Best Practices for Generating and Using Alpha-Synuclein Pre-Formed Fibrils to Model Parkinson’s Disease in Rodents

Critical appraisal of pathology transmission in the α-synuclein fibril model of Lewy body disorders

(2018) Negin Nouraei et al.   EXPERIMENTAL NEUROLOGY

Selective imaging of internalized proteopathic α-synuclein seeds in primary neurons reveals mechanistic insight into transmission of synucleinopathies

(2017) Richard J. Karpowicz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

α-Synuclein fibril-induced inclusion spread in rats and mice correlates with dopaminergic Neurodegeneration

(2017) Hisham Abdelmotilib et al.   NEUROBIOLOGY OF DISEASE

Modeling Parkinson’s disease pathology by combination of fibril seeds and α-synuclein overexpression in the rat brain

(2017) Poonam Thakur et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phosphorylated exogenous alpha-synuclein fibrils exacerbate pathology and induce neuronal dysfunction in mice

(2017) Mantia Karampetsou et al.   Scientific Reports

The Effect of Fragmented Pathogenic α-Synuclein Seeds on Prion-like Propagation

(2016) Airi Tarutani et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Widespread transneuronal propagation of α-synucleinopathy triggered in olfactory bulb mimics prodromal Parkinson’s disease

(2016) Nolwen L. Rey et al.   JOURNAL OF EXPERIMENTAL MEDICINE

How can rAAV-α-synuclein and the fibril α-synuclein models advance our understanding of Parkinson's disease?

(2016) Laura A. Volpicelli-Daley et al.   JOURNAL OF NEUROCHEMISTRY

Challenges of modifying disease progression in prediagnostic Parkinson's disease

(2016) David Salat et al.   LANCET NEUROLOGY

Induction of de novo α-synuclein fibrillization in a neuronal model for Parkinson’s disease

(2016) Mohamed-Bilal Fares et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

α-Synuclein-Based Animal Models of Parkinson's Disease: Challenges and Opportunities in a New Era

(2016) Naomi P. Visanji et al.   TRENDS IN NEUROSCIENCES

Molecular and Biological Compatibility with Host Alpha-Synuclein Influences Fibril Pathogenicity

(2016) Kelvin C. Luk et al.   Cell Reports

Retrograde Axonal Degeneration in Parkinson Disease

(2016) Patricia Tagliaferro et al.   Journal of Parkinsons Disease

Structural and functional properties of prefibrillar α-synuclein oligomers

(2016) Laura Pieri et al.   Scientific Reports

Intact-Brain Analyses Reveal Distinct Information Carried by SNc Dopamine Subcircuits

(2015) Talia N. Lerner et al.   CELL

Intrastriatal injection of pre-formed mouse α-synuclein fibrils into rats triggers α-synuclein pathology and bilateral nigrostriatal degeneration

(2015) Katrina L. Paumier et al.   NEUROBIOLOGY OF DISEASE

Progressive Aggregation of Alpha-Synuclein and Selective Degeneration of Lewy Inclusion-Bearing Neurons in a Mouse Model of Parkinsonism

(2015) Valerie R. Osterberg et al.   Cell Reports

Cold Denaturation of α-Synuclein Amyloid Fibrils

(2014) Tatsuya Ikenoue et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Addition of exogenous α-synuclein preformed fibrils to primary neuronal cultures to seed recruitment of endogenous α-synuclein to Lewy body and Lewy neurite–like aggregates

(2014) Laura A Volpicelli-Daley et al.   Nature Protocols

Parkinson’s disease: animal models and dopaminergic cell vulnerability

(2014) Javier Blesa et al.   Frontiers in Neuroanatomy

Prion-like spreading of pathological α-synuclein in brain

(2013) Masami Masuda-Suzukake et al.   BRAIN

Disease duration and the integrity of the nigrostriatal system in Parkinson’s disease

(2013) Jeffrey H. Kordower et al.   BRAIN

Distinct α-Synuclein Strains Differentially Promote Tau Inclusions in Neurons

(2013) Jing L. Guo et al.   CELL

Morphological and Behavioral Impact of AAV2/5-Mediated Overexpression of Human Wildtype Alpha-Synuclein in the Rat Nigrostriatal System

(2013) Sara E. Gombash et al.   PLoS One

Structural and functional characterization of two alpha-synuclein strains

(2013) Luc Bousset et al.   Nature Communications

Animal Models of Parkinson's Disease: Vertebrate Genetics

(2013) Y. Lee et al.   Cold Spring Harbor Perspectives in Medicine

Axon degeneration in Parkinson's disease

(2012) Robert E. Burke et al.   EXPERIMENTAL NEUROLOGY

Intracerebral inoculation of pathological α-synuclein initiates a rapidly progressive neurodegenerative α-synucleinopathy in mice

(2012) Kelvin C. Luk et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Pathological  -Synuclein Transmission Initiates Parkinson-like Neurodegeneration in Nontransgenic Mice

(2012) K. C. Luk et al.   SCIENCE

Changes in the solubility and phosphorylation of α-synuclein over the course of Parkinson’s disease

(2011) Jinxia Zhou et al.   ACTA NEUROPATHOLOGICA

Use of viral vectors to create animal models for Parkinson's disease

(2011) Karin Löw et al.   NEUROBIOLOGY OF DISEASE

Exogenous α-Synuclein Fibrils Induce Lewy Body Pathology Leading to Synaptic Dysfunction and Neuron Death

(2011) Laura A. Volpicelli-Daley et al.   NEURON

Animal models of Parkinson's disease

(2011) Vernice Jackson-Lewis et al.   PARKINSONISM & RELATED DISORDERS

Progressive Neurodegeneration or Endogenous Compensation in an Animal Model of Parkinson's Disease Produced by Decreasing Doses of Alpha-Synuclein

(2011) James B. Koprich et al.   PLoS One

The scientific and clinical basis for the treatment of Parkinson disease (2009)

(2009) C. W. Olanow et al.   NEUROLOGY

Exogenous  -synuclein fibrils seed the formation of Lewy body-like intracellular inclusions in cultured cells

(2009) K. C. Luk et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA