Do STAT3 inhibitors have potential in the future for cancer therapy?

Targeting transcription factor STAT3 for cancer prevention and therapy

(2016) Edna Zhi Pei Chai et al.   PHARMACOLOGY & THERAPEUTICS

Phase I and biomarker study of OPB-51602, a novel signal transducer and activator of transcription (STAT) 3 inhibitor, in patients with refractory solid malignancies

(2015) A. L. Wong et al.   ANNALS OF ONCOLOGY

JAK Inhibition Impairs NK Cell Function in Myeloproliferative Neoplasms

(2015) Kathrin Schönberg et al.   CANCER RESEARCH

AZD9150, a next-generation antisense oligonucleotide inhibitor of STAT3 with early evidence of clinical activity in lymphoma and lung cancer

(2015) David Hong et al.   Science Translational Medicine

STAT3-Mediated Metabolic Reprograming in Cellular Transformation and Implications for Drug Resistance

(2015) Valeria Poli et al.   Frontiers in Oncology

Drug Resistance via Feedback Activation of Stat3 in Oncogene-Addicted Cancer Cells

(2014) Ho-June Lee et al.   CANCER CELL

Pharmacologic Suppression of JAK1/2 by JAK1/2 Inhibitor AZD1480 Potently Inhibits IL-6-Induced Experimental Prostate Cancer Metastases Formation

(2014) L. Gu et al.   MOLECULAR CANCER THERAPEUTICS

STAT inhibitors for cancer therapy

(2013) Muhammad Furqan et al.   Journal of Hematology & Oncology

SOCS3 Deletion in T Lymphocytes Suppresses Development of Chronic Ocular Inflammation via Upregulation of CTLA-4 and Expansion of Regulatory T Cells

(2013) C.-R. Yu et al.   JOURNAL OF IMMUNOLOGY

Effect of AZD1480 in an epidermal growth factor receptor-driven lung cancer model

(2013) Toshi Murakami et al.   LUNG CANCER

Mutant B-RAF-Mcl-1 survival signaling depends on the STAT3 transcription factor

(2013) T M Becker et al.   ONCOGENE

SomaticSTAT3Mutations in Large Granular Lymphocytic Leukemia

(2012) Hanna L.M. Koskela et al.   NEW ENGLAND JOURNAL OF MEDICINE

JAK Inhibition with Ruxolitinib versus Best Available Therapy for Myelofibrosis

(2012) Claire Harrison et al.   NEW ENGLAND JOURNAL OF MEDICINE

First-in-Human Trial of a STAT3 Decoy Oligonucleotide in Head and Neck Tumors: Implications for Cancer Therapy

(2012) Malabika Sen et al.   Cancer Discovery

Tyk2/STAT3 Signaling Mediates  -Amyloid-Induced Neuronal Cell Death: Implications in Alzheimer's Disease

(2010) J. Wan et al.   JOURNAL OF NEUROSCIENCE

CELL BIOLOGY: Moonlighting in Mitochondria

(2009) M. G. Myers Jr.   SCIENCE