Antidepressant-like effects of the phosphodiesterase-4 inhibitor etazolate and phosphodiesterase-5 inhibitor sildenafil via cyclic AMP or cyclic GMP signaling in mice

Sildenafil, a phosphodiesterase type 5 inhibitor, reduces antidepressant-like activity of paroxetine in the forced swim test in mice

(2014) Katarzyna Socała et al.   Pharmacological Reports

Phosphodiesterase-5 inhibitor sildenafil prevents neuroinflammation, lowers beta-amyloid levels and improves cognitive performance in APP/PS1 transgenic mice

(2013) Junfang Zhang et al.   BEHAVIOURAL BRAIN RESEARCH

Etazolate rescues behavioral deficits in chronic unpredictable mild stress model: Modulation of hypothalamic–pituitary–adrenal axis activity and brain-derived neurotrophic factor level

(2013) Ankur Jindal et al.   NEUROCHEMISTRY INTERNATIONAL

Etazolate, a phosphodiesterase 4 inhibitor reverses chronic unpredictable mild stress-induced depression-like behavior and brain oxidative damage

(2013) Ankur Jindal et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Implication of the VGF-derived peptide TLQP-21 in mouse acute and chronic stress responses

(2012) M. Razzoli et al.   BEHAVIOURAL BRAIN RESEARCH

EHT0202 in Alzheimers Disease: A 3-Month, Randomized, Placebo- Controlled, Double-Blind Study

(2012) B. Vellas et al.   Current Alzheimer Research

Antidepressant-like effect of etazolate, a cyclic nucleotide phosphodiesterase 4 inhibitor—an approach using rodent behavioral antidepressant tests battery

(2012) Ankur Jindal et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Chronic treatment with the phosphodiesterase type 5 inhibitors sildenafil and tadalafil display anxiolytic effects in Flinders Sensitive Line rats

(2012) Nico Liebenberg et al.   METABOLIC BRAIN DISEASE

cGMP Signaling, Phosphodiesterases and Major Depressive Disorder

(2011) Gillian W. Reierson et al.   Current Neuropharmacology

The phosphodiesterase-4 inhibitor rolipram reverses Aβ-induced cognitive impairment and neuroinflammatory and apoptotic responses in rats

(2011) Chuang Wang et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Hippocampal Neuronal Nitric Oxide Synthase Mediates the Stress-Related Depressive Behaviors of Glucocorticoids by Downregulating Glucocorticoid Receptor

(2011) Q.-G. Zhou et al.   JOURNAL OF NEUROSCIENCE

Antidepressant-like effect of sildenafil through oxytocin-dependent cyclic AMP response element-binding protein phosphorylation

(2011) H. Matsushita et al.   NEUROSCIENCE

Investigating the role of protein kinase-G in the antidepressant-like response of sildenafil in combination with muscarinic acetylcholine receptor antagonism

(2010) Nico Liebenberg et al.   BEHAVIOURAL BRAIN RESEARCH

The 5-HT7 receptor as a mediator and modulator of antidepressant-like behavior

(2010) Gor Sarkisyan et al.   BEHAVIOURAL BRAIN RESEARCH

Antidepressant-like properties of phosphodiesterase type 5 inhibitors and cholinergic dependency in a genetic rat model of depression

(2010) Nico Liebenberg et al.   BEHAVIOURAL PHARMACOLOGY

Etazolate improves performance in a foraging and homing task in aged rats

(2010) Jason Drott et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Involvement of NMDA receptors and l-arginine-nitric oxide-cyclic guanosine monophosphate pathway in the antidepressant-like effects of escitalopram in the forced swimming test

(2010) Andréa D.E. Zomkowski et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Cyclic AMP-Specific Phosphodiesterase-4 as a Target for the Development of Antidepressant Drugs

(2009) Han-Ting Zhang   CURRENT PHARMACEUTICAL DESIGN

Antidepressant- and Anxiolytic-like Effects of the Phosphodiesterase-4 Inhibitor Rolipram on Behavior Depend on Cyclic AMP Response Element Binding Protein-Mediated Neurogenesis in the Hippocampus

(2009) Yun-Feng Li et al.   NEUROPSYCHOPHARMACOLOGY

Antidepressant-like effect of folic acid: Involvement of NMDA receptors and l-arginine-nitric oxide-cyclic guanosine monophosphate pathway

(2008) Patrícia de Souza Brocardo et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Etazolate, a neuroprotective drug linking GABAAreceptor pharmacology to amyloid precursor protein processing

(2008) Maryline Marcade et al.   JOURNAL OF NEUROCHEMISTRY

Reversal of Oxidative Stress-Induced Anxiety by Inhibition of Phosphodiesterase-2 in Mice

(2008) A. Masood et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

The molecular neurobiology of depression

(2008) Vaishnav Krishnan et al.   NATURE

Involvement of l-arginine–nitric oxide–cyclic guanosine monophosphate pathway in the antidepressant-like effect of tramadol in the rat forced swimming test

(2008) Cristiano R. Jesse et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

The link between childhood trauma and depression: Insights from HPA axis studies in humans

(2008) Christine Heim et al.   PSYCHONEUROENDOCRINOLOGY

Nitric oxide involvement in the antidepressant-like effects of acute lithium administration in the mouse forced swimming test

(2007) Mehdi Ghasemi et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Diphenyl diselenide exerts antidepressant-like and anxiolytic-like effects in mice: Involvement of l-arginine-nitric oxide-soluble guanylate cyclase pathway in its antidepressant-like action

(2007) L SAVEGNAGO et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR