Individual Amino Acid Supplementation Can Improve Energy Metabolism and Decrease ROS Production in Neuronal Cells Overexpressing Alpha-Synuclein

Lactate Shuttles in Neuroenergetics—Homeostasis, Allostasis and Beyond

(2017) Shayne Mason   Frontiers in Neuroscience

Alpha-synuclein-induced oxidative stress correlates with altered superoxide dismutase and glutathione synthesis in human neuroblastoma SH-SY5Y cells

(2016) Rita Perfeito et al.   ARCHIVES OF TOXICOLOGY

Baicalein reverts L-valine-induced persistent sodium current up-modulation in primary cortical neurons

(2016) Silvia Caioli et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Gut Microbiota Regulate Motor Deficits and Neuroinflammation in a Model of Parkinson’s Disease

(2016) Timothy R. Sampson et al.   CELL

Coenzyme Q10 for Patients with Parkinson';s Disease: A Systematic Review and Meta-Analysis

(2016) Ahmed Negida et al.   CNS & Neurological Disorders-Drug Targets

Oxaloacetate enhances neuronal cell bioenergetic fluxes and infrastructure

(2016) Heather M. Wilkins et al.   JOURNAL OF NEUROCHEMISTRY

Monomeric Alpha-Synuclein Exerts a Physiological Role on Brain ATP Synthase

(2016) M. H. R. Ludtmann et al.   JOURNAL OF NEUROSCIENCE

α-Synuclein binds to TOM20 and inhibits mitochondrial protein import in Parkinson’s disease

(2016) Roberto Di Maio et al.   Science Translational Medicine

A LON-ClpP Proteolytic Axis Degrades Complex I to Extinguish ROS Production in Depolarized Mitochondria

(2016) Kenneth Robert Pryde et al.   Cell Reports

Branched-chain amino acids, mitochondrial biogenesis, and healthspan: an evolutionary perspective

(2016) Alessandra Valerio et al.   Aging-US

Protective role of SIRT5 against motor deficit and dopaminergic degeneration in MPTP-induced mice model of Parkinson's disease

(2015) Lei Liu et al.   BEHAVIOURAL BRAIN RESEARCH

Mechanisms of amino acid-mediated lifespan extension in Caenorhabditis elegans

(2015) Clare Edwards et al.   BMC GENETICS

Defining the Role of the Monoamine Oxidase-B Inhibitors for Parkinson’s Disease

(2015) Daphne Robakis et al.   CNS DRUGS

Keratins in health and disease

(2015) Diana M Toivola et al.   CURRENT OPINION IN CELL BIOLOGY

 -synuclein assemblies sequester neuronal  3-Na+/K+-ATPase and impair Na+ gradient

(2015) A. N. Shrivastava et al.   EMBO JOURNAL

Depressive-like phenotype induced by AAV-mediated overexpression of human α-synuclein in midbrain dopaminergic neurons

(2015) D. Caudal et al.   EXPERIMENTAL NEUROLOGY

Extracellular α-synuclein alters synaptic transmission in brain neurons by perforating the neuronal plasma membrane

(2015) Carla R. Pacheco et al.   JOURNAL OF NEUROCHEMISTRY

A53T Human  -Synuclein Overexpression in Transgenic Mice Induces Pervasive Mitochondria Macroautophagy Defects Preceding Dopamine Neuron Degeneration

(2015) L. Chen et al.   JOURNAL OF NEUROSCIENCE

Sustained Arginase 1 Expression Modulates Pathological Tau Deposits in a Mouse Model of Tauopathy

(2015) J. B. Hunt et al.   JOURNAL OF NEUROSCIENCE

Mitochondrial iron homeostasis and its dysfunctions in neurodegenerative disorders

(2015) Natalia P. Mena et al.   MITOCHONDRION

Activation of Mitochondrial Complex II-Dependent Respiration Is Beneficial for α-Synucleinopathies

(2015) Christina Fröhlich et al.   MOLECULAR NEUROBIOLOGY

Parkinson-causing α-synuclein missense mutations shift native tetramers to monomers as a mechanism for disease initiation

(2015) Ulf Dettmer et al.   Nature Communications

Analysis of the Catecholaminergic Phenotype in Human SH-SY5Y and BE(2)-M17 Neuroblastoma Cell Lines upon Differentiation

(2015) Roberta Filograna et al.   PLoS One

Mutual exacerbation of peroxisome proliferator-activated receptor γ coactivator 1α deregulation and α-synuclein oligomerization

(2014) Judith Eschbach et al.   ANNALS OF NEUROLOGY

Purification of α-Synuclein from Human Brain Reveals an Instability of Endogenous Multimers as the Protein Approaches Purity

(2014) Eric S. Luth et al.   BIOCHEMISTRY

N-Acyl amino acids and their impact on biological processes

(2014) Lumír Hanuš et al.   BIOFACTORS

α-Synuclein amino terminus regulates mitochondrial membrane permeability

(2014) Jiamei Shen et al.   BRAIN RESEARCH

Hydrogen Peroxide Produced by Mitochondrial Monoamine Oxidase Catalysis: Biological Implications

(2014) Dale Edmondson   CURRENT PHARMACEUTICAL DESIGN

Oxaloacetate activates brain mitochondrial biogenesis, enhances the insulin pathway, reduces inflammation and stimulates neurogenesis

(2014) Heather M. Wilkins et al.   HUMAN MOLECULAR GENETICS

Soluble, Prefibrillar α-Synuclein Oligomers Promote Complex I-dependent, Ca2+-induced Mitochondrial Dysfunction

(2014) Eric S. Luth et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Evidence of Native α-Synuclein Conformers in the Human Brain

(2014) Neal Gould et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Linking alpha-synuclein phosphorylation to reactive oxygen species formation and mitochondrial dysfunction in SH-SY5Y cells

(2014) Rita Perfeito et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Inhibition of Neuroinflammation and Mitochondrial Dysfunctions by Carbenoxolone in the Rotenone Model of Parkinson’s Disease

(2014) Poonam Thakur et al.   MOLECULAR NEUROBIOLOGY

Region specific mitochondrial impairment in mice with widespread overexpression of alpha-synuclein

(2014) Sudhakar Raja Subramaniam et al.   NEUROBIOLOGY OF DISEASE

Divalent metal ions enhance DOPAL-induced oligomerization of alpha-synuclein

(2014) Yunden Jinsmaa et al.   NEUROSCIENCE LETTERS

Systems-Based Analyses of Brain Regions Functionally Impacted in Parkinson's Disease Reveals Underlying Causal Mechanisms

(2014) Brigit E. Riley et al.   PLoS One

Network Analysis Identifies SOD2 mRNA as a Potential Biomarker for Parkinson's Disease

(2014) Jose A. Santiago et al.   PLoS One

Lysosomes and α-synuclein form a dangerous duet leading to neuronal cell death

(2014) Mathieu Bourdenx et al.   Frontiers in Neuroanatomy

Nigral Iron Elevation Is an Invariable Feature of Parkinson’s Disease and Is a Sufficient Cause of Neurodegeneration

(2014) Scott Ayton et al.   Biomed Research International

Morphological and functional differentiation in BE(2)-M17 human neuroblastoma cells by treatment with Trans-retinoic acid

(2013) Devon Andres et al.   BMC NEUROSCIENCE

Changes in mitochondrial function are pivotal in neurodegenerative and psychiatric disorders: How important is BDNF?

(2013) A Markham et al.   BRITISH JOURNAL OF PHARMACOLOGY

Monoamine oxidase-A knockdown in human neuroblastoma cells reveals protection against mitochondrial toxins

(2013) Julia C. Fitzgerald et al.   FASEB JOURNAL

Neuroprotective effects of alpha-ketoglutarate and ethyl pyruvate against motor dysfunction and oxidative changes caused by repeated 1-methyl-4-phenyl-1,2,3,6 tetrahydropyridine exposure in mice

(2013) R. Satpute et al.   HUMAN & EXPERIMENTAL TOXICOLOGY

Brain delivery of proteins via their fatty acid and block copolymer modifications

(2013) Xiang Yi et al.   JOURNAL OF DRUG TARGETING

Determinants of buildup of the toxic dopamine metabolite DOPAL in Parkinson's disease

(2013) David S. Goldstein et al.   JOURNAL OF NEUROCHEMISTRY

A Novel Activator of CBP/p300 Acetyltransferases Promotes Neurogenesis and Extends Memory Duration in Adult Mice

(2013) S. Chatterjee et al.   JOURNAL OF NEUROSCIENCE

Mitochondrial quality control by the ubiquitin–proteasome system: Figure 1

(2012) Eric B. Taylor et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

SILAC-based proteomic analysis to investigate the impact of amyloid precursor protein expression in neuronal-like B103 cells

(2012) Dale Chaput et al.   ELECTROPHORESIS

Expression of human E46K-mutated α-synuclein in BAC-transgenic rats replicates early-stage Parkinson's disease features and enhances vulnerability to mitochondrial impairment

(2012) Jason R. Cannon et al.   EXPERIMENTAL NEUROLOGY

Selective binding of nuclear alpha-synuclein to the PGC1alpha promoter under conditions of oxidative stress may contribute to losses in mitochondrial function: Implications for Parkinson’s disease

(2012) Almas Siddiqui et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mao-B elevation decreases parkin's ability to efficiently clear damaged mitochondria: protective effects of rapamycin

(2012) Almas Siddiqui et al.   FREE RADICAL RESEARCH

Retinoic acid-induced differentiation increases the rate of oxygen consumption and enhances the spare respiratory capacity of mitochondria in SH-SY5Y cells

(2012) Zhiyin Xun et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Alpha-synuclein and Protein Degradation Systems: a Reciprocal Relationship

(2012) Maria Xilouri et al.   MOLECULAR NEUROBIOLOGY

Toxin Models of Mitochondrial Dysfunction in Parkinson's Disease

(2011) Terina N. Martinez et al.   ANTIOXIDANTS & REDOX SIGNALING

PINK1-parkin-dependent mitophagy involves ubiquitination of mitofusins 1 and 2: Implications for Parkinson disease pathogenesis

(2011) Matthew E. Gegg et al.   Autophagy

Differentiation of SH-SY5Y cells to a neuronal phenotype changes cellular bioenergetics and the response to oxidative stress

(2011) Lonnie Schneider et al.   FREE RADICAL BIOLOGY AND MEDICINE

PKA/AKAP1 and PP2A/B 2 Regulate Neuronal Morphogenesis via Drp1 Phosphorylation and Mitochondrial Bioenergetics

(2011) A. S. Dickey et al.   JOURNAL OF NEUROSCIENCE

Imputation of sequence variants for identification of genetic risks for Parkinson's disease: a meta-analysis of genome-wide association studies

(2011)   LANCET

α-Synuclein occurs physiologically as a helically folded tetramer that resists aggregation

(2011) Tim Bartels et al.   NATURE

α-Synuclein overexpression increases dopamine toxicity in BE(2)-M17 cells

(2010) Marco Bisaglia et al.   BMC NEUROSCIENCE

Overexpression of α-Synuclein Down-Regulates BDNF Expression

(2010) Yuhe Yuan et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Parkin degrades estrogen-related receptors to limit the expression of monoamine oxidases

(2010) Y. Ren et al.   HUMAN MOLECULAR GENETICS

Alpha-synuclein aggregation is involved in the toxicity induced by ferric iron to SK-N-SH neuroblastoma cells

(2010) Qing He et al.   JOURNAL OF NEURAL TRANSMISSION

Fumaric acid dialkyl esters deprive cultured rat oligodendroglial cells of glutathione and upregulate the expression of heme oxygenase 1

(2010) Anette Thiessen et al.   NEUROSCIENCE LETTERS

Neuroprotective Upregulation of Endogenous Alpha-Synuclein Precedes Ubiquitination in Cultured Dopaminergic Neurons

(2010) R. E. J. Musgrove et al.   NEUROTOXICITY RESEARCH

Reversible acetylation of PGC-1: connecting energy sensors and effectors to guarantee metabolic flexibility

(2010) E H Jeninga et al.   ONCOGENE

A Novel Endogenous Indole Protects Rodent Mitochondria and Extends Rotifer Lifespan

(2010) Burkhard Poeggeler et al.   PLoS One

Alpha-synuclein overexpression and aggregation exacerbates impairment of mitochondrial functions by augmenting oxidative stress in human neuroblastoma cells

(2009) Mordhwaj S. Parihar et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Mutual Dependence of Foxo3a and PGC-1α in the Induction of Oxidative Stress Genes

(2009) Yolanda Olmos et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Universal sample preparation method for proteome analysis

(2009) Jacek R Wiśniewski et al.   NATURE METHODS

Function of Mitochondrial Stat3 in Cellular Respiration

(2009) J. Wegrzyn et al.   SCIENCE

Differential regulation of central BDNF protein levels by antidepressant and non-antidepressant drug treatments

(2008) Darrick T. Balu et al.   BRAIN RESEARCH

DCFH2 interactions with hydroxyl radicals and other oxidants – Influence of organic solvents

(2008) Hans-Jürgen Brömme et al.   EXPERIMENTAL GERONTOLOGY

Mitochondrial Import and Accumulation of α-Synuclein Impair Complex I in Human Dopaminergic Neuronal Cultures and Parkinson Disease Brain

(2008) Latha Devi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MAO-B Elevation in Mouse Brain Astrocytes Results in Parkinson's Pathology

(2008) Jyothi K. Mallajosyula et al.   PLoS One

Sensitization of Neuronal Cells to Oxidative Stress with Mutated Human α-Synuclein

(2003) Li-wen Ko et al.   JOURNAL OF NEUROCHEMISTRY