Pharmacological inhibition of CSF1R by GW2580 reduces microglial proliferation and is protective against neuroinflammation and dopaminergic neurodegeneration

Depletion of microglia augments the dopaminergic neurotoxicity of MPTP

(2018) Xiaoxia Yang et al.   FASEB JOURNAL

The glycoprotein GPNMB attenuates astrocyte inflammatory responses through the CD44 receptor

(2018) Matthew L. Neal et al.   Journal of Neuroinflammation

The effect of manganese exposure in Atp13a2-deficient mice

(2018) Sheila M. Fleming et al.   NEUROTOXICOLOGY

IL-34 and CSF-1 display an equivalent macrophage differentiation ability but a different polarization potential

(2018) Sonia Boulakirba et al.   Scientific Reports

Selective M2 Macrophage Depletion Leads to Prolonged Inflammation in Surgical Wounds

(2017) Kerstin Klinkert et al.   EUROPEAN SURGICAL RESEARCH

Analysis of monocyte infiltration in MPTP mice reveals that microglial CX3CR1 protects against neurotoxic over-induction of monocyte-attracting CCL2 by astrocytes

(2017) Vincent R. Parillaud et al.   Journal of Neuroinflammation

Alternative microglial activation is associated with cessation of progressive dopamine neuron loss in mice systemically administered lipopolysaccharide

(2017) Eric E. Beier et al.   NEUROBIOLOGY OF DISEASE

Single low doses of MPTP decrease tyrosine hydroxylase expression in the absence of overt neuron loss

(2017) Gelareh Alam et al.   NEUROTOXICOLOGY

Pathological α-synuclein exacerbates the progression of Parkinson’s disease through microglial activation

(2017) Qiu-Shuang Zhang et al.   TOXICOLOGY LETTERS

Studies on Colony Stimulating Factor Receptor-1 and Ligands Colony Stimulating Factor-1 and Interleukin-34 in Alzheimer's Disease Brains and Human Microglia

(2017) Douglas G. Walker et al.   Frontiers in Aging Neuroscience

Depletion of Tumor-Associated Macrophages with a CSF-1R Kinase Inhibitor Enhances Antitumor Immunity and Survival Induced by DC Immunotherapy

(2017) Floris Dammeijer et al.   Cancer Immunology Research

Colony-stimulating factor 1 receptor (CSF1R) inhibitors in cancer therapy

(2017) Michael A. Cannarile et al.   Journal for ImmunoTherapy of Cancer

Pharmacological targeting of CSF1R inhibits microglial proliferation and prevents the progression of Alzheimer’s-like pathology

(2016) Adrian Olmos-Alonso et al.   BRAIN

LPS-induced Murine Neuroinflammation Model: Main Features and Suitability for Pre-clinical Assessment of Nutraceuticals

(2016) Miryam Nava Catorce et al.   Current Neuropharmacology

Microglia: Architects of the Developing Nervous System

(2016) Jeffrey L. Frost et al.   TRENDS IN CELL BIOLOGY

CSF1R blockade slows the progression of amyotrophic lateral sclerosis by reducing microgliosis and invasion of macrophages into peripheral nerves

(2016) Anna Martínez-Muriana et al.   Scientific Reports

Systemic and Cardiac Depletion of M2 Macrophage through CSF-1R Signaling Inhibition Alters Cardiac Function Post Myocardial Infarction

(2015) Anne-Laure Leblond et al.   PLoS One

Characterizing and Overriding the Structural Mechanism of the Quizartinib-Resistant FLT3 "Gatekeeper" F691L Mutation with PLX3397

(2015) C. C. Smith et al.   Cancer Discovery

Characterizing Newly Repopulated Microglia in the Adult Mouse: Impacts on Animal Behavior, Cell Morphology, and Neuroinflammation

(2015) Monica R. P. Elmore et al.   PLoS One

CSF1 overexpression has pleiotropic effects on microgliain vivo

(2014) Ishani De et al.   GLIA

Conditional Ablation of Astroglial CCL2 Suppresses CNS Accumulation of M1 Macrophages and Preserves Axons in Mice with MOG Peptide EAE

(2014) M. Moreno et al.   JOURNAL OF NEUROSCIENCE

IL-34 and CSF-1: similarities and differences

(2013) Yuko Nakamichi et al.   JOURNAL OF BONE AND MINERAL METABOLISM

Colony-stimulating factor 1 receptor (CSF1R) signaling in injured neurons facilitates protection and survival

(2013) Jian Luo et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Regulation of Microglial Proliferation during Chronic Neurodegeneration

(2013) D. Gomez-Nicola et al.   JOURNAL OF NEUROSCIENCE

CSF-1R inhibition alters macrophage polarization and blocks glioma progression

(2013) Stephanie M Pyonteck et al.   NATURE MEDICINE

Toll like receptor 4 mediates cell death in a mouse MPTP model of Parkinson disease

(2013) Carmen Noelker et al.   Scientific Reports

Bidirectional Microglia-Neuron Communication in the Healthy Brain

(2013) Ukpong B. Eyo et al.   NEURAL PLASTICITY

Stroma-Derived Interleukin-34 Controls the Development and Maintenance of Langerhans Cells and the Maintenance of Microglia

(2012) Melanie Greter et al.   IMMUNITY

Functions of microglia in the central nervous system – beyond the immune response

(2012) Hiroaki Wake et al.   Neuron Glia Biology

Therapeutic applications of macrophage colony-stimulating factor-1 (CSF-1) and antagonists of CSF-1 receptor (CSF-1R) signaling

(2011) D. A. Hume et al.   BLOOD

Phosphorylation of CSF-1R Y721 mediates its association with PI3K to regulate macrophage motility and enhancement of tumor cell invasion

(2011) N. G. Sampaio et al.   JOURNAL OF CELL SCIENCE

Absence of Colony Stimulation Factor-1 Receptor Results in Loss of Microglia, Disrupted Brain Development and Olfactory Deficits

(2011) Bryna Erblich et al.   PLoS One

A pilot trial of the microtubule-interacting peptide (NAP) in mice overexpressing alpha-synuclein shows improvement in motor function and reduction of alpha-synuclein inclusions

(2010) Sheila M. Fleming et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Targeting distinct tumor-infiltrating myeloid cells by inhibiting CSF-1 receptor: combating tumor evasion of antiangiogenic therapy

(2009) S. J. Priceman et al.   BLOOD

Relationship between microglial activation and dopaminergic neuronal loss in the substantia nigra: a time course study in a 6-hydroxydopamine model of Parkinson’s disease

(2009) Lilia Marinova-Mutafchieva et al.   JOURNAL OF NEUROCHEMISTRY

Selective reduction in microglia density and function in the white matter of colony-stimulating factor-1-deficient mice

(2009) Yoichi Kondo et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Neuroinflammation in Parkinson's disease: a target for neuroprotection?

(2009) Etienne C Hirsch et al.   LANCET NEUROLOGY

Effects of the cFMS Kinase Inhibitor 5-(3-Methoxy-4-((4-methoxybenzyl)oxy)benzyl)pyrimidine-2,4-diamine (GW2580) in Normal and Arthritic Rats

(2008) J. G. Conway et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Inflammation as a causative factor in the aetiology of Parkinson's disease

(2007) P S Whitton   BRITISH JOURNAL OF PHARMACOLOGY