A Syntenic Cross Species Aneuploidy Genetic Screen Links RCAN1 Expression to β-Cell Mitochondrial Dysfunction in Type 2 Diabetes

RCAN1 Regulates Mitochondrial Function and Increases Susceptibility to Oxidative Stress in Mammalian Cells

(2014) Heshan Peiris et al.   Oxidative Medicine and Cellular Longevity

Global genomic and transcriptomic analysis of human pancreatic islets reveals novel genes influencing glucose metabolism

(2014) J. Fadista et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genome-Wide DNA Methylation Analysis of Human Pancreatic Islets from Type 2 Diabetic and Non-Diabetic Donors Identifies Candidate Genes That Influence Insulin Secretion

(2014) Tasnim Dayeh et al.   PLoS Genetics

Calmodulin-controlled spatial decoding of oscillatory Ca2+ signals by calcineurin

(2014) Sohum Mehta et al.   eLife

Adaptive Downregulation of Mitochondrial Function in Down Syndrome

(2013) Pablo Helguera et al.   Cell Metabolism

Deficiency in Type I Interferon Signaling Prevents the Early Interferon-Induced Gene Signature in Pancreatic Islets but Not Type 1 Diabetes in NOD Mice

(2013) H. S. Quah et al.   DIABETES

The Expression Pattern of EVA1C, a Novel Slit Receptor, Is Consistent with an Axon Guidance Role in the Mouse Nervous System

(2013) Gregory James et al.   PLoS One

Increased Expression of the Glucose-Responsive Gene,RCAN1, Causes Hypoinsulinemia, β-Cell Dysfunction, and Diabetes

(2012) Heshan Peiris et al.   ENDOCRINOLOGY

Chronic Expression of RCAN1-1L Protein Induces Mitochondrial Autophagy and Metabolic Shift from Oxidative Phosphorylation to Glycolysis in Neuronal Cells

(2012) Gennady Ermak et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Leptin, insulin and thyroid hormones in a cohort of Egyptian obese Down syndrome children: a comparative study

(2012) Sohier Yahia et al.   BMC Endocrine Disorders

Glucokinase activation repairs defective bioenergetics of islets of Langerhans isolated from type 2 diabetics

(2011) Nicolai M. Doliba et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Genome-wide association studies and type 2 diabetes

(2011) E. Wheeler et al.   Briefings in Functional Genomics

DHA Protects Against Zinc Mediated Alterations in Neuronal Cellular Bioenergetics

(2011) Sean L. McGee et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Effects of individual segmental trisomies of human chromosome 21 syntenic regions on hippocampal long-term potentiation and cognitive behaviors in mice

(2010) Tao Yu et al.   BRAIN RESEARCH

Down’s syndrome in diabetic patients aged

(2010) T. R. Rohrer et al.   DIABETOLOGIA

Gene Expression Profiles of Beta-Cell Enriched Tissue Obtained by Laser Capture Microdissection from Subjects with Type 2 Diabetes

(2010) Lorella Marselli et al.   PLoS One

Runx1 is required for the endothelial to haematopoietic cell transition but not thereafter

(2009) Michael J. Chen et al.   NATURE

Regional- and temporal-dependent changes in the differentiation of Olig2 progenitors in the forebrain, and the impact on astrocyte development in the dorsal pallium

(2008) Katsuhiko Ono et al.   DEVELOPMENTAL BIOLOGY

Pancreatic β-cell mass in European subjects with type 2 diabetes

(2008) J. Rahier et al.   DIABETES OBESITY & METABOLISM

A gene expression network model of type 2 diabetes links cell cycle regulation in islets with diabetes susceptibility

(2008) M. P. Keller et al.   GENOME RESEARCH

DSCR1/RCAN1 regulates vesicle exocytosis and fusion pore kinetics: implications for Down syndrome and Alzheimer's disease

(2008) Damien J. Keating et al.   HUMAN MOLECULAR GENETICS

Dynamin-related protein 1 mediates high glucose induced pancreatic beta cell apoptosis

(2008) Xiuli Men et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY