Tanycytic TSPO inhibition induces lipophagy to regulate lipid metabolism and improve energy balance

Forced lipophagy reveals that lipid droplets are required for early embryonic development in mouse

(2018) Takayuki Tatsumi et al.   DEVELOPMENT

Tanycytes and hypothalamic control of energy metabolism

(2018) Francis J. P. Ebling et al.   GLIA

Autophagy-Dependent Generation of Free Fatty Acids Is Critical for Normal Neutrophil Differentiation

(2017) Thomas Riffelmacher et al.   IMMUNITY

ATP Evokes Ca2+Responses and CXCL5 Secretion via P2X4Receptor Activation in Human Monocyte-Derived Macrophages

(2017) Janice A. Layhadi et al.   JOURNAL OF IMMUNOLOGY

Differential spatial expression of peripheral olfactory neuron-derived BACE1 induces olfactory impairment by region-specific accumulation of β-amyloid oligomer

(2017) Seung-Jun Yoo et al.   Cell Death & Disease

A role for TSPO in mitochondrial Ca2+ homeostasis and redox stress signaling

(2017) Jemma Gatliff et al.   Cell Death & Disease

Single-Cell RNA-Seq Reveals Hypothalamic Cell Diversity

(2017) Renchao Chen et al.   Cell Reports

ATGL Promotes Autophagy/Lipophagy via SIRT1 to Control Hepatic Lipid Droplet Catabolism

(2017) Aishwarya Sathyanarayan et al.   Cell Reports

Amino acid sensing in hypothalamic tanycytes via umami taste receptors

(2017) Greta Lazutkaite et al.   Molecular Metabolism

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

(2016) Daniel J Klionsky et al.   Autophagy

Hypothalamic AMPK-induced autophagy increases food intake by regulating NPY and POMC expression

(2016) Tae Seok Oh et al.   Autophagy

A translocator protein 18 kDa ligand, Ro5-4864, inhibits ATP-induced NLRP3 inflammasome activation

(2016) Ji-Won Lee et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Translocator Protein (TSPO) Affects Mitochondrial Fatty Acid Oxidation in Steroidogenic Cells

(2016) Lan N. Tu et al.   ENDOCRINOLOGY

Tanycytes and a differential fatty acid metabolism in the hypothalamus

(2016) Kristina Hofmann et al.   GLIA

Methionine and S-adenosylmethionine levels are critical regulators of PP2A activity modulating lipophagy during steatosis

(2016) Imanol Zubiete-Franco et al.   JOURNAL OF HEPATOLOGY

Variants in the autophagy-related gene IRGM confer susceptibility to non-alcoholic fatty liver disease by modulating lipophagy

(2016) Yu-Cheng Lin et al.   JOURNAL OF HEPATOLOGY

Design, synthesis and biological evaluation of methyl-2-(2-(5-bromo benzoxazolone)acetamido)-3-(1H-indol-3-yl)propanoate: TSPO ligand for SPECT

(2016) Pooja Srivastava et al.   RSC Advances

Inhibition of hypothalamic MCT1 expression increases food intake and alters orexigenic and anorexigenic neuropeptide expression

(2016) Roberto Elizondo-Vega et al.   Scientific Reports

Targeting the 18-kDa translocator protein: recent perspectives for neuroprotection

(2015) Eleonora Da Pozzo et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Reduced mitochondrial Ca2+ transients stimulate autophagy in human fibroblasts carrying the 13514A>G mutation of the ND5 subunit of NADH dehydrogenase

(2015) V Granatiero et al.   CELL DEATH AND DIFFERENTIATION

Neuronal Regulation of Energy Homeostasis: Beyond the Hypothalamus and Feeding

(2015) Michael J. Waterson et al.   Cell Metabolism

The role of tanycytes in hypothalamic glucosensing

(2015) Roberto Elizondo-Vega et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Conditional steroidogenic cell-targeted deletion of TSPO unveils a crucial role in viability and hormone-dependent steroid formation

(2015) Jinjiang Fan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Astrocytes Control Food Intake by Inhibiting AGRP Neuron Activity via Adenosine A1 Receptors

(2015) Liang Yang et al.   Cell Reports

Hypothalamic tanycytes—masters and servants of metabolic, neuroendocrine, and neurogenic functions

(2015) Timothy Goodman et al.   Frontiers in Neuroscience

TSPO interacts with VDAC1 and triggers a ROS-mediated inhibition of mitochondrial quality control

(2014) Jemma Gatliff et al.   Autophagy

Hypothalamic Tanycytes Are an ERK-Gated Conduit for Leptin into the Brain

(2014) Eglantine Balland et al.   Cell Metabolism

Hypothalamic Tanycytes: Gatekeepers to Metabolic Control

(2014) Yuanqing Gao et al.   Cell Metabolism

Translocator Protein 18 kDa Negatively Regulates Inflammation in Microglia

(2014) Keun-Ryung Bae et al.   Journal of Neuroimmune Pharmacology

Rax-CreERT2 Knock-In Mice: A Tool for Selective and Conditional Gene Deletion in Progenitor Cells and Radial Glia of the Retina and Hypothalamus

(2014) Thomas Pak et al.   PLoS One

Tanycytic VEGF-A Boosts Blood-Hypothalamus Barrier Plasticity and Access of Metabolic Signals to the Arcuate Nucleus in Response to Fasting

(2013) Fanny Langlet et al.   Cell Metabolism

Activation of lysosomal function in the course of autophagy via mTORC1 suppression and autophagosome-lysosome fusion

(2013) Jing Zhou et al.   CELL RESEARCH

Raxregulates hypothalamic tanycyte differentiation and barrier function in mice

(2013) Ana L. Miranda-Angulo et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Autophagosomes contribute to intracellular lipid distribution in enterocytes

(2013) Salem Ait Khaldoun et al.   MOLECULAR BIOLOGY OF THE CELL

ULK1 targets Beclin-1 in autophagy

(2013) Volodymyr Y. Nazarko et al.   NATURE CELL BIOLOGY

Hypothalamic tanycytes: potential roles in the control of feeding and energy balance

(2013) Matei Bolborea et al.   TRENDS IN NEUROSCIENCES

Regulation of lipid stores and metabolism by lipophagy

(2012) K Liu et al.   CELL DEATH AND DIFFERENTIATION

Peripheral benzodiazepine receptor regulates vascular endothelial activations via suppression of the voltage-dependent anion channel-1

(2012) Hee Kyoung Joo et al.   FEBS LETTERS

Whole-organism screening for gluconeogenesis identifies activators of fasting metabolism

(2012) Philipp Gut et al.   Nature Chemical Biology

Emerging role of glial cells in the control of body weight

(2012) Cristina García-Cáceres et al.   Molecular Metabolism

Autophagy in Hypothalamic AgRP Neurons Regulates Food Intake and Energy Balance

(2011) Susmita Kaushik et al.   Cell Metabolism

Autophagy Regulates Cholesterol Efflux from Macrophage Foam Cells via Lysosomal Acid Lipase

(2011) Mireille Ouimet et al.   Cell Metabolism

AMPK and autophagy get connected

(2011) D Grahame Hardie   EMBO JOURNAL

ATP-mediated glucosensing by hypothalamic tanycytes

(2011) Cameron Frayling et al.   JOURNAL OF PHYSIOLOGY-LONDON

MCT Expression and Lactate Influx/Efflux in Tanycytes Involved in Glia-Neuron Metabolic Interaction

(2011) Christian Cortés-Campos et al.   PLoS One

Regulation of lipid droplets by autophagy

(2011) Hanqing Dong et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Hypothalamic control of energy metabolism via the autonomic nervous system

(2010) A. Kalsbeek et al.   Annals of the New York Academy of Sciences

Regulation of the Inner Membrane Mitochondrial Permeability Transition by the Outer Membrane Translocator Protein (Peripheral Benzodiazepine Receptor)

(2010) Justina Šileikytė et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of translocator protein 18kDa (TSPO) expression in health and disease states☆

(2010) Amani Batarseh et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Phosphorylation of ULK1 (hATG1) by AMP-Activated Protein Kinase Connects Energy Sensing to Mitophagy

(2010) D. F. Egan et al.   SCIENCE

Lipophagy: Selective Catabolism Designed for Lipids

(2009) Hilla Weidberg et al.   DEVELOPMENTAL CELL

Hypothalamic cell lines to investigate neuroendocrine control mechanisms

(2009) Christopher M. Mayer et al.   FRONTIERS IN NEUROENDOCRINOLOGY

Autophagy regulates lipid metabolism

(2009) Rajat Singh et al.   NATURE

Modulation of intracellular Ca2+ signalling in HeLa cells by the apoptotic cell death enhancer PK11195

(2008) Michelangelo Campanella et al.   BIOCHEMICAL PHARMACOLOGY

AMPK: a key regulator of energy balance in the single cell and the whole organism

(2008) D G Hardie   INTERNATIONAL JOURNAL OF OBESITY

VDAC activation by the 18 kDa translocator protein (TSPO), implications for apoptosis

(2008) Leo Veenman et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Parkin is recruited selectively to impaired mitochondria and promotes their autophagy

(2008) Derek Narendra et al.   JOURNAL OF CELL BIOLOGY

Translocator protein 18 kDa (TSPO): Molecular sensor of brain injury and repair

(2008) Ming-Kai Chen et al.   PHARMACOLOGY & THERAPEUTICS