Emerging routes to the generation of functional β-cells for diabetes mellitus cell therapy

Targeting the cytoskeleton to direct pancreatic differentiation of human pluripotent stem cells

(2020) Nathaniel J. Hogrebe et al.   NATURE BIOTECHNOLOGY

State of Type 1 Diabetes Management and Outcomes from the T1D Exchange in 2016–2018

(2019) Nicole C. Foster et al.   Diabetes Technology & Therapeutics

Acquisition of Dynamic Function in Human Stem Cell-Derived β Cells

(2019) Leonardo Velazco-Cruz et al.   Stem Cell Reports

Recapitulating endocrine cell clustering in culture promotes maturation of human stem-cell-derived β cells

(2019) Gopika G. Nair et al.   NATURE CELL BIOLOGY

Hypoimmunogenic derivatives of induced pluripotent stem cells evade immune rejection in fully immunocompetent allogeneic recipients

(2019) Tobias Deuse et al.   NATURE BIOTECHNOLOGY

Diabetes relief in mice by glucose-sensing insulin-secreting human α-cells

(2019) Kenichiro Furuyama et al.   NATURE

Charting cellular identity during human in vitro β-cell differentiation

(2019) Adrian Veres et al.   NATURE

Generation of hypoimmunogenic human pluripotent stem cells

(2019) Xiao Han et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Wnt Signaling Separates the Progenitor and Endocrine Compartments during Pancreas Development

(2019) Nadav Sharon et al.   Cell Reports

A review on insulin trafficking and exocytosis

(2019) Mehrdad Vakilian et al.   GENE

YAP inhibition enhances the differentiation of functional stem cell-derived insulin-producing β cells

(2019) Edwin A. Rosado-Olivieri et al.   Nature Communications

Induction of functional islet-like cells from human iPS cells by suspension culture

(2019) Shigeharu G. Yabe et al.   Regenerative Therapy

Liver to Pancreas Transdifferentiation

(2019) Irit Meivar-Levy et al.   Current Diabetes Reports

Next-generation regulatory T cell therapy

(2019) Leonardo M. R. Ferreira et al.   NATURE REVIEWS DRUG DISCOVERY

Six-Month Randomized, Multicenter Trial of Closed-Loop Control in Type 1 Diabetes

(2019) Sue A. Brown et al.   NEW ENGLAND JOURNAL OF MEDICINE

Lipid Droplet Accumulation in Human Pancreatic Islets Is Dependent On Both Donor Age and Health

(2019) Xin Tong et al.   DIABETES

Artemether Does Not Turn α Cells into β Cells

(2018) Talitha van der Meulen et al.   Cell Metabolism

Pancreatic β Cell Regeneration as a Possible Therapy for Diabetes

(2018) Cristina Aguayo-Mazzucato et al.   Cell Metabolism

Endogenous Reprogramming of Alpha Cells into Beta Cells, Induced by Viral Gene Therapy, Reverses Autoimmune Diabetes

(2018) Xiangwei Xiao et al.   Cell Stem Cell

Synaptotagmin 4 Regulates Pancreatic β Cell Maturation by Modulating the Ca 2+ Sensitivity of Insulin Secretion Vesicles

(2018) Chen Huang et al.   DEVELOPMENTAL CELL

Economic Costs of Diabetes in the U.S. in 2017

(2018)   DIABETES CARE

The role of beta cell heterogeneity in islet function and insulin release

(2018) Daniela Nasteska et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Derivation of Cortical Spheroids from Human Induced Pluripotent Stem Cells in a Suspension Bioreactor

(2018) Yuanwei Yan et al.   TISSUE ENGINEERING PART A

Artificial pancreas treatment for outpatients with type 1 diabetes: systematic review and meta-analysis

(2018) Eleni Bekiari et al.   BMJ-British Medical Journal

Artificial pancreas treatment for outpatients with type 1 diabetes: systematic review and meta-analysis

(2018) Eleni Bekiari et al.   BMJ-British Medical Journal

Expansion of Adult Human Pancreatic Tissue Yields Organoids Harboring Progenitor Cells with Endocrine Differentiation Potential

(2018) Cindy J.M. Loomans et al.   Stem Cell Reports

A Rapamycin-Based GMP-Compatible Process for the Isolation and Expansion of Regulatory T Cells for Clinical Trials

(2018) Henrieta Fraser et al.   Molecular Therapy-Methods & Clinical Development

GABA and Artesunate Do Not Induce Pancreatic α-to-β Cell Transdifferentiation In Vivo

(2018) Amanda M. Ackermann et al.   Cell Metabolism

Glucagon-Like Peptide-1 Increases Beta Cell Regeneration by Promoting Alpha- to Beta-Cell Transdifferentiation

(2018) Young-Sun Lee et al.   DIABETES

Ectonucleoside Triphosphate Diphosphohydrolase-3 Antibody Targets Adult Human Pancreatic β Cells for In Vitro and In Vivo Analysis

(2018) Diane C. Saunders et al.   Cell Metabolism

Post-Transplant Characterization of Long-Term Functional hESC-Derived Pancreatic Endoderm Grafts

(2018) Andrew R. Pepper et al.   DIABETES

Closed-loop insulin delivery in suboptimally controlled type 1 diabetes: a multicentre, 12-week randomised trial

(2018) Martin Tauschmann et al.   LANCET

Mechanosignalling via integrins directs fate decisions of pancreatic progenitors

(2018) Anant Mamidi et al.   NATURE

The Difference δ-Cells Make in Glucose Control

(2018) Mark O. Huising et al.   PHYSIOLOGY

Single-Cell Transcriptome Profiling of Mouse and hESC-Derived Pancreatic Progenitors

(2018) Nicole A.J. Krentz et al.   Stem Cell Reports

Production of pancreatic progenitor cells from human induced pluripotent stem cells using a three-dimensional suspension bioreactor system

(2017) Yuichiro Mihara et al.   Journal of Tissue Engineering and Regenerative Medicine

Synthetic beta cells for fusion-mediated dynamic insulin secretion

(2017) Zhaowei Chen et al.   Nature Chemical Biology

Mechanical forces direct stem cell behaviour in development and regeneration

(2017) Kyle H. Vining et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Reprogramming human gallbladder cells into insulin-producing β-like cells

(2017) Feorillo Galivo et al.   PLoS One

Smartphone-controlled optogenetically engineered cells enable semiautomatic glucose homeostasis in diabetic mice

(2017) Jiawei Shao et al.   Science Translational Medicine

Optimizing Human Induced Pluripotent Stem Cell Expansion in Stirred-Suspension Culture

(2017) Guoliang Meng et al.   STEM CELLS AND DEVELOPMENT

Stepwise reprogramming of liver cells to a pancreas progenitor state by the transcriptional regulator Tgif2

(2017) Nuria Cerdá-Esteban et al.   Nature Communications

Disallowed and Allowed Gene Expression: Two Faces of Mature Islet Beta Cells

(2016) Katleen Lemaire et al.   Annual Review of Nutrition

Beta Cell Hubs Dictate Pancreatic Islet Responses to Glucose

(2016) Natalie R. Johnston et al.   Cell Metabolism

Age-Dependent Pancreatic Gene Regulation Reveals Mechanisms Governing Human β Cell Function

(2016) H. Efsun Arda et al.   Cell Metabolism

ERRγ Is Required for the Metabolic Maturation of Therapeutically Functional Glucose-Responsive β Cells

(2016) Eiji Yoshihara et al.   Cell Metabolism

Dclk1 Defines Quiescent Pancreatic Progenitors that Promote Injury-Induced Regeneration and Tumorigenesis

(2016) C. Benedikt Westphalen et al.   Cell Stem Cell

Reprogrammed Stomach Tissue as a Renewable Source of Functional β Cells for Blood Glucose Regulation

(2016) Chaiyaboot Ariyachet et al.   Cell Stem Cell

Hypothyroidism Impairs Human Stem Cell–Derived Pancreatic Progenitor Cell Maturation in Mice

(2016) Jennifer E. Bruin et al.   DIABETES

Identification of proliferative and mature β-cells in the islets of Langerhans

(2016) Erik Bader et al.   NATURE

Quality cell therapy manufacturing by design

(2016) Yonatan Y Lipsitz et al.   NATURE BIOTECHNOLOGY

Advances in islet encapsulation technologies

(2016) Tejal Desai et al.   NATURE REVIEWS DRUG DISCOVERY

Clinical pancreatic islet transplantation

(2016) A. M. James Shapiro et al.   Nature Reviews Endocrinology

 -cell-mimetic designer cells provide closed-loop glycemic control

(2016) M. Xie et al.   SCIENCE

Impact of Feeding Strategies on the Scalable Expansion of Human Pluripotent Stem Cells in Single-Use Stirred Tank Bioreactors

(2016) Christina Kropp et al.   Stem Cells Translational Medicine

Day and night glycaemic control with a bionic pancreas versus conventional insulin pump therapy in preadolescent children with type 1 diabetes: a randomised crossover trial

(2016) Steven J Russell et al.   Lancet Diabetes & Endocrinology

Engineering Xeno-Free Microcarriers with Recombinant Vitronectin, Albumin and UV Irradiation for Human Pluripotent Stem Cell Bioprocessing

(2016) Yongjia Fan et al.   ACS Biomaterials-Science & Engineering

Engineering Xeno-Free Microcarriers with Recombinant Vitronectin, Albumin and UV Irradiation for Human Pluripotent Stem Cell Bioprocessing

(2016) Yongjia Fan et al.   ACS Biomaterials Science & Engineering

Dynamics of glucose-induced insulin secretion in normal human islets

(2015) Jean-Claude Henquin et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Pancreatic β-cell identity, glucose sensing and the control of insulin secretion

(2015) Guy A. Rutter et al.   BIOCHEMICAL JOURNAL

Islet formation in mice and men: lessons for the generation of functional insulin-producing β-cells from human pluripotent stem cells

(2015) Gopika Nair et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Controlled induction of human pancreatic progenitors produces functional beta-like cells in vitro

(2015) H. A. Russ et al.   EMBO JOURNAL

Isocitrate-to-SENP1 signaling amplifies insulin secretion and rescues dysfunctional β cells

(2015) Mourad Ferdaoussi et al.   JOURNAL OF CLINICAL INVESTIGATION

Urocortin3 mediates somatostatin-dependent negative feedback control of insulin secretion

(2015) Talitha van der Meulen et al.   NATURE MEDICINE

Type 1 diabetes immunotherapy using polyclonal regulatory T cells

(2015) Jeffrey A. Bluestone et al.   Science Translational Medicine

Adenylosuccinate Is an Insulin Secretagogue Derived from Glucose-Induced Purine Metabolism

(2015) Jessica R. Gooding et al.   Cell Reports

Concise Review: Manufacturing of Pancreatic Endoderm Cells for Clinical Trials in Type 1 Diabetes

(2015) Thomas C. Schulz   Stem Cells Translational Medicine

Understanding Pharmaceutical Quality by Design

(2014) Lawrence X. Yu et al.   AAPS Journal

Composition and function of macroencapsulated human embryonic stem cell-derived implants: comparison with clinical human islet cell grafts

(2014) Evi Motté et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Incretins and Amylin: Neuroendocrine Communication Between the Gut, Pancreas, and Brain in Control of Food Intake and Blood Glucose

(2014) Matthew R. Hayes et al.   Annual Review of Nutrition

Generation of Functional Human Pancreatic β Cells In Vitro

(2014) Felicia W. Pagliuca et al.   CELL

α/β-Hydrolase Domain-6-Accessible Monoacylglycerol Controls Glucose-Stimulated Insulin Secretion

(2014) Shangang Zhao et al.   Cell Metabolism

Effect of Intensive Diabetes Therapy on the Progression of Diabetic Retinopathy in Patients With Type 1 Diabetes: 18 Years of Follow-up in the DCCT/EDIC

(2014)   DIABETES

High Oxygen Condition Facilitates the Differentiation of Mouse and Human Pluripotent Stem Cells into Pancreatic Progenitors and Insulin-producing Cells

(2014) Farzana Hakim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Diabetes recovery by age-dependent conversion of pancreatic δ-cells into insulin producers

(2014) Simona Chera et al.   NATURE

Reversal of diabetes with insulin-producing cells derived in vitro from human pluripotent stem cells

(2014) Alireza Rezania et al.   NATURE BIOTECHNOLOGY

The Temporal and Hierarchical Control of Transcription Factors-Induced Liver to Pancreas Transdifferentiation

(2014) Dana Berneman-Zeitouni et al.   PLoS One

De Novo Formation of Insulin-Producing “Neo-β Cell Islets” from Intestinal Crypts

(2014) Yi-Ju Chen et al.   Cell Reports

Controlling Expansion and Cardiomyogenic Differentiation of Human Pluripotent Stem Cells in Scalable Suspension Culture

(2014) Henning Kempf et al.   Stem Cell Reports

Interactions between the central nervous system and pancreatic islet secretions: a historical perspective

(2013) Denovan P. Begg et al.   ADVANCES IN PHYSIOLOGY EDUCATION

Suppression of Epithelial-to-Mesenchymal Transitioning Enhances Ex Vivo Reprogramming of Human Exocrine Pancreatic Tissue Toward Functional Insulin-Producing β-Like Cells

(2013) Maria João Lima et al.   DIABETES

Thyroid Hormone Promotes Postnatal Rat Pancreatic  -Cell Development and Glucose-Responsive Insulin Secretion Through MAFA

(2013) C. Aguayo-Mazzucato et al.   DIABETES

SMAD2 disruption in mouse pancreatic beta cells leads to islet hyperplasia and impaired insulin secretion due to the attenuation of ATP-sensitive K+ channel activity

(2013) Masatoshi Nomura et al.   DIABETOLOGIA

Mechanisms of Hypoglycemia-Associated Autonomic Failure in Diabetes

(2013) Philip E. Cryer   NEW ENGLAND JOURNAL OF MEDICINE

Factorial Experimental Design for the Culture of Human Embryonic Stem Cells as Aggregates in Stirred Suspension Bioreactors Reveals the Potential for Interaction Effects Between Bioprocess Parameters

(2013) Megan M. Hunt et al.   TISSUE ENGINEERING PART C-METHODS

Glucose-stimulated insulin secretion: A newer perspective

(2013) Mitsuhisa Komatsu et al.   Journal of Diabetes Investigation

Nkx6.1 Is Essential for Maintaining the Functional State of Pancreatic Beta Cells

(2013) Brandon L. Taylor et al.   Cell Reports

Regulatory T-Cell Therapy in Transplantation: Moving to the Clinic

(2013) Q. Tang et al.   Cold Spring Harbor Perspectives in Medicine

The Inactivation of Arx in Pancreatic α-Cells Triggers Their Neogenesis and Conversion into Functional β-Like Cells

(2013) Monica Courtney et al.   PLoS Genetics

Generating an iPSC Bank for HLA-Matched Tissue Transplantation Based on Known Donor and Recipient HLA Types

(2012) Craig J. Taylor et al.   Cell Stem Cell

Maturation of Human Embryonic Stem Cell-Derived Pancreatic Progenitors Into Functional Islets Capable of Treating Pre-existing Diabetes in Mice

(2012) A. Rezania et al.   DIABETES

Administration of CD4+CD25highCD127- Regulatory T Cells Preserves  -Cell Function in Type 1 Diabetes in Children

(2012) N. Marek-Trzonkowska et al.   DIABETES CARE

Improvement in Outcomes of Clinical Islet Transplantation: 1999-2010

(2012) F. B. Barton et al.   DIABETES CARE

The metabolic and toxicological considerations for immunosuppressive drugs used during pancreas transplantation

(2012) Erika B Rangel   Expert Opinion on Drug Metabolism & Toxicology

Clinical scale rapid expansion of lymphocytes for adoptive cell transfer therapy in the WAVE® bioreactor

(2012) Robert PT Somerville et al.   Journal of Translational Medicine

Pax6 Is Crucial for β-Cell Function, Insulin Biosynthesis, and Glucose-Induced Insulin Secretion

(2012) Yvan Gosmain et al.   MOLECULAR ENDOCRINOLOGY

Intrapatient Variations in Type 1 Diabetes-specific iPS Cell Differentiation Into Insulin-producing Cells

(2012) Tayaramma Thatava et al.   MOLECULAR THERAPY

Functional beta-cell maturation is marked by an increased glucose threshold and by expression of urocortin 3

(2012) Barak Blum et al.   NATURE BIOTECHNOLOGY

Generation of functional insulin-producing cells in the gut by Foxo1 ablation

(2012) Chutima Talchai et al.   NATURE GENETICS

Microcarrier Suspension Cultures for High-Density Expansion and Differentiation of Human Pluripotent Stem Cells to Neural Progenitor Cells

(2012) Jo'an Bardy et al.   TISSUE ENGINEERING PART C-METHODS

Immunohistochemical characterisation of cells co-producing insulin and glucagon in the developing human pancreas

(2011) M. J. Riedel et al.   DIABETOLOGIA

Activin, BMP and FGF pathways cooperate to promote endoderm and pancreatic lineage cell differentiation from human embryonic stem cells

(2011) Xiaofang Xu et al.   MECHANISMS OF DEVELOPMENT

A Synthetic Optogenetic Transcription Device Enhances Blood-Glucose Homeostasis in Mice

(2011) H. Ye et al.   SCIENCE

The Role of Human Leukocyte Antigen Matching in the Development of Multiethnic “Haplobank” of Induced Pluripotent Stem Cell Lines

(2011) Pierre-Antoine Gourraud et al.   STEM CELLS

Functional assessment of automatically sorted pancreatic islets using large particle flow cytometry

(2011) Anja Steffen et al.   Islets

Pancreatic β Cells Require NeuroD to Achieve and Maintain Functional Maturity

(2010) Chunyan Gu et al.   Cell Metabolism

Cardiac Cell Generation from Encapsulated Embryonic Stem Cells in Static and Scalable Culture Systems

(2010) Donghui Jing et al.   CELL TRANSPLANTATION

Production of Functional Glucagon-Secreting  -Cells From Human Embryonic Stem Cells

(2010) A. Rezania et al.   DIABETES

Regulation of insulin secretion: role of mitochondrial signalling

(2010) S. Jitrapakdee et al.   DIABETOLOGIA

Tissue-specific disallowance of housekeeping genes: The other face of cell differentiation

(2010) L. Thorrez et al.   GENOME RESEARCH

Quantitative analysis of cell composition and purity of human pancreatic islet preparations

(2010) Anna Pisania et al.   LABORATORY INVESTIGATION

Conversion of adult pancreatic α-cells to β-cells after extreme β-cell loss

(2010) Fabrizio Thorel et al.   NATURE

The Senescence-Related Mitochondrial/Oxidative Stress Pathway is Repressed in Human Induced Pluripotent Stem Cells

(2010) Alessandro Prigione et al.   STEM CELLS

Identification of genes selectively disallowed in the pancreatic islet

(2010) Timothy J. Pullen et al.   Islets

Oxygen Tension Regulates Pancreatic  -Cell Differentiation Through Hypoxia-Inducible Factor 1 

(2009) M. Heinis et al.   DIABETES

Transforming Growth Factor-β/Smad3 Signaling Regulates Insulin Gene Transcription and Pancreatic Islet β-Cell Function

(2009) Huei-Min Lin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Expansion and Differentiation of Human Embryonic Stem Cells to Endoderm Progeny in a Microcarrier Stirred-Suspension Culture

(2009) Lye T. Lock et al.   TISSUE ENGINEERING PART A

Scalable Stirred-Suspension Bioreactor Culture of Human Pluripotent Stem Cells

(2009) Daniel E. Kehoe et al.   TISSUE ENGINEERING PART A

Large-Scale Expansion of Pluripotent Human Embryonic Stem Cells in Stirred-Suspension Bioreactors

(2009) Roman Krawetz et al.   TISSUE ENGINEERING PART C-METHODS

In vivo reprogramming of adult pancreatic exocrine cells to β-cells

(2008) Qiao Zhou et al.   NATURE

Pancreatic endoderm derived from human embryonic stem cells generates glucose-responsive insulin-secreting cells in vivo

(2008) Evert Kroon et al.   NATURE BIOTECHNOLOGY

HLA-haplotype banking and iPS cells

(2008) Norio Nakatsuji et al.   NATURE BIOTECHNOLOGY