Comparison of the Pharmacological Profiles of Selective PDE4B and PDE4D Inhibitors in the Central Nervous System

PDE4B as a microglia target to reduce neuroinflammation

(2016) Damien D. Pearse et al.   GLIA

Coping with the Forced Swim Stressor: Towards Understanding an Adaptive Mechanism

(2016) E. R. de Kloet et al.   NEURAL PLASTICITY

Inhibition of phosphodiesterase 2 reverses impaired cognition and neuronal remodeling caused by chronic stress

(2015) Ying Xu et al.   NEUROBIOLOGY OF AGING

Protective effects of phosphodiesterase 2 inhibitor on depression- and anxiety-like behaviors: Involvement of antioxidant and anti-apoptotic mechanisms

(2014) Lianshu Ding et al.   BEHAVIOURAL BRAIN RESEARCH

Phosphodiesterase-4 (PDE4) Molecular Pharmacology and Alzheimer’s Disease

(2014) Mark E. Gurney et al.   Neurotherapeutics

Select 3′,5′-cyclic nucleotide phosphodiesterases exhibit altered expression in the aged rodent brain

(2013) Michy P. Kelly et al.   CELLULAR SIGNALLING

Structural basis for the design of selective phosphodiesterase 4B inhibitors

(2013) David Fox et al.   CELLULAR SIGNALLING

PDE4 as a target for cognition enhancement

(2013) Wito Richter et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Object recognition test in mice

(2013) Marianne Leger et al.   Nature Protocols

Improvement of spatial memory function in APPswe/PS1dE9 mice after chronic inhibition of phosphodiesterase type 4D

(2013) A.S.R. Sierksma et al.   NEUROPHARMACOLOGY

Evidence for Global Reduction in Brain Cyclic Adenosine Monophosphate Signaling in Depression

(2012) James M. O'Donnell et al.   BIOLOGICAL PSYCHIATRY

RNA interference-mediated phosphodiesterase 4D splice variants knock-down in the prefrontal cortex produces antidepressant-like and cognition-enhancing effects

(2012) Zhen-Zhen Wang et al.   BRITISH JOURNAL OF PHARMACOLOGY

Phosphodiesterase-2 inhibitor reverses corticosterone-induced neurotoxicity and related behavioural changes via cGMP/PKG dependent pathway

(2012) Ying Xu et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Antidepressant-like effect of flaxseed secoisolariciresinol diglycoside in ovariectomized mice subjected to unpredictable chronic stress

(2012) Xing Ma et al.   METABOLIC BRAIN DISEASE

GEBR-7b, a novel PDE4D selective inhibitor that improves memory in rodents at non-emetic doses

(2011) O Bruno et al.   BRITISH JOURNAL OF PHARMACOLOGY

The phosphodiesterase-4 inhibitor rolipram reverses Aβ-induced cognitive impairment and neuroinflammatory and apoptotic responses in rats

(2011) Chuang Wang et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Phosphodiesterase-4D Knock-Out and RNA Interference-Mediated Knock-Down Enhance Memory and Increase Hippocampal Neurogenesis via Increased cAMP Signaling

(2011) Y.-F. Li et al.   JOURNAL OF NEUROSCIENCE

Enhanced long-term depression and impaired reversal learning in phosphodiesterase 4B-knockout (PDE4B−/−) mice

(2011) Kris Rutten et al.   NEUROPHARMACOLOGY

Synergistic interactions between PDE4B and GSK-3: DISC1 mutant mice

(2011) Tatiana V. Lipina et al.   NEUROPHARMACOLOGY

Corticosterone induced morphological changes of hippocampal and amygdaloid cell lines are dependent on 5-HT7 receptor related signal pathway

(2011) Y. Xu et al.   NEUROSCIENCE

The human area postrema and other nuclei related to the emetic reflex express cAMP phosphodiesterases 4B and 4D

(2010) F. Mori et al.   JOURNAL OF CHEMICAL NEUROANATOMY

Levels of phosphodiesterase 4A and 4B are altered by chronic treatment with psychotropic medications in rat frontal cortex

(2010) S. Hossein Fatemi et al.   SYNAPSE

Discovery of selective PDE4B inhibitors

(2009) Kenji Naganuma et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Cyclic AMP-Specific Phosphodiesterase-4 as a Target for the Development of Antidepressant Drugs

(2009) Han-Ting Zhang   CURRENT PHARMACEUTICAL DESIGN

Design of phosphodiesterase 4D (PDE4D) allosteric modulators for enhancing cognition with improved safety

(2009) Alex B Burgin et al.   NATURE BIOTECHNOLOGY

Antidepressant- and Anxiolytic-like Effects of the Phosphodiesterase-4 Inhibitor Rolipram on Behavior Depend on Cyclic AMP Response Element Binding Protein-Mediated Neurogenesis in the Hippocampus

(2009) Yun-Feng Li et al.   NEUROPSYCHOPHARMACOLOGY

Gene expression and association analyses of the phosphodiesterase 4B (PDE4B) gene in major depressive disorder in the Japanese population

(2008) Shusuke Numata et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS

PDE4B polymorphisms and decreased PDE4B expression are associated with schizophrenia

(2008) S. Hossein Fatemi et al.   SCHIZOPHRENIA RESEARCH