Down Syndrome Is a Metabolic Disease: Altered Insulin Signaling Mediates Peripheral and Brain Dysfunctions

The re‐emerging pathophysiological role of the cystathionine‐β‐synthase ‐ hydrogen sulfide system in Down syndrome

(2020) Csaba Szabo   FEBS Journal

HLA Class II Allele Analyses Implicate Common Genetic Components in Type 1 and Non–Insulin-Treated Type 2 Diabetes

(2020) Thomas Jacobi et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Selective DYRK1A Inhibitor for the Treatment of Type 1 Diabetes: Discovery of 6-Azaindole Derivative GNF2133

(2020) Yahu A. Liu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Palmitate Is Increased in the Cerebrospinal Fluid of Humans with Obesity and Induces Memory Impairment in Mice via Pro-inflammatory TNF-α

(2020) Helen M. Melo et al.   Cell Reports

A chromosomal connectome for psychiatric and metabolic risk variants in adult dopaminergic neurons

(2020) Sergio Espeso-Gil et al.   Genome Medicine

The Novel Dual GLP-1/GIP Receptor Agonist DA-CH5 Is Superior to Single GLP-1 Receptor Agonists in the MPTP Model of Parkinson’s Disease

(2020) Lingyu Zhang et al.   Journal of Parkinsons Disease

Targeting Mitochondrial Network Architecture in Down Syndrome and Aging

(2020) Nunzia Mollo et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Brain insulin resistance triggers early onset Alzheimer disease in Down syndrome

(2020) Antonella Tramutola et al.   NEUROBIOLOGY OF DISEASE

ApoE and cerebral insulin: Trafficking, receptors, and resistance

(2020) Elizabeth M. Rhea et al.   NEUROBIOLOGY OF DISEASE

Down syndrome: neurobiological alterations and therapeutic targets

(2019) Rosa Anna Vacca et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Insulin action in the brain regulates mitochondrial stress responses and reduces diet-induced weight gain

(2019) Kristina Wardelmann et al.   Molecular Metabolism

Restoration of aberrant mTOR signaling by intranasal rapamycin reduces oxidative damage: Focus on HNE-modified proteins in a mouse model of down syndrome

(2019) Fabio Di Domenico et al.   Redox Biology

Dementia in Down syndrome: unique insights for Alzheimer disease research

(2019) Ira T. Lott et al.   Nature Reviews Neurology

Insulin Resistance and Oxidative Stress in the Brain: What’s New?

(2019) Mateusz Maciejczyk et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Reduced biliverdin reductase-A levels are associated with early alterations of insulin signaling in obesity

(2019) Flavia Agata Cimini et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Trisomy 21 is a Cause of Permanent Neonatal Diabetes that is Autoimmune but not HLA Associated

(2019) Matthew B Johnson et al.   DIABETES

Loss of biliverdin reductase-A favors Tau hyper-phosphorylation in Alzheimer's disease

(2019) Nidhi Sharma et al.   NEUROBIOLOGY OF DISEASE

mTOR hyperactivation in Down Syndrome underlies deficits in autophagy induction, autophagosome formation, and mitophagy

(2019) Matteo Bordi et al.   Cell Death & Disease

Plasma metabolites related to cellular energy metabolism are altered in adults with Down syndrome and Alzheimer's disease

(2019) Thomas J. Gross et al.   Developmental Neurobiology

Overproduction of H2S, generated by CBS, inhibits mitochondrial Complex IV and suppresses oxidative phosphorylation in Down syndrome

(2019) Theodora Panagaki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activation of the ISR mediates the behavioral and neurophysiological abnormalities in Down syndrome

(2019) Ping Jun Zhu et al.   SCIENCE

Suppressing Aneuploidy-Associated Phenotypes Improves the Fitness of Trisomy 21 Cells

(2019) Sunyoung Hwang et al.   Cell Reports

Biliverdin reductase-A impairment links brain insulin resistance with increased Aβ production in an animal model of aging: Implications for Alzheimer disease

(2018) Francesca Triani et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Disturbance of redox homeostasis in Down Syndrome: Role of iron dysmetabolism

(2018) Eugenio Barone et al.   FREE RADICAL BIOLOGY AND MEDICINE

Increased levels of inflammatory plasma markers and obesity risk in a mouse model of Down syndrome

(2018) M. Fructuoso et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mitochondria as pharmacological targets in Down syndrome

(2018) Daniela Valenti et al.   FREE RADICAL BIOLOGY AND MEDICINE

Dysfunction of autophagy and endosomal-lysosomal pathways: Roles in pathogenesis of Down syndrome and Alzheimer's Disease

(2018) Daniel J. Colacurcio et al.   FREE RADICAL BIOLOGY AND MEDICINE

Targeting Insulin for Alzheimer’s Disease: Mechanisms, Status and Potential Directions

(2018) Jung Hyun Lee et al.   JOURNAL OF ALZHEIMERS DISEASE

Early and Selective Activation and Subsequent Alterations to the Unfolded Protein Response in Down Syndrome Mouse Models

(2018) Chiara Lanzillotta et al.   JOURNAL OF ALZHEIMERS DISEASE

The diabetes drug liraglutide reverses cognitive impairment in mice and attenuates insulin receptor and synaptic pathology in a non-human primate model of Alzheimer's disease

(2018) Andre F Batista et al.   JOURNAL OF PATHOLOGY

Mitochondrial dysfunction in down syndrome: molecular mechanisms and therapeutic targets

(2018) Antonella Izzo et al.   MOLECULAR MEDICINE

Brain insulin resistance in type 2 diabetes and Alzheimer disease: concepts and conundrums

(2018) Steven E. Arnold et al.   Nature Reviews Neurology

Lactate in the brain: from metabolic end-product to signalling molecule

(2018) Pierre J. Magistretti et al.   NATURE REVIEWS NEUROSCIENCE

Novel dual GLP-1/GIP receptor agonists show neuroprotective effects in Alzheimer's and Parkinson's disease models

(2018) Christian Hölscher   NEUROPHARMACOLOGY

Plasma and urinary metabolomic profiles of Down syndrome correlate with alteration of mitochondrial metabolism

(2018) Maria Caracausi et al.   Scientific Reports

Metabolic and Vascular Imaging Biomarkers in Down Syndrome Provide Unique Insights Into Brain Aging and Alzheimer Disease Pathogenesis

(2018) Elizabeth Head et al.   Frontiers in Aging Neuroscience

Integrated Quantitative Transcriptome Maps of Human Trisomy 21 Tissues and Cells

(2018) Maria Chiara Pelleri et al.   Frontiers in Genetics

Oxidative and Nitrosative Modifications of Biliverdin Reductase-A in the Brain of Subjects with Alzheimer's Disease and Amnestic Mild Cognitive Impairment

(2018) Eugenio Barone et al.   JOURNAL OF ALZHEIMERS DISEASE

HO-1/BVR-A System Analysis in Plasma from Probable Alzheimer's Disease and Mild Cognitive Impairment Subjects: A Potential Biochemical Marker for the Prediction of the Disease

(2018) Fabio Di Domenico et al.   JOURNAL OF ALZHEIMERS DISEASE

Sex and ApoE Genotype Differences in Treatment Response to Two Doses of Intranasal Insulin in Adults with Mild Cognitive Impairment or Alzheimer's Disease

(2018) Amy Claxton et al.   JOURNAL OF ALZHEIMERS DISEASE

Biliverdin Reductase-A Mediates the Beneficial Effects of Intranasal Insulin in Alzheimer Disease

(2018) Eugenio Barone et al.   MOLECULAR NEUROBIOLOGY

Lipidome alterations in human prefrontal cortex during development, aging, and cognitive disorders

(2018) Qianhui Yu et al.   MOLECULAR PSYCHIATRY

Common metabolic pathways implicated in resistance to chemotherapy point to a key mitochondrial role in breast cancer

(2018) Etna Abad et al.   MOLECULAR & CELLULAR PROTEOMICS

A single extra copy of Down syndrome critical region 1–4 results in impaired hepatic glucose homeostasis

(2018) Dong Soo Seo et al.   Molecular Metabolism

Intranasal rapamycin ameliorates Alzheimer-like cognitive decline in a mouse model of Down syndrome

(2018) Antonella Tramutola et al.   Translational Neurodegeneration

mTORC1 inhibition with rapamycin exacerbates adipose tissue inflammation in obese mice and dissociates macrophage phenotype from function

(2017) Vivian A. Paschoal et al.   IMMUNOBIOLOGY

Triglycerides cross the blood–brain barrier and induce central leptin and insulin receptor resistance

(2017) W A Banks et al.   INTERNATIONAL JOURNAL OF OBESITY

Effects of Regular and Long-Acting Insulin on Cognition and Alzheimer’s Disease Biomarkers: A Pilot Clinical Trial

(2017) Suzanne Craft et al.   JOURNAL OF ALZHEIMERS DISEASE

Amyloid-β oligomers transiently inhibit AMP-activated kinase and cause metabolic defects in hippocampal neurons

(2017) Gisele S. Seixas da Silva et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Concentrations of leptin, adiponectin and other metabolic parameters in non-obese children with Down syndrome

(2017) Nikhil Tenneti et al.   JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM

Biochemical and cellular properties of insulin receptor signalling

(2017) Rebecca A. Haeusler et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Brain insulin resistance impairs hippocampal synaptic plasticity and memory by increasing GluA1 palmitoylation through FoxO3a

(2017) Matteo Spinelli et al.   Nature Communications

Aberrations in circulating inflammatory cytokine levels in patients with Down syndrome: a meta-analysis

(2017) Yan Zhang et al.   Oncotarget

p70 S6 Kinase and Tau in Alzheimer's Disease

(2017) Jin-Jing Pei et al.   JOURNAL OF ALZHEIMERS DISEASE

An inflammatory and trophic disconnect biomarker profile revealed in Down syndrome plasma: Relation to cognitive decline and longitudinal evaluation

(2016) M. Florencia Iulita et al.   Alzheimers & Dementia

Adipose extracellular matrix remodelling in obesity and insulin resistance

(2016) De Lin et al.   BIOCHEMICAL PHARMACOLOGY

The polyphenols resveratrol and epigallocatechin-3-gallate restore the severe impairment of mitochondria in hippocampal progenitor cells from a Down syndrome mouse model

(2016) Daniela Valenti et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Adipose tissue inflammation: a cause or consequence of obesity-related insulin resistance?

(2016) M. Bluher   CLINICAL SCIENCE

DYRK1A: A Promising Drug Target for Islet Transplant–Based Diabetes Therapies

(2016) Bengt-Frederik Belgardt et al.   DIABETES

Lipid profiles in a large cohort of Italian children with Down syndrome

(2016) Paola Sabrina Buonuomo et al.   European Journal of Medical Genetics

Interaction of human biliverdin reductase with Akt/protein kinase B and phosphatidylinositol-dependent kinase 1 regulates glycogen synthase kinase 3 activity: a novel mechanism of Akt activation

(2016) Tihomir Miralem et al.   FASEB JOURNAL

Impairment of biliverdin reductase-A promotes brain insulin resistance in Alzheimer disease: A new paradigm

(2016) Eugenio Barone et al.   FREE RADICAL BIOLOGY AND MEDICINE

The contribution of the citrate pathway to oxidative stress in Down syndrome

(2016) Paolo Convertini et al.   IMMUNOLOGY

Changes in insulin and insulin signaling in Alzheimer’s disease: cause or consequence?

(2016) Molly Stanley et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Sirt1 decreased adipose inflammation by interacting with Akt2 and inhibiting mTOR/S6K1 pathway in mice

(2016) Zhenjiang Liu et al.   JOURNAL OF LIPID RESEARCH

Safety and efficacy of cognitive training plus epigallocatechin-3-gallate in young adults with Down's syndrome (TESDAD): a double-blind, randomised, placebo-controlled, phase 2 trial

(2016) Rafael de la Torre et al.   LANCET NEUROLOGY

Mouse models of Down syndrome: gene content and consequences

(2016) Meenal Gupta et al.   MAMMALIAN GENOME

Chromosomal contacts connect loci associated with autism, BMI and head circumference phenotypes

(2016) M N Loviglio et al.   MOLECULAR PSYCHIATRY

Down syndrome and the complexity of genome dosage imbalance

(2016) Stylianos E. Antonarakis   NATURE REVIEWS GENETICS

Impaired fasting glucose is associated with increased regional cerebral amyloid

(2016) Jill K. Morris et al.   NEUROBIOLOGY OF AGING

A Syntenic Cross Species Aneuploidy Genetic Screen Links RCAN1 Expression to β-Cell Mitochondrial Dysfunction in Type 2 Diabetes

(2016) Heshan Peiris et al.   PLoS Genetics

Down syndrome and Alzheimer's disease: Common pathways, common goals

(2015) Dean Hartley et al.   Alzheimers & Dementia

Redox- and non-redox-metal-induced formation of free radicals and their role in human disease

(2015) Marian Valko et al.   ARCHIVES OF TOXICOLOGY

Chromosome 21-derived hsa-miR-155-5p regulates mitochondrial biogenesis by targeting Mitochondrial Transcription Factor A (TFAM)

(2015) Adolfo Quiñones-Lombraña et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Aging in Down Syndrome and the Development of Alzheimer's Disease Neuropathology

(2015) Elizabeth Head et al.   Current Alzheimer Research

Morbidity and medication in a large population of individuals with Down syndrome compared to the general population

(2015) Myriam Alexander et al.   DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY

DYRK1A BAC Transgenic Mouse: A New Model of Thyroid Dysgenesis in Down Syndrome

(2015) Dulanjalee Kariyawasam et al.   ENDOCRINOLOGY

Galectin-3 in autoimmunity and autoimmune diseases

(2015) Felipe L de Oliveira et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Inhibition of BACE2 counteracts hIAPP-induced insulin secretory defects in pancreatic β-cells

(2015) Gema Alcarraz-Vizán et al.   FASEB JOURNAL

Physiological roles of miR-155

(2015) Ryuichi Mashima   IMMUNOLOGY

Alteration of mTOR signaling occurs early in the progression of Alzheimer disease (AD): analysis of brain from subjects with pre-clinical AD, amnestic mild cognitive impairment and late-stage AD

(2015) Antonella Tramutola et al.   JOURNAL OF NEUROCHEMISTRY

A high-throughput chemical screen reveals that harmine-mediated inhibition of DYRK1A increases human pancreatic beta cell replication

(2015) Peng Wang et al.   NATURE MEDICINE

A genetic cause of Alzheimer disease: mechanistic insights from Down syndrome

(2015) Frances K. Wiseman et al.   NATURE REVIEWS NEUROSCIENCE

Down syndrome individuals with Alzheimer's disease have a distinct neuroinflammatory phenotype compared to sporadic Alzheimer's disease

(2015) Donna M. Wilcock et al.   NEUROBIOLOGY OF AGING

The role of type 2 diabetes in neurodegeneration

(2015) Giuseppe Verdile et al.   NEUROBIOLOGY OF DISEASE

Increased Mammalian Target of Rapamycin Signaling Contributes to the Accumulation of Protein Oxidative Damage in a Mouse Model of Down's Syndrome

(2015) Antonella Tramutola et al.   Neurodegenerative Diseases

Semantic Verbal Fluency Pattern, Dementia Rating Scores and Adaptive Behavior Correlate With Plasma Aβ42 Concentrations in Down Syndrome Young Adults

(2015) Laura Del Hoyo et al.   Frontiers in Behavioral Neuroscience

The Brain Response to Peripheral Insulin Declines with Age: A Contribution of the Blood-Brain Barrier?

(2015) Tina Sartorius et al.   PLoS One

Risk of Major Cardiovascular Events in People with Down Syndrome

(2015) Christopher G. Sobey et al.   PLoS One

Associations of ghrelin with eating behaviors, stress, metabolic factors, and telomere length among overweight and obese women: Preliminary evidence of attenuated ghrelin effects in obesity?

(2014) Julia Buss et al.   APPETITE

Redox proteomics analysis to decipher the neurobiology of Alzheimer-like neurodegeneration: overlaps in Down's syndrome and Alzheimer's disease brain

(2014) D. Allan Butterfield et al.   BIOCHEMICAL JOURNAL

Neuropathological role of PI3K/Akt/mTOR axis in Down syndrome brain

(2014) Marzia Perluigi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Elevated risk of type 2 diabetes for development of Alzheimer disease: A key role for oxidative stress in brain

(2014) D. Allan Butterfield et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Dyrk1A induces pancreatic β cell mass expansion and improves glucose tolerance

(2014) Latif Rachdi et al.   CELL CYCLE

Dyrk1a haploinsufficiency induces diabetes in mice through decreased pancreatic beta cell mass

(2014) Latif Rachdi et al.   DIABETOLOGIA

Redox proteomics analysis of HNE-modified proteins in Down syndrome brain: clues for understanding the development of Alzheimer disease

(2014) Fabio Di Domenico et al.   FREE RADICAL BIOLOGY AND MEDICINE

Phosphorylation and Inactivation of Glycogen Synthase Kinase 3β (GSK3β) by Dual-specificity Tyrosine Phosphorylation-regulated Kinase 1A (Dyrk1A)

(2014) Woo-Joo Song et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Autoimmune Predisposition in Down Syndrome May Result from a Partial Central Tolerance Failure due to Insufficient Intrathymic Expression ofAIREand Peripheral Antigens

(2014) Mireia Giménez-Barcons et al.   JOURNAL OF IMMUNOLOGY

Alzheimer's Disease-Like Pathology Induced by Amyloid-β Oligomers in Nonhuman Primates

(2014) Leticia Forny-Germano et al.   JOURNAL OF NEUROSCIENCE

Hyperhomocysteinemia: Related genetic diseases and congenital defects, abnormal DNA methylation and newborn screening issues

(2014) Vito Iacobazzi et al.   MOLECULAR GENETICS AND METABOLISM

Domains of genome-wide gene expression dysregulation in Down’s syndrome

(2014) Audrey Letourneau et al.   NATURE

Mitochondrial dysfunction as a central actor in intellectual disability-related diseases: An overview of Down syndrome, autism, Fragile X and Rett syndrome

(2014) Daniela Valenti et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Thyroid Hormone Regulation of Metabolism

(2014) Rashmi Mullur et al.   PHYSIOLOGICAL REVIEWS

Impairment of proteostasis network in Down syndrome prior to the development of Alzheimer's disease neuropathology: Redox proteomics analysis of human brain

(2013) Fabio Di Domenico et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

TNF-α Mediates PKR-Dependent Memory Impairment and Brain IRS-1 Inhibition Induced by Alzheimer’s β-Amyloid Oligomers in Mice and Monkeys

(2013) Mychael V. Lourenco et al.   Cell Metabolism

Adaptive Downregulation of Mitochondrial Function in Down Syndrome

(2013) Pablo Helguera et al.   Cell Metabolism

Elevated levels of extracellular heat-shock protein 72 (eHSP72) are positively correlated with insulin resistancein vivoand cause pancreatic β-cell dysfunction and deathin vitro

(2013) Mauricio Krause et al.   CLINICAL SCIENCE

A major role for RCAN1 in atherosclerosis progression

(2013) Nerea Méndez-Barbero et al.   EMBO Molecular Medicine

Protein profiles in Tc1 mice implicate novel pathway perturbations in the Down syndrome brain

(2013) M. M. Ahmed et al.   HUMAN MOLECULAR GENETICS

Mammalian target of rapamycin hyperactivity mediates the detrimental effects of a high sucrose diet on Alzheimer's disease pathology

(2013) Miranda E. Orr et al.   NEUROBIOLOGY OF AGING

Impaired glycemia increases disease progression in mild cognitive impairment

(2013) Jill K. Morris et al.   NEUROBIOLOGY OF AGING

Bioelectrical impedance for measuring percentage body fat in young persons with Down syndrome: validation with dual-energy absorptiometry

(2012) Sarah J Loveday et al.   ACTA PAEDIATRICA

Selective Insulin and Leptin Resistance in Metabolic Disorders

(2012) A. Christine Könner et al.   Cell Metabolism

Regulation of insulin sensitivity by serine/threonine phosphorylation of insulin receptor substrate proteins IRS1 and IRS2

(2012) K. D. Copps et al.   DIABETOLOGIA

Increased Expression of the Glucose-Responsive Gene,RCAN1, Causes Hypoinsulinemia, β-Cell Dysfunction, and Diabetes

(2012) Heshan Peiris et al.   ENDOCRINOLOGY

Down Syndrome and Thyroid Function

(2012) Evan Graber et al.   ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA

Association between diabetes, family history of diabetes, and risk of nonalcoholic steatohepatitis and fibrosis

(2012) Rohit Loomba et al.   HEPATOLOGY

Chronic pro-oxidative state and mitochondrial dysfunctions are more pronounced in fibroblasts from Down syndrome foeti with congenital heart defects

(2012) C. Piccoli et al.   HUMAN MOLECULAR GENETICS

An anti-diabetes agent protects the mouse brain from defective insulin signaling caused by Alzheimer’s disease–associated Aβ oligomers

(2012) Theresa R. Bomfim et al.   JOURNAL OF CLINICAL INVESTIGATION

Demonstrated brain insulin resistance in Alzheimer’s disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline

(2012) Konrad Talbot et al.   JOURNAL OF CLINICAL INVESTIGATION

Blood biomarkers of methylation in Down syndrome and metabolic simulations using a mathematical model

(2012) Rima Obeid et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Prevalence of Overweight in Dutch Children With Down Syndrome

(2012) H. B. M. van Gameren-Oosterom et al.   PEDIATRICS

Lipid Profiles of Children With Down Syndrome Compared With Their Siblings

(2012) T. Adelekan et al.   PEDIATRICS

Leptin, insulin and thyroid hormones in a cohort of Egyptian obese Down syndrome children: a comparative study

(2012) Sohier Yahia et al.   BMC Endocrine Disorders

Minibrain/Dyrk1a Regulates Food Intake through the Sir2-FOXO-sNPF/NPY Pathway in Drosophila and Mammals

(2012) Seung-Hyun Hong et al.   PLoS Genetics

Intranasal Insulin Therapy for Alzheimer Disease and Amnestic Mild Cognitive Impairment

(2011) Suzanne Craft   ARCHIVES OF NEUROLOGY

Deficit of complex I activity in human skin fibroblasts with chromosome 21 trisomy and overproduction of reactive oxygen species by mitochondria: involvement of the cAMP/PKA signalling pathway

(2011) Daniela Valenti et al.   BIOCHEMICAL JOURNAL

Biliverdin reductase-A protein levels and activity in the brains of subjects with Alzheimer disease and mild cognitive impairment

(2011) Eugenio Barone et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Association between frontal cortex oxidative damage and beta-amyloid as a function of age in Down syndrome

(2011) Giovanna Cenini et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Bace2 Is a β Cell-Enriched Protease that Regulates Pancreatic β Cell Function and Mass

(2011) Daria Esterházy et al.   Cell Metabolism

Inflammation Is Necessary for Long-Term but Not Short-Term High-Fat Diet-Induced Insulin Resistance

(2011) Y. S. Lee et al.   DIABETES

Naturally Secreted Amyloid-β Increases Mammalian Target of Rapamycin (mTOR) Activity via a PRAS40-mediated Mechanism

(2011) Antonella Caccamo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Fighting neurodegeneration with rapamycin: mechanistic insights

(2011) Jordi Bové et al.   NATURE REVIEWS NEUROSCIENCE

Behavioral Characterization of a Mouse Model Overexpressing DSCR1/ RCAN1

(2011) Mara Dierssen et al.   PLoS One

Oxidative stress occurs early in Down syndrome pregnancy: A redox proteomics analysis of amniotic fluid

(2011) Marzia Perluigi et al.   Proteomics Clinical Applications

Trisomy 21 and early brain development

(2011) Tarik F. Haydar et al.   TRENDS IN NEUROSCIENCES

Impairment of F1F0-ATPase, adenine nucleotide translocator and adenylate kinase causes mitochondrial energy deficit in human skin fibroblasts with chromosome 21 trisomy

(2010) Daniela Valenti et al.   BIOCHEMICAL JOURNAL

Prevalence of Nonalcoholic Fatty Liver Disease and Nonalcoholic Steatohepatitis Among a Largely Middle-Aged Population Utilizing Ultrasound and Liver Biopsy: A Prospective Study

(2010) Christopher D. Williams et al.   GASTROENTEROLOGY

Molecular Interplay between Mammalian Target of Rapamycin (mTOR), Amyloid-β, and Tau

(2010) Antonella Caccamo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of mTOR by Rapamycin Abolishes Cognitive Deficits and Reduces Amyloid-β Levels in a Mouse Model of Alzheimer's Disease

(2010) Patricia Spilman et al.   PLoS One

Function and regulation of Dyrk1A: towards understanding Down syndrome

(2009) Joongkyu Park et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Molecular genetic analysis of Down syndrome

(2009) David Patterson   HUMAN GENETICS

Protection of synapses against Alzheimer's-linked toxins: Insulin signaling prevents the pathogenic binding of Aβ oligomers

(2009) Fernanda G. De Felice et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Pharmacology of mTOR Inhibition

(2009) D. A. Guertin et al.   Science Signaling

Defects in IGF-1 receptor, insulin receptor and IRS-1/2 in Alzheimer's disease indicate possible resistance to IGF-1 and insulin signalling

(2008) Aileen M. Moloney et al.   NEUROBIOLOGY OF AGING

Mitochondria in Neuroplasticity and Neurological Disorders

(2008) Mark P. Mattson et al.   NEURON

Amyloid beta oligomers induce impairment of neuronal insulin receptors

(2007) Wei-Qin Zhao et al.   FASEB JOURNAL

Leptin Levels among Prepubertal Children with Down Syndrome Compared with Their Siblings

(2007) Sheela N. Magge et al.   JOURNAL OF PEDIATRICS