The re‐emerging pathophysiological role of the cystathionine‐β‐synthase ‐ hydrogen sulfide system in Down syndrome

The Shape of Mitochondrial Dysfunction in Down Syndrome

(2019) E. Zamponi et al.   Developmental Neurobiology

Transcriptome and Proteome Profiling of Neural Induced Pluripotent Stem Cells from Individuals with Down Syndrome Disclose Dynamic Dysregulations of Key Pathways and Cellular Functions

(2019) Maria Sobol et al.   MOLECULAR NEUROBIOLOGY

Overproduction of H2S, generated by CBS, inhibits mitochondrial Complex IV and suppresses oxidative phosphorylation in Down syndrome

(2019) Theodora Panagaki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mental retardation in Down syndrome: Two ways to treat

(2019) Pierre P. Kamoun   MEDICAL HYPOTHESES

A timeline of hydrogen sulfide (H 2 S) research: From environmental toxin to biological mediator

(2018) Csaba Szabo   BIOCHEMICAL PHARMACOLOGY

Cystathionine γ Lyase Sulfhydrates the RNA Binding Protein HuR to Preserve Endothelial Cell Function and Delay Atherogenesis

(2018) Sofia-Iris Bibli et al.   CIRCULATION

Mitochondrial DNA damage and reactive oxygen species in neurodegenerative disease

(2018) Nadee Nissanka et al.   FEBS LETTERS

Mitochondrial dysfunction in down syndrome: molecular mechanisms and therapeutic targets

(2018) Antonella Izzo et al.   MOLECULAR MEDICINE

Antitumor effect of sikokianin C, a selective cystathionine β-synthase inhibitor, against human colon cancer in vitro and in vivo

(2018) Weining Niu et al.   MedChemComm

Plasma and urinary metabolomic profiles of Down syndrome correlate with alteration of mitochondrial metabolism

(2018) Maria Caracausi et al.   Scientific Reports

Integrated Quantitative Transcriptome Maps of Human Trisomy 21 Tissues and Cells

(2018) Maria Chiara Pelleri et al.   Frontiers in Genetics

Alterations in the Serotonin and Dopamine Pathways by Cystathionine Beta Synthase Overexpression in Murine Brain

(2018) J. London et al.   MOLECULAR NEUROBIOLOGY

Aminooxyacetic acid improves learning and memory in a rat model of chronic alcoholism

(2018) Yu-Ming Xu et al.   Neural Regeneration Research

A pharmacological probe identifies cystathionine β-synthase as a new negative regulator for ferroptosis

(2018) Li Wang et al.   Cell Death & Disease

Trisomy of a Down Syndrome Critical Region Globally Amplifies Transcription via HMGN1 Overexpression

(2018) Cody T. Mowery et al.   Cell Reports

International Union of Basic and Clinical Pharmacology. CII: Pharmacological Modulation of H 2 S Levels: H 2 S Donors and H 2 S Biosynthesis Inhibitors

(2017) Csaba Szabo et al.   PHARMACOLOGICAL REVIEWS

H2S-Induced Sulfhydration: Biological Function and Detection Methodology

(2017) Da Zhang et al.   Frontiers in Pharmacology

H2S biosynthesis and catabolism: new insights from molecular studies

(2016) Peter Rose et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Cystathionine-β-Synthase Inhibition for Colon Cancer: Enhancement of the Efficacy of Aminooxyacetic Acid via the Prodrug Approach

(2016) Celia Chao et al.   MOLECULAR MEDICINE

Screening of a composite library of clinically used drugs and well-characterized pharmacological compounds for cystathionine β-synthase inhibition identifies benserazide as a drug potentially suitable for repurposing for the experimental therapy of colon cancer

(2016) Nadiya Druzhyna et al.   PHARMACOLOGICAL RESEARCH

Trisomy 21 consistently activates the interferon response

(2016) Kelly D Sullivan et al.   eLife

Inhibition of hydrogen sulfide biosynthesis sensitizes lung adenocarcinoma to chemotherapeutic drugs by inhibiting mitochondrial DNA repair and suppressing cellular bioenergetics

(2016) Bartosz Szczesny et al.   Scientific Reports

Emergence of Hydrogen Sulfide as an Endogenous Gaseous Signaling Molecule in Cardiovascular Disease

(2014) David J. Polhemus et al.   CIRCULATION RESEARCH

Thiosulfate: a readily accessible source of hydrogen sulfide in oxygen sensing

(2013) Kenneth R. Olson et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Production and Physiological Effects of Hydrogen Sulfide

(2013) Hideo Kimura   ANTIOXIDANTS & REDOX SIGNALING

Sulfide inhibition of and metabolism by cytochromecoxidase

(2013) Peter Nicholls et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Selectivity of commonly used pharmacological inhibitors for cystathionine β synthase (CBS) and cystathionine γ lyase (CSE)

(2013) Antonia Asimakopoulou et al.   BRITISH JOURNAL OF PHARMACOLOGY

The hydrogen sulfide donor, GYY4137, exhibits anti-atherosclerotic activity in high fat fed apolipoprotein E−/−mice

(2013) Zhen Liu et al.   BRITISH JOURNAL OF PHARMACOLOGY

Regulation of mitochondrial bioenergetic function by hydrogen sulfide. Part II. Pathophysiological and therapeutic aspects

(2013) Katalin Módis et al.   BRITISH JOURNAL OF PHARMACOLOGY

Regulation of mitochondrial bioenergetic function by hydrogen sulfide. Part I. Biochemical and physiological mechanisms

(2013) Csaba Szabo et al.   BRITISH JOURNAL OF PHARMACOLOGY

Decreased Endogenous Production of Hydrogen Sulfide Accelerates Atherosclerosis

(2013) Sarathi Mani et al.   CIRCULATION

Tumor-derived hydrogen sulfide, produced by cystathionine- -synthase, stimulates bioenergetics, cell proliferation, and angiogenesis in colon cancer

(2013) C. Szabo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Functional and biochemical characterization of soleus muscle in Down syndrome mice: insight into the muscle dysfunction seen in the human condition

(2012) Patrick M. Cowley et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Chronic pro-oxidative state and mitochondrial dysfunctions are more pronounced in fibroblasts from Down syndrome foeti with congenital heart defects

(2012) C. Piccoli et al.   HUMAN MOLECULAR GENETICS

Oxidative Phosphorylation, Not Glycolysis, Powers Presynaptic and Postsynaptic Mechanisms Underlying Brain Information Processing

(2012) C. N. Hall et al.   JOURNAL OF NEUROSCIENCE

H2S signalling through protein sulfhydration and beyond

(2012) Bindu D. Paul et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Physiological Implications of Hydrogen Sulfide: A Whiff Exploration That Blossomed

(2012) Rui Wang   PHYSIOLOGICAL REVIEWS

Brain Phenotype of Transgenic Mice Overexpressing Cystathionine β-Synthase

(2012) Vinciane Régnier et al.   PLoS One

Interdependency of Cystathione  -Lyase and Cystathione  -Synthase in Hydrogen Sulfide-Induced Blood Pressure Regulation in Rats

(2011) A. Roy et al.   AMERICAN JOURNAL OF HYPERTENSION

Hydrogen Sulfide and Cell Signaling

(2011) Ling Li et al.   Annual Review of Pharmacology and Toxicology

Gases in the mitochondria

(2009) Pamela B.L. Pun et al.   MITOCHONDRION

Hydrogen sulfide: A novel signaling molecule in the central nervous system

(2009) Boon Hian Tan et al.   NEUROCHEMISTRY INTERNATIONAL