Dominant-Negative Attenuation of cAMP-Selective Phosphodiesterase PDE4D Action Affects Learning and Behavior

Design and Synthesis of Selective Phosphodiesterase 4D (PDE4D) Allosteric Inhibitors for the Treatment of Fragile X Syndrome and Other Brain Disorders

(2019) Mark E. Gurney et al.   JOURNAL OF MEDICINAL CHEMISTRY

Acute treatment with the PDE4 inhibitor roflumilast improves verbal word memory in healthy old individuals: a double-blind placebo-controlled study

(2019) Arjan Blokland et al.   NEUROBIOLOGY OF AGING

Protection from amyloid β peptide-induced memory, biochemical and morphological deficits by a phosphodiesterase-4D (PDE4D) allosteric inhibitor

(2019) Su-Ying Cui et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Therapeutic targeting of 3′,5′-cyclic nucleotide phosphodiesterases: inhibition and beyond

(2019) George S. Baillie et al.   NATURE REVIEWS DRUG DISCOVERY

Molecular Bases of PDE4D Inhibition by Memory-Enhancing GEBR Library Compounds

(2018) Tommaso Prosdocimi et al.   BIOCHEMISTRY

Cyclic nucleotide signaling changes associated with normal aging and age-related diseases of the brain

(2018) Michy P. Kelly   CELLULAR SIGNALLING

Novel Phosphodiesterase Inhibitors for Cognitive Improvement in Alzheimer’s Disease

(2018) Yinuo Wu et al.   JOURNAL OF MEDICINAL CHEMISTRY

A negative allosteric modulator of PDE4D enhances learning after traumatic brain injury

(2018) David J. Titus et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Acute administration of roflumilast enhances immediate recall of verbal word memory in healthy young adults

(2018) M.A. Van Duinen et al.   NEUROPHARMACOLOGY

RNA Interference-Mediated Knockdown of Long-Form Phosphodiesterase-4D (PDE4D) Enzyme Reverses Amyloid-β42-Induced Memory Deficits in Mice

(2018) Cong Zhang et al.   JOURNAL OF ALZHEIMERS DISEASE

Memory enhancing effects of BPN14770, an allosteric inhibitor of phosphodiesterase-4D, in wild-type and humanized mice

(2018) Chong Zhang et al.   NEUROPSYCHOPHARMACOLOGY

Investigational phosphodiesterase inhibitors in phase I and phase II clinical trials for Alzheimer’s disease

(2017) Jos Prickaerts et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Therapeutic benefits of phosphodiesterase 4B inhibition after traumatic brain injury

(2017) Nicole M. Wilson et al.   PLoS One

The phosphodiesterase-4 inhibitor roflumilast decreases ethanol consumption in C57BL/6J mice

(2017) Xin Liu et al.   PSYCHOPHARMACOLOGY

Acute administration of roflumilast enhances sensory gating in healthy young humans in a randomized trial

(2017) Pim R. A. Heckman et al.   PSYCHOPHARMACOLOGY

Comparison of the Pharmacological Profiles of Selective PDE4B and PDE4D Inhibitors in the Central Nervous System

(2017) Chong Zhang et al.   Scientific Reports

Memory-enhancing effects of GEBR-32a, a new PDE4D inhibitor holding promise for the treatment of Alzheimer’s disease

(2017) Roberta Ricciarelli et al.   Scientific Reports

The PDE4 inhibitor roflumilast improves memory in rodents at non-emetic doses

(2016) Tim Vanmierlo et al.   BEHAVIOURAL BRAIN RESEARCH

Identification of a multifunctional docking site on the catalytic unit of phosphodiesterase-4 (PDE4) that is utilised by multiple interaction partners

(2016) Kirsty F. Houslay et al.   BIOCHEMICAL JOURNAL

RACK1 and β-arrestin2 attenuate dimerization of PDE4 cAMP phosphodiesterase PDE4D5

(2016) Graeme B. Bolger   CELLULAR SIGNALLING

New insights into selective PDE4D inhibitors: 3-(Cyclopentyloxy)-4-methoxybenzaldehyde O-(2-(2,6-dimethylmorpholino)-2-oxoethyl) oxime (GEBR-7b) structural development and promising activities to restore memory impairment

(2016) Chiara Brullo et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Compartmentalized PDE4A5 Signaling Impairs Hippocampal Synaptic Plasticity and Long-Term Memory

(2016) R. Havekes et al.   JOURNAL OF NEUROSCIENCE

Chronic Cognitive Dysfunction after Traumatic Brain Injury Is Improved with a Phosphodiesterase 4B Inhibitor

(2016) D. J. Titus et al.   JOURNAL OF NEUROSCIENCE

Further Insights in the Binding Mode of Selective Inhibitors to Human PDE4D Enzyme Combining Docking and Molecular Dynamics

(2016) Pasqualina D'Ursi et al.   Molecular Informatics

Interaction between integrin α5 and PDE4D regulates endothelial inflammatory signalling

(2016) Sanguk Yun et al.   NATURE CELL BIOLOGY

Rolipram-induced improvement of cognitive function correlates with changes in hippocampal CREB phosphorylation, BDNF and Arc protein levels

(2016) Yuan Zhong et al.   NEUROSCIENCE LETTERS

The Popeye domain containing protein family – A novel class of cAMP effectors with important functions in multiple tissues

(2016) Roland F.R. Schindler et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

Sleep deprivation causes memory deficits by negatively impacting neuronal connectivity in hippocampal area CA1

(2016) Robbert Havekes et al.   eLife

Dimerization of cAMP phosphodiesterase-4 (PDE4) in living cells requires interfaces located in both the UCR1 and catalytic unit domains

(2015) Graeme B. Bolger et al.   CELLULAR SIGNALLING

Phosphodiesterase 4 inhibitors for the treatment of chronic obstructive pulmonary disease: a review of current and developing drugs

(2015) Aaron M Mulhall et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Specific Inhibition of Phosphodiesterase-4B Results in Anxiolysis and Facilitates Memory Acquisition

(2015) Alexander McGirr et al.   NEUROPSYCHOPHARMACOLOGY

Engineered stabilization and structural analysis of the autoinhibited conformation of PDE4

(2015) Peder Cedervall et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phosphodiesterase-4D Knock-down in the Prefrontal Cortex Alleviates Chronic Unpredictable Stress-Induced Depressive-Like Behaviors and Memory Deficits in Mice

(2015) Zhen-Zhen Wang et al.   Scientific Reports

The upstream conserved regions (UCRs) mediate homo- and hetero-oligomerization of type 4 cyclic nucleotide phosphodiesterases (PDE4s)

(2014) Moses Xie et al.   BIOCHEMICAL JOURNAL

Antidepressant-like effects of the phosphodiesterase-4 inhibitor etazolate and phosphodiesterase-5 inhibitor sildenafil via cyclic AMP or cyclic GMP signaling in mice

(2014) Chuang Wang et al.   METABOLIC BRAIN DISEASE

Advances in targeting cyclic nucleotide phosphodiesterases

(2014) Donald H. Maurice et al.   NATURE REVIEWS DRUG DISCOVERY

Mice deficient in phosphodiesterase-4A display anxiogenic-like behavior

(2014) Rolf T. Hansen et al.   PSYCHOPHARMACOLOGY

Select 3′,5′-cyclic nucleotide phosphodiesterases exhibit altered expression in the aged rodent brain

(2013) Michy P. Kelly et al.   CELLULAR SIGNALLING

Anchored PDE4 regulates chloride conductance in wild-type and ΔF508-CFTR human airway epithelia

(2013) Elise Blanchard et al.   FASEB JOURNAL

Different mutations inPDE4Dassociated with developmental disorders with mirror phenotypes

(2013) Anna Lindstrand et al.   JOURNAL OF MEDICAL GENETICS

Phosphodiesterase Inhibition Rescues Chronic Cognitive Deficits Induced by Traumatic Brain Injury

(2013) D. J. Titus et al.   JOURNAL OF NEUROSCIENCE

DISC1–ATF4 transcriptional repression complex: dual regulation of the cAMP-PDE4 cascade by DISC1

(2013) T Soda et al.   MOLECULAR PSYCHIATRY

Improvement of spatial memory function in APPswe/PS1dE9 mice after chronic inhibition of phosphodiesterase type 4D

(2013) A.S.R. Sierksma et al.   NEUROPHARMACOLOGY

ERK regulation of phosphodiesterase 4 enhances dopamine-stimulated AMPA receptor membrane insertion

(2013) R. S. Song et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neuropsychological functioning in young subjects with generalized anxiety disorder with and without pharmacotherapy

(2013) D. Tempesta et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Exome Sequencing Identifies PDE4D Mutations in Acrodysostosis

(2012) Hane Lee et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Exome Sequencing Identifies PDE4D Mutations as Another Cause of Acrodysostosis

(2012) Caroline Michot et al.   AMERICAN JOURNAL OF HUMAN GENETICS

RNA interference-mediated phosphodiesterase 4D splice variants knock-down in the prefrontal cortex produces antidepressant-like and cognition-enhancing effects

(2012) Zhen-Zhen Wang et al.   BRITISH JOURNAL OF PHARMACOLOGY

A new model ofPde4ddeficiency: genetic knock-down of PDE4D enzyme in rats produces an antidepressant phenotype without spatial cognitive effects

(2012) T. L. Schaefer et al.   GENES BRAIN AND BEHAVIOR

Identification of Novel Mutations ConfirmsPde4das a Major Gene Causing Acrodysostosis

(2012) Danielle C. Lynch et al.   HUMAN MUTATION

PRKAR1AandPDE4DMutations Cause Acrodysostosis but Two Distinct Syndromes with or without GPCR-Signaling Hormone Resistance

(2012) Agnès Linglart et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Phosphodiesterase isoform-specific expression induced by traumatic brain injury

(2012) Anthony A. Oliva et al.   JOURNAL OF NEUROCHEMISTRY

Social, Communication, and Cortical Structural Impairments in Epac2-Deficient Mice

(2012) D. P. Srivastava et al.   JOURNAL OF NEUROSCIENCE

Efficacy of apremilast in the treatment of moderate to severe psoriasis: a randomised controlled trial

(2012) Kim Papp et al.   LANCET

Administration of the phosphodiesterase type 4 inhibitor rolipram into the amygdala at a specific time interval after learning increases recognition memory persistence

(2012) A. Werenicz et al.   LEARNING & MEMORY

EPAC Null Mutation Impairs Learning and Social Interactions via Aberrant Regulation of miR-124 and Zif268 Translation

(2012) Ying Yang et al.   NEURON

Phosphodiesterase 4 Inhibition Impairs Cocaine-Induced Inhibitory Synaptic Plasticity and Conditioned Place Preference

(2012) Peng Zhong et al.   NEUROPSYCHOPHARMACOLOGY

Comparison of cAMP-specific phosphodiesterase mRNAs distribution in mouse and rat brain

(2012) Emily M. Johansson et al.   NEUROSCIENCE LETTERS

PDE4 inhibition enhances hippocampal synaptic plasticity in vivo and rescues MK801-induced impairment of long-term potentiation and object recognition memory in an animal model of psychosis

(2012) V Wiescholleck et al.   Translational Psychiatry

Efficacy and safety of roflumilast in patients with chronic obstructive pulmonary disease: a systematic review and meta-analysis

(2012) Yuji Oba et al.   Therapeutic Advances in Respiratory Disease

β2-Agonists upregulate PDE4 mRNA but not protein or activity in human airway smooth muscle cells from asthmatic and nonasthmatic volunteers

(2011) Kyoko Niimi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Phosphorylation of cAMP-specific PDE4A5 (phosphodiesterase-4A5) by MK2 (MAPKAPK2) attenuates its activation through protein kinase A phosphorylation

(2011) Kirsty F. MacKenzie et al.   BIOCHEMICAL JOURNAL

The phosphodiesterase-4 inhibitor rolipram reverses Aβ-induced cognitive impairment and neuroinflammatory and apoptotic responses in rats

(2011) Chuang Wang et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Phosphodiesterase-4D Knock-Out and RNA Interference-Mediated Knock-Down Enhance Memory and Increase Hippocampal Neurogenesis via Increased cAMP Signaling

(2011) Y.-F. Li et al.   JOURNAL OF NEUROSCIENCE

PKA Phosphorylation of NDE1 Is DISC1/PDE4 Dependent and Modulates Its Interaction with LIS1 and NDEL1

(2011) N. J. Bradshaw et al.   JOURNAL OF NEUROSCIENCE

Enhanced long-term depression and impaired reversal learning in phosphodiesterase 4B-knockout (PDE4B−/−) mice

(2011) Kris Rutten et al.   NEUROPHARMACOLOGY

Synergistic interactions between PDE4B and GSK-3: DISC1 mutant mice

(2011) Tatiana V. Lipina et al.   NEUROPHARMACOLOGY

Mammalian Cyclic Nucleotide Phosphodiesterases: Molecular Mechanisms and Physiological Functions

(2011) Sharron H. Francis et al.   PHYSIOLOGICAL REVIEWS

Phosphodiesterase 4 inhibition enhances the dopamine D1 receptor/PKA/DARPP-32 signaling cascade in frontal cortex

(2011) Mahomi Kuroiwa et al.   PSYCHOPHARMACOLOGY

Epac: Defining a New Mechanism for cAMP Action

(2010) Martijn Gloerich et al.   Annual Review of Pharmacology and Toxicology

An evolutionary analysis of cAMP-specific Phosphodiesterase 4 alternative splicing

(2010) Keven R Johnson et al.   BMC EVOLUTIONARY BIOLOGY

A Complex between FAK, RACK1, and PDE4D5 Controls Spreading Initiation and Cancer Cell Polarity

(2010) Bryan Serrels et al.   CURRENT BIOLOGY

The human area postrema and other nuclei related to the emetic reflex express cAMP phosphodiesterases 4B and 4D

(2010) F. Mori et al.   JOURNAL OF CHEMICAL NEUROANATOMY

The type IV phosphodiesterase inhibitor rolipram disturbs expression and extinction of conditioned fear in mice

(2010) Erik M. Mueller et al.   NEUROPHARMACOLOGY

Quantitative comparison of phosphodiesterase mRNA distribution in human brain and peripheral tissues

(2010) Viktor Lakics et al.   NEUROPHARMACOLOGY

Inhibition of phosphodiesterase-4 reverses memory deficits produced by Aβ25–35 or Aβ1–40 peptide in rats

(2010) Yu-Fang Cheng et al.   PSYCHOPHARMACOLOGY

Mechanism regulating proasthmatic effects of prolonged homologous β2-adrenergic receptor desensitization in airway smooth muscle

(2009) Gustavo Nino et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Sleep deprivation impairs cAMP signalling in the hippocampus

(2009) Christopher G. Vecsey et al.   NATURE

Design of phosphodiesterase 4D (PDE4D) allosteric modulators for enhancing cognition with improved safety

(2009) Alex B Burgin et al.   NATURE BIOTECHNOLOGY

Antidepressant- and Anxiolytic-like Effects of the Phosphodiesterase-4 Inhibitor Rolipram on Behavior Depend on Cyclic AMP Response Element Binding Protein-Mediated Neurogenesis in the Hippocampus

(2009) Yun-Feng Li et al.   NEUROPSYCHOPHARMACOLOGY

Phosphodiesterase Inhibitors Enhance Object Memory Independent of Cerebral Blood Flow and Glucose Utilization in Rats

(2009) Kris Rutten et al.   NEUROPSYCHOPHARMACOLOGY

The novel distribution of phosphodiesterase-4 subtypes within the rat retina

(2009) C.M. Whitaker et al.   NEUROSCIENCE

Prolonged heterologous β2-adrenoceptor desensitization promotes proasthmatic airway smooth muscle function via PKA/ERK1/2-mediated phosphodiesterase-4 induction

(2008) Aihua Hu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

DISC1, PDE4B, and NDE1 at the centrosome and synapse

(2008) Nicholas J. Bradshaw et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Identification and molecular characterization of a novel PDE4D11 cAMP-specific phosphodiesterase isoform

(2008) Clare N. Lynex et al.   CELLULAR SIGNALLING

Signaling from β1- and β2-adrenergic receptors is defined by differential interactions with PDE4

(2008) Wito Richter et al.   EMBO JOURNAL

Enhanced long-term potentiation and impaired learning in phosphodiesterase 4D-knockout (PDE4D−/−) mice

(2008) Kris Rutten et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Distinct Roles of PDE4 and PDE10A in the Regulation of cAMP/PKA Signaling in the Striatum

(2008) A. Nishi et al.   JOURNAL OF NEUROSCIENCE

Sub-chronic rolipram treatment leads to a persistent improvement in long-term object memory in rats

(2008) K. Rutten et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

A Major Functional Role for Phosphodiesterase 4D5 in Human Airway Smooth Muscle Cells

(2007) Charlotte K. Billington et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Identification and characterization of novel mouse PDE4D isoforms: Molecular cloning, subcellular distribution and detection of isoform-specific intracellular localization signals

(2007) Ananth Chandrasekaran et al.   CELLULAR SIGNALLING