Protein profiles in Tc1 mice implicate novel pathway perturbations in the Down syndrome brain

Reversal of Impaired Hippocampal Long-Term Potentiation and Contextual Fear Memory Deficits in Angelman Syndrome Model Mice by ErbB Inhibitors

(2012) Hanoch Kaphzan et al.   BIOLOGICAL PSYCHIATRY

Loss of Correlations among Proteins in Brains of the Ts65Dn Mouse Model of Down Syndrome

(2012) Md. Mahiuddin Ahmed et al.   JOURNAL OF PROTEOME RESEARCH

Memantine for dementia in adults older than 40 years with Down's syndrome (MEADOWS): a randomised, double-blind, placebo-controlled trial

(2012) Marisa Hanney et al.   LANCET

BDNF and DYRK1A Are Variable and Inversely Correlated in Lymphoblastoid Cell Lines from Down Syndrome Patients

(2012) Asma Tlili et al.   MOLECULAR NEUROBIOLOGY

Global analysis of genome, transcriptome and proteome reveals the response to aneuploidy in human cells

(2012) Silvia Stingele et al.   Molecular Systems Biology

Roles of AMP-activated Protein Kinase in Alzheimer’s Disease

(2012) Zhiyou Cai et al.   NEUROMOLECULAR MEDICINE

Auditory Function in the Tc1 Mouse Model of Down Syndrome Suggests a Limited Region of Human Chromosome 21 Involved in Otitis Media

(2012) Stephanie Kuhn et al.   PLoS One

Intersectin (ITSN) Family of Scaffolds Function as Molecular Hubs in Protein Interaction Networks

(2012) Katy A. Wong et al.   PLoS One

Antagonism of NMDA receptors as a potential treatment for Down syndrome: a pilot randomized controlled trial

(2012) R Boada et al.   Translational Psychiatry

Down syndrome and dementia: A randomized, controlled trial of antioxidant supplementation

(2011) Ira T. Lott et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Meta-analysis of heterogeneous Down Syndrome data reveals consistent genome-wide dosage effects related to neurological processes

(2011) Mireia Vilardell et al.   BMC GENOMICS

Expression of T-cell lymphoma invasion and metastasis 2 (TIAM2) promotes proliferation and invasion of liver cancer

(2011) Jia-Shing Chen et al.   INTERNATIONAL JOURNAL OF CANCER

Machine Learning Methods Predict Locomotor Response to MK-801 in Mouse Models of Down Syndrome

(2011) Cao D. Nguyen et al.   JOURNAL OF NEUROGENETICS

An Increase in Basal BDNF Provokes Hyperactivation of the Akt-Mammalian Target of Rapamycin Pathway and Deregulation of Local Dendritic Translation in a Mouse Model of Down's Syndrome

(2011) J. A. Troca-Marin et al.   JOURNAL OF NEUROSCIENCE

Preserving protein profiles in tissue samples: Differing outcomes with and without heat stabilization

(2011) Md. Mahiuddin Ahmed et al.   JOURNAL OF NEUROSCIENCE METHODS

Identification of the translocation breakpoints in the Ts65Dn and Ts1Cje mouse lines: relevance for modeling down syndrome

(2011) Arnaud Duchon et al.   MAMMALIAN GENOME

Global quantification of mammalian gene expression control

(2011) Björn Schwanhäusser et al.   NATURE

Altered regulation of tau phosphorylation in a mouse model of down syndrome aging

(2011) Olivia Sheppard et al.   NEUROBIOLOGY OF AGING

The ERBB4 intracellular domain (4ICD) regulates NRG1-induced gene expression in hippocampal neurons

(2011) June G. Allison et al.   NEUROSCIENCE RESEARCH

Development and validation of the Arizona Cognitive Test Battery for Down syndrome

(2010) Jamie O. Edgin et al.   Journal of Neurodevelopmental Disorders

Hydrogen peroxide inhibits mTOR signaling by activation of AMPKα leading to apoptosis of neuronal cells

(2010) Long Chen et al.   LABORATORY INVESTIGATION

Cognitive deficits and associated neurological complications in individuals with Down's syndrome

(2010) Ira T Lott et al.   LANCET NEUROLOGY

Molecular Responses Transduced by Serial Oxidative Stress in the Retinal Pigment Epithelium: Feedback Control Modeling of Gene Expression

(2010) Edward Chaum et al.   NEUROCHEMICAL RESEARCH

Metabolic Regulation of Neuronal Plasticity by the Energy Sensor AMPK

(2010) Wyatt B. Potter et al.   PLoS One

ErbB4 in parvalbumin-positive interneurons is critical for neuregulin 1 regulation of long-term potentiation

(2010) Y.-J. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fibroblasts from long-lived mutant mice show diminished ERK1/2 phosphorylation but exaggerated induction of immediate early genes

(2009) Liou Y. Sun et al.   FREE RADICAL BIOLOGY AND MEDICINE

Amyloid precursor protein 695 associates with assembled NR2A- and NR2B-containing NMDA receptors to result in the enhancement of their cell surface delivery

(2009) Sarah L. Cousins et al.   JOURNAL OF NEUROCHEMISTRY

Selective Expression of ErbB4 in Interneurons, But Not Pyramidal Cells, of the Rodent Hippocampus

(2009) D. Vullhorst et al.   JOURNAL OF NEUROSCIENCE

Heat Stabilization of the Tissue Proteome: A New Technology for Improved Proteomics

(2009) Marcus Svensson et al.   JOURNAL OF PROTEOME RESEARCH

MAP'ing CNS Development and Cognition: An ERKsome Process

(2009) Ivy S. Samuels et al.   NEURON

Twenty-year trends in prevalence and survival of Down syndrome

(2008) Claire Irving et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Molecular responses of the Ts65Dn and Ts1Cje mouse models of Down syndrome to MK-801

(2008) A. Siddiqui et al.   GENES BRAIN AND BEHAVIOR

Preservation of long-term memory and synaptic plasticity despite short-term impairments in the Tc1 mouse model of Down syndrome

(2008) E. Morice et al.   LEARNING & MEMORY

Quantitative Proteomics Characterization of a Mouse Embryonic Stem Cell Model of Down Syndrome

(2008) Yuqin Wang et al.   MOLECULAR & CELLULAR PROTEOMICS

Neuregulin 1 in neural development, synaptic plasticity and schizophrenia

(2008) Lin Mei et al.   NATURE REVIEWS NEUROSCIENCE