Article
Gastroenterology & Hepatology
Dewei Ye, Jianyu Yao, Wenfa Du, Cuishan Chen, Yong Yang, Kaixuan Yan, Jufei Li, Ying Xu, Shufei Zang, Yuying Zhang, Xianglu Rong, Rongxin Zhang, Aimin Xu, Jiao Guo
Summary: The miR-223/NE axis was found to be a key regulator of NETs in acute liver failure (ALF), exacerbating oxidative stress and neutrophilic inflammation, and potentiating hepatocellular damage and liver necrosis during ALF development.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Environmental Sciences
Yanjun Wu, Hongmei Huang, Jiayun Wu, Yiru Qin, Na Zhao, Baowei Chen, Qiying Nong, Yongshun Huang, Ligang Hu
Summary: This study investigates the mechanism of lead-induced myocardial injury and finds that neutrophil degranulation plays a significant role in this process. The findings suggest that lead exposure can initiate early myocardial injury by promoting neutrophil degranulation.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Biochemistry & Molecular Biology
Xinlei Sun, Fujie Shi, Weiran Wang, Yunfei Wu, Shuang Qu, Jing Li, Hongwei Liang, Ke Zen
Summary: Infiltration of polymorphonuclear neutrophils (PMNs) is critical in acute lung injury (ALI). This study reveals that pyruvate kinase type M2 (PKM2) plays a crucial role in PMN inflammatory responses, and deletion of PKM2 in PMNs impairs their function but protects against LPS-induced ALI.
Article
Critical Care Medicine
Katharine M. Lodge, Arlette Vassallo, Bin Liu, Merete Long, Zhen Tong, Paul R. Newby, Danya Agha-Jaffar, Koralia Paschalaki, Clara E. Green, Kylie B. R. Belchamber, Victoria C. Ridger, Robert A. Stockley, Elizabeth Sapey, Charlotte Summers, Andrew S. Cowburn, Edwin R. Chilvers, Wei Li, Alison M. Condliffe
Summary: Patients with chronic obstructive pulmonary disease (COPD) have a high incidence and mortality rate of cardiovascular diseases, and exacerbations further increase the risk. Hypoxia drives the release of neutrophil elastase, leading to tissue injury. This study found that under hypoxic conditions, COPD neutrophils release more elastase and cause damage to pulmonary endothelial cells, as well as increased adherence to endothelial cells. Plasma from COPD patients also showed higher levels of hypoxia-upregulated neutrophil-derived proteins and protease activity, indicating vascular injury.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Chia-Lun Liu, Yang-Hong Dai
Summary: This study compared the gene expression differences between non-chylomicronemia syndrome (CS)-associated acute pancreatitis (AP) and CS-associated AP, and found different gene expression patterns as well as lower estimated neutrophil infiltration in CS-associated AP.
Review
Biochemistry & Molecular Biology
Salma A. Rizo-Tellez, Meriem Sekheri, Janos G. Filep
Summary: This article explores the multifaceted roles of the neutrophil protein MPO in immunity, focusing on its impact on host defense, tissue damage, repair, and autoimmunity. Novel therapeutic approaches targeting MPO activity, expression, or signaling for the treatment of inflammatory and autoimmune diseases are also discussed.
Article
Oncology
Javed Akhtar, Vaishali Jain, Radhika Kansal, Ratna Priya, Puja Sakhuja, Surbhi Goyal, Anil Kumar Agarwal, Vivek Ghose, Ravindra Varma Polisetty, Ravi Sirdeshmukh, Sudeshna Kar, Poonam Gautam
Summary: In this study, a quantitative proteomic analysis was performed to identify proteins associated with early stage gallbladder cancer. The results showed differential expression of proteins involved in neutrophil degranulation and extracellular matrix degradation, suggesting their importance in the development of early stage gallbladder cancer. Additionally, certain proteins were identified as potential circulatory markers for early detection of gallbladder cancer.
FRONTIERS IN ONCOLOGY
(2023)
Article
Medicine, General & Internal
Salti Talal, Khoury Mona, Awad Karem, Lerenthal Yaniv, Harari-Misgav Reut, Shemesh Ariel, Avraham-Kelbert Moran, Eitam Harel, Salvatore Campisi-Pinto, Abu-Amna Mahmoud, Colodner Raul, Tovbin David, Bar-Sela Gil, Cohen Idan
Summary: In this study, it was found that patients undergoing hemodialysis have impaired neutrophil functionality, leading to increased susceptibility to infections. Targeting NETosis may reduce the occurrence and mortality rate of infections in these patients.
Article
Immunology
Dylan A. McCreedy, Clare L. Abram, Yongmei Hu, Sun Won Min, Madison E. Platt, Megan A. Kirchhoff, Shelby K. Reid, Frank L. Jalufka, Clifford A. Lowell
Summary: The deficiency of Syk in neutrophils can improve long-term functional recovery after spinal cord injury, but does not promote long-term white matter sparing. Syk has an impact on neutrophil activation, cytokine expression, and cell death in the acutely injured spinal cord.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Immunology
Xiaoling Qiang, Jianhua Li, Shu Zhu, Mingzhu He, Weiqiang Chen, Yousef Al-Abed, Max Brenner, Kevin J. Tracey, Ping Wang, Haichao Wang
Summary: The study suggests that DCD and its analog have protective effects in hepatic ischemia-reperfusion injury, possibly by attenuating inflammation through impairing the EGFR signaling pathway.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Marta Martin-Fernandez, Alvaro Tamayo-Velasco, Rocio Aller, Hugo Gonzalo-Benito, Pedro Martinez-Paz, Eduardo Tamayo
Summary: Sepsis is a major global health problem with a high mortality rate. Early diagnosis is crucial for reducing the mortality rate. Endothelial dysfunction and neutrophil dysregulation play important roles in the pathophysiology of sepsis, and the use of biomarkers may provide a fast and accurate diagnostic tool. New biomarkers and treatments related to endothelial dysfunction and neutrophil dysregulation should be further researched to improve the diagnosis, treatment, and prognosis of sepsis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Joanna Wessely-Szponder, Joanna Zdziennicka, Andrzej Junkuszew, Michal Latalski, Michal Swieca, Tomasz Szponder
Summary: This review outlines the functions, clinical applications, and future hopes associated with using autologous or heterologous products obtained from circulating neutrophils in regenerative medicine. It also describes the interactions between neutrophils and platelets.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Renuka Bankar, Kruthi Suvarna, Saicharan Ghantasala, Arghya Banerjee, Deeptarup Biswas, Manisha Choudhury, Viswanthram Palanivel, Akanksha Salkar, Ayushi Verma, Avinash Singh, Amrita Mukherjee, Medha Gayathri J. Pai, Jyotirmoy Roy, Alisha Srivastava, Apoorva Badaya, Sachee Agrawal, Om Shrivastav, Jayanthi Shastri, Sanjeeva Srivastava
Summary: This study conducted a comprehensive proteomics-based investigation of nasopharyngeal swab samples from patients with COVID-19, identifying some host proteins that were upregulated in COVID-19-positive patients, and important pathways that provide detailed insights into the host response in COVID-19 infection. Additionally, the docking of potential drugs with host proteins involved in the interleukin-12 signaling pathway may aid in COVID-19 therapeutic interventions.
Article
Chemistry, Multidisciplinary
Xiaoyu Ding, Xiaowen Xing, Jianfeng Liu, Pengchong Zhu, Cui Wang, Rui Bai, Bo Kong, Chuyang Zeng, Wei Zhang, Yin Yue, Haitao Zhang, Jiajia Xiang, Zengqiang Yuan, Zhiqiang Liu
Summary: This study designs a microreticular nanosystem inspired by the cobweb that adheres to tissue and is responsive to multiple stimuli in the ischaemic microenvironment. It is fabricated from hyaluronic acid (HA), ROS-responsive B-PDEA, and hypoxia-sensitive VEGF-expressing plasmids (EPODNA). The nanosystem sequentially responds to various stimuli, and in vitro and in vivo evaluations indicate its potential for tissue repair after complex damage.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Review
Cell Biology
Nan Zhang, Xiahenazi Aiyasiding, Wen-jing Li, Hai-han Liao, Qi-zhu Tang
Summary: Myocardial infarction is a common and life-threatening cardiac emergency. Neutrophils, through the release of granule proteins, play an important role in the inflammation and immune response associated with myocardial infarction.
CELL COMMUNICATION AND SIGNALING
(2022)
Article
Multidisciplinary Sciences
Bo Meng, Adam Abdullahi, Isabella A. T. M. Ferreira, Niluka Goonawardane, Akatsuki Saito, Izumi Kimura, Daichi Yamasoba, Pehuen Pereyra Gerber, Saman Fatihi, Surabhi Rathore, Samantha K. Zepeda, Guido Papa, Steven A. Kemp, Terumasa Ikeda, Mako Toyoda, Toong Seng Tan, Jin Kuramochi, Shigeki Mitsunaga, Takamasa Ueno, Kotaro Shirakawa, Akifumi Takaori-Kondo, Teresa Brevini, Donna L. Mallery, Oscar J. Charles, John E. Bowen, Anshu Joshi, Alexandra C. Walls, Laurelle Jackson, Darren Martin, Kenneth G. C. Smith, John Bradley, John A. G. Briggs, Jinwook Choi, Elo Madissoon, Kerstin B. Meyer, Petra Mlcochova, Lourdes Ceron-Gutierrez, Rainer Doffinger, Sarah A. Teichmann, Andrew J. Fisher, Matteo S. Pizzuto, Anna de Marco, Davide Corti, Myra Hosmillo, Joo Hyeon Lee, Leo C. James, Lipi Thukral, David Veesler, Alex Sigal, Fotios Sampaziotis, Ian G. Goodfellow, Nicholas J. Matheson, Kei Sato, Ravindra K. Gupta
Summary: The Omicron variant of SARS-CoV-2 has a higher affinity for ACE2 and can evade neutralizing antibodies more effectively compared to the Delta variant. A third dose of mRNA vaccine can provide enhanced protection. Omicron has lower replication in lung and gut cells and less efficiently cleaves its spike protein compared to Delta.
Article
Transplantation
Michael K. Sullivan, Jennifer S. Lees, Thomas M. Drake, Annemarie B. Docherty, Georgia Oates, Hayley E. Hardwick, Clark D. Russell, Laura Merson, Jake Dunning, Jonathan S. Nguyen-Van-Tam, Peter Openshaw, Ewen M. Harrison, J. Kenneth Baillie, Malcolm G. Semple, Antonia Ho, Patrick B. Mark
Summary: This study investigated the occurrence of acute kidney injury (AKI) in hospitalized COVID-19 patients and found that AKI was common and associated with an increased risk of mortality. Chronic kidney disease, male sex, and Black race were identified as main risk factors for AKI and acute kidney replacement therapy.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2022)
Article
Health Care Sciences & Services
Matt J. Keeling, Louise Dyson, Glen Guyver-Fletcher, Alex Holmes, Malcolm G. Semple, Michael J. Tildesley, Edward M. Hill
Summary: The researchers analyzed and predicted the COVID-19 pandemic using mathematical models and epidemiological data. They found that the effective reproduction number, R, is crucial for understanding the control of the epidemic. However, assimilating information from multiple changing data sources is a major challenge due to the nature of epidemiological data not being designed for modeling.
STATISTICAL METHODS IN MEDICAL RESEARCH
(2022)
Article
Multidisciplinary Sciences
Maryam Khan, Carolina Rosadas, Ksenia Katsanovskaja, Isaac D. Weber, Justin Shute, Samreen Ijaz, Federica Marchesin, Eleanor McClure, Salem Elias, Barnaby Flower, He Gao, Rachael Quinlan, Charlotte Short, Annachiara Rosa, Chloe Roustan, Maya Moshe, Graham P. Taylor, Paul Elliott, Graham S. Cooke, Peter Cherepanov, Eleanor Parker, Myra O. McClure, Richard S. Tedder
Summary: At-home self-sampling using dried blood spot (DBS) is crucial for large scale seroprevalence studies, providing a highly sensitive and specific antibody assay with a strong correlation to serum reactivities. DBS self-sampling offers sensitivity comparable to serum and can be used in seroprevalence studies and post-vaccine response monitoring.
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
David M. Maslove, Benjamin Tang, Manu Shankar-Hari, Patrick R. Lawler, Derek C. Angus, J. Kenneth Baillie, Rebecca M. Baron, Michael Bauer, Timothy G. Buchman, Carolyn S. Calfee, Claudia C. dos Santos, Evangelos J. Giamarellos-Bourboulis, Anthony C. Gordon, John A. Kellum, Julian C. Knight, Aleksandra Leligdowicz, Daniel F. McAuley, Anthony S. McLean, David K. Menon, Nuala J. Meyer, Lyle L. Moldawer, Kiran Reddy, John P. Reilly, James A. Russell, Jonathan E. Sevransky, Christopher W. Seymour, Nathan I. Shapiro, Mervyn Singer, Charlotte Summers, Timothy E. Sweeney, B. Taylor Thompson, Tom van der Poll, Balasubramanian Venkatesh, Keith R. Walley, Timothy S. Walsh, Lorraine B. Ware, Hector R. Wong, Zsolt E. Zador, John C. Marshall
Summary: The authors propose a new conceptual model of critical illness that moves away from the current syndrome-based framework and focuses on more precise biological descriptors. They discuss the need to reconsider the current approach based on syndromes and instead emphasize the underlying biological changes that underpin critical illness states. By doing so, they believe it will lead to a better understanding of the pathobiology of critical illness and improved patient outcomes.
Article
Cell Biology
Bo Meng, Rawlings Datir, Jinwook Choi, John R. Bradley, Kenneth G. C. Smith, Joo Hyeon Lee, Ravindra K. Gupta
Summary: The N-terminal domain (NTD) of the spike protein in the Delta variant of SARS-CoV-2 increases the virus's infectivity and cell-to-cell fusion. However, the combination of NTD from the Omicron BA.1 and BA.2 variants does not show enhanced effects. This suggests that the NTD modulates the spike protein's functions in a context-dependent manner.
Article
Multidisciplinary Sciences
Esteban Garcia-Gallo, Laura Merson, Kalynn Kennon, Sadie Kelly, Barbara Wanjiru Citarella, Daniel Vidali Fryer, Sally Shrapnel, James Lee, Sara Duque, Yuli V. Fuentes, Valeria Balan, Sue Smith, Jia Wei, Bronner P. Goncalves, Clark D. Russell, Louise Sigfrid, Andrew Dagens, Piero L. Olliaro, Joaquin Baruch, Christiana Kartsonaki, Jake Dunning, Amanda Rojek, Aasiyah Rashan, Abi Beane, Srinivas Murthy, Luis Felipe Reyes
Summary: The ISARIC COVID-19 dataset is one of the largest international databases of clinical data on hospitalized COVID-19 patients. It includes data from hospitals worldwide and provides comprehensive information on patient characteristics and treatments.
Article
Respiratory System
Jatin Patel, Damon Bass, Albertus Beishuizen, Xavier Bocca Ruiz, Hatem Boughanmi, Anthony Cahn, Hugo Colombo, Gerard J. Criner, Katherine Davy, Javier de-Miguel-Diez, Pablo A. Doreski, Sofia Fernandes, Bruno Francois, Anubha Gupta, Kate Hanrott, Timothy Hatlen, Dave Inman, John D. Isaacs, Emily Jarvis, Natalia Kostina, Tatiana Kropotina, Jean-Claude Lacherade, Divya Lakshminarayanan, Pedro Martinez-Ayala, Charlen McEvoy, Ferhat Meziani, Mehran Monchi, Sumanta Mukherjee, Rosana Munoz-Bermudez, Jessica Neisen, Ciara O'Shea, Gaetan Plantefeve, Lorrie Schifano, Lee E. Schwab, Zainab Shahid, Michinori Shirano, Julia E. Smith, Eduardo Sprinz, Charlotte Summers, Nicolas Terzi, Mark A. Tidswell, Yuliya Trefilova, Russell Williamson, Duncan Wyncoll, Mark Layton
Summary: Treatment with anti-interleukin-6 did not significantly reduce mortality or respiratory failure in COVID-19 patients, but showed a reduction in inflammatory markers and had an acceptable safety profile.
EUROPEAN RESPIRATORY JOURNAL
(2023)
Review
Immunology
Emily Naish, Alexander J. T. Wood, Andrew P. Stewart, Matthew Routledge, Andrew Conway Morris, Edwin R. Chilvers, Katharine M. Lodge
Summary: Neutrophils, the most abundant circulating leukocytes, play a crucial role in the initial innate immune response to infection. They eliminate pathogens through phagocytosis and a complex interplay of multiple systems and mechanisms within the phagosome creates an antimicrobial environment. However, gaps in knowledge and controversies exist regarding how neutrophil phagosomes optimize pathogen killing.
IMMUNOLOGICAL REVIEWS
(2023)
Article
Medicine, General & Internal
Fergus W. Hamilton, Matt J. Thomas, David Arnold, Tom Palmer, Ed Moran, Alexander J. Mentzer, Nick Maskell, Kenneth M. Baillie, Charlotte Summers, Aroon Hingorani, Alasdair MacGowan, Golam M. J. Khandaker, Ruth Mitchell, George Davey Smith, Peter Ghazal, Nicholas J. Timpson
Summary: IL6R blockade is associated with a decreased risk of sepsis and improved survival, similar to its effect in severe COVID-19. Randomized controlled trials of IL-6 receptor antagonists in sepsis should be considered.
Article
Biochemistry & Molecular Biology
Varsha Ramineni, Philip Millroth, Lalitha Iyadurai, Thomas Jaki, Jonathan Kingslake, Julie Highfield, Charlotte Summers, Michael B. Bonsall, Emily A. Holmes
Summary: ICU staff who have experienced work-related traumatic events during the COVID-19 pandemic often suffer from intrusive memories (IMs). In this study, a novel behavioral intervention was developed to reduce the number of IMs for ICU staff experiencing post-traumatic symptoms. Using Bayesian statistical approaches, a digitized version of the intervention was evaluated for remote delivery and showed a significant positive treatment effect in reducing IMs.
MOLECULAR PSYCHIATRY
(2023)
Article
Respiratory System
Rohit Saha, Tai Pham, Pratik Sinha, Manoj Maddali, Giacomo Bellani, Eddy Fan, Charlotte Summers, Abdel Douiri, Gordon D. Rubenfeld, Carolyn S. Calfee, John Gerard Laffey, Daniel Francis McAuley, Manu Shankar-Hari, LUNG SAFE Investigators
Summary: This study estimated the mortality rate of acute respiratory distress syndrome (ARDS) using a case-control matching method and analyzed it in different patient subgroups. The results showed that there were variations in the mortality rate of ARDS among different subgroups. Depending on the severity of hypoxemia, the number of lung quadrants involved, and the inflammatory phenotype, the mortality rate of ARDS ranged from 20.9% to 38.0%.
Article
Psychiatry
Lalitha Iyadurai, Julie Highfield, Marie Kanstrup, Alfred Markham, Varsha Ramineni, Boliang Guo, Thomas Jaki, Jonathan Kingslake, Guy M. Goodwin, Charlotte Summers, Michael B. Bonsall, Emily A. Holmes
Summary: We evaluated the impact of a brief remotely-delivered digital imagery-competing task intervention on reducing intrusive memories and improving mental health and functioning for ICU staff during the COVID-19 pandemic.
TRANSLATIONAL PSYCHIATRY
(2023)
Correction
Multidisciplinary Sciences
Steven A. Kemp, Dami A. Collier, Rawlings P. Datir, Isabella A. T. M. Ferreira, Salma Gayed, Aminu Jahun, Chloe Rees-Spear, Petra Mlcochova, Ines Ushiro Lumb, David J. Roberts, Anita Chandra, Nigel Temperton, Katherine Sharrocks, Elizabeth Blane, Yorgo Modis, Kendra E. Leigh, John A. G. Briggs, Marit J. van Gils, Kenneth G. C. Smith, John R. Bradley, Chris Smith, Rainer Doffinger, Lourdes Ceron-Gutierrez, Gabriela Barcenas-Morales, David D. Pollock, Richard A. Goldstein, Anna Smielewska, Jordan P. Skittrall, Theodore Gouliouris, Ian G. Goodfellow, Effrossyni Gkrania-Klotsas, Christopher J. R. Illingworth, Laura E. Mccoy, Ravindra K. Gupta