Spread of α-synuclein pathology through the brain connectome is modulated by selective vulnerability and predicted by network analysis

LRRK2 inhibition does not impart protection from α-synuclein pathology and neuron death in non-transgenic mice

(2019) Michael X. Henderson et al.   Acta Neuropathologica Communications

LRRK2 modifies α-syn pathology and spread in mouse models and human neurons

(2019) Gregor Bieri et al.   ACTA NEUROPATHOLOGICA

Robust kinase- and age-dependent dopaminergic and norepinephrine neurodegeneration in LRRK2 G2019S transgenic mice

(2018) Yulan Xiong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Progression in the LRRK2-Associated Parkinson Disease Population

(2018) Rachel Saunders-Pullman et al.   JAMA Neurology

G2019S LRRK2 mutation facilitates α-synuclein neuropathology in aged mice

(2018) Salvatore Novello et al.   NEUROBIOLOGY OF DISEASE

Colloquium : Control of dynamics in brain networks

(2018) Evelyn Tang et al.   REVIEWS OF MODERN PHYSICS

LRRK2 activation in idiopathic Parkinson’s disease

(2018) Roberto Di Maio et al.   Science Translational Medicine

Functional and behavioral consequences of Parkinson's disease-associated LRRK2-G2019S mutation

(2018) Deanna L. Benson et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Unbiased Proteomics of Early Lewy Body Formation Model Implicates Active Microtubule Affinity-Regulating Kinases (MARKs) in Synucleinopathies

(2017) Michael X. Henderson et al.   JOURNAL OF NEUROSCIENCE

Penetrance estimate of LRRK2 p.G2019S mutation in individuals of non-Ashkenazi Jewish ancestry

(2017) Annie J. Lee et al.   MOVEMENT DISORDERS

Selective neuronal vulnerability in Parkinson disease

(2017) D. James Surmeier et al.   NATURE REVIEWS NEUROSCIENCE

Age-Dependent Dopaminergic Neurodegeneration and Impairment of the Autophagy-Lysosomal Pathway in LRRK -Deficient Mice

(2017) Emilie Giaime et al.   NEURON

Predictive Model of Spread of Progressive Supranuclear Palsy Using Directional Network Diffusion

(2017) Sneha Pandya et al.   Frontiers in Neurology

Universal framework for edge controllability of complex networks

(2017) Shao-Peng Pang et al.   Scientific Reports

Widespread transneuronal propagation of α-synucleinopathy triggered in olfactory bulb mimics prodromal Parkinson’s disease

(2016) Nolwen L. Rey et al.   JOURNAL OF EXPERIMENTAL MEDICINE

G2019S-LRRK2 Expression Augments  -Synuclein Sequestration into Inclusions in Neurons

(2016) L. A. Volpicelli-Daley et al.   JOURNAL OF NEUROSCIENCE

Pathological  -synuclein transmission initiated by binding lymphocyte-activation gene 3

(2016) X. Mao et al.   SCIENCE

Bent out of shape: α-Synuclein misfolding and the convergence of pathogenic pathways in Parkinson's disease

(2015) Esteban Luna et al.   FEBS LETTERS

Progressive Aggregation of Alpha-Synuclein and Selective Degeneration of Lewy Inclusion-Bearing Neurons in a Mouse Model of Parkinsonism

(2015) Valerie R. Osterberg et al.   Cell Reports

A mesoscale connectome of the mouse brain

(2014) Seung Wook Oh et al.   NATURE

Addition of exogenous α-synuclein preformed fibrils to primary neuronal cultures to seed recruitment of endogenous α-synuclein to Lewy body and Lewy neurite–like aggregates

(2014) Laura A Volpicelli-Daley et al.   Nature Protocols

α-Synuclein Immunotherapy Blocks Uptake and Templated Propagation of Misfolded α-Synuclein and Neurodegeneration

(2014) Hien T. Tran et al.   Cell Reports

(G2019S) LRRK2 activates MKK4-JNK pathway and causes degeneration of SN dopaminergic neurons in a transgenic mouse model of PD

(2012) C-Y Chen et al.   CELL DEATH AND DIFFERENTIATION

A Network Diffusion Model of Disease Progression in Dementia

(2012) Ashish Raj et al.   NEURON

Pathological  -Synuclein Transmission Initiates Parkinson-like Neurodegeneration in Nontransgenic Mice

(2012) K. C. Luk et al.   SCIENCE

Ser1292 Autophosphorylation Is an Indicator of LRRK2 Kinase Activity and Contributes to the Cellular Effects of PD Mutations

(2012) Z. Sheng et al.   Science Translational Medicine

Exogenous α-Synuclein Fibrils Induce Lewy Body Pathology Leading to Synaptic Dysfunction and Neuron Death

(2011) Laura A. Volpicelli-Daley et al.   NEURON

Dopaminergic Neuronal Loss, Reduced Neurite Complexity and Autophagic Abnormalities in Transgenic Mice Expressing G2019S Mutant LRRK2

(2011) David Ramonet et al.   PLoS One

Neuromelanin, neurotransmitter status and brainstem location determine the differential vulnerability of catecholaminergic neurons to mitochondrial DNA deletions

(2011) Matthias Elstner et al.   Molecular Brain

Enhanced Striatal Dopamine Transmission and Motor Performance with LRRK2 Overexpression in Mice Is Eliminated by Familial Parkinson's Disease Mutation G2019S

(2010) X. Li et al.   JOURNAL OF NEUROSCIENCE

Fast stable restricted maximum likelihood and marginal likelihood estimation of semiparametric generalized linear models

(2010) Simon N. Wood   JOURNAL OF THE ROYAL STATISTICAL SOCIETY SERIES B-STATISTICAL METHODOLOGY

Who was the man who discovered the “Lewy bodies”?

(2010) Antonio M. Rodrigues e Silva et al.   MOVEMENT DISORDERS

Loss of leucine-rich repeat kinase 2 causes impairment of protein degradation pathways, accumulation of  -synuclein, and apoptotic cell death in aged mice

(2010) Y. Tong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Unified staging system for Lewy body disorders: correlation with nigrostriatal degeneration, cognitive impairment and motor dysfunction

(2009) Thomas G. Beach et al.   ACTA NEUROPATHOLOGICA

Exogenous  -synuclein fibrils seed the formation of Lewy body-like intracellular inclusions in cultured cells

(2009) K. C. Luk et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phenotype, genotype, and worldwide genetic penetrance of LRRK2-associated Parkinson's disease: a case-control study

(2008) Daniel G Healy et al.   LANCET NEUROLOGY