Reactive Oxygen Species Induces Lipid Droplet Accumulation in HepG2 Cells by Increasing Perilipin 2 Expression

A giant amphipathic helix from a perilipin that is adapted for coating lipid droplets

(2018) Alenka Čopič et al.   Nature Communications

Probing Protein-Protein Interactions Using Asymmetric Labeling and Carbonyl-Carbon Selective Heteronuclear NMR Spectroscopy

(2018) Erik Larsen et al.   MOLECULES

Autophagy regulates turnover of lipid droplets via ROS-dependent Rab25 activation in hepatic stellate cell

(2017) Zili Zhang et al.   Redox Biology

Pathogenesis of alcoholic liver disease: Role of oxidative metabolism

(2017) Elisabetta Ceni et al.   WORLD JOURNAL OF GASTROENTEROLOGY

PPARα-Deficient ob/ob Obese Mice Become More Obese and Manifest Severe Hepatic Steatosis Due to Decreased Fatty Acid Oxidation

(2015) Qian Gao et al.   AMERICAN JOURNAL OF PATHOLOGY

Glial Lipid Droplets and ROS Induced by Mitochondrial Defects Promote Neurodegeneration

(2015) Lucy Liu et al.   CELL

Fatty Acid Trafficking in Starved Cells: Regulation by Lipid Droplet Lipolysis, Autophagy, and Mitochondrial Fusion Dynamics

(2015) Angelika S. Rambold et al.   DEVELOPMENTAL CELL

Perilipin 5–Driven Lipid Droplet Accumulation in Skeletal Muscle Stimulates the Expression of Fibroblast Growth Factor 21

(2015) Lydia-Ann L.S. Harris et al.   DIABETES

Endoplasmic reticulum stress and Oxidative stress in the pathogenesis of Non-alcoholic fatty liver disease

(2015) N. U. Ashraf et al.   FREE RADICAL RESEARCH

Perilipin 3 Differentially Regulates Skeletal Muscle Lipid Oxidation in Active, Sedentary, and Type 2 Diabetic Males

(2015) Jeffrey D. Covington et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Molecular mechanism of PPARα action and its impact on lipid metabolism, inflammation and fibrosis in non-alcoholic fatty liver disease

(2015) Michal Pawlak et al.   JOURNAL OF HEPATOLOGY

Skeletal Muscle Perilipin 3 and Coatomer Proteins Are Increased following Exercise and Are Associated with Fat Oxidation

(2014) Jeffrey D. Covington et al.   PLoS One

Absence of Perilipin 2 Prevents Hepatic Steatosis, Glucose Intolerance and Ceramide Accumulation in Alcohol-Fed Mice

(2014) Rotonya M. Carr et al.   PLoS One

Skeletal muscle PLIN proteins, ATGL and CGI-58, interactions at rest and following stimulated contraction

(2013) Rebecca E. K. MacPherson et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Overexpression of PLIN5 in skeletal muscle promotes oxidative gene expression and intramyocellular lipid content without compromising insulin sensitivity

(2013) M. Bosma et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Cell-to-Cell Heterogeneity in Lipid Droplets Suggests a Mechanism to Reduce Lipotoxicity

(2013) Albert Herms et al.   CURRENT BIOLOGY

Perilipin-2-null mice are protected against diet-induced obesity, adipose inflammation, and fatty liver disease

(2013) James L. McManaman et al.   JOURNAL OF LIPID RESEARCH

Nonalcoholic fatty liver disease and lipids

(2012) Anthony S. Wierzbicki et al.   CURRENT OPINION IN LIPIDOLOGY

Perilipin 2 Improves Insulin Sensitivity in Skeletal Muscle Despite Elevated Intramuscular Lipid Levels

(2012) M. Bosma et al.   DIABETES

Reactive Oxygen Species Facilitate Translocation of Hormone Sensitive Lipase to the Lipid Droplet During Lipolysis in Human Differentiated Adipocytes

(2012) Sarah A. Krawczyk et al.   PLoS One

A polymorphism of the CREB binding protein (CREBBP) gene is a risk factor for addiction

(2011) Deepak Kumar et al.   BRAIN RESEARCH

The lipid droplet coat protein perilipin 5 also localizes to muscle mitochondria

(2011) Madeleen Bosma et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Molecular mechanisms of human lipodystrophies: From adipocyte lipid droplet to oxidative stress and lipotoxicity

(2011) Corinne Vigouroux et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Inhibition of mitochondrial function by efavirenz increases lipid content in hepatic cells

(2010) Ana Blas-García et al.   HEPATOLOGY

Absence of adipose differentiation related protein upregulates hepatic VLDL secretion, relieves hepatosteatosis, and improves whole body insulin resistance in leptin-deficient mice

(2010) Benny Hung-Junn Chang et al.   JOURNAL OF LIPID RESEARCH

Molecular mechanisms involved in NAFLD progression

(2009) Mariano Malaguarnera et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Adipophilin affects the expression of TNF-α, MCP-1, and IL-6 in THP-1 macrophages

(2009) F. L. Chen et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Oxidative stress induced lipid accumulation via SREBP1c activation in HepG2 cells

(2008) Mika Sekiya et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Hydrogen peroxide-induced translocation of glycolipid-anchored (c)AMP-hydrolases to lipid droplets mediates inhibition of lipolysis in rat adipocytes

(2008) G Müller et al.   BRITISH JOURNAL OF PHARMACOLOGY

Consequences of Lipid Droplet Coat Protein Downregulation in Liver Cells: Abnormal Lipid Droplet Metabolism and Induction of Insulin Resistance

(2008) M. Bell et al.   DIABETES

Molecular Mechanisms and Therapeutic Targets in Steatosis and Steatohepatitis

(2008) N. Anderson et al.   PHARMACOLOGICAL REVIEWS