What’s to like about the prion-like hypothesis for the spreading of aggregated α-synuclein in Parkinson disease?

Direct Observation of the Interconversion of Normal and Toxic Forms of α-Synuclein

(2012) Nunilo Cremades et al.   CELL

Regionally-specific microglial activation in young mice over-expressing human wildtype alpha-synuclein

(2012) Melanie B. Watson et al.   EXPERIMENTAL NEUROLOGY

α-Synuclein Controls Mitochondrial Calcium Homeostasis by Enhancing Endoplasmic Reticulum-Mitochondria Interactions

(2012) Tito Calì et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Intracerebral inoculation of pathological α-synuclein initiates a rapidly progressive neurodegenerative α-synucleinopathy in mice

(2012) Kelvin C. Luk et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Alpha-synuclein impairs normal dynamics of mitochondria in cell and animal models of Parkinson’s disease

(2012) Weilin Xie et al.   JOURNAL OF NEUROCHEMISTRY

Parkinson’s disease and immune system: is the culprit LRRKing in the periphery?

(2012) Elisa Greggio et al.   Journal of Neuroinflammation

Inflammation and α-Synuclein’s Prion-like Behavior in Parkinson's Disease—Is There a Link?

(2012) Carla M. Lema Tomé et al.   MOLECULAR NEUROBIOLOGY

Alpha-Synuclein Cell-to-Cell Transfer and Seeding in Grafted Dopaminergic Neurons In Vivo

(2012) Elodie Angot et al.   PLoS One

Pathological  -Synuclein Transmission Initiates Parkinson-like Neurodegeneration in Nontransgenic Mice

(2012) K. C. Luk et al.   SCIENCE

The role of α-synuclein in neurodegeneration — An update

(2012) Kurt Jellinger   Translational Neuroscience

Multifaceted Roles of Tunneling Nanotubes in Intercellular Communication

(2012) Ludovica Marzo et al.   Frontiers in Physiology

Transmission of Synucleinopathies in the Enteric Nervous System of A53T Alpha-Synuclein Transgenic Mice

(2012) He-Jin Lee et al.   Experimental Neurobiology

Folding and misfolding of alpha-synuclein on membranes

(2011) Igor Dikiy et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Dopamine promotes formation and secretion of non-fibrillar alpha-synuclein oligomers

(2011) He-Jin Lee et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Mutant A53T α-Synuclein Induces Neuronal Death by Increasing Mitochondrial Autophagy

(2011) Vinay Choubey et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Direct Membrane Association Drives Mitochondrial Fission by the Parkinson Disease-associated Protein α-Synuclein

(2011) Ken Nakamura et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Expression of mutant alpha-synuclein modulates microglial phenotype in vitro

(2011) Lalida Rojanathammanee et al.   Journal of Neuroinflammation

Etiology and pathogenesis of Parkinson's disease

(2011) Anthony H. Schapira et al.   MOVEMENT DISORDERS

Alpha-synuclein in colonic submucosa in early untreated Parkinson's disease

(2011) Kathleen M. Shannon et al.   MOVEMENT DISORDERS

Ageing as a primary risk factor for Parkinson's disease: evidence from studies of non-human primates

(2011) Timothy J. Collier et al.   NATURE REVIEWS NEUROSCIENCE

Prion-like acceleration of a synucleinopathy in a transgenic mouse model

(2011) Anne-Laure Mougenot et al.   NEUROBIOLOGY OF AGING

Transfer of host-derived alpha synuclein to grafted dopaminergic neurons in rat

(2011) Jeffrey H. Kordower et al.   NEUROBIOLOGY OF DISEASE

Exogenous α-Synuclein Fibrils Induce Lewy Body Pathology Leading to Synaptic Dysfunction and Neuron Death

(2011) Laura A. Volpicelli-Daley et al.   NEURON

ExoCarta 2012: database of exosomal proteins, RNA and lipids

(2011) S. Mathivanan et al.   NUCLEIC ACIDS RESEARCH

Molecular pathways in sporadic PD

(2011) Enza Maria Valente et al.   PARKINSONISM & RELATED DISORDERS

Can Parkinson's disease pathology be propagated from one neuron to another?

(2011) Christopher J.R. Dunning et al.   PROGRESS IN NEUROBIOLOGY

When Does Parkinson Disease Start?

(2010) Rodolfo Savica et al.   ARCHIVES OF NEUROLOGY

Inhibition of mitochondrial fusion by α-synuclein is rescued by PINK1, Parkin and DJ-1

(2010) Frits Kamp et al.   EMBO JOURNAL

α-Synuclein impairs macroautophagy: implications for Parkinson’s disease

(2010) Ashley R. Winslow et al.   JOURNAL OF CELL BIOLOGY

Increased Expression of α-Synuclein Reduces Neurotransmitter Release by Inhibiting Synaptic Vesicle Reclustering after Endocytosis

(2010) Venu M. Nemani et al.   NEURON

Mitochondrial alpha-synuclein accumulation impairs complex I function in dopaminergic neurons and results in increased mitophagy in vivo

(2010) Shankar J. Chinta et al.   NEUROSCIENCE LETTERS

Selective cell death in neurodegeneration: Why are some neurons spared in vulnerable regions?

(2010) K.L. Double et al.   PROGRESS IN NEUROBIOLOGY

Metabolic Activity Determines Efficacy of Macroautophagic Clearance of Pathological Oligomeric α-Synuclein

(2009) Wai Haung Yu et al.   AMERICAN JOURNAL OF PATHOLOGY

Beclin 1 Gene Transfer Activates Autophagy and Ameliorates the Neurodegenerative Pathology in  -Synuclein Models of Parkinson's and Lewy Body Diseases

(2009) B. Spencer et al.   JOURNAL OF NEUROSCIENCE

Abberant α-Synuclein Confers Toxicity to Neurons in Part through Inhibition of Chaperone-Mediated Autophagy

(2009) Maria Xilouri et al.   PLoS One

Exogenous  -synuclein fibrils seed the formation of Lewy body-like intracellular inclusions in cultured cells

(2009) K. C. Luk et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular Mechanisms of Prion Pathogenesis

(2008) Adriano Aguzzi et al.   Annual Review of Pathology-Mechanisms of Disease

Oxidative Stress Involvement in α-Synuclein Oligomerization in Parkinson's Disease Cybrids

(2008) A. Raquel Esteves et al.   ANTIOXIDANTS & REDOX SIGNALING

A critical evaluation of current staging of α-synuclein pathology in Lewy body disorders

(2008) Kurt A. Jellinger   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Wild Type α-Synuclein Is Degraded by Chaperone-mediated Autophagy and Macroautophagy in Neuronal Cells

(2008) Tereza Vogiatzi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondrial Import and Accumulation of α-Synuclein Impair Complex I in Human Dopaminergic Neuronal Cultures and Parkinson Disease Brain

(2008) Latha Devi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Targeted Overexpression of Human α-Synuclein Triggers Microglial Activation and an Adaptive Immune Response in a Mouse Model of Parkinson Disease

(2008) Shaji Theodore et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Neuroinflammation and Oxidation/Nitration of  -Synuclein Linked to Dopaminergic Neurodegeneration

(2008) H.-M. Gao et al.   JOURNAL OF NEUROSCIENCE

Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation

(2008) Jia-Yi Li et al.   NATURE MEDICINE

Lewy body–like pathology in long-term embryonic nigral transplants in Parkinson's disease

(2008) Jeffrey H Kordower et al.   NATURE MEDICINE

Research in motion: the enigma of Parkinson's disease pathology spread

(2008) Patrik Brundin et al.   NATURE REVIEWS NEUROSCIENCE

Genetic variability in the SNCA gene influences α-synuclein levels in the blood and brain

(2007) Julia Fuchs et al.   FASEB JOURNAL