Proximal Tubule Autophagy Differs in Type 1 and 2 Diabetes

A more tubulocentric view of diabetic kidney disease

(2017) Letizia Zeni et al.   JOURNAL OF NEPHROLOGY

Rapamycin Induces Autophagy and Reduces the Apoptosis of Podocytes Under a Stimulated Condition of Immunoglobulin A Nephropathy

(2017) Shikai Liang et al.   KIDNEY & BLOOD PRESSURE RESEARCH

Niclosamide attenuates inflammatory cytokines via the autophagy pathway leading to improved outcomes in renal ischemia/reperfusion injury

(2017) Lin-Xia Zhang et al.   Molecular Medicine Reports

Green Tea Polyphenols, Mimicking the Effects of Dietary Restriction, Ameliorate High-Fat Diet-Induced Kidney Injury via Regulating Autophagy Flux

(2017) Xiao Xie et al.   Nutrients

Nanoparticles restore lysosomal acidification defects: Implications for Parkinson and other lysosomal-related diseases

(2016) Mathieu Bourdenx et al.   Autophagy

Time-dependent dysregulation of autophagy: Implications in aging and mitochondrial homeostasis in the kidney proximal tubule

(2016) Takeshi Yamamoto et al.   Autophagy

High-Fat Diet–Induced Lysosomal Dysfunction and Impaired Autophagic Flux Contribute to Lipotoxicity in the Kidney

(2016) Takeshi Yamamoto et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

A Meta-analysis of the Association of Estimated GFR, Albuminuria, Diabetes Mellitus, and Hypertension With Acute Kidney Injury

(2015) Matthew T. James et al.   AMERICAN JOURNAL OF KIDNEY DISEASES

Autophagic adaptations in diabetic cardiomyopathy differ between type 1 and type 2 diabetes

(2015) Hiromitsu Kanamori et al.   Autophagy

Altered TFEB-mediated lysosomal biogenesis in Gaucher disease iPSC-derived neuronal cells

(2015) Ola Awad et al.   HUMAN MOLECULAR GENETICS

Autophagy-Lysosome Pathway in Renal Tubular Epithelial Cells Is Disrupted by Advanced Glycation End Products in Diabetic Nephropathy

(2015) Wei Jing Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Exploring the origin and limitations of kidney regeneration

(2015) Tomomi Endo et al.   JOURNAL OF PATHOLOGY

Epidermal Growth Factor Receptor Inhibition Slows Progression of Diabetic Nephropathy in Association With a Decrease in Endoplasmic Reticulum Stress and an Increase in Autophagy

(2014) Ming-Zhi Zhang et al.   DIABETES

Disruption of Renal Tubular Mitochondrial Quality Control by Myo-Inositol Oxygenase in Diabetic Kidney Disease

(2014) M. Zhan et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Autophagic Clearance of Mitochondria in the Kidney Copes with Metabolic Acidosis

(2014) T. Namba et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Autophagy and the kidney: health and disease

(2014) Y. Takabatake et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Role of Nutrient-Sensing Signals in the Pathogenesis of Diabetic Nephropathy

(2014) Shinji Kume et al.   Biomed Research International

Hypoxia in Diabetic Kidneys

(2014) Yumi Takiyama et al.   Biomed Research International

Autophagy protects kidney proximal tubule epithelial cells from mitochondrial metabolic stress

(2013) Tomonori Kimura et al.   Autophagy

Autophagy sequesters damaged lysosomes to control lysosomal biogenesis and kidney injury

(2013) Ikuko Maejima et al.   EMBO JOURNAL

Differential Contribution of Insulin and Amino Acids to the mTORC1-Autophagy Pathway in the Liver and Muscle

(2013) Takako Naito et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Obesity-Mediated Autophagy Insufficiency Exacerbates Proteinuria-induced Tubulointerstitial Lesions

(2013) K. Yamahara et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Autophagy in Human Health and Disease

(2013) Augustine M.K. Choi et al.   NEW ENGLAND JOURNAL OF MEDICINE

Autophagy Guards Against Cisplatin-Induced Acute Kidney Injury

(2012) Atsushi Takahashi et al.   AMERICAN JOURNAL OF PATHOLOGY

Autophagy: Renovation of Cells and Tissues

(2011) Noboru Mizushima et al.   CELL

Dietary Restriction Ameliorates Diabetic Nephropathy through Anti-Inflammatory Effects and Regulation of the Autophagy via Restoration of Sirt1 in Diabetic Wistar Fatty (fa/fa) Rats: A Model of Type 2 Diabetes

(2011) Munehiro Kitada et al.   Experimental Diabetes Research

Autophagy Protects the Proximal Tubule from Degeneration and Acute Ischemic Injury

(2011) T. Kimura et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

The Tuberin/mTOR Pathway Promotes Apoptosis of Tubular Epithelial Cells in Diabetes

(2011) C. Velagapudi et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

A Genome-Wide siRNA Screen Reveals Multiple mTORC1 Independent Signaling Pathways Regulating Autophagy under Normal Nutritional Conditions

(2010) Marta M. Lipinski et al.   DEVELOPMENTAL CELL

Autophagy influences glomerular disease susceptibility and maintains podocyte homeostasis in aging mice

(2010) Björn Hartleben et al.   JOURNAL OF CLINICAL INVESTIGATION

Autophagy basics

(2010) Isei Tanida   MICROBIOLOGY AND IMMUNOLOGY

Autophagy and the Integrated Stress Response

(2010) Guido Kroemer et al.   MOLECULAR CELL

Autophagy gone awry in neurodegenerative diseases

(2010) Esther Wong et al.   NATURE NEUROSCIENCE

The mTOR pathway is highly activated in diabetic nephropathy and rapamycin has a strong therapeutic potential

(2009) Hiroyuki Mori et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Rapamycin has dual opposing effects on proteinuric experimental nephropathies: is it a matter of podocyte damage?

(2009) J. Torras et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION