IRF-5-Mediated Inflammation Limits CD8+ T Cell Expansion by Inducing HIF-1α and Impairing Dendritic Cell Functions during Leishmania Infection

Bystander Chronic Infection Negatively Impacts Development of CD8+ T Cell Memory

(2014) Erietta Stelekati et al.   IMMUNITY

PD-L1 is a novel direct target of HIF-1α, and its blockade under hypoxia enhanced MDSC-mediated T cell activation

(2014) Muhammad Zaeem Noman et al.   JOURNAL OF EXPERIMENTAL MEDICINE

LeishmaniaPromastigotes Induce Cytokine Secretion in Macrophages through the Degradation of Synaptotagmin XI

(2014) Guillermo Arango Duque et al.   JOURNAL OF IMMUNOLOGY

Functional polarization of tumour-associated macrophages by tumour-derived lactic acid

(2014) Oscar R. Colegio et al.   NATURE

Forward Genetic Screening Identifies a Small Molecule That Blocks Toxoplasma gondii Growth by Inhibiting Both Host- and Parasite-Encoded Kinases

(2014) Kevin M. Brown et al.   PLoS Pathogens

HIF-1  is a negative regulator of plasmacytoid DC development in vitro and in vivo

(2012) A. Weigert et al.   BLOOD

Influence of hypoxia-inducible factor 1α on dendritic cell differentiation and migration

(2012) Theresa Köhler et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Pathogen-Specific Inflammatory Milieux Tune the Antigen Sensitivity of CD8+ T Cells by Enhancing T Cell Receptor Signaling

(2012) Martin J. Richer et al.   IMMUNITY

Marginal Zone B Cells Regulate Antigen-Specific T Cell Responses during Infection

(2012) R. Bankoti et al.   JOURNAL OF IMMUNOLOGY

Low Oxygen Tension Enhances Hepatitis C Virus Replication

(2012) N. Vassilaki et al.   JOURNAL OF VIROLOGY

Intracellular Pathogen Leishmania donovani Activates Hypoxia Inducible Factor-1 by Dual Mechanism for Survival Advantage within Macrophage

(2012) Amit Kumar Singh et al.   PLoS One

Hypoxia-inducible factor 1 transcriptional activity in endothelial cells is required for acute phase cardioprotection induced by ischemic preconditioning

(2012) K. Sarkar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Kaposi's Sarcoma-Associated Herpesvirus Latency-Associated Nuclear Antigen Induction by Hypoxia and Hypoxia-Inducible Factors

(2011) R. P. Veeranna et al.   JOURNAL OF VIROLOGY

Hypoxia Induces the Gene Expression and Extracellular Transmission of Persistent Lymphocytic Choriomeningitis Virus

(2011) J. Tomaskova et al.   JOURNAL OF VIROLOGY

The Influence of Low Oxygen on Macrophage Response to Leishmania Infection

(2011) A. Degrossoli et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

Critical Role of IRF-5 in the Development of T helper 1 responses to Leishmania donovani infection

(2011) Andrea Paun et al.   PLoS Pathogens

Macrophage Expression of Hypoxia-Inducible Factor-1  Suppresses T-Cell Function and Promotes Tumor Progression

(2010) A. L. Doedens et al.   CANCER RESEARCH

Inflammatory cytokines as a third signal for T cell activation

(2010) Julie M Curtsinger et al.   CURRENT OPINION IN IMMUNOLOGY

The mTOR Kinase Determines Effector versus Memory CD8 + T Cell Fate by Regulating the Expression of Transcription Factors T-bet and Eomesodermin

(2010) Rajesh R. Rao et al.   IMMUNITY

HIF-1α regulates function and differentiation of myeloid-derived suppressor cells in the tumor microenvironment

(2010) Cesar A. Corzo et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Effects of TLR Agonists on the Hypoxia-Regulated Transcription Factor HIF-1α and Dendritic Cell Maturation under Normoxic Conditions

(2010) Rolf Spirig et al.   PLoS One

Differential Regulation of Effector- and Central-Memory Responses to Toxoplasma gondii Infection by IL-12 Revealed by Tracking of Tgd057-Specific CD8+ T Cells

(2010) Douglas C. Wilson et al.   PLoS Pathogens

Programming for CD8 T Cell Memory Development Requires IL-12 or Type I IFN

(2009) Z. Xiao et al.   JOURNAL OF IMMUNOLOGY

Regulation of Oxygen Homeostasis by Hypoxia-Inducible Factor 1

(2009) Gregg L. Semenza   PHYSIOLOGY

A human IL10 BAC transgene reveals tissue-specific control of IL-10 expression and alters disease outcome

(2009) D. Ranatunga et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

B7-H1 Blockade Increases Survival of Dysfunctional CD8+ T Cells and Confers Protection against Leishmania donovani Infections

(2009) Trupti Joshi et al.   PLoS Pathogens

Divergent effects of hypoxia on dendritic cell functions

(2008) A. Mancino et al.   BLOOD

Hypoxia controls CD4+CD25+ regulatory T-cell homeostasis via hypoxia-inducible factor-1α

(2008) Jeremy Ben-Shoshan et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Adenosine A2A receptor activation inhibits T helper 1 and T helper 2 cell development and effector function

(2008) Balázs Csóka et al.   FASEB JOURNAL

Posttranscriptional Regulation of Il10 Gene Expression Allows Natural Killer Cells to Express Immunoregulatory Function

(2008) Asher Maroof et al.   IMMUNITY

Role of HIF-1 and NF-κB Transcription Factors in the Modulation of Transferrin Receptor by Inflammatory and Anti-inflammatory Signals

(2008) Lorenza Tacchini et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NF-κB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1α

(2008) Jordi Rius et al.   NATURE

Adenosine receptors: therapeutic aspects for inflammatory and immune diseases

(2008) György Haskó et al.   NATURE REVIEWS DRUG DISCOVERY

In Vivo Imaging Reveals an Essential Role for Neutrophils in Leishmaniasis Transmitted by Sand Flies

(2008) N. C. Peters et al.   SCIENCE

Regulation of cancer cell metabolism by hypoxia-inducible factor 1

(2008) Gregg L. Semenza   SEMINARS IN CANCER BIOLOGY