Heat Shock Protein 70.1 (Hsp70.1) Affects Neuronal Cell Fate by Regulating Lysosomal Acid Sphingomyelinase

Human heat shock protein 70 (Hsp70) as a peripheral membrane protein

(2014) Ajay K. Mahalka et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Transformation-Associated Changes in Sphingolipid Metabolism Sensitize Cells to Lysosomal Cell Death Induced by Inhibitors of Acid Sphingomyelinase

(2013) Nikolaj H.T. Petersen et al.   CANCER CELL

Sunitinib and SU11652 Inhibit Acid Sphingomyelinase, Destabilize Lysosomes, and Inhibit Multidrug Resistance

(2013) A.-M. Ellegaard et al.   MOLECULAR CANCER THERAPEUTICS

Killing from the inside

(2013) Paul Saftig et al.   NATURE

Oral administration of glutathione improves memory deficits following transient brain ischemia by reducing brain oxidative stress

(2013) Y. Yabuki et al.   NEUROSCIENCE

Global changes in phospholipids identified by MALDI MS in rats with focal cerebral ischemia

(2012) Selina Rahman Shanta et al.   JOURNAL OF LIPID RESEARCH

Why are hippocampal CA1 neurons vulnerable but motor cortex neurons resistant to transient ischemia?

(2011) Hong Zhu et al.   JOURNAL OF NEUROCHEMISTRY

Hsp70.1 and related lysosomal factors for necrotic neuronal death

(2011) Tetsumori Yamashima   JOURNAL OF NEUROCHEMISTRY

Calpain-mediated Hsp70.1 cleavage in hippocampal CA1 neuronal death

(2010) Shunya Sahara et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Connecting Hsp70, sphingolipid metabolism and lysosomal stability

(2010) Nikolaj H.T. Petersen et al.   CELL CYCLE

The Acid Sphingomyelinase/Ceramide Pathway: Biomedical Significance and Mechanisms of Regulation

(2010) Y.H. Zeidan et al.   CURRENT MOLECULAR MEDICINE

A Novel Mechanism of Lysosomal Acid Sphingomyelinase Maturation

(2010) Russell W. Jenkins et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hsp70 stabilizes lysosomes and reverts Niemann–Pick disease-associated lysosomal pathology

(2010) Thomas Kirkegaard et al.   NATURE

Heat shock proteins: Cellular and molecular mechanisms in the central nervous system

(2010) R. Anne Stetler et al.   PROGRESS IN NEUROBIOLOGY

Protective Role of Endogenous Gangliosides for Lysosomal Pathology in a Cellular Model of Synucleinopathies

(2009) Jianshe Wei et al.   AMERICAN JOURNAL OF PATHOLOGY

Redox Proteomic Analysis of Carbonylated Brain Proteins in Mild Cognitive Impairment and Early Alzheimer's Disease

(2009) Rukhsana Sultana et al.   ANTIOXIDANTS & REDOX SIGNALING

Protective effect of transgenic expression of porcine heat shock protein 70 on hypothalamic ischemic and oxidative damage in a mouse model of heatstroke

(2009) Zhih-Cherng Chen et al.   BMC NEUROSCIENCE

Proteomic identification of carbonylated proteins in the monkey hippocampus after ischemia–reperfusion

(2009) Shinji Oikawa et al.   FREE RADICAL BIOLOGY AND MEDICINE

The role of lysosomal rupture in neuronal death

(2009) Tetsumori Yamashima et al.   PROGRESS IN NEUROBIOLOGY

Bis(monoacylglycero)phosphate, a peculiar phospholipid to control the fate of cholesterol: Implications in pathology

(2009) F. Hullin-Matsuda et al.   PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS

Lysosomal involvement in cell death and cancer

(2008) Thomas Kirkegaard et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Selective decrease of bis(monoacylglycero)phosphate content in macrophages by high supplementation with docosahexaenoic acid

(2008) Jérôme Bouvier et al.   JOURNAL OF LIPID RESEARCH

Plasma lipids are altered in Gaucher disease: Biochemical markers to evaluate therapeutic intervention

(2007) Peter J. Meikle et al.   BLOOD CELLS MOLECULES AND DISEASES