Targeting Microglial Population Dynamics in Alzheimer’s Disease: Are We Ready for a Potential Impact on Immune Function?
Published 2020 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Targeting Microglial Population Dynamics in Alzheimer’s Disease: Are We Ready for a Potential Impact on Immune Function?
Authors
Keywords
-
Journal
Frontiers in Cellular Neuroscience
Volume 14, Issue -, Pages -
Publisher
Frontiers Media SA
Online
2020-06-05
DOI
10.3389/fncel.2020.00149
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Porphyromonas gingivalis in Alzheimer’s disease brains: Evidence for disease causation and treatment with small-molecule inhibitors
- (2019) Stephen S. Dominy et al. Science Advances
- Alzheimer’s Disease and Cancer: When Two Monsters Cannot Be Together
- (2019) Shohreh Majd et al. Frontiers in Neuroscience
- The Alzheimer’s Disease Clinical Spectrum
- (2019) Alireza Atri MEDICAL CLINICS OF NORTH AMERICA
- CSF1R antagonism limits local restimulation of antiviral CD8+ T cells during viral encephalitis
- (2019) Kristen E. Funk et al. Journal of Neuroinflammation
- Inflammatory mechanisms in neurodegeneration
- (2019) Michael R. Nichols et al. JOURNAL OF NEUROCHEMISTRY
- Homozygous Mutations in CSF1R Cause a Pediatric-Onset Leukoencephalopathy and Can Result in Congenital Absence of Microglia
- (2019) Nynke Oosterhof et al. AMERICAN JOURNAL OF HUMAN GENETICS
- Deletion of a Csf1r enhancer selectively impacts CSF1R expression and development of tissue macrophage populations
- (2019) Rocío Rojo et al. Nature Communications
- CSF1R inhibitor JNJ-40346527 attenuates microglial proliferation and neurodegeneration in P301S mice
- (2019) Renzo Mancuso et al. BRAIN
- Microglia in Alzheimer Disease: Well-Known Targets and New Opportunities
- (2019) Anne-Laure Hemonnot et al. Frontiers in Aging Neuroscience
- Microglial Drug Targets in AD: Opportunities and Challenges in Drug Discovery and Development
- (2019) Knut Biber et al. Frontiers in Pharmacology
- CSF1R Ligands IL-34 and CSF1 Are Differentially Required for Microglia Development and Maintenance in White and Gray Matter Brain Regions
- (2019) Courtney Easley-Neal et al. Frontiers in Immunology
- Pharmacological inhibition of CSF1R by GW2580 reduces microglial proliferation and is protective against neuroinflammation and dopaminergic neurodegeneration
- (2019) Matthew L. Neal et al. FASEB JOURNAL
- NIA-AA Research Framework: Toward a biological definition of Alzheimer's disease
- (2018) Clifford R. Jack et al. Alzheimers & Dementia
- Fetal monocytes and the origins of tissue-resident macrophages
- (2018) Guillaume Hoeffel et al. CELLULAR IMMUNOLOGY
- Niche signals and transcription factors involved in tissue-resident macrophage development
- (2018) Wouter T'Jonck et al. CELLULAR IMMUNOLOGY
- Csf1R inhibition attenuates experimental autoimmune encephalomyelitis and promotes recovery
- (2018) Jillian C. Nissen et al. EXPERIMENTAL NEUROLOGY
- Recent Advances of Colony-Stimulating Factor-1 Receptor (CSF-1R) Kinase and Its Inhibitors
- (2018) Mohammed I. El-Gamal et al. JOURNAL OF MEDICINAL CHEMISTRY
- Granulocyte-macrophage colony-stimulating factor neuroprotective activities in Alzheimer’s disease mice
- (2018) Tomomi Kiyota et al. JOURNAL OF NEUROIMMUNOLOGY
- Early long-term administration of the CSF1R inhibitor PLX3397 ablates microglia and reduces accumulation of intraneuronal amyloid, neuritic plaque deposition and pre-fibrillar oligomers in 5XFAD mouse model of Alzheimer’s disease
- (2018) Justyna Sosna et al. Molecular Neurodegeneration
- The Evolving Dialogue of Microglia and Neurons in Alzheimer’s Disease: Microglia as Necessary Transducers of Pathology
- (2018) E. Simon et al. NEUROSCIENCE
- Understanding Alzheimer Disease at the Interface between Genetics and Transcriptomics
- (2018) Jan Verheijen et al. TRENDS IN GENETICS
- OUP accepted manuscript
- (2018) AGE AND AGEING
- Inflammation: the link between comorbidities, genetics, and Alzheimer’s disease
- (2018) Estella A. Newcombe et al. Journal of Neuroinflammation
- PU.1 regulates Alzheimer’s disease-associated genes in primary human microglia
- (2018) Justin Rustenhoven et al. Molecular Neurodegeneration
- CSF1R inhibitors exhibit anti-tumor activity in acute myeloid leukemia by blocking paracrine signals from support cells
- (2018) David K. Edwards et al. BLOOD
- Partial reduction of microglia does not affect tau pathology in aged mice
- (2018) Rachel E. Bennett et al. Journal of Neuroinflammation
- Complement C3aR Inactivation Attenuates Tau Pathology and Reverses an Immune Network Deregulated in Tauopathy Models and Alzheimer’s Disease
- (2018) Alexandra Litvinchuk et al. NEURON
- CSF1R Inhibition Reduces Microglia Proliferation, Promotes Tissue Preservation and Improves Motor Recovery After Spinal Cord Injury
- (2018) Yannick Nicolas Gerber et al. Frontiers in Cellular Neuroscience
- Transcriptional mechanism of IRF8 and PU.1 governs microglial activation in neurodegenerative condition
- (2018) Nan Zhou et al. Protein & Cell
- Microglia in Alzheimer’s disease
- (2017) David V. Hansen et al. JOURNAL OF CELL BIOLOGY
- Pharmacological inhibition of the transcription factor PU.1 in leukemia
- (2017) Iléana Antony-Debré et al. JOURNAL OF CLINICAL INVESTIGATION
- Inflammatory mechanisms linking obesity and metabolic disease
- (2017) Alan R. Saltiel et al. JOURNAL OF CLINICAL INVESTIGATION
- Alzheimer’s disease: A matter of blood–brain barrier dysfunction?
- (2017) Axel Montagne et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Late onset Alzheimer’s disease genetics implicates microglial pathways in disease risk
- (2017) Anastasia G. Efthymiou et al. Molecular Neurodegeneration
- A common haplotype lowers PU.1 expression in myeloid cells and delays onset of Alzheimer's disease
- (2017) Kuan-lin Huang et al. NATURE NEUROSCIENCE
- Changes in phagocytosis and potassium channel activity in microglia of 5xFAD mice indicate alterations in purinergic signaling in a mouse model of Alzheimer's disease
- (2017) Stefan Wendt et al. NEUROBIOLOGY OF AGING
- Association of comorbidity and health service usage among patients with dementia in the UK: a population-based study
- (2017) Jorge Browne et al. BMJ Open
- Neuroinflammation in Alzheimer's disease: Current evidence and future directions
- (2016) Valeria Calsolaro et al. Alzheimers & Dementia
- Pharmacological targeting of CSF1R inhibits microglial proliferation and prevents the progression of Alzheimer’s-like pathology
- (2016) Adrian Olmos-Alonso et al. BRAIN
- Eliminating microglia in Alzheimer’s mice prevents neuronal loss without modulating amyloid-β pathology
- (2016) Elizabeth E. Spangenberg et al. BRAIN
- Adipose tissue macrophages: going off track during obesity
- (2016) Lily Boutens et al. DIABETOLOGIA
- Inflammatory processes in cardiovascular disease: a route to targeted therapies
- (2016) Neil Ruparelia et al. Nature Reviews Cardiology
- Pharmacologic efficacy of PU.1 inhibition by heterocyclic dications: a mechanistic analysis
- (2016) Dominique C. Stephens et al. NUCLEIC ACIDS RESEARCH
- Emerging Roles for CSF-1 Receptor and its Ligands in the Nervous System
- (2016) Violeta Chitu et al. TRENDS IN NEUROSCIENCES
- CSF1R blockade slows the progression of amyotrophic lateral sclerosis by reducing microgliosis and invasion of macrophages into peripheral nerves
- (2016) Anna Martínez-Muriana et al. Scientific Reports
- Colony-stimulating factor 1 receptor inhibition prevents microglial plaque association and improves cognition in 3xTg-AD mice
- (2015) Nabil N. Dagher et al. Journal of Neuroinflammation
- Results from a Phase IIA Parallel Group Study of JNJ-40346527, an Oral CSF-1R Inhibitor, in Patients with Active Rheumatoid Arthritis despite Disease-modifying Antirheumatic Drug Therapy
- (2015) M. C. Genovese et al. JOURNAL OF RHEUMATOLOGY
- Functions and development of red pulp macrophages
- (2015) Daisuke Kurotaki et al. MICROBIOLOGY AND IMMUNOLOGY
- Conserved epigenomic signals in mice and humans reveal immune basis of Alzheimer’s disease
- (2015) Elizabeta Gjoneska et al. NATURE
- Innate immunity in Alzheimer's disease
- (2015) Michael T Heneka et al. NATURE IMMUNOLOGY
- Development and function of tissue resident macrophages in mice
- (2015) Katrin Kierdorf et al. SEMINARS IN IMMUNOLOGY
- Comorbidity of dementia: a cross-sectional study of primary care older patients
- (2014) Beatriz Poblador-Plou et al. BMC Psychiatry
- Sustained Inhibition of Receptor Tyrosine Kinases and Macrophage Depletion by PLX3397 and Rapamycin as a Potential New Approach for the Treatment of MPNSTs
- (2014) P. P. Patwardhan et al. CLINICAL CANCER RESEARCH
- Interkeukin-34, a cytokine crucial for the differentiation and maintenance of tissue resident macrophages and Langerhans cells
- (2014) Yaming Wang et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- Macrophage heterogeneity in tissues: phenotypic diversity and functions
- (2014) Siamon Gordon et al. IMMUNOLOGICAL REVIEWS
- Pleiotropic effects of extended blockade of CSF1R signaling in adult mice
- (2014) K. A. Sauter et al. JOURNAL OF LEUKOCYTE BIOLOGY
- Mutant Huntingtin promotes autonomous microglia activation via myeloid lineage-determining factors
- (2014) Andrea Crotti et al. NATURE NEUROSCIENCE
- Colony-Stimulating Factor 1 Receptor Signaling Is Necessary for Microglia Viability, Unmasking a Microglia Progenitor Cell in the Adult Brain
- (2014) Monica R.P. Elmore et al. NEURON
- Microglial Dynamics and Role in the Healthy and Diseased Brain
- (2014) Diego Gomez-Nicola et al. NEUROSCIENTIST
- CSF-1 Receptor Signaling in Myeloid Cells
- (2014) E. R. Stanley et al. Cold Spring Harbor Perspectives in Biology
- Obesity and cognitive decline: role of inflammation and vascular changes
- (2014) Jason C. D. Nguyen et al. Frontiers in Neuroscience
- Nr4a1-Dependent Ly6Clow Monocytes Monitor Endothelial Cells and Orchestrate Their Disposal
- (2013) Leo M. Carlin et al. CELL
- The transcription factor PU.1 is critical for viability and function of human brain microglia
- (2013) Amy M. Smith et al. GLIA
- Microglia, neuroinflammation, and beta-amyloid protein in Alzheimer's disease
- (2013) Zhiyou Cai et al. INTERNATIONAL JOURNAL OF NEUROSCIENCE
- IL-34 and CSF-1: similarities and differences
- (2013) Yuko Nakamichi et al. JOURNAL OF BONE AND MINERAL METABOLISM
- Regulation of Microglial Proliferation during Chronic Neurodegeneration
- (2013) D. Gomez-Nicola et al. JOURNAL OF NEUROSCIENCE
- Macrophage biology in development, homeostasis and disease
- (2013) Thomas A. Wynn et al. NATURE
- Tissue-resident macrophages
- (2013) Luke C Davies et al. NATURE IMMUNOLOGY
- CD169+ macrophages provide a niche promoting erythropoiesis under homeostasis and stress
- (2013) Andrew Chow et al. NATURE MEDICINE
- Microglia emerge from erythromyeloid precursors via Pu.1- and Irf8-dependent pathways
- (2013) Katrin Kierdorf et al. NATURE NEUROSCIENCE
- Neuroinflammation: The role and consequences
- (2013) Monty Lyman et al. NEUROSCIENCE RESEARCH
- Structure-dependent inhibition of the ETS-family transcription factor PU.1 by novel heterocyclic diamidines
- (2013) M. Munde et al. NUCLEIC ACIDS RESEARCH
- Mechanisms of in vivo binding site selection of the hematopoietic master transcription factor PU.1
- (2013) Thu-Hang Pham et al. NUCLEIC ACIDS RESEARCH
- Intestinal macrophages: well educated exceptions from the rule
- (2013) Ehud Zigmond et al. TRENDS IN IMMUNOLOGY
- Macrophages and CSF-1
- (2013) Christina V Jones et al. Organogenesis
- Early-onset Alzheimer's Disease: Nonamnestic Subtypes and Type 2 AD
- (2012) Mario F. Mendez ARCHIVES OF MEDICAL RESEARCH
- The CSF-1 receptor ligands IL-34 and CSF-1 exhibit distinct developmental brain expression patterns and regulate neural progenitor cell maintenance and maturation
- (2012) Sayan Nandi et al. DEVELOPMENTAL BIOLOGY
- Stroma-Derived Interleukin-34 Controls the Development and Maintenance of Langerhans Cells and the Maintenance of Microglia
- (2012) Melanie Greter et al. IMMUNITY
- Macrophages and Systemic Iron Homeostasis
- (2012) Tomas Ganz Journal of Innate Immunity
- Innate Immune Functions of Macrophage Subpopulations in the Spleen
- (2012) Joke M.M. den Haan et al. Journal of Innate Immunity
- IL-34 is a tissue-restricted ligand of CSF1R required for the development of Langerhans cells and microglia
- (2012) Yaming Wang et al. NATURE IMMUNOLOGY
- TGF-β induced by interleukin-34-stimulated microglia regulates microglial proliferation and attenuates oligomeric amyloid β neurotoxicity
- (2012) Di Ma et al. NEUROSCIENCE LETTERS
- Variant of TREM2 Associated with the Risk of Alzheimer's Disease
- (2012) Thorlakur Jonsson et al. NEW ENGLAND JOURNAL OF MEDICINE
- TREM2 Variants in Alzheimer's Disease
- (2012) Rita Guerreiro et al. NEW ENGLAND JOURNAL OF MEDICINE
- Interleukin-34 Selectively Enhances the Neuroprotective Effects of Microglia to Attenuate Oligomeric Amyloid-β Neurotoxicity
- (2011) Tetsuya Mizuno et al. AMERICAN JOURNAL OF PATHOLOGY
- Increased Serum Enzyme Levels Associated with Kupffer Cell Reduction with No Signs of Hepatic or Skeletal Muscle Injury
- (2011) Zaher A. Radi et al. AMERICAN JOURNAL OF PATHOLOGY
- Therapeutic applications of macrophage colony-stimulating factor-1 (CSF-1) and antagonists of CSF-1 receptor (CSF-1R) signaling
- (2011) D. A. Hume et al. BLOOD
- Soothing the Inflamed Brain: Effect of Non-Steroidal Anti-Inflammatory Drugs on Alzheimers Disease Pathology
- (2011) J. J.M. Hoozemans et al. CNS & Neurological Disorders-Drug Targets
- c-FMS inhibitors: a patent review
- (2011) Christopher J Burns et al. EXPERT OPINION ON THERAPEUTIC PATENTS
- Tyrosine Kinase Inhibitors Ameliorate Autoimmune Encephalomyelitis in a Mouse Model of Multiple Sclerosis
- (2011) Oliver Crespo et al. JOURNAL OF CLINICAL IMMUNOLOGY
- Bone marrow CD169+macrophages promote the retention of hematopoietic stem and progenitor cells in the mesenchymal stem cell niche
- (2011) Andrew Chow et al. JOURNAL OF EXPERIMENTAL MEDICINE
- The Renal Mononuclear Phagocytic System
- (2011) P. J. Nelson et al. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
- The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeutics
- (2011) Eric Karran et al. NATURE REVIEWS DRUG DISCOVERY
- Cytokine expression and microglial activation in progressive supranuclear palsy
- (2011) Rafael Fernández-Botrán et al. PARKINSONISM & RELATED DISORDERS
- GM-CSF up-regulated in reumatoid arthritis reverses cognitive impairment and amyloidosis in Alzheimer mice
- (2010) Timothy D. Boyd Alzheimers & Dementia
- An antibody against the colony-stimulating factor 1 receptor depletes the resident subset of monocytes and tissue- and tumor-associated macrophages but does not inhibit inflammation
- (2010) K. P. A. MacDonald et al. BLOOD
- Functional overlap but differential expression of CSF-1 and IL-34 in their CSF-1 receptor-mediated regulation of myeloid cells
- (2010) Suwen Wei et al. JOURNAL OF LEUKOCYTE BIOLOGY
- Development and homeostasis of ‘resident’ myeloid cells: the case of the Langerhans cell
- (2010) Laurent Chorro et al. TRENDS IN IMMUNOLOGY
- Targeting distinct tumor-infiltrating myeloid cells by inhibiting CSF-1 receptor: combating tumor evasion of antiangiogenic therapy
- (2009) S. J. Priceman et al. BLOOD
- Neutralization of granulocyte macrophage colony-stimulating factor decreases amyloid beta 1-42 and suppresses microglial activity in a transgenic mouse model of Alzheimer's disease
- (2009) Maria Manczak et al. HUMAN MOLECULAR GENETICS
- JNJ-28312141, a novel orally active colony-stimulating factor-1 receptor/FMS-related receptor tyrosine kinase-3 receptor tyrosine kinase inhibitor with potential utility in solid tumors, bone metastases, and acute myeloid leukemia
- (2009) C. L. Manthey et al. MOLECULAR CANCER THERAPEUTICS
- The selective M-CSF receptor tyrosine kinase inhibitor Ki20227 suppresses experimental autoimmune encephalomyelitis
- (2008) Yasunori Uemura et al. JOURNAL OF NEUROIMMUNOLOGY
- Microglia, amyloid, and cognition in Alzheimer's disease: An [11C](R)PK11195-PET and [11C]PIB-PET study
- (2008) Paul Edison et al. NEUROBIOLOGY OF DISEASE
- Discovery of a Cytokine and Its Receptor by Functional Screening of the Extracellular Proteome
- (2008) H. Lin et al. SCIENCE
- The orally-active and selective c-Fms tyrosine kinase inhibitor Ki20227 inhibits disease progression in a collagen-induced arthritis mouse model
- (2007) Hiroaki Ohno et al. EUROPEAN JOURNAL OF IMMUNOLOGY
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started