Lysosomal dysfunction–induced autophagic stress in diabetic kidney disease

The selective autophagy receptor SQSTM1/p62 improves lifespan and proteostasis in an evolutionarily conserved manner

(2020) Ricardo Aparicio et al.   Autophagy

Protective role of podocyte autophagy against glomerular endothelial dysfunction in diabetes

(2020) Mamoru Yoshibayashi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The tubular hypothesis of nephron filtration and diabetic kidney disease

(2020) Volker Vallon et al.   Nature Reviews Nephrology

High Dose Vitamin E Attenuates Diabetic Nephropathy via Alleviation of Autophagic Stress

(2019) Yuxue Zhao et al.   Frontiers in Physiology

Autophagy as a Homeostatic Mechanism in Response to Stress Conditions in the Central Nervous System

(2019) Cristian Gerónimo-Olvera et al.   MOLECULAR NEUROBIOLOGY

FoxO1 inhibits autophagosome-lysosome fusion leading to endothelial autophagic-apoptosis in diabetes

(2019) Hui Zhang et al.   CARDIOVASCULAR RESEARCH

Mitochondrial respiratory chain deficiency inhibits lysosomal hydrolysis

(2019) Lorena Fernandez-Mosquera et al.   Autophagy

Proximal Tubule Autophagy Differs in Type 1 and 2 Diabetes

(2019) Shinsuke Sakai et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

New insights into the mechanisms of diabetic complications: role of lipids and lipid metabolism

(2019) Stephanie Eid et al.   DIABETOLOGIA

Diabetic nephropathy: an insight into molecular mechanisms and emerging therapies

(2019) Annabelle M. Warren et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Autophagy in Neurotrauma: Good, Bad, or Dysregulated

(2019) Junfang Wu et al.   Cells

Mitochondrial ROS-induced lysosomal dysfunction impairs autophagic flux and contributes to M1 macrophage polarization in a diabetic condition

(2019) Yujia Yuan et al.   CLINICAL SCIENCE

Molecular Interactions Between Reactive Oxygen Species and Autophagy in Kidney Disease

(2019) Gur P. Kaushal et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Repair or Lysophagy: Dealing with Damaged Lysosomes

(2019) Chrisovalantis Papadopoulos et al.   JOURNAL OF MOLECULAR BIOLOGY

Lysosome Fission: Planning for an Exit

(2019) Golam T. Saffi et al.   TRENDS IN CELL BIOLOGY

Autophagy in Kidney Disease

(2019) Mary E. Choi   Annual Review of Physiology

mTORC1 feedback to AKT modulates lysosomal biogenesis through MiT/TFE regulation

(2019) Kaushal Asrani et al.   JOURNAL OF CLINICAL INVESTIGATION

Lysosomes as dynamic regulators of cell and organismal homeostasis

(2019) Andrea Ballabio et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Lysosome restoration to activate podocyte autophagy: a new therapeutic strategy for diabetic kidney disease

(2019) Wei Jing Liu et al.   Cell Death & Disease

Oxidation of multiple MiT/TFE transcription factors links oxidative stress to transcriptional control of autophagy and lysosome biogenesis

(2019) Hongfeng Wang et al.   Autophagy

Trehalose reduces retinal degeneration, neuroinflammation and storage burden caused by a lysosomal hydrolase deficiency

(2018) Parisa Lotfi et al.   Autophagy

Chloroquine inhibits autophagic flux by decreasing autophagosome-lysosome fusion

(2018) Mario Mauthe et al.   Autophagy

Rab7 empowers renal tubular epithelial cells with autophagy-mediated protection against albumin-induced injury

(2018) Lei Liu et al.   EXPERIMENTAL CELL RESEARCH

Advanced glycation end-products suppress autophagic flux in podocytes by activating mammalian target of rapamycin and inhibiting nuclear translocation of transcription factor EB

(2018) Xingchen Zhao et al.   JOURNAL OF PATHOLOGY

Optineurin-mediated mitophagy protects renal tubular epithelial cells against accelerated senescence in diabetic nephropathy

(2018) Kehong Chen et al.   Cell Death & Disease

HDAC6 Inhibition Promotes Transcription Factor EB Activation and Is Protective in Experimental Kidney Disease

(2018) Angela S. Brijmohan et al.   Frontiers in Pharmacology

Lysosomes in nutrient signalling: A focus on pancreatic β-cells

(2018) Gergő Mészáros et al.   DIABETES OBESITY & METABOLISM

Promoting the clearance of neurotoxic proteins in neurodegenerative disorders of ageing

(2018) Barry Boland et al.   NATURE REVIEWS DRUG DISCOVERY

Lysosomal membrane permeabilization and cell death

(2018) Fengjuan Wang et al.   TRAFFIC

Finding the Middle Ground for Autophagic Fusion Requirements

(2018) Abigail K. Corona et al.   TRENDS IN CELL BIOLOGY

Trehalose induces autophagy via lysosomal-mediated TFEB activation in models of motoneuron degeneration

(2018) Paola Rusmini et al.   Autophagy

The role of STAT3/mTOR-regulated autophagy in angiotensin II-induced senescence of human glomerular mesangial cells

(2018) Shuang Yang et al.   CELLULAR SIGNALLING

Artificial Intelligence for Drug Discovery, Biomarker Development, and Generation of Novel Chemistry

(2018) Alex Zhavoronkov   MOLECULAR PHARMACEUTICS

Enhancing TFEB-Mediated Cellular Degradation Pathways by the mTORC1 Inhibitor Quercetin

(2018) Yi Huang et al.   Oxidative Medicine and Cellular Longevity

Autophagy: An Essential Degradation Program for Cellular Homeostasis and Life

(2018) Yoomi Chun et al.   Cells

Transcription factor EB (TFEB)-mediated autophagy protects against ethyl carbamate-induced cytotoxicity

(2018) Yuting Li et al.   JOURNAL OF HAZARDOUS MATERIALS

Accumulation of autophagosomes confers cytotoxicity

(2017) Robert W. Button et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Journey of the Autophagosome through Mammalian Cell Organelles and Membranes

(2017) Diana Molino et al.   JOURNAL OF MOLECULAR BIOLOGY

Janus Kinase 2 Regulates Transcription Factor EB Expression and Autophagy Completion in Glomerular Podocytes

(2017) Tamadher A. Alghamdi et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Pharmacological modulation of autophagy: therapeutic potential and persisting obstacles

(2017) Lorenzo Galluzzi et al.   NATURE REVIEWS DRUG DISCOVERY

Endoplasmic reticulum stress, the unfolded protein response and autophagy in kidney diseases

(2017) Andrey V. Cybulsky   Nature Reviews Nephrology

High glucose–induced ROS activates TRPM2 to trigger lysosomal membrane permeabilization and Zn2+-mediated mitochondrial fission

(2017) Nada Abuarab et al.   Science Signaling

Trehalose protects against cadmium-induced cytotoxicity in primary rat proximal tubular cells via inhibiting apoptosis and restoring autophagic flux

(2017) Xin-Yu Wang et al.   Cell Death & Disease

Blockage of the lysosome-dependent autophagic pathway contributes to complement membrane attack complex-induced podocyte injury in idiopathic membranous nephropathy

(2017) Wei Jing Liu et al.   Scientific Reports

High glucose–induced ROS activates TRPM2 to trigger lysosomal membrane permeabilization and Zn2+-mediated mitochondrial fission

(2017) Nada Abuarab et al.   Science Signaling

Autophagy Protects against Palmitic Acid-Induced Apoptosis in Podocytes in vitro

(2017) Xu-shun Jiang et al.   Scientific Reports

Disorders of lysosomal acidification—The emerging role of v-ATPase in aging and neurodegenerative disease

(2016) Daniel J. Colacurcio et al.   AGEING RESEARCH REVIEWS

Lysosomal cell death mechanisms in aging

(2016) Raquel Gómez-Sintes et al.   AGEING RESEARCH REVIEWS

TFEB and TFE3: Linking Lysosomes to Cellular Adaptation to Stress

(2016) Nina Raben et al.   Annual Review of Cell and Developmental Biology

Diabetes and Kidney Disease: Role of Oxidative Stress

(2016) Jay C. Jha et al.   ANTIOXIDANTS & REDOX SIGNALING

Autophagy impairment with lysosomal and mitochondrial dysfunction is an important characteristic of oxidative stress-induced senescence

(2016) Haoran Tai et al.   Autophagy

A novel curcumin analog binds to and activates TFEB in vitro and in vivo independent of MTOR inhibition

(2016) Ju-Xian Song et al.   Autophagy

Time-dependent dysregulation of autophagy: Implications in aging and mitochondrial homeostasis in the kidney proximal tubule

(2016) Takeshi Yamamoto et al.   Autophagy

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

(2016) Daniel J Klionsky et al.   Autophagy

Podocytes: the Weakest Link in Diabetic Kidney Disease?

(2016) Jamie S. Lin et al.   Current Diabetes Reports

High-Fat Diet–Induced Lysosomal Dysfunction and Impaired Autophagic Flux Contribute to Lipotoxicity in the Kidney

(2016) Takeshi Yamamoto et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Cathepsin D in Podocytes Is Important in the Pathogenesis of Proteinuria and CKD

(2016) K. Yamamoto-Nonaka et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Activation of the transcription factor EB rescues lysosomal abnormalities in cystinotic kidney cells

(2016) Laura R. Rega et al.   KIDNEY INTERNATIONAL

Trends in Chronic Kidney Disease in China

(2016) Luxia Zhang et al.   NEW ENGLAND JOURNAL OF MEDICINE

Ubiquitin-Dependent And Independent Signals In Selective Autophagy

(2016) Aliaksandr Khaminets et al.   TRENDS IN CELL BIOLOGY

Inhibition of autophagy increased AGE/ROS-mediated apoptosis in mesangial cells

(2016) Li Xu et al.   Cell Death & Disease

MCOLN1 is a ROS sensor in lysosomes that regulates autophagy

(2016) Xiaoli Zhang et al.   Nature Communications

Sub-lethal oxidative stress induces lysosome biogenesis via a lysosomal membrane permeabilization-cathepsin-caspase 3-transcription factor EB-dependent pathway

(2016) San Min Leow et al.   Oncotarget

Curcumin targets the TFEB-lysosome pathway for induction of autophagy

(2016) Jianbin Zhang et al.   Oncotarget

Involvement of Endoplasmic Reticulum Stress, Autophagy and Apoptosis in Advanced Glycation End Products-Induced Glomerular Mesangial Cell Injury

(2016) Chih-Kang Chiang et al.   Scientific Reports

Endothelial cell and podocyte autophagy synergistically protect from diabetes-induced glomerulosclerosis

(2015) Olivia Lenoir et al.   Autophagy

Autophagic adaptations in diabetic cardiomyopathy differ between type 1 and type 2 diabetes

(2015) Hiromitsu Kanamori et al.   Autophagy

Mitophagy programs: mechanisms and physiological implications of mitochondrial targeting by autophagy

(2015) Anne Hamacher-Brady et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Impaired Podocyte Autophagy Exacerbates Proteinuria in Diabetic Nephropathy

(2015) Atsuko Tagawa et al.   DIABETES

High-fat diet increases autophagic flux in pancreatic beta cells in vivo and ex vivo in mice

(2015) Kwan Yi Chu et al.   DIABETOLOGIA

Heme oxygenase-1 enhances autophagy in podocytes as a protective mechanism against high glucose-induced apoptosis

(2015) Chenglong Dong et al.   EXPERIMENTAL CELL RESEARCH

Autophagy-Lysosome Pathway in Renal Tubular Epithelial Cells Is Disrupted by Advanced Glycation End Products in Diabetic Nephropathy

(2015) Wei Jing Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Megalin/Cubulin-Lysosome-mediated Albumin Reabsorption Is Involved in the Tubular Cell Activation of NLRP3 Inflammasome and Tubulointerstitial Inflammation

(2015) Dan Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The renoprotective role of autophagy activation in proximal tubular epithelial cells in diabetic nephropathy

(2015) Ying Xu et al.   JOURNAL OF DIABETES AND ITS COMPLICATIONS

Megalin-Mediated Tubuloglomerular Alterations in High-Fat Diet-Induced Kidney Disease

(2015) S. Kuwahara et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Lysosomal calcium signalling regulates autophagy through calcineurin and TFEB

(2015) Diego L. Medina et al.   NATURE CELL BIOLOGY

Oleanolic acid andN-acetylcysteine ameliorate diabetic nephropathy through reduction of oxidative stress and endoplasmic reticulum stress in a type 2 diabetic rat model

(2015) Eun Soo Lee et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Autophagosome–lysosome fusion is independent of V-ATPase-mediated acidification

(2015) Caroline Mauvezin et al.   Nature Communications

In Vivo Evidence for Lysosome Depletion and Impaired Autophagic Clearance in Hereditary Spastic Paraplegia Type SPG11

(2015) Rita-Eva Varga et al.   PLoS Genetics

Diabetic kidney disease

(2015) Merlin C. Thomas et al.   Nature Reviews Disease Primers

Autophagy activation reduces renal tubular injury induced by urinary proteins

(2014) Wei Jing Liu et al.   Autophagy

Lysosomotropic agents: impact on lysosomal membrane permeabilization and cell death

(2014) Ana M. Villamil Giraldo et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Fatty acids are novel nutrient factors to regulate mTORC1 lysosomal localization and apoptosis in podocytes

(2014) Mako Yasuda et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Oxidative stress and autophagy: the clash between damage and metabolic needs

(2014) G Filomeni et al.   CELL DEATH AND DIFFERENTIATION

Selenium nanoparticles involve HSP-70 and SIRT1 in preventing the progression of type 1 diabetic nephropathy

(2014) Goru Santosh Kumar et al.   CHEMICO-BIOLOGICAL INTERACTIONS

The Phytoestrogen Genistein Modulates Lysosomal Metabolism and Transcription Factor EB (TFEB) Activation

(2014) Marta Moskot et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Heat Shock Protein 70.1 (Hsp70.1) Affects Neuronal Cell Fate by Regulating Lysosomal Acid Sphingomyelinase

(2014) Hong Zhu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lipid-induced NOX2 activation inhibits autophagic flux by impairing lysosomal enzyme activity

(2014) Bharat Jaishy et al.   JOURNAL OF LIPID RESEARCH

Crosstalk between protective autophagy and NF-κB signal in high glucose-induced podocytes

(2014) Miaomiao Wei et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Defective fatty acid oxidation in renal tubular epithelial cells has a key role in kidney fibrosis development

(2014) Hyun Mi Kang et al.   NATURE MEDICINE

Podocytes Degrade Endocytosed Albumin Primarily in Lysosomes

(2014) John M. Carson et al.   PLoS One

The Nutrient-Responsive Transcription Factor TFE3 Promotes Autophagy, Lysosomal Biogenesis, and Clearance of Cellular Debris

(2014) J. A. Martina et al.   Science Signaling

Lysosome: regulator of lipid degradation pathways

(2014) Carmine Settembre et al.   TRENDS IN CELL BIOLOGY

Autophagy in Kidney Health and Disease

(2013) Zhibo Wang et al.   ANTIOXIDANTS & REDOX SIGNALING

Autophagy sequesters damaged lysosomes to control lysosomal biogenesis and kidney injury

(2013) Ikuko Maejima et al.   EMBO JOURNAL

Lysosomal cell death at a glance

(2013) S. Aits et al.   JOURNAL OF CELL SCIENCE

Obesity-Mediated Autophagy Insufficiency Exacerbates Proteinuria-induced Tubulointerstitial Lesions

(2013) K. Yamahara et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Increased lysosomal proteolysis counteracts protein accumulation in the proximal tubule during focal segmental glomerulosclerosis

(2013) Rikke Nielsen et al.   KIDNEY INTERNATIONAL

Regulation of lipid accumulation by AMK-activated kinase in high fat diet–induced kidney injury

(2013) Anne-Emilie Declèves et al.   KIDNEY INTERNATIONAL

Signals from the lysosome: a control centre for cellular clearance and energy metabolism

(2013) Carmine Settembre et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Autophagy and metabolic changes in obesity-related chronic kidney disease

(2013) J. Satriano et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

At the end of the autophagic road: an emerging understanding of lysosomal functions in autophagy

(2013) Han-Ming Shen et al.   TRENDS IN BIOCHEMICAL SCIENCES

Lysosomal enzymes are decreased in the kidney of diabetic rats

(2012) Giovani B. Peres et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Effect of curcumin and quercetin on lysosomal enzyme activities in streptozotocin-induced diabetic rats

(2012) Mallikarjun B. Chougala et al.   CLINICAL NUTRITION

Catalase Deficiency Accelerates Diabetic Renal Injury Through Peroxisomal Dysfunction

(2012) I. Hwang et al.   DIABETES

Poor lysosomal membrane integrity in proximal tubule cells of haptoglobin 2-2 genotype mice with diabetes mellitus

(2012) Rabea Asleh et al.   FREE RADICAL BIOLOGY AND MEDICINE

The intersecting roles of endoplasmic reticulum stress, ubiquitin–proteasome system, and autophagy in the pathogenesis of proteinuric kidney disease

(2012) Andrey V. Cybulsky   KIDNEY INTERNATIONAL

Transcriptional Activation of Lysosomal Exocytosis Promotes Cellular Clearance

(2011) Diego L. Medina et al.   DEVELOPMENTAL CELL

Fatty Acids Suppress Autophagic Turnover in β-Cells

(2011) Guy Las et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lysosomal positioning coordinates cellular nutrient responses

(2011) Viktor I. Korolchuk et al.   NATURE CELL BIOLOGY

TFEB Links Autophagy to Lysosomal Biogenesis

(2011) C. Settembre et al.   SCIENCE

Autophagosome Formation and Molecular Mechanism of Autophagy

(2010) Isei Tanida   ANTIOXIDANTS & REDOX SIGNALING

Altered lipid content inhibits autophagic vesicular fusion

(2010) Hiroshi Koga et al.   FASEB JOURNAL

Autophagy influences glomerular disease susceptibility and maintains podocyte homeostasis in aging mice

(2010) Björn Hartleben et al.   JOURNAL OF CLINICAL INVESTIGATION

Termination of autophagy and reformation of lysosomes regulated by mTOR

(2010) Li Yu et al.   NATURE

Hsp70 stabilizes lysosomes and reverts Niemann–Pick disease-associated lysosomal pathology

(2010) Thomas Kirkegaard et al.   NATURE

The late stage of autophagy: cellular events and molecular regulation

(2010) Jingjing Tong et al.   Protein & Cell

Receptor-mediated endocytosis in renal proximal tubule

(2009) Erik Ilsø Christensen et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

A Gene Network Regulating Lysosomal Biogenesis and Function

(2009) Marco Sardiello et al.   SCIENCE

Proteinuria in diabetic kidney disease: A mechanistic viewpoint

(2008) J.A. Jefferson et al.   KIDNEY INTERNATIONAL