The role of beta cell heterogeneity in islet function and insulin release

Conditional and Reversible Activation of Class A and B G Protein-Coupled Receptors Using Tethered Pharmacology

(2018) Tom Podewin et al.   ACS Central Science

Glucose but not KCl diminishes submembrane granule turnover in mouse beta-cells

(2017) Dennis Brüning et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

δ-cells and β-cells are electrically coupled and regulate α-cell activity via somatostatin

(2017) L. J. B. Briant et al.   JOURNAL OF PHYSIOLOGY-LONDON

Dual optical control and mechanistic insights into photoswitchable group II and III metabotropic glutamate receptors

(2017) Joshua Levitz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Deconstructing behavioral neuropharmacology with cellular specificity

(2017) Brenda C. Shields et al.   SCIENCE

Optical control of GPR40 signalling in pancreatic β-cells

(2017) James Allen Frank et al.   Chemical Science

Different developmental histories of beta-cells generate functional and proliferative heterogeneity during islet growth

(2017) Sumeet Pal Singh et al.   Nature Communications

Remote control of glucose homeostasis in vivo using photopharmacology

(2017) Zenobia B. Mehta et al.   Scientific Reports

Pancreatic Islet Blood Flow Dynamics in Primates

(2017) Juan A. Diez et al.   Cell Reports

Interrogating islets in health and disease with single-cell technologies

(2017) Andrea C. Carrano et al.   Molecular Metabolism

Heterogeneity of the Pancreatic Beta Cell

(2017) Giselle Dominguez Gutierrez et al.   Frontiers in Genetics

Quantitative Live Single-cell Mass Spectrometry with Spatial Evaluation by Three-Dimensional Holographic and Tomographic Laser Microscopy

(2016) Ahmed ALI et al.   ANALYTICAL SCIENCES

Allosteric Optical Control of a Class B G-Protein-Coupled Receptor

(2016) Johannes Broichhagen et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Beta Cell Hubs Dictate Pancreatic Islet Responses to Glucose

(2016) Natalie R. Johnston et al.   Cell Metabolism

Liraglutide Compromises Pancreatic β Cell Function in a Humanized Mouse Model

(2016) Midhat H. Abdulreda et al.   Cell Metabolism

Single-Cell Mass Cytometry Analysis of the Human Endocrine Pancreas

(2016) Yue J. Wang et al.   Cell Metabolism

The Genetic Program of Pancreatic β-Cell Replication In Vivo

(2016) Agnes Klochendler et al.   DIABETES

Single-Cell Transcriptomics of the Human Endocrine Pancreas

(2016) Yue J. Wang et al.   DIABETES

Single-cell transcriptomes identify human islet cell signatures and reveal cell-type–specific expression changes in type 2 diabetes

(2016) Nathan Lawlor et al.   GENOME RESEARCH

Worldwide trends in diabetes since 1980: a pooled analysis of 751 population-based studies with 4·4 million participants

(2016)   LANCET

Identification of proliferative and mature β-cells in the islets of Langerhans

(2016) Erik Bader et al.   NATURE

An updated view of hypothalamic–vascular–pituitary unit function and plasticity

(2016) Paul Le Tissier et al.   Nature Reviews Endocrinology

Metabolomics: beyond biomarkers and towards mechanisms

(2016) Caroline H. Johnson et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Brain Insulin Resistance at the Crossroads of Metabolic and Cognitive Disorders in Humans

(2016) Stephanie Kullmann et al.   PHYSIOLOGICAL REVIEWS

Use of the Fluidigm C1 platform for RNA sequencing of single mouse pancreatic islet cells

(2016) Yurong Xin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human islets contain four distinct subtypes of β cells

(2016) Craig Dorrell et al.   Nature Communications

Spatially coordinated dynamic gene transcription in living pituitary tissue

(2016) Karen Featherstone et al.   eLife

The incretin effect in healthy individuals and those with type 2 diabetes: physiology, pathophysiology, and response to therapeutic interventions

(2016) Michael A Nauck et al.   Lancet Diabetes & Endocrinology

A Single-Cell Transcriptome Atlas of the Human Pancreas

(2016) Mauro J. Muraro et al.   Cell Systems

A Single-Cell Transcriptomic Map of the Human and Mouse Pancreas Reveals Inter- and Intra-cell Population Structure

(2016) Maayan Baron et al.   Cell Systems

Non-invasive cell type selective in vivo monitoring of insulin resistance dynamics

(2016) Meike Paschen et al.   Scientific Reports

Optical Control of Insulin Secretion Using an Incretin Switch

(2015) Johannes Broichhagen et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Pancreatic β-cell identity, glucose sensing and the control of insulin secretion

(2015) Guy A. Rutter et al.   BIOCHEMICAL JOURNAL

A red-shifted photochromic sulfonylurea for the remote control of pancreatic beta cell function

(2015) J. Broichhagen et al.   CHEMICAL COMMUNICATIONS

Metabolism Regulates Exposure of Pancreatic Islets to Circulating Molecules In Vivo

(2015) Aurélien Michau et al.   DIABETES

Monitoring C-Peptide Storage and Secretion in Islet β-Cells In Vitro and In Vivo

(2015) Shuaishuai Zhu et al.   DIABETES

Spatial and temporal coordination of insulin granule exocytosis in intact human pancreatic islets

(2015) Joana Almaça et al.   DIABETOLOGIA

Optogenetic control of insulin secretion by pancreatic β-cells in vitro and in vivo

(2015) T Kushibiki et al.   GENE THERAPY

Single-cell technologies are revolutionizing the approach to rare cells

(2015) Valentina Proserpio et al.   IMMUNOLOGY AND CELL BIOLOGY

Low Level Pro-inflammatory Cytokines Decrease Connexin36 Gap Junction Coupling in Mouse and Human Islets through Nitric Oxide-mediated Protein Kinase Cδ

(2015) Nikki L. Farnsworth et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Aged insulin granules display reduced microtubule-dependent mobility and are disposed within actin-positive multigranular bodies

(2015) Peter Hoboth et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Orthogonal Optical Control of a G Protein-Coupled Receptor with a SNAP-Tethered Photochromic Ligand

(2015) Johannes Broichhagen et al.   ACS Central Science

How Many Genes Are Expressed in a Transcriptome? Estimation and Results for RNA-Seq

(2015) Luis Fernando García-Ortega et al.   PLoS One

Testing Pancreatic Islet Function at the Single Cell Level by Calcium Influx with Associated Marker Expression

(2015) Jennifer H. R. Kenty et al.   PLoS One

Patch Clamp Electrophysiology and Capillary Electrophoresis–Mass Spectrometry Metabolomics for Single Cell Characterization

(2014) Jordan T. Aerts et al.   ANALYTICAL CHEMISTRY

Intrinsic Islet Heterogeneity and Gap Junction Coupling Determine Spatiotemporal Ca2+ Wave Dynamics

(2014) Richard K.P. Benninger et al.   BIOPHYSICAL JOURNAL

Beta cell connectivity in pancreatic islets: a type 2 diabetes target?

(2014) Guy A. Rutter et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

ADCY5 Couples Glucose to Insulin Secretion in Human Islets

(2014) D. J. Hodson et al.   DIABETES

The MafA Transcription Factor Becomes Essential to Islet β-Cells Soon After Birth

(2014) Yan Hang et al.   DIABETES

Insulin Therapy in People With Type 2 Diabetes: Opportunities and Challenges?

(2014) Philip Home et al.   DIABETES CARE

β-Cell Failure in Type 2 Diabetes: Postulated Mechanisms and Prospects for Prevention and Treatment

(2014) Philippe A. Halban et al.   DIABETES CARE

The secretory deficit in islets from db/db mice is mainly due to a loss of responding beta cells

(2014) Oanh H. Do et al.   DIABETOLOGIA

Insulin secretion from beta cells in intact mouse islets is targeted towards the vasculature

(2014) Jiun T. Low et al.   DIABETOLOGIA

Selective disruption of Tcf7l2 in the pancreatic β cell impairs secretory function and lowers β cell mass

(2014) Ryan K. Mitchell et al.   HUMAN MOLECULAR GENETICS

Pancreatic and Duodenal Homeobox Protein 1 (Pdx-1) Maintains Endoplasmic Reticulum Calcium Levels through Transcriptional Regulation of Sarco-endoplasmic Reticulum Calcium ATPase 2b (SERCA2b) in the Islet β Cell

(2014) Justin S. Johnson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Photopharmacology: Beyond Proof of Principle

(2014) Willem A. Velema et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Transcriptome in vivo analysis (TIVA) of spatially defined single cells in live tissue

(2014) Ditte Lovatt et al.   NATURE METHODS

Highly multiplexed imaging of tumor tissues with subcellular resolution by mass cytometry

(2014) Charlotte Giesen et al.   NATURE METHODS

Cellular communication and heterogeneity in pancreatic islet insulin secretion dynamics

(2014) Richard K.P. Benninger et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Ciliary dysfunction impairs beta-cell insulin secretion and promotes development of type 2 diabetes in rodents

(2014) Jantje M. Gerdes et al.   Nature Communications

Optical control of insulin release using a photoswitchable sulfonylurea

(2014) Johannes Broichhagen et al.   Nature Communications

Optogenetic control of insulin secretion in intact pancreatic islets with β-cell-specific expression of Channelrhodopsin-2

(2014) Thomas M Reinbothe et al.   Islets

Pharmacology, Physiology, and Mechanisms of Incretin Hormone Action

(2013) Jonathan E. Campbell et al.   Cell Metabolism

Implanted islets in the anterior chamber of the eye are prone to autoimmune attack in a mouse model of diabetes

(2013) Majid Mojibian et al.   DIABETOLOGIA

Oscillations of sub-membrane ATP in glucose-stimulated beta cells depend on negative feedback from Ca2+

(2013) J. Li et al.   DIABETOLOGIA

Glucose principally regulates insulin secretion in mouse islets by controlling the numbers of granule fusion events per cell

(2013) Jiun T. Low et al.   DIABETOLOGIA

Lipotoxicity disrupts incretin-regulated human β cell connectivity

(2013) David J. Hodson et al.   JOURNAL OF CLINICAL INVESTIGATION

Minireview: Intraislet Regulation of Insulin Secretion in Humans

(2013) Guy A. Rutter et al.   MOLECULAR ENDOCRINOLOGY

Mechanisms of Diabetic Complications

(2013) Josephine M. Forbes et al.   PHYSIOLOGICAL REVIEWS

Glucose-Stimulated Calcium Dynamics in Islets of Langerhans in Acute Mouse Pancreas Tissue Slices

(2013) Andraž Stožer et al.   PLoS One

Mass spectrometry-based metabolomics of single yeast cells

(2013) A. J. Ibanez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of Insulin Secretion in Human Pancreatic Islets

(2012) Patrik Rorsman et al.   Annual Review of Physiology

Mechanisms for Insulin Resistance: Common Threads and Missing Links

(2012) Varman T. Samuel et al.   CELL

Connexin-36 Gap Junctions Regulate In Vivo First- and Second-Phase Insulin Secretion Dynamics and Glucose Tolerance in the Conscious Mouse

(2012) W. S. Head et al.   DIABETES

Functional beta-cell maturation is marked by an increased glucose threshold and by expression of urocortin 3

(2012) Barak Blum et al.   NATURE BIOTECHNOLOGY

Optogenetic silencing strategies differ in their effects on inhibitory synaptic transmission

(2012) Joseph V Raimondo et al.   NATURE NEUROSCIENCE

Noninvasive in vivo model demonstrating the effects of autonomic innervation on pancreatic islet function

(2012) R. Rodriguez-Diaz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Existence of long-lasting experience-dependent plasticity in endocrine cell networks

(2012) David J. Hodson et al.   Nature Communications

Molecular mechanisms underlying bile acid-stimulated glucagon-like peptide-1 secretion

(2011) HE Parker et al.   BRITISH JOURNAL OF PHARMACOLOGY

Paracrine signalling loops in adult human and mouse pancreatic islets: netrins modulate beta cell apoptosis signalling via dependence receptors

(2011) Y. H. C. Yang et al.   DIABETOLOGIA

Pulsatile patterns of pituitary hormone gene expression change during development

(2011) K. Featherstone et al.   JOURNAL OF CELL SCIENCE

Nutrient detection by incretin hormone secreting cells

(2011) Eleftheria Diakogiannaki et al.   PHYSIOLOGY & BEHAVIOR

Molecular physiology of glucagon-like peptide-1 insulin secretagogue action in pancreatic β cells

(2011) Colin A. Leech et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

Glucose-dependent blood flow dynamics in murine pancreatic islets in vivo

(2010) Lara R. Nyman et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Is the Diminished Incretin Effect in Type 2 Diabetes Just an Epi-Phenomenon of Impaired  -Cell Function?

(2010) J. J. Meier et al.   DIABETES

Unique Arrangement of  - and  -Cells in Human Islets of Langerhans

(2010) D. Bosco et al.   DIABETES

RNA sequencing: advances, challenges and opportunities

(2010) Fatih Ozsolak et al.   NATURE REVIEWS GENETICS

Pituitary growth hormone network responses are sexually dimorphic and regulated by gonadal steroids in adulthood

(2010) C. Sanchez-Cardenas et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pancreatic islet plasticity: Interspecies comparison of islet architecture and composition

(2010) Donald J. Steiner et al.   Islets

Rescuing the Subprime Meltdown in Insulin Exocytosis in Diabetes

(2009) Edwin P. Kwan et al.   Annals of the New York Academy of Sciences

Pdx1 (MODY4) regulates pancreatic beta cell susceptibility to ER stress

(2009) Mira M. Sachdeva et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Gap Junction Coupling and Calcium Waves in the Pancreatic Islet

(2008) Richard K.P. Benninger et al.   BIOPHYSICAL JOURNAL

Insulin secretion from human beta cells is heterogeneous and dependent on cell-to-cell contacts

(2008) A. Wojtusciszyn et al.   DIABETOLOGIA

Maturation of Adult β-Cells Revealed Using aPdx1/InsulinDual-Reporter Lentivirus

(2008) Marta Szabat et al.   ENDOCRINOLOGY

Real-time, multidimensional in vivo imaging used to investigate blood flow in mouse pancreatic islets

(2008) Lara R. Nyman et al.   JOURNAL OF CLINICAL INVESTIGATION

Noninvasive in vivo imaging of pancreatic islet cell biology

(2008) Stephan Speier et al.   NATURE MEDICINE

Noninvasive high-resolution in vivo imaging of cell biology in the anterior chamber of the mouse eye

(2008) Stephan Speier et al.   Nature Protocols

Kiss-and-run exocytosis and fusion pores of secretory vesicles in human β-cells

(2008) Salma T. Hanna et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Cell coupling in mouse pancreatic  -cells measured in intact islets of Langerhans

(2008) Q. Zhang et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES