Further Insights in the Binding Mode of Selective Inhibitors to Human PDE4D Enzyme Combining Docking and Molecular Dynamics

Synthesis, biological activities and pharmacokinetic properties of new fluorinated derivatives of selective PDE4D inhibitors

(2015) Chiara Brullo et al.   BIOORGANIC & MEDICINAL CHEMISTRY

The upstream conserved regions (UCRs) mediate homo- and hetero-oligomerization of type 4 cyclic nucleotide phosphodiesterases (PDE4s)

(2014) Moses Xie et al.   BIOCHEMICAL JOURNAL

Multipose Binding in Molecular Docking

(2014) Kalina Atkovska et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Synthesis, Biological Evaluation, and Molecular Modeling of New 3-(Cyclopentyloxy)-4-methoxybenzaldehyde O-(2-(2,6-Dimethylmorpholino)-2-oxoethyl) Oxime (GEBR-7b) Related Phosphodiesterase 4D (PDE4D) Inhibitors

(2014) Chiara Brullo et al.   JOURNAL OF MEDICINAL CHEMISTRY

Phosphodiesterase-4 (PDE4) Molecular Pharmacology and Alzheimer’s Disease

(2014) Mark E. Gurney et al.   Neurotherapeutics

Structural basis for the design of selective phosphodiesterase 4B inhibitors

(2013) David Fox et al.   CELLULAR SIGNALLING

Homology Modeling, Docking Studies and Molecular Dynamic Simulations Using Graphical Processing Unit Architecture to Probe the Type-11 Phosphodiesterase Catalytic Site: A Computational Approach for the Rational Design of Selective Inhibitors

(2013) Elena Cichero et al.   Chemical Biology & Drug Design

Identification of Novel Phosphodiesterase-4D Inhibitors Prescreened by Molecular Dynamics-Augmented Modeling and Validated by Bioassay

(2013) Zhe Li et al.   Journal of Chemical Information and Modeling

Improvement of spatial memory function in APPswe/PS1dE9 mice after chronic inhibition of phosphodiesterase type 4D

(2013) A.S.R. Sierksma et al.   NEUROPHARMACOLOGY

Routine Microsecond Molecular Dynamics Simulations with AMBER on GPUs. 1. Generalized Born

(2012) Andreas W. Götz et al.   Journal of Chemical Theory and Computation

GEBR-7b, a novel PDE4D selective inhibitor that improves memory in rodents at non-emetic doses

(2011) O Bruno et al.   BRITISH JOURNAL OF PHARMACOLOGY

Synthesis and biological activity of pyrido[3′,2′:4,5]furo[3,2-d]pyrimidine derivatives as novel and potent phosphodiesterase type 4 inhibitors

(2011) Joan Taltavull et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

The discovery and synthesis of highly potent subtype selective phosphodiesterase 4D inhibitors

(2010) Renee Aspiotis et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility

(2009) Garrett M. Morris et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

New Selective Phosphodiesterase 4D Inhibitors Differently Acting on Long, Short, and Supershort Isoforms

(2009) Olga Bruno et al.   JOURNAL OF MEDICINAL CHEMISTRY

Design of phosphodiesterase 4D (PDE4D) allosteric modulators for enhancing cognition with improved safety

(2009) Alex B Burgin et al.   NATURE BIOTECHNOLOGY