Diabetes relief in mice by glucose-sensing insulin-secreting human α-cells

Artemether Does Not Turn α Cells into β Cells

(2018) Talitha van der Meulen et al.   Cell Metabolism

Endogenous Reprogramming of Alpha Cells into Beta Cells, Induced by Viral Gene Therapy, Reverses Autoimmune Diabetes

(2018) Xiangwei Xiao et al.   Cell Stem Cell

Integrating single-cell transcriptomic data across different conditions, technologies, and species

(2018) Andrew Butler et al.   NATURE BIOTECHNOLOGY

Pancreas regeneration

(2018) Qiao Zhou et al.   NATURE

Pancreatic islet-autonomous insulin and smoothened-mediated signalling modulate identity changes of glucagon+ α-cells

(2018) Valentina Cigliola et al.   NATURE CELL BIOLOGY

Autoimmunity against a defective ribosomal insulin gene product in type 1 diabetes

(2017) Maria J L Kracht et al.   NATURE MEDICINE

Single-cell mRNA quantification and differential analysis with Census

(2017) Xiaojie Qiu et al.   NATURE METHODS

Reversed graph embedding resolves complex single-cell trajectories

(2017) Xiaojie Qiu et al.   NATURE METHODS

PDX1, Neurogenin-3, and MAFA: critical transcription regulators for beta cell development and regeneration

(2017) Yaxi Zhu et al.   Stem Cell Research & Therapy

Age-Dependent Pancreatic Gene Regulation Reveals Mechanisms Governing Human β Cell Function

(2016) H. Efsun Arda et al.   Cell Metabolism

Single-Cell Transcriptome Profiling of Human Pancreatic Islets in Health and Type 2 Diabetes

(2016) Åsa Segerstolpe et al.   Cell Metabolism

Regeneration of pancreatic insulin-producing cells by in situ adaptive cell conversion

(2016) Simona Chera et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Immunogenicity of human embryonic stem cell-derived beta cells

(2016) Cornelis R. van der Torren et al.   DIABETOLOGIA

Insulin Knockout Mice Have Extended Survival but Volatile Blood Glucose Levels on Leptin Therapy

(2016) Ursula H. Neumann et al.   ENDOCRINOLOGY

A Triple Knockout (TKO) Proteomics Standard for Diagnosing Ion Interference in Isobaric Labeling Experiments

(2016) Joao A. Paulo et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Human islets contain four distinct subtypes of β cells

(2016) Craig Dorrell et al.   Nature Communications

Blockade of glucagon signaling prevents or reverses diabetes onset only if residual β-cells persist

(2016) Nicolas Damond et al.   eLife

Innate and adaptive immunity to human beta cell lines: implications for beta cell therapy

(2015) Cornelis R. van der Torren et al.   DIABETOLOGIA

A cis-eQTL in PFKFB2 is associated with diabetic nephropathy, adiposity and insulin secretion in American Indians

(2015) Yunhua L. Muller et al.   HUMAN MOLECULAR GENETICS

Controlled aggregation of primary human pancreatic islet cells leads to glucose-responsive pseudoislets comparable to native islets

(2015) Janneke Hilderink et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

MultiNotch MS3 Enables Accurate, Sensitive, and Multiplexed Detection of Differential Expression across Cancer Cell Line Proteomes

(2014) Graeme C. McAlister et al.   ANALYTICAL CHEMISTRY

Summary of the Keystone Islet Workshop (April 2014): The Increasing Demand for Human Islet Availability in Diabetes Research

(2014) R. N. Kulkarni et al.   DIABETES

Diabetes recovery by age-dependent conversion of pancreatic δ-cells into insulin producers

(2014) Simona Chera et al.   NATURE

Reversal of diabetes with insulin-producing cells derived in vitro from human pluripotent stem cells

(2014) Alireza Rezania et al.   NATURE BIOTECHNOLOGY

A comprehensive proteomic and phosphoproteomic analysis of yeast deletion mutants of 14-3-3 orthologs and associated effects of rapamycin

(2014) Joao A. Paulo et al.   PROTEOMICS

Ectonucleotidase NTPDase3 is abundant in pancreatic β-cells and regulates glucose-induced insulin secretion

(2013) Samreen K. Syed et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Marked Expansion of Exocrine and Endocrine Pancreas With Incretin Therapy in Humans With Increased Exocrine Pancreas Dysplasia and the Potential for Glucagon-Producing Neuroendocrine Tumors

(2013) A. E. Butler et al.   DIABETES

Suppression of Epithelial-to-Mesenchymal Transitioning Enhances Ex Vivo Reprogramming of Human Exocrine Pancreatic Tissue Toward Functional Insulin-Producing β-Like Cells

(2013) Maria João Lima et al.   DIABETES

Conversion of Mature Human  -Cells Into Glucagon-Producing  -Cells

(2013) H. S. Spijker et al.   DIABETES

Expression of Mesenchymal and  -Cell Phenotypic Markers in Islet  -Cells in Recently Diagnosed Diabetes

(2013) M. G. White et al.   DIABETES CARE

Predominance of β-Cell Neogenesis Rather Than Replication in Humans With an Impaired Glucose Tolerance and Newly Diagnosed Diabetes

(2013) S. Yoneda et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Epigenomic plasticity enables human pancreatic α to β cell reprogramming

(2013) Nuria C. Bramswig et al.   JOURNAL OF CLINICAL INVESTIGATION

Vascularized and functional human liver from an iPSC-derived organ bud transplant

(2013) Takanori Takebe et al.   NATURE

Nkx6.1 Controls a Gene Regulatory Network Required for Establishing and Maintaining Pancreatic Beta Cell Identity

(2013) Ashleigh E. Schaffer et al.   PLoS Genetics

Potential role of mesenchymal stromal cells in pancreatic islet transplantation

(2013) Peiman Hematti et al.   Transplantation Reviews

Expansion and conversion of human pancreatic ductal cells into insulin-secreting endocrine cells

(2013) Jonghyeob Lee et al.   eLife

Ultrastructural morphometric analysis of insulin secretory granules in human type 2 diabetes

(2012) Matilde Masini et al.   ACTA DIABETOLOGICA

Increasing the Multiplexing Capacity of TMTs Using Reporter Ion Isotopologues with Isobaric Masses

(2012) Graeme C. McAlister et al.   ANALYTICAL CHEMISTRY

Reduced insulin secretion correlates with decreased expression of exocytotic genes in pancreatic islets from patients with type 2 diabetes

(2012) Sofia A. Andersson et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Normal Glucagon Signaling and β-Cell Function After Near-Total α-Cell Ablation in Adult Mice

(2011) Fabrizio Thorel et al.   DIABETES

Ubiquitin C-terminal hydrolase L1 is required for pancreatic beta cell survival and function in lipotoxic conditions

(2011) K. Y. Chu et al.   DIABETOLOGIA

CrbpI Modulates Glucose Homeostasis and Pancreas 9-cis-Retinoic Acid Concentrations

(2011) M. A. Kane et al.   MOLECULAR AND CELLULAR BIOLOGY

Ectopic PDX-1 Expression Directly Reprograms Human Keratinocytes along Pancreatic Insulin-Producing Cells Fate

(2011) Michal Mauda-Havakuk et al.   PLoS One

A Tissue-Specific Atlas of Mouse Protein Phosphorylation and Expression

(2010) Edward L. Huttlin et al.   CELL

Conversion of adult pancreatic α-cells to β-cells after extreme β-cell loss

(2010) Fabrizio Thorel et al.   NATURE

Universal sample preparation method for proteome analysis

(2009) Jacek R Wiśniewski et al.   NATURE METHODS

In vivo reprogramming of adult pancreatic exocrine cells to β-cells

(2008) Qiao Zhou et al.   NATURE