Hypoxia Induces Macrophage tnfa Expression via Cyclooxygenase and Prostaglandin E2 in vivo

15-keto-prostaglandin E2 activates host peroxisome proliferator-activated receptor gamma (PPAR-γ) to promote Cryptococcus neoformans growth during infection

(2019) Robert J. Evans et al.   PLoS Pathogens

Targeting the 15-keto-PGE2-PTGR2 axis modulates systemic inflammation and survival in experimental sepsis

(2018) Ing-Jung Chen et al.   FREE RADICAL BIOLOGY AND MEDICINE

PGE2 production at sites of tissue injury promotes an anti-inflammatory neutrophil phenotype and determines the outcome of inflammation resolution in vivo

(2018) Catherine A. Loynes et al.   Science Advances

Hif-1α–Induced Expression of Il-1β Protects against Mycobacterial Infection in Zebrafish

(2018) Nikolay V. Ogryzko et al.   JOURNAL OF IMMUNOLOGY

Stabilization of HIF-1α by FG-4592 promotes functional recovery and neural protection in experimental spinal cord injury

(2016) Kai Wu et al.   BRAIN RESEARCH

Polarization of immune responses in fish: The ‘macrophages first’ point of view

(2016) Geert F. Wiegertjes et al.   MOLECULAR IMMUNOLOGY

BLT1 signalling protects the liver against acetaminophen hepatotoxicity by preventing excessive accumulation of hepatic neutrophils

(2016) Ken Kojo et al.   Scientific Reports

Cryptococcus neoformans Intracellular Proliferation and Capsule Size Determines Early Macrophage Control of Infection

(2016) Aleksandra Bojarczuk et al.   Scientific Reports

Epigenetic control of intestinal barrier function and inflammation in zebrafish

(2015) Lindsay Marjoram et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Immunometabolism within the tuberculosis granuloma: amino acids, hypoxia, and cellular respiration

(2015) Joseph E. Qualls et al.   Seminars in Immunopathology

Protection and pathology in TB: learning from the zebrafish model

(2015) Annemarie H. Meijer   Seminars in Immunopathology

COX2 is involved in hypoxia-induced TNF-α expression in osteoblast

(2015) Yonggang Xing et al.   Scientific Reports

Identification of polarized macrophage subsets in zebrafish

(2015) Mai Nguyen-Chi et al.   eLife

Macrophage Polarization in Bacterial Infections

(2014) M. Benoit et al.   JOURNAL OF IMMUNOLOGY

Mycobacteria Counteract a TLR-Mediated Nitrosative Defense Mechanism in a Zebrafish Infection Model

(2014) Philip M. Elks et al.   PLoS One

Macrophage arginase-1 controls bacterial growth and pathology in hypoxic tuberculosis granulomas

(2014) M. A. Duque-Correa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular Mechanisms That Influence the Macrophage M1–M2 Polarization Balance

(2014) Nan Wang et al.   Frontiers in Immunology

Functional analysis of a zebrafish myd88 mutant identifies key transcriptional components of the innate immune system

(2013) M. van der Vaart et al.   Disease Models & Mechanisms

Tumor Necrosis Factor Alpha-Induced Hypoxia-Inducible Factor 1 - -Catenin Axis Regulates Major Histocompatibility Complex Class I Gene Activation through Chromatin Remodeling

(2013) S. Ghosh et al.   MOLECULAR AND CELLULAR BIOLOGY

Hypoxia Inducible Factor Signaling Modulates Susceptibility to Mycobacterial Infection via a Nitric Oxide Dependent Mechanism

(2013) Philip M. Elks et al.   PLoS Pathogens

The Immunobiology of Prostanoid Receptor Signaling in Connecting Innate and Adaptive Immunity

(2013) Hedi Harizi   Biomed Research International

Endothelial cells provide an instructive niche for the differentiation and functional polarization of M2-like macrophages

(2012) H. He et al.   BLOOD

Host Genotype-Specific Therapies Can Optimize the Inflammatory Response to Mycobacterial Infections

(2012) David M. Tobin et al.   CELL

Live Imaging of Tumor Initiation in Zebrafish Larvae Reveals a Trophic Role for Leukocyte-Derived PGE2

(2012) Yi Feng et al.   CURRENT BIOLOGY

Macrophage plasticity and polarization in tissue repair and remodelling

(2012) Alberto Mantovani et al.   JOURNAL OF PATHOLOGY

Mycobacterial signaling through toll-like receptors

(2012) Joyoti Basu et al.   Frontiers in Cellular and Infection Microbiology

Activation of hypoxia-inducible factor-1  (Hif-1 ) delays inflammation resolution by reducing neutrophil apoptosis and reverse migration in a zebrafish inflammation model

(2011) P. M. Elks et al.   BLOOD

Zebrafish embryo screen for mycobacterial genes involved in the initiation of granuloma formation reveals a newly identified ESX-1 component

(2011) E. J. M. Stoop et al.   Disease Models & Mechanisms

The cardinal role of the phospholipase A2/cyclooxygenase-2/prostaglandin E synthase/prostaglandin E2 (PCPP) axis in inflammostasis

(2011) A. D. Mancini et al.   INFLAMMATION RESEARCH

Involvement of COX-2/PGE2 signalling in hypoxia-induced angiogenic response in endothelial cells

(2011) Lixing Zhao et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Regulation of Immune Responses by Prostaglandin E2

(2011) P. Kalinski   JOURNAL OF IMMUNOLOGY

Specificity of eicosanoid production depends on the TLR-4-stimulated macrophage phenotype

(2011) Paul C. Norris et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Pharmacological Characterization of 1-(5-Chloro-6-(trifluoromethoxy)-1H-benzoimidazol-2-yl)-1H-pyrazole-4-carboxylic Acid (JNJ-42041935), a Potent and Selective Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitor

(2011) T. D. Barrett et al.   MOLECULAR PHARMACOLOGY

Staphylococcal enterotoxin A induction of pro-inflammatory cytokines and lethality in mice is primarily dependent on MyD88

(2010) Teri L. Kissner et al.   IMMUNOLOGY

An Integrated Model of Eicosanoid Metabolism and Signaling Based on Lipidomics Flux Analysis

(2009) Shakti Gupta et al.   BIOPHYSICAL JOURNAL

Hypoxia activates the cyclooxygenase-2–prostaglandin E synthase axis

(2009) James J. Lee et al.   CARCINOGENESIS

The COX-2/PGE2 pathway: key roles in the hallmarks of cancer and adaptation to the tumour microenvironment

(2009) A. Greenhough et al.   CARCINOGENESIS

Pivotal Advance: Pharmacological manipulation of inflammation resolution during spontaneously resolving tissue neutrophilia in the zebrafish

(2009) Catherine A. Loynes et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Specificity of the zebrafish host transcriptome response to acute and chronic mycobacterial infection and the role of innate and adaptive immune components

(2009) Astrid M. van der Sar et al.   MOLECULAR IMMUNOLOGY