Current Strategies and Future Perspectives of Skin-on-a-Chip Platforms: Innovations, Technical Challenges and Commercial Outlook

Microfluidic platforms for modeling biological barriers in the circulatory system

(2018) Fang Yu et al.   DRUG DISCOVERY TODAY

Skin corrosion test: a comparison between reconstructed human epidermis and full thickness skin models

(2018) Carolina Motter Catarino et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Lipid nanocarriers as skin drug delivery systems: Properties, mechanisms of skin interactions and medical applications

(2018) M. Sala et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Mechanical forces in skin disorders

(2018) Chao-Kai Hsu et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

Development of 3D skin-equivalent in a pump-less microfluidic chip

(2018) Hyun Jeong Song et al.   JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY

Skin-on-a-Chip: Transepithelial Electrical Resistance and Extracellular Acidification Measurements through an Automated Air-Liquid Interface

(2018) Frank Alexander et al.   Genes

Dermal and transdermal delivery of pharmaceutically relevant macromolecules

(2017) S. Münch et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Advances in Skin Regeneration Using Tissue Engineering

(2017) Komal Vig et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Insights on in vitro models for safety and toxicity assessment of cosmetic ingredients

(2017) Andreia Almeida et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Nanofiber based drug delivery systems for skin: A promising therapeutic approach

(2017) Pallavi Kamble et al.   JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY

Fabrication of a pumpless, microfluidic skin chip from different collagen sources

(2017) Hyun Jeong Song et al.   JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY

Organ-on-a-chip devices advance to market

(2017) Boyang Zhang et al.   LAB ON A CHIP

Progress and Future Prospectives in Skin-on-Chip Development with Emphasis on the use of Different Cell Types and Technical Challenges

(2017) Lenie J. van den Broek et al.   Stem Cell Reviews and Reports

Langerhans Cells – The Macrophage in Dendritic Cell Clothing

(2017) Thomas Doebel et al.   TRENDS IN IMMUNOLOGY

Recent lab-on-chip developments for novel drug discovery

(2017) Nauman Khalid et al.   Wiley Interdisciplinary Reviews-Systems Biology and Medicine

Three-dimensional nanofiber scaffolds with arrayed holes for engineering skin tissue constructs

(2017) Lina Fu et al.   MRS Communications

Progress and Future Prospectives in Skin-on-Chip Development with Emphasis on the use of Different Cell Types and Technical Challenges

(2017) Lenie J. van den Broek et al.   Stem Cell Reviews and Reports

Noninvasive measurement of transdermal drug delivery by impedance spectroscopy

(2017) Pasquale Arpaia et al.   Scientific Reports

Role of fibroblast-derived factors in the pathogenesis of melasma

(2016) J. W. Byun et al.   CLINICAL AND EXPERIMENTAL DERMATOLOGY

Transport efficiency in transdermal drug delivery: What is the role of fluid microstructure?

(2016) Roberta Liuzzi et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Immune-competent human skin disease models

(2016) Lambert I.J.C. Bergers et al.   DRUG DISCOVERY TODAY

The role of tight junctions in skin barrier function and dermal absorption

(2016) Katja Bäsler et al.   JOURNAL OF CONTROLLED RELEASE

In vitro models for evaluating safety and efficacy of novel technologies for skin drug delivery

(2016) Viktoria Planz et al.   JOURNAL OF CONTROLLED RELEASE

Innovation in the pharmaceutical industry: New estimates of R&D costs

(2016) Joseph A. DiMasi et al.   JOURNAL OF HEALTH ECONOMICS

In vitro micro-physiological immune-competent model of the human skin

(2016) Qasem Ramadan et al.   LAB ON A CHIP

Advances in electrospun skin substitutes

(2016) J.R. Dias et al.   PROGRESS IN MATERIALS SCIENCE

Organ-on-a-Chip Systems: Microengineering to Biomimic Living Systems

(2016) Fuyin Zheng et al.   Small

Skin Bioprinting: Impending Reality or Fantasy?

(2016) Wei Long Ng et al.   TRENDS IN BIOTECHNOLOGY

Skin Diseases Modeling using Combined Tissue Engineering and Microfluidic Technologies

(2016) Mohammad Hossein Mohammadi et al.   Advanced Healthcare Materials

Human Skin Constructs with Spatially Controlled Vasculature Using Primary and iPSC-Derived Endothelial Cells

(2016) Hasan E. Abaci et al.   Advanced Healthcare Materials

Skin-on-a-chip model simulating inflammation, edema and drug-based treatment

(2016) Maierdanjiang Wufuer et al.   Scientific Reports

In vitro micro-physiological models for translational immunology

(2015) Qasem Ramadan et al.   LAB ON A CHIP

A four-organ-chip for interconnected long-term co-culture of human intestine, liver, skin and kidney equivalents

(2015) Ilka Maschmeyer et al.   LAB ON A CHIP

Pumpless microfluidic platform for drug testing on human skin equivalents

(2015) Hasan Erbil Abaci et al.   LAB ON A CHIP

Multi-layered, membrane-integrated microfluidics based on replica molding of a thiol–ene epoxy thermoset for organ-on-a-chip applications

(2015) Drago Sticker et al.   LAB ON A CHIP

Small airway-on-a-chip enables analysis of human lung inflammation and drug responses in vitro

(2015) Kambez H Benam et al.   NATURE METHODS

Organs-on-chips at the frontiers of drug discovery

(2015) Eric W. Esch et al.   NATURE REVIEWS DRUG DISCOVERY

Development of a Full-Thickness Human Skin EquivalentIn VitroModel Derived from TERT-Immortalized Keratinocytes and Fibroblasts

(2015) Christianne M.A. Reijnders et al.   TISSUE ENGINEERING PART A

MUTZ-3 derived Langerhans cells in human skin equivalents show differential migration and phenotypic plasticity after allergen or irritant exposure

(2015) Ilona J. Kosten et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Merkel cells and neurons keep in touch

(2015) Seung-Hyun Woo et al.   TRENDS IN CELL BIOLOGY

Non-animal models of epithelial barriers (skin, intestine and lung) in research, industrial applications and regulatory toxicology

(2015) Sarah Gordon   ALTEX-Alternatives to Animal Experimentation

Photocrosslinkable Gelatin Hydrogel for Epidermal Tissue Engineering

(2015) Xin Zhao et al.   Advanced Healthcare Materials

A Novel Dynamic Neonatal Blood-Brain Barrier on a Chip

(2015) Sudhir P. Deosarkar et al.   PLoS One

How multi-organ microdevices can help foster drug development

(2014) Mandy B. Esch et al.   ADVANCED DRUG DELIVERY REVIEWS

The use of skin models in drug development

(2014) Stephanie H. Mathes et al.   ADVANCED DRUG DELIVERY REVIEWS

Challenges and promises in modeling dermatologic disorders with bioengineered skin

(2014) Narat J Eungdamrong et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Organ-on-a-chip platforms for studying drug delivery systems

(2014) Nupura S. Bhise et al.   JOURNAL OF CONTROLLED RELEASE

Approaching the in vitro clinical trial: engineering organs on chips

(2014) A. K. Capulli et al.   LAB ON A CHIP

Body-on-a-chip simulation with gastrointestinal tract and liver tissues suggests that ingested nanoparticles have the potential to cause liver injury

(2014) Mandy B. Esch et al.   LAB ON A CHIP

Clinical development success rates for investigational drugs

(2014) Michael Hay et al.   NATURE BIOTECHNOLOGY

Microfluidic organs-on-chips

(2014) Sangeeta N Bhatia et al.   NATURE BIOTECHNOLOGY

Impedance Spectroscopy for the Non-Destructive Evaluation of In Vitro Epidermal Models

(2014) F. Groeber et al.   PHARMACEUTICAL RESEARCH

Advances in skin grafting and treatment of cutaneous wounds

(2014) B. K. Sun et al.   SCIENCE

Engineering Three-Dimensional Collagen-IKVAV Matrix to Mimic Neural Microenvironment

(2013) Hossein Hosseinkhani et al.   ACS Chemical Neuroscience

Microfluidic Platform for Combinatorial Synthesis and Optimization of Targeted Nanoparticles for Cancer Therapy

(2013) Pedro M. Valencia et al.   ACS Nano

Micropatterned dermal–epidermal regeneration matrices create functional niches that enhance epidermal morphogenesis

(2013) Amanda L. Clement et al.   Acta Biomaterialia

One-Step Two-Dimensional Microfluidics-Based Synthesis of Three-Dimensional Particles

(2013) Navid Hakimi et al.   ADVANCED MATERIALS

Melanosome uptake is associated with the proliferation and differentiation of keratinocytes

(2013) Hye-In Choi et al.   ARCHIVES OF DERMATOLOGICAL RESEARCH

Skin Membrane Electrical Impedance Properties under the Influence of a Varying Water Gradient

(2013) Sebastian Björklund et al.   BIOPHYSICAL JOURNAL

Fabrication of sonicated chitosan nanofiber mat with enlarged porosity for use as hemostatic materials

(2013) Bon Kang Gu et al.   CARBOHYDRATE POLYMERS

Organs-on-a-chip for drug discovery

(2013) Šeila Selimović et al.   CURRENT OPINION IN PHARMACOLOGY

Evidence-based management of common chronic lower extremity ulcers

(2013) Nicholas A. Richmond et al.   Dermatologic Therapy

Burden of Diabetic Foot Ulcers for Medicare and Private Insurers

(2013) J. Bradford Rice et al.   DIABETES CARE

Systematic Reviews of Animal Models: Methodology versus Epistemology

(2013) Ray Greek et al.   International Journal of Medical Sciences

Skin penetration enhancers

(2013) Majella E. Lane   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Efficient Keratinocyte Differentiation Strictly Depends on JNK-Induced Soluble Factors in Fibroblasts

(2013) Marion Schumacher et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Crosstalk between Keratinocytes and T Cells in a 3D Microenvironment: A Model to Study Inflammatory Skin Diseases

(2013) Ellen H. van den Bogaard et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Tissue Engineering of Skin

(2013) Rami A. Kamel et al.   JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS

Microfabricated mammalian organ systems and their integration into models of whole animals and humans

(2013) Jong H. Sung et al.   LAB ON A CHIP

Integrating biological vasculature into a multi-organ-chip microsystem

(2013) Katharina Schimek et al.   LAB ON A CHIP

Skin and hair on-a-chip: in vitro skin models versus ex vivo tissue maintenance with dynamic perfusion

(2013) Beren Ataç et al.   LAB ON A CHIP

Three-dimensional co-cultures of human endothelial cells and embryonic stem cell-derived pericytes inside a microfluidic device

(2013) Andries D. van der Meer et al.   LAB ON A CHIP

A dynamic multi-organ-chip for long-term cultivation and substance testing proven by 3D human liver and skin tissue co-culture

(2013) Ilka Wagner et al.   LAB ON A CHIP

Advanced biofabrication strategies for skin regeneration and repair

(2013) Rúben F Pereira et al.   Nanomedicine

Genomic responses in mouse models poorly mimic human inflammatory diseases

(2013) Junhee Seok et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Design and Fabrication of Human Skin by Three-Dimensional Bioprinting

(2013) Vivian Lee et al.   TISSUE ENGINEERING PART C-METHODS

The development of a 3D immunocompetent model of human skin

(2013) David Y S Chau et al.   Biofabrication

Building a microphysiological skin model from induced pluripotent stem cells

(2013) Zongyou Guo et al.   Stem Cell Research & Therapy

In vitro characterization of a chitosan skin regenerating template as a scaffold for cells cultivation

(2013) Abu Mohd Hilmi et al.   SpringerPlus

Silk fibroin biomaterials for tissue regenerations

(2012) Banani Kundu et al.   ADVANCED DRUG DELIVERY REVIEWS

Tubeless microfluidic angiogenesis assay with three-dimensional endothelial-lined microvessels

(2012) Lauren L. Bischel et al.   BIOMATERIALS

Penetration of drugs through skin, a complex rate-controlling membrane

(2012) Marie-Alexandrine Bolzinger et al.   CURRENT OPINION IN COLLOID & INTERFACE SCIENCE

Approaches for breaking the barriers of drug permeation through transdermal drug delivery

(2012) Amit Alexander et al.   JOURNAL OF CONTROLLED RELEASE

Extracellular epimorphin modulates epidermal differentiation signals mediated by epidermal growth factor receptor

(2012) Yoji Okugawa et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

Production of human tissue-engineered skin trilayer on a plasma-based hypodermis

(2012) Asun Monfort et al.   Journal of Tissue Engineering and Regenerative Medicine

Microengineered physiological biomimicry: Organs-on-Chips

(2012) Dongeun Huh et al.   LAB ON A CHIP

Human gut-on-a-chip inhabited by microbial flora that experiences intestinal peristalsis-like motions and flow

(2012) Hyun Jung Kim et al.   LAB ON A CHIP

Construction of a Microstructured Collagen Membrane Mimicking the Papillary Dermis Architecture and Guiding Keratinocyte Morphology and Gene Expression

(2012) Gerwen Lammers et al.   MACROMOLECULAR BIOSCIENCE

In vitro 3D Full-Thickness Skin-Equivalent Tissue Model Using Silk and Collagen Biomaterials

(2012) Evangelia Bellas et al.   MACROMOLECULAR BIOSCIENCE

Microfluidic assay for simultaneous culture of multiple cell types on surfaces or within hydrogels

(2012) Yoojin Shin et al.   Nature Protocols

Human Skin Model Containing Melanocytes: Essential Role of Keratinocyte Growth Factor for Constitutive Pigmentation—Functional Response to α-Melanocyte Stimulating Hormone and Forskolin

(2012) Christine Duval et al.   TISSUE ENGINEERING PART C-METHODS

Skin regeneration scaffolds: a multimodal bottom-up approach

(2012) Lara Yildirimer et al.   TRENDS IN BIOTECHNOLOGY

Tissue Engineered Human Skin Equivalents

(2012) Zheng Zhang et al.   Pharmaceutics

Skin tissue engineering — In vivo and in vitro applications

(2011) Florian Groeber et al.   ADVANCED DRUG DELIVERY REVIEWS

Organs-on-a-Chip: A Focus on Compartmentalized Microdevices

(2011) Christopher Moraes et al.   ANNALS OF BIOMEDICAL ENGINEERING

The Role of Body-on-a-Chip Devices in Drug and Toxicity Studies

(2011) M.B. Esch et al.   Annual Review of Biomedical Engineering

Biomimetic tissues on a chip for drug discovery

(2011) Amir M. Ghaemmaghami et al.   DRUG DISCOVERY TODAY

In vitro modeling of the microvascular occlusion and thrombosis that occur in hematologic diseases using microfluidic technology

(2011) Michelle Tsai et al.   JOURNAL OF CLINICAL INVESTIGATION

Technical Advance: Langerhans cells derived from a human cell line in a full-thickness skin equivalent undergo allergen-induced maturation and migration

(2011) Krista Ouwehand et al.   JOURNAL OF LEUKOCYTE BIOLOGY

A living system on a chip

(2011) Monya Baker   NATURE

A high-throughput label-free nanoparticle analyser

(2011) Jean-Luc Fraikin et al.   Nature Nanotechnology

From 3D cell culture to organs-on-chips

(2011) Dongeun Huh et al.   TRENDS IN CELL BIOLOGY

The effect of fiber alignment and heparin coating on cell infiltration into nanofibrous PLLA scaffolds

(2010) Kyle T. Kurpinski et al.   BIOMATERIALS

A microfluidic device for a pharmacokinetic–pharmacodynamic (PK–PD) model on a chip

(2010) Jong Hwan Sung et al.   LAB ON A CHIP

Simple room temperature bonding of thermoplastics and poly(dimethylsiloxane)

(2010) Vijaya Sunkara et al.   LAB ON A CHIP

How to improve R&D productivity: the pharmaceutical industry's grand challenge

(2010) Steven M. Paul et al.   NATURE REVIEWS DRUG DISCOVERY

Stress, immunity and skin collagen integrity: Evidence from animal models and clinical conditions

(2009) V. Kahan et al.   BRAIN BEHAVIOR AND IMMUNITY

Tissue engineering of skin

(2009) Sophie Böttcher-Haberzeth et al.   BURNS

Tissue-engineered skin substitutes in regenerative medicine

(2009) Jonathan N Mansbridge   CURRENT OPINION IN BIOTECHNOLOGY

Spending on new drug development

(2009) Christopher Paul Adams et al.   HEALTH ECONOMICS

H-Ras Expression in Immortalized Keratinocytes Produces an Invasive Epithelium in Cultured Skin Equivalents

(2009) Melville B. Vaughan et al.   PLoS One

Relative absorption and dermal loading of chemical substances: Consequences for risk assessment

(2009) Harrie E. Buist et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

The Phenion® Full-Thickness Skin Model for Percutaneous Absorption Testing

(2009) K. Ackermann et al.   SKIN PHARMACOLOGY AND PHYSIOLOGY

Human Embryonic Stem Cell-Derived Keratinocytes Exhibit an Epidermal Transcription Program and Undergo Epithelial Morphogenesis in Engineered Tissue Constructs

(2009) Christian M. Metallo et al.   TISSUE ENGINEERING PART A

Microcirculation in mixed arterial/venous ulcers and the surrounding skin: Clinical study using a laser Doppler perfusion imager and capillary microscopy

(2009) Ewald Ambrozy et al.   WOUND REPAIR AND REGENERATION

Cell Culture Models in Microfluidic Systems

(2008) Ivar Meyvantsson et al.   Annual Review of Analytical Chemistry

The clinical application of autologous bioengineered skin based on a hyaluronic acid scaffold

(2008) Nicolò Scuderi et al.   BIOMATERIALS

Multi-layered culture of human skin fibroblasts and keratinocytes through three-dimensional freeform fabrication

(2008) Wonhye Lee et al.   BIOMATERIALS

Matriderm® versus Integra®: A comparative experimental study

(2008) Joerg Schneider et al.   BURNS

The skin: an indispensable barrier

(2008) Ehrhardt Proksch et al.   EXPERIMENTAL DERMATOLOGY

Overexpression of Extracellular Epimorphin Leads to Impaired Epidermal Differentiation in HaCaT Keratinocytes

(2008) Yoji Okugawa et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Preparation of nanoparticles by continuous-flow microfluidics

(2008) Andreas Jahn et al.   JOURNAL OF NANOPARTICLE RESEARCH

Biomaterials for tissue engineering of skin

(2008) Sheila MacNeil   Materials Today

IFATS Collection: Using Human Adipose-Derived Stem/Stromal Cells for the Production of New Skin Substitutes

(2008) Valérie Trottier et al.   STEM CELLS

Three-Dimensional Cell Culture Matrices: State of the Art

(2008) Jungwoo Lee et al.   TISSUE ENGINEERING PART B-REVIEWS

Desmosome structure, composition and function

(2007) David Garrod et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES