINARS IN IMMUNOLOGY

Organizing Principles of Mammalian Nonsense-Mediated mRNA Decay

(2013) Maximilian Wei-Lin Popp et al.   Annual Review of Genetics

Malt1-Induced Cleavage of Regnase-1 in CD4+ Helper T Cells Regulates Immune Activation

(2013) Takuya Uehata et al.   CELL

Arid5a controls IL-6 mRNA stability, which contributes to elevation of IL-6 level in vivo

(2013) Kazuya Masuda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mutations in the interleukin receptorIL11RAcause autosomal recessive Crouzon-like craniosynostosis

(2013) Katharina Keupp et al.   Molecular Genetics & Genomic Medicine

Interleukin-6 receptor pathways in coronary heart disease: a collaborative meta-analysis of 82 studies

(2012)   LANCET

The interleukin-6 receptor as a target for prevention of coronary heart disease: a mendelian randomisation analysis

(2012)   LANCET

The composition and signaling of the IL-35 receptor are unconventional

(2012) Lauren W Collison et al.   NATURE IMMUNOLOGY

Selective blockade of interleukin-6 trans-signaling improves survival in a murine polymicrobial sepsis model*

(2011) Tanja Barkhausen et al.   CRITICAL CARE MEDICINE

Tristetraprolin Regulates Interleukin-6 Expression Through p38 MAPK-Dependent Affinity Changes with mRNA 3′ Untranslated Region

(2011) Wenpu Zhao et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

The IκB kinase complex regulates the stability of cytokine-encoding mRNA induced by TLR–IL-1R by controlling degradation of regnase-1

(2011) Hidenori Iwasaki et al.   NATURE IMMUNOLOGY

Aryl hydrocarbon receptor deficiency in T cells suppresses the development of collagen-induced arthritis

(2011) T. Nakahama et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MicroRNA-155 Regulates Inflammatory Cytokine Production in Tumor-associated Macrophages via Targeting C/EBPβ

(2010) Min He et al.   Cellular & Molecular Immunology

A role for IL-27p28 as an antagonist of gp130-mediated signaling

(2010) Jason S Stumhofer et al.   NATURE IMMUNOLOGY

Interleukin (IL)-35 is raising our expectations

(2010) ZHAO NING-WEI   REVISTA MEDICA DE CHILE

Aryl hydrocarbon receptor in combination with Stat1 regulates LPS-induced inflammatory responses

(2009) Akihiro Kimura et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Zc3h12a is an RNase essential for controlling immune responses by regulating mRNA decay

(2009) Kazufumi Matsushita et al.   NATURE

Zcchc11-dependent uridylation of microRNA directs cytokine expression

(2009) Matthew R. Jones et al.   NATURE CELL BIOLOGY

Alveolar Epithelial STAT3, IL-6 Family Cytokines, and Host Defense duringEscherichia coliPneumonia

(2008) Lee J. Quinton et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Genome-wide Analysis Identifies Interleukin-10 mRNA as Target of Tristetraprolin

(2008) Georg Stoecklin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Frequent in-frame somatic deletions activate gp130 in inflammatory hepatocellular tumours

(2008) Sandra Rebouissou et al.   NATURE

Stress granules: the Tao of RNA triage

(2008) Paul Anderson et al.   TRENDS IN BIOCHEMICAL SCIENCES